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Search results 1 to 98 out of 98 for Depdc5

0.029s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Dibbens LM
Year: 2013
Journal: Nat Genet
Title: Mutations in DEPDC5 cause familial focal epilepsy with variable foci.
Volume: 45
Issue: 5
Pages: 546-51
Publication
First Author: Hughes J
Year: 2017
Journal: Sci Rep
Title: Knockout of the epilepsy gene Depdc5 in mice causes severe embryonic dysmorphology with hyperactivity of mTORC1 signalling.
Volume: 7
Issue: 1
Pages: 12618
Publication
First Author: Yuskaitis CJ
Year: 2019
Journal: Hum Mol Genet
Title: Chronic mTORC1 inhibition rescues behavioral and biochemical deficits resulting from neuronal Depdc5 loss in mice.
Volume: 28
Issue: 17
Pages: 2952-2964
Publication  
First Author: Yuskaitis CJ
Year: 2018
Journal: Neurobiol Dis
Title: A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility.
Volume: 111
Pages: 91-101
Publication
First Author: Graber TG
Year: 2019
Journal: J Biol Chem
Title: Skeletal muscle-specific knockout of DEP domain containing 5 protein increases mTORC1 signaling, muscle cell hypertrophy, and mitochondrial respiration.
Volume: 294
Issue: 11
Pages: 4091-4102
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression  
Probe: MGI:4845290
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1738219
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4848916
Age: embryonic day 11.5
Note: Staining is present in the external genitalia.
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4845290
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1611817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848916
Age: embryonic day 10.5
Note: Staining is present in the mandibular arch.
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4845290
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1627217
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848916
Age: embryonic day 10.5
Note: Staining is present in the hyoid arch.
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4845290
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1638817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848916
Age: embryonic day 10.5
Note: Staining is present in the maxillary process.
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4845290
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1640519
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:4848916
Age: embryonic day 11.5
Note: Staining is present in the antero-distal and posterior-distal regions of the limb.
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4845290
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3270519
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:4848916
Age: embryonic day 11.5
Note: Staining is present in the progress zone and middle limb.
Detected: true
Specimen Num: 2
Publication
First Author: Licatalosi DD
Year: 2012
Journal: Genes Dev
Title: Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain.
Volume: 26
Issue: 14
Pages: 1626-42
Publication      
First Author: The Australian Phenomics Facility at The Australian National University
Year: 2006
Journal: MGI Direct Data Submission
Title: Heritable mouse mutants from the ENU mutagenesis program at the Australian Phenomics Facility at The Australian National University
Publication
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
Publication
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
Publication
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
Publication      
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics, the Protein Information Resource and the Protein Ontology Consortium
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
UniProt Feature
Begin: 1
Description: GATOR complex protein DEPDC5
Type: chain
End: 1591
Protein
Organism: Mus musculus
Length: 44  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1085  
Fragment?: false
Protein
Organism: Mus musculus
Length: 153  
Fragment?: false
Protein
Organism: Mus musculus
Length: 137  
Fragment?: true
Protein
Organism: Mus musculus
Length: 206  
Fragment?: true
Protein
Organism: Mus musculus
Length: 161  
Fragment?: true
Protein
Organism: Mus musculus
Length: 205  
Fragment?: true
Protein
Organism: Mus musculus
Length: 657  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1591  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1530  
Fragment?: false
Protein
Organism: Mus musculus
Length: 976  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1569  
Fragment?: false
Protein
Organism: Mus musculus
Length: 31  
Fragment?: true
Protein
Organism: Mus musculus
Length: 35  
Fragment?: true
Allele
Name: DEP domain containing 5; endonuclease-mediated mutation 1, Paul Q Thomas
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Publication categories: ProxyCollection
Protein
Organism: Mus musculus
Length: 1085  
Fragment?: false
Protein
Organism: Mus musculus
Length: 166  
Fragment?: false
Publication
First Author: Wu X
Year: 2011
Journal: Mol Biol Cell
Title: Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation.
Volume: 22
Issue: 21
Pages: 4124-33
Publication
First Author: Dokudovskaya S
Year: 2011
Journal: Autophagy
Title: A novel coatomer-related SEA complex dynamically associates with the vacuole in yeast and is implicated in the response to nitrogen starvation.
Volume: 7
Issue: 11
Pages: 1392-3
Publication
First Author: Parmigiani A
Year: 2014
Journal: Cell Rep
Title: Sestrins inhibit mTORC1 kinase activation through the GATOR complex.
Volume: 9
Issue: 4
Pages: 1281-91
Protein Domain
Type: Family
Description: Proteins in this family contain a DEP domain, which is a globular domain of about 80 residues. This entry includes GTPase-activating proteins (GAPs), such as Iml1 from fungi and GATOR complex protein DEPDC5 from mammals. In Saccharomyces cerevisiae, Iml1 is a GAP subunit of both the SEA (Seh1-associated) and Iml1 complexes (Iml1-Npr2-Npr3). SEA complex is associates dynamically with the vacuole and is involved in autophagy [, , ]. Iml1 complex is required for non-nitrogen-starvation (NNS)-induced autophagy []. In mammals, DEPDC5 is a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway [, ].
Publication
First Author: Panchaud N
Year: 2013
Journal: Sci Signal
Title: Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1.
Volume: 6
Issue: 277
Pages: ra42
Publication
First Author: Chen J
Year: 2018
Journal: Nature
Title: KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing.
Volume: 557
Issue: 7706
Pages: 585-589
Publication
First Author: Bar-Peled L
Year: 2013
Journal: Science
Title: A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
Volume: 340
Issue: 6136
Pages: 1100-6
Publication
First Author: Dokudovskaya S
Year: 2011
Journal: Mol Cell Proteomics
Title: A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae.
Volume: 10
Issue: 6
Pages: M110.006478
Publication
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 4
Pages: 167-80
Publication
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
Publication
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
Publication
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112