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Search results 1 to 69 out of 69 for Defb4

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Type Details Score
Gene
64389 | Defb4
Type: gene
Organism: rat
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Gene
100169969 | DEFB4
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1927667 | Defb4
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
20068036 | J:233575
First Author: Röhrl J
Year: 2010
Journal: J Biol Chem
Title: Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells.
Volume: 285
Issue: 10
Pages: 7028-34
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Protein Coding Gene
MGP_CAROLIEiJ_G0030877 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0033416 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0033397 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0033327 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0033397 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0033109 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1927667 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0033910 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0032432 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0033083 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0033237 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0033185 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0033330 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0033222 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0033927 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0032145 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0032549 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_SPRETEiJ_G0031986 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
12644567 | J:82526
First Author: Morrison GM
Year: 2003
Journal: Mol Biol Evol
Title: Signal sequence conservation and mature peptide divergence within subgroups of the murine beta-defensin gene family.
Volume: 20
Issue: 3
Pages: 460-70
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
10922379 | J:65459
First Author: Jia HP
Year: 2000
Journal: J Biol Chem
Title: A novel murine beta -defensin expressed in tongue, esophagus, and trachea.
Volume: 275
Issue: 43
Pages: 33314-20
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Publication
12226710 | J:78153
First Author: Morrison GM
Year: 2002
Journal: Mamm Genome
Title: Identification and characterization of a novel murine beta-defensin-related gene.
Volume: 13
Issue: 8
Pages: 445-51
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
33412104 | J:320744
First Author: Koren N
Year: 2021
Journal: Cell Host Microbe
Title: Maturation of the neonatal oral mucosa involves unique epithelium-microbiota interactions.
Volume: 29
Issue: 2
Pages: 197-209.e5
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Publication
31220272 | J:277277
First Author: Zieman AG
Year: 2019
Journal: Hum Mol Genet
Title: Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma.
Volume: 28
Issue: 13
Pages: 2255-2270
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Publication
21115716 | J:168725
First Author: Augustin DK
Year: 2011
Journal: Infect Immun
Title: Role of defensins in corneal epithelial barrier function against Pseudomonas aeruginosa traversal.
Volume: 79
Issue: 2
Pages: 595-605
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Publication
23670560 | J:199719
First Author: Kolar SS
Year: 2013
Journal: Infect Immun
Title: Protective role of murine β-defensins 3 and 4 and cathelin-related antimicrobial peptide in Fusarium solani keratitis.
Volume: 81
Issue: 8
Pages: 2669-77
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Publication
20483750 | J:161146
First Author: Röhrl J
Year: 2010
Journal: J Immunol
Title: Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2.
Volume: 184
Issue: 12
Pages: 6688-94
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Publication
- | J:346132
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
25122636 | -
First Author: Diao R
Year: 2014
Journal: Sci Transl Med
Title: Deficient human β-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection.
Volume: 6
Issue: 249
Pages: 249ra108
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Publication
9169459 | -
First Author: Baba M
Year: 1997
Journal: J Biol Chem
Title: Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC.
Volume: 272
Issue: 23
Pages: 14893-8
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Publication
9886385 | -
First Author: Liao F
Year: 1999
Journal: J Immunol
Title: CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3 alpha.
Volume: 162
Issue: 1
Pages: 186-94
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Publication
9294137 | -
First Author: Power CA
Year: 1997
Journal: J Exp Med
Title: Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3alpha from lung dendritic cells.
Volume: 186
Issue: 6
Pages: 825-35
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Publication
17486092 | -
First Author: Acosta-Rodriguez EV
Year: 2007
Journal: Nat Immunol
Title: Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells.
Volume: 8
Issue: 6
Pages: 639-46
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Publication
10521347 | -
First Author: Yang D
Year: 1999
Journal: Science
Title: Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6.
Volume: 286
Issue: 5439
Pages: 525-8
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Publication
19249008 | -
First Author: Wang K
Year: 2009
Journal: Am J Hum Genet
Title: Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease.
Volume: 84
Issue: 3
Pages: 399-405
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Protein Domain
IPR004067 | Chemokine_CCR6
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).CC chemokine receptors are a subfamily of the chemokine receptors that specifically bind and respond to cytokines of the CC chemokine family. There are currently ten members of the CC chemokine receptor subfamily, named CCR1 to 10. The receptors receptors are found in monocytes, lymphocytes, basophils and eosinophils.This entry represents CC chemokine receptor 6 (CCR6). It is expressed on unactivated memory T-cells [, ]and some dendritic cells [, ]. CCR6 is also expressed on Th17 cells [], but is down-regulated in activated T-cells []. The receptor is noted as playing a role in Crohn's disease []. CCR6 major ligand is CCL20, also known as Liver and Activation-Regulated Chemokine but it can also bind non-chemokine ligands such as beta-defensines [, ]. Binding to beta-defensine 1 (DEFB1) is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity []and it mediates the chemotactic effects of defensins DEFB4 and DEFB4A/B [].
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Protein
O54689
Organism: Mus musculus/domesticus
Length: 367  
Fragment?: false
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Protein
Q3U467
Organism: Mus musculus/domesticus
Length: 143  
Fragment?: true
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Protein
Q9R1V0
Organism: Mus musculus/domesticus
Length: 367  
Fragment?: false
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Protein
Q542B6
Organism: Mus musculus/domesticus
Length: 367  
Fragment?: false
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Publication
9689100 | J:49070
First Author: Ma Q
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice.
Volume: 95
Issue: 16
Pages: 9448-53
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Publication
11544102 | -
First Author: Horuk R
Year: 2001
Journal: Cytokine Growth Factor Rev
Title: Chemokine receptors.
Volume: 12
Issue: 4
Pages: 313-35
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Publication
10601351 | -
First Author: Charbonnier AS
Year: 1999
Journal: J Exp Med
Title: Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cells.
Volume: 190
Issue: 12
Pages: 1755-68
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Publication
9500790 | -
First Author: Sallusto F
Year: 1998
Journal: J Exp Med
Title: Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes.
Volume: 187
Issue: 6
Pages: 875-83
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Publication
7592998 | -
First Author: Strieter RM
Year: 1995
Journal: J Biol Chem
Title: The functional role of the ELR motif in CXC chemokine-mediated angiogenesis.
Volume: 270
Issue: 45
Pages: 27348-57
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Publication
10714678 | -
First Author: Zlotnik A
Year: 2000
Journal: Immunity
Title: Chemokines: a new classification system and their role in immunity.
Volume: 12
Issue: 2
Pages: 121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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