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Search results 1 to 100 out of 220 for Dek

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Hits by Pathway

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Hits by Category

Type Details Score
Gene
7913 | DEK
Type: gene
Organism: human
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Gene
540945 | DEK
Type: gene
Organism: cattle
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Gene
420828 | DEK
Type: gene
Organism: chicken
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Gene
692304 | dek
Type: gene
Organism: zebrafish
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Gene
712460 | DEK
Type: gene
Organism: macaque, rhesus
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Gene
493252 | dek
Type: gene
Organism: frog, western clawed
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Gene
306817 | Dek
Type: gene
Organism: rat
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Gene
610538 | DEK
Type: gene
Organism: dog, domestic
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Gene
462460 | DEK
Type: gene
Organism: chimpanzee
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Protein Domain
IPR044198 | DEK
Type: Family
Description: Protein DEK is an abundant and ubiquitous chromatin protein in multicellular organisms (not in yeast) [, ]. It preferentially binds to superhelical and cruciform DNA, and induces positive supercoils into closed circular DNA []. This protein has two DNA binding domains, the SAP/SAF box located at the centre of the protein, and the second one at the C-terminal, which contains several phosphorylation sites important for its activity. It is involved in cell proliferation, differentiation, senescence and apoptosis, being associated with cancers and autoimmune diseases and a possible therapeutic drug target []. In humans DEK can be secreted by macrophages, and the secreted DEK regulates the proliferation of hematopoietic stem cells and hematopoietic progenitor cells through CXCR2 signaling [].
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Protein Coding Gene
MGI:1926209 | Dek
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
31107242 | J:295528
First Author: Capitano ML
Year: 2019
Journal: J Clin Invest
Title: Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling.
Volume: 129
Issue: 6
Pages: 2555-2570
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Publication
17524367 | -
First Author: Hu HG
Year: 2007
Journal: Biochem Biophys Res Commun
Title: The distribution of the DEK protein in mammalian chromatin.
Volume: 358
Issue: 4
Pages: 1008-14
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Publication
25765544 | J:224953
First Author: Sandén C
Year: 2015
Journal: Leukemia
Title: The DEK oncoprotein and its emerging roles in gene regulation.
Volume: 29
Issue: 8
Pages: 1632-6
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Protein
Q3UR53
Organism: Mus musculus/domesticus
Length: 196  
Fragment?: false
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Publication
21943234 | J:304339
First Author: Broxmeyer HE
Year: 2012
Journal: Stem Cells Dev
Title: DEK regulates hematopoietic stem engraftment and progenitor cell proliferation.
Volume: 21
Issue: 9
Pages: 1449-54
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Publication
28317934 | J:315039
 
First Author: Smith EA
Year: 2017
Journal: Sci Rep
Title: DEK is required for homologous recombination repair of DNA breaks.
Volume: 7
Pages: 44662
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Publication
29288703 | J:303228
 
First Author: Serrano-Lopez J
Year: 2018
Journal: Exp Hematol
Title: Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors.
Volume: 59
Pages: 40-50.e3
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Protein
Q7TNV0
Organism: Mus musculus/domesticus
Length: 380  
Fragment?: false
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Publication
15563827 | -
First Author: Waldmann T
Year: 2004
Journal: Gene
Title: The DEK protein--an abundant and ubiquitous constituent of mammalian chromatin.
Volume: 343
Issue: 1
Pages: 1-9
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Protein
E9Q8Y1
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: true
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Protein
D3YVJ6
Organism: Mus musculus/domesticus
Length: 258  
Fragment?: true
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Publication
21653549 | J:183050
First Author: Kavanaugh GM
Year: 2011
Journal: Nucleic Acids Res
Title: The human DEK oncogene regulates DNA damage response signaling and repair.
Volume: 39
Issue: 17
Pages: 7465-76
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Publication
19223548 | J:146608
First Author: Wise-Draper TM
Year: 2009
Journal: Cancer Res
Title: Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo.
Volume: 69
Issue: 5
Pages: 1792-9
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Publication
24608431 | J:218626
First Author: Adams AK
Year: 2015
Journal: Oncogene
Title: DEK promotes HPV-positive and -negative head and neck cancer cell proliferation.
Volume: 34
Issue: 7
Pages: 868-77
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Publication
29175155 | J:258084
 
First Author: Ghisays V
Year: 2018
Journal: Neuroscience
Title: Neuroanatomical Distribution of DEK Protein in Corticolimbic Circuits Associated with Learning and Memory in Adult Male and Female Mice.
Volume: 371
Pages: 254-267
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Publication
29538372 | J:261249
First Author: Matrka MC
Year: 2018
Journal: PLoS Genet
Title: Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence.
Volume: 14
Issue: 3
Pages: e1007227
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Publication
32708944 | J:304509
 
