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Search results 1 to 100 out of 333 for Dgcr8

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Type Details Score
Gene
54487 | DGCR8
Type: gene
Organism: human
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Gene
540254 | DGCR8
Type: gene
Organism: cattle
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Gene
101059245 | DGCR8
Type: gene
Organism: chimpanzee
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Gene
563963 | dgcr8
Type: gene
Organism: zebrafish
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Gene
100425351 | DGCR8
Type: gene
Organism: macaque, rhesus
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Gene
100144670 | dgcr8
Type: gene
Organism: frog, western clawed
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Gene
119866241 | DGCR8
Type: gene
Organism: dog, domestic
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Gene
287954 | Dgcr8
Type: gene
Organism: rat
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Gene
416785 | DGCR8
Type: gene
Organism: chicken
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Protein Domain
IPR040375 | DGCR8
Type: Family
Description: Primary microRNA transcripts (pri-miRs) are cleaved by Microprocessor, a complex containing RNase III DROSHA and its cofactor DGCR8 []. DGCR8 functions as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs [, ]. DGCR8 binds heme, and this binding activates DGCR8 to recognize pri-miRs by specifically binding the terminal loop near the 3' single-stranded segment [].
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Protein Coding Gene
MGI:2151114 | Dgcr8
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
29170488 | -
First Author: Partin AC
Year: 2017
Journal: Nat Commun
Title: Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs.
Volume: 8
Issue: 1
Pages: 1737
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Protein
Q9EQM6
Organism: Mus musculus/domesticus
Length: 773  
Fragment?: false
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Protein
A0A338P691
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: true
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Publication
26027739 | -
First Author: Nguyen TA
Year: 2015
Journal: Cell
Title: Functional Anatomy of the Human Microprocessor.
Volume: 161
Issue: 6
Pages: 1374-87
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Publication
17259983 | J:141670
First Author: Wang Y
Year: 2007
Journal: Nat Genet
Title: DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal.
Volume: 39
Issue: 3
Pages: 380-5
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Publication
12705904 | J:83362
First Author: Shiohama A
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Molecular cloning and expression analysis of a novel gene DGCR8 located in the DiGeorge syndrome chromosomal region.
Volume: 304
Issue: 1
Pages: 184-90
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Publication
26748718 | -
First Author: Kwon SC
Year: 2016
Journal: Cell
Title: Structure of Human DROSHA.
Volume: 164
Issue: 1-2
Pages: 81-90
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Publication
22138056 | J:180151
First Author: Chapnik E
Year: 2012
Journal: Dev Biol
Title: Dgcr8 controls neural crest cells survival in cardiovascular development.
Volume: 362
Issue: 1
Pages: 50-6
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Publication
28739418 | J:255130
 
First Author: Choi YJ
Year: 2017
Journal: Bone
Title: Deficiency of DGCR8 increases bone formation through downregulation of miR-22 expression.
Volume: 103
Pages: 287-294
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Publication
36591274 | J:332443
 
First Author: Daum P
Year: 2022
Journal: Front Immunol
Title: The microRNA processing subunit DGCR8 is required for a T cell-dependent germinal center response.
Volume: 13
Pages: 991347
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Publication
26206718 | J:224835
First Author: Belair CD
Year: 2015
Journal: EMBO Rep
Title: DGCR8 is essential for tumor progression following PTEN loss in the prostate.
Volume: 16
Issue: 9
Pages: 1219-32
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Publication
28232627 | J:241293
First Author: Marinaro F
Year: 2017
Journal: EMBO Rep
Title: MicroRNA-independent functions of DGCR8 are essential for neocortical development and TBR1 expression.
Volume: 18
Issue: 4
Pages: 603-618
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Publication
33771876 | J:332377
 
First Author: Killy B
Year: 2021
Journal: Life Sci Alliance
Title: DGCR8 deficiency impairs macrophage growth and unleashes the interferon response to mycobacteria.
Volume: 4
Issue: 6
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Publication
25934699 | J:232835
First Author: Modzelewski AJ
Year: 2015
Journal: J Cell Sci
Title: Dgcr8 and Dicer are essential for sex chromosome integrity during meiosis in males.
Volume: 128
Issue: 12
Pages: 2314-27
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Publication
29362439 | J:259678
First Author: Zou Y
Year: 2018
Journal: Sci Rep
Title: Deletion of DGCR8 in VSMCs of adult mice results in loss of vascular reactivity, reduced blood pressure and neointima formation.
Volume: 8
Issue: 1
Pages: 1468
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Publication
29760646 | J:264394
 
