Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Inoue A |
Year: |
2007 |
Journal: |
Cell Cycle |
Title: |
Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation. |
Volume: |
6 |
Issue: |
13 |
Pages: |
1646-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Inoue A |
Year: |
2011 |
Journal: |
Exp Cell Res |
Title: |
Mammalian ChlR1 has a role in heterochromatin organization. |
Volume: |
317 |
Issue: |
17 |
Pages: |
2522-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cota CD |
Year: |
2012 |
Journal: |
Dev Dyn |
Title: |
The ENU-induced cetus mutation reveals an essential role of the DNA helicase DDX11 for mesoderm development during early mouse embryogenesis. |
Volume: |
241 |
Issue: |
8 |
Pages: |
1249-59 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5470546 |
Assay Type: |
RNA in situ |
Annotation Date: |
2013-03-29 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:3568928 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5470555 |
Age: |
embryonic day 8.5 |
Image: |
9A |
|
Specimen Label: |
9A |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2459864 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-05-29 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271122 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:7643320 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
Supplementary table 2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5470546 |
Assay Type: |
RNA in situ |
Annotation Date: |
2013-03-29 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603915 |
Pattern: |
Widespread |
Stage: |
TS15 |
Assay Id: |
MGI:5470555 |
Age: |
embryonic day 9.5 |
Image: |
9B |
|
Specimen Label: |
9B |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5470546 |
Assay Type: |
RNA in situ |
Annotation Date: |
2013-03-29 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603913 |
Pattern: |
Widespread |
Stage: |
TS13 |
Assay Id: |
MGI:5470555 |
Age: |
embryonic day 8.5 |
Image: |
9A |
|
Specimen Label: |
9A |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5470546 |
Assay Type: |
RNA in situ |
Annotation Date: |
2013-03-29 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603915 |
Pattern: |
Widespread |
Stage: |
TS15 |
Assay Id: |
MGI:5470555 |
Age: |
embryonic day 9.5 |
Image: |
9D |
|
Specimen Label: |
9D |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5470546 |
Assay Type: |
RNA in situ |
Annotation Date: |
2013-03-29 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1608613 |
Pattern: |
Regionally restricted |
Stage: |
TS13 |
Assay Id: |
MGI:5470555 |
Age: |
embryonic day 8.5 |
Image: |
9C |
Note: |
Expression was detected in the visceral endoderm layer of the yolk sac. |
Specimen Label: |
9C |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5470546 |
Assay Type: |
RNA in situ |
Annotation Date: |
2013-03-29 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610713 |
Pattern: |
Not Specified |
Stage: |
TS13 |
Assay Id: |
MGI:5470555 |
Age: |
embryonic day 8.5 |
Image: |
9A |
|
Specimen Label: |
9A |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2459864 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-05-29 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754722 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:7643320 |
Age: |
embryonic day 14.5 |
|
Note: |
Ventricular zone expression was greater than in the cortical plate. |
Specimen Label: |
Supplementary table 2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
GarcÃa-GarcÃa MJ |
Year: |
2005 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Analysis of mouse embryonic patterning and morphogenesis by forward genetics. |
Volume: |
102 |
Issue: |
17 |
Pages: |
5913-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration |
Year: |
2001 |
|
Title: |
LocusLink Collaboration |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GO Central curators, GOA curators, Rhea curators |
Year: |
2020 |
|
Title: |
Automatic Gene Ontology annotation based on Rhea mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators, MGI curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation based on Enzyme Commission mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
Journal: |
Database Download |
Title: |
Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
|
Pages: |
686034 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
443
 |
Fragment?: |
true |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
1 |
Description: |
ATP-dependent DNA helicase DDX11 |
Type: |
chain |