First Author: Pease NA
Year: 2020
Journal: Cancers (Basel)
Title: DEK Expression in Breast Cancer Cells Leads to the Alternative Activation of Tumor Associated Macrophages.
Volume: 12
Issue: 7
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Publication
33755722 | J:322182
 
First Author: Chen Z
Year: 2021
Journal: J Exp Med
Title: Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis.
Volume: 218
Issue: 5
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Publication
32502396 | J:328634
First Author: Yue L
Year: 2020
Journal: Dev Cell
Title: Dek Modulates Global Intron Retention during Muscle Stem Cells Quiescence Exit.
Volume: 53
Issue: 6
Pages: 661-676.e6
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Publication
24954505 | J:221258
First Author: Privette Vinnedge LM
Year: 2015
Journal: Oncogene
Title: The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers.
Volume: 34
Issue: 18
Pages: 2325-36
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Publication
28165452 | J:243932
 
First Author: Mor-Vaknin N
Year: 2017
Journal: Nat Commun
Title: DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis.
Volume: 8
Pages: 14252
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Protein
Q3U4W4
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: true
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Protein
Q9CVL7
Organism: Mus musculus/domesticus
Length: 282  
Fragment?: true
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Publication
26303528 | J:228214
First Author: Lohmann F
Year: 2015
Journal: Mol Cell Biol
Title: The DEK Oncoprotein Is a Critical Component of the EKLF/KLF1 Enhancer in Erythroid Cells.
Volume: 35
Issue: 21
Pages: 3726-38
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Protein Coding Gene
MGP_CAROLIEiJ_G0018488 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0020520 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0020474 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0020451 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0020470 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0020269 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1926209 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0020903 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0019784 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0020230 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0020352 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0020331 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0020427 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0020360 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0020946 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0019540 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0019846 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0019556 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0019368 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:3765925
Assay Type: RT-PCR
Annotation Date: 2007-12-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:3765929
Age: postnatal day 7
Specimen Label: P7
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3765925
Assay Type: RT-PCR
Annotation Date: 2007-12-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:3765929
Age: postnatal adult
Specimen Label: AMR
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3765925
Assay Type: RT-PCR
Annotation Date: 2007-12-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716823
Stage: TS23
Assay Id: MGI:3765934
Age: embryonic day 15.0
Specimen Label: E15
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3765925
Assay Type: RT-PCR
Annotation Date: 2007-12-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716826
Stage: TS26
Assay Id: MGI:3765934
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3765925
Assay Type: RT-PCR
Annotation Date: 2007-12-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716827
Stage: TS27
Assay Id: MGI:3765934
Age: postnatal day 0
Specimen Label: P0
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:3765925
Assay Type: RT-PCR
Annotation Date: 2007-12-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716827
Stage: TS27
Assay Id: MGI:3765934
Age: postnatal day 2
Specimen Label: P2
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:3765925
Assay Type: RT-PCR
Annotation Date: 2007-12-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:3765934
Age: postnatal day 7
Specimen Label: P7
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:3765925
Assay Type: RT-PCR
Annotation Date: 2007-12-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:3765934
Age: postnatal adult
Specimen Label: AMR
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:3815692
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:3816496
Age: postnatal
Specimen Label: Metaphase II
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3815692
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:3816496
Age: embryonic day 1.5
Specimen Label: 2-cell embryo
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3815692
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360433
Stage: TS03
Assay Id: MGI:3816496
Age: embryonic day 2.0
Specimen Label: 4-cell embryo
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:3815692
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360443
Stage: TS03
Assay Id: MGI:3816496
Age: embryonic day 2.5
Specimen Label: 8-cell embryo
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:3815692
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:3816496
Age: embryonic day 3.0
Specimen Label: Morula
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:3815692
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:3816496
Age: embryonic day 3.5
Specimen Label: E3.5 blastocyst
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:3815692
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360465
Stage: TS05
Assay Id: MGI:3816496
Age: embryonic day 4.5
Specimen Label: E4.5 blastocyst
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:3815692
Assay Type: RT-PCR
Annotation Date: 2008-11-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160415
Stage: TS05
Assay Id: MGI:3816496
Age: embryonic day 4.5
Specimen Label: E4.5 inner cell mass
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:4845187
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1640517
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:4848858
Age: embryonic day 10.5
Note: Staining is present in the posterior limb.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4845187
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1640519
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:4848858
Age: embryonic day 11.5
Note: Staining is present in the interdigital region of the limb.
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:3070581
Assay Type: RNA in situ
Annotation Date: 2005-12-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160415
Pattern: Not Specified
Stage: TS05
Assay Id: MGI:3607314
Age: embryonic day 3.5
Image: blastocyst
Note: When a less concentrated dilution of probe is used, no expression is seen.
Specimen Label: blastocyst
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4845187
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3270517
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:4848858
Age: embryonic day 10.5
Note: Staining is present in the progress zone.
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4845187
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3270519
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:4848858
Age: embryonic day 11.5
Note: Staining is present in the progress zone.
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:996489
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Ubiquitous
Stage: TS23
Assay Id: MGI:4824281
Age: embryonic day 14.5
Image: euxassay_011243_16
Specimen Label: euxassay_011243_16
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4845187
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1684619
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4848858
Age: embryonic day 11.5
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:3070581
Assay Type: RNA in situ
Annotation Date: 2005-12-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160465
Pattern: Not Specified
Stage: TS05
Assay Id: MGI:3607314
Age: embryonic day 3.5
Image: blastocyst
Note: When a less concentrated dilution of probe is used, no expression is seen.
Specimen Label: blastocyst
Detected: true
Specimen Num: 1
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Publication
16180235 | J:103456
First Author: Orlic M
Year: 2006
Journal: Genes Chromosomes Cancer
Title: Expression analysis of 6p22 genomic gain in retinoblastoma.
Volume: 45
Issue: 1
Pages: 72-82
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Publication
22358842 | J:181629
First Author: Cheung TH
Year: 2012
Journal: Nature
Title: Maintenance of muscle stem-cell quiescence by microRNA-489.
Volume: 482
Issue: 7386
Pages: 524-8
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Publication
8938453 | J:36739
First Author: Kobayashi T
Year: 1996
Journal: Genomics
Title: Cloning, RNA expression, and chromosomal location of a mouse histamine H2 receptor gene.
Volume: 37
Issue: 3
Pages: 390-4
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Publication
7959747 | J:19349
First Author: Avraham KB
Year: 1994
Journal: Genomics
Title: Mapping of murine fibroblast growth factor receptors refines regions of homology between mouse and human chromosomes.
Volume: 21
Issue: 3
Pages: 656-8
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Publication
23555303 | J:319968
First Author: Sarshad A
Year: 2013
Journal: PLoS Genet
Title: Nuclear myosin 1c facilitates the chromatin modifications required to activate rRNA gene transcription and cell cycle progression.
Volume: 9
Issue: 3
Pages: e1003397
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Publication
26044184 | J:319696
 
First Author: Almuzzaini B
Year: 2015
Journal: BMC Biol
Title: Nuclear myosin 1 contributes to a chromatin landscape compatible with RNA polymerase II transcription activation.
Volume: 13
Pages: 35
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Publication
12769854 | J:320057
First Author: Fan HY
Year: 2003
Journal: Mol Cell
Title: Distinct strategies to make nucleosomal DNA accessible.
Volume: 11
Issue: 5
Pages: 1311-22
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Publication
10716735 | J:64959
First Author: Misawa K
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: A method to identify cDNAs based on localization of green fluorescent protein fusion products.
Volume: 97
Issue: 7
Pages: 3062-6
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Publication
8521822 | J:29949
First Author: Hurlin PJ
Year: 1995
Journal: EMBO J
Title: Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.
Volume: 14
Issue: 22
Pages: 5646-59
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Publication
8211130 | J:14384
First Author: Copeland NG
Year: 1993
Journal: Science
Title: A genetic linkage map of the mouse: current applications and future prospects.
Volume: 262
Issue: 5130
Pages: 57-66
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UniProt Feature
UniProt Feature
Begin: 1
Description: Protein DEK
Type: chain
End: 380
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Publication
16325481 | J:102143
First Author: Yoshikawa T
Year: 2006
Journal: Gene Expr Patterns
Title: High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization.
Volume: 6
Issue: 2
Pages: 213-24
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Publication
21194568 | J:171293
First Author: Campbell GR
Year: 2011
Journal: Mol Cell Neurosci
Title: Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling.
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Journal: MGI Direct Data Submission
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Year: 2023
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Journal: Dev Cell
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Journal: Dev Cell
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Title: FANTOM2 Data Curation in Mouse Genome Informatics
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First Author: Mouse Genome Informatics Scientific Curators
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Title: Gene Ontology Annotation by the MGI Curatorial Staff
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