End: |
906 |
|
•
•
•
•
•
|
Publication |
First Author: |
van Schie JJM |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion. |
Volume: |
11 |
Issue: |
1 |
Pages: |
4287 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
906
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
880
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
168
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
393
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
van der Lelij P |
Year: |
2010 |
Journal: |
Am J Hum Genet |
Title: |
Warsaw breakage syndrome, a cohesinopathy associated with mutations in the XPD helicase family member DDX11/ChlR1. |
Volume: |
86 |
Issue: |
2 |
Pages: |
262-6 |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Hirota Y |
Year: |
2000 |
Journal: |
Nucleic Acids Res |
Title: |
Characterization of the enzymatic activity of hChlR1, a novel human DNA helicase. |
Volume: |
28 |
Issue: |
4 |
Pages: |
917-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Amann J |
Year: |
1997 |
Journal: |
J Biol Chem |
Title: |
Characterization of putative human homologues of the yeast chromosome transmission fidelity gene, CHL1. |
Volume: |
272 |
Issue: |
6 |
Pages: |
3823-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rudra S |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Chl1 DNA helicase regulates Scc2 deposition specifically during DNA-replication in Saccharomyces cerevisiae. |
Volume: |
8 |
Issue: |
9 |
Pages: |
e75435 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
CHL1 DNA helicase plays a critical role in sister chromatid cohesion []. DDX11 is the mammalian homologue of the yeast CHL1. DDX11 is a DNA helicase involved in cellular proliferation []. In humans a second homologue has been identified, DDX12 []. DDX11 translocates on single-stranded DNA in the 5' to 3' direction in the presence of ATP and, to a lesser extent, dATP. Its unwinding activity requires a 5'-single-stranded region for helicase loading, since flush-ended duplex structures do not support unwinding []. Defects in DDX11 are the cause of Warsaw breakage syndrome (WBRS), a syndrome characterised by severe microcephaly, growth retardation, facial dysmorphism and abnormal skin pigmentation []. |
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Publication |
First Author: |
L Holloway S |
Year: |
2000 |
Journal: |
Nucleic Acids Res |
Title: |
CHL1 is a nuclear protein with an essential ATP binding site that exhibits a size-dependent effect on chromosome segregation. |
Volume: |
28 |
Issue: |
16 |
Pages: |
3056-64 |
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Publication |
First Author: |
Petronczki M |
Year: |
2004 |
Journal: |
J Cell Sci |
Title: |
Sister-chromatid cohesion mediated by the alternative RF-CCtf18/Dcc1/Ctf8, the helicase Chl1 and the polymerase-alpha-associated protein Ctf4 is essential for chromatid disjunction during meiosis II. |
Volume: |
117 |
Issue: |
Pt 16 |
Pages: |
3547-59 |
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Protein Domain |
Type: |
Family |
Description: |
This entry includes a group of ATP-dependent helicases, including Rad3/XPD (ERCC2), Chl1/DDX11, DDX12, RTEL1 and BRIP1. Rad3/XPD is a subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3) [, ]. DDX11/Chl1 is required for sister-chromatid cohesion [, , ]. Defects in DDX11 are the cause of Warsaw breakage syndrome (WBRS). It is a syndrome characterised by severe microcephaly, pre- and postnatal growth retardation, facial dysmorphism and abnormal skin pigmentation []. |
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Publication |
First Author: |
Sung P |
Year: |
1996 |
Journal: |
J Biol Chem |
Title: |
Reconstitution of TFIIH and requirement of its DNA helicase subunits, Rad3 and Rad25, in the incision step of nucleotide excision repair. |
Volume: |
271 |
Issue: |
18 |
Pages: |
10821-6 |
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Publication |
First Author: |
Svejstrup JQ |
Year: |
1994 |
Journal: |
J Biol Chem |
Title: |
RNA polymerase transcription factor IIH holoenzyme from yeast. |
Volume: |
269 |
Issue: |
45 |
Pages: |
28044-8 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1203
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
824
 |
Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
992
 |
Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
508
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
760
 |
Fragment?: |
false |
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