First Author: Hoffmann N
Year: 2018
Journal: Front Neurosci
Title: DGCR8 Promotes Neural Progenitor Expansion and Represses Neurogenesis in the Mouse Embryonic Neocortex.
Volume: 12
Pages: 281
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Publication
30128894 | J:315974
First Author: Chen X
Year: 2019
Journal: Protein Cell
Title: Dgcr8 deletion in the primitive heart uncovered novel microRNA regulating the balance of cardiac-vascular gene program.
Volume: 10
Issue: 5
Pages: 327-346
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Publication
38110169 | J:344102
 
First Author: Racedo SE
Year: 2024
Journal: Dev Biol
Title: Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals.
Volume: 506
Pages: 72-84
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Publication
26126715 | J:259443
First Author: Tu CC
Year: 2015
Journal: Sci Signal
Title: The kinase ABL phosphorylates the microprocessor subunit DGCR8 to stimulate primary microRNA processing in response to DNA damage.
Volume: 8
Issue: 383
Pages: ra64
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Publication
33496365 | J:307387
First Author: Kim YS
Year: 2021
Journal: Cell Prolif
Title: Different Cre systems induce differential microRNA landscapes and abnormalities in the female reproductive tracts of Dgcr8 conditional knockout mice.
Volume: 54
Issue: 3
Pages: e12996
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Publication
21466685 | J:171661
 
First Author: Schofield CM
Year: 2011
Journal: Neural Dev
Title: Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex.
Volume: 6
Pages: 11
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Publication
21712401 | J:267300
First Author: Babiarz JE
Year: 2011
Journal: RNA
Title: A role for noncanonical microRNAs in the mammalian brain revealed by phenotypic differences in Dgcr8 versus Dicer1 knockouts and small RNA sequencing.
Volume: 17
Issue: 8
Pages: 1489-501
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Publication
25244517 | J:220631
First Author: Zimmermann C
Year: 2014
Journal: PLoS One
Title: Germ cell-specific targeting of DICER or DGCR8 reveals a novel role for endo-siRNAs in the progression of mammalian spermatogenesis and male fertility.
Volume: 9
Issue: 9
Pages: e107023
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Publication
32060266 | J:285391
First Author: Eom TY
Year: 2020
Journal: Nat Commun
Title: Schizophrenia-related microdeletion causes defective ciliary motility and brain ventricle enlargement via microRNA-dependent mechanisms in mice.
Volume: 11
Issue: 1
Pages: 912
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Publication
18978791 | J:143230
First Author: Wang Y
Year: 2008
Journal: Nat Genet
Title: Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation.
Volume: 40
Issue: 12
Pages: 1478-83
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Publication
25002228 | J:215642
First Author: Busskamp V
Year: 2014
Journal: Neuron
Title: miRNAs 182 and 183 are necessary to maintain adult cone photoreceptor outer segments and visual function.
Volume: 83
Issue: 3
Pages: 586-600
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Publication
23719809 | J:198659
First Author: Ouchi Y
Year: 2013
Journal: J Neurosci
Title: Reduced adult hippocampal neurogenesis and working memory deficits in the Dgcr8-deficient mouse model of 22q11.2 deletion-associated schizophrenia can be rescued by IGF2.
Volume: 33
Issue: 22
Pages: 9408-19
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Publication
28102192 | J:244240
 
First Author: Gambardella G
Year: 2017
Journal: Nat Commun
Title: The impact of microRNAs on transcriptional heterogeneity and gene co-expression across single embryonic stem cells.
Volume: 8
Pages: 14126
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Publication
20116247 | J:158511
First Author: Suh N
Year: 2010
Journal: Curr Biol
Title: MicroRNA function is globally suppressed in mouse oocytes and early embryos.
Volume: 20
Issue: 3
Pages: 271-7
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Publication
25008181 | J:230141
First Author: Kim HJ
Year: 2014
Journal: Diabetes
Title: MicroRNAs are required for the feature maintenance and differentiation of brown adipocytes.
Volume: 63
Issue: 12
Pages: 4045-56
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Publication
24027283 | J:202335
First Author: Fénelon K
Year: 2013
Journal: J Neurosci
Title: The pattern of cortical dysfunction in a mouse model of a schizophrenia-related microdeletion.
Volume: 33
Issue: 37
Pages: 14825-39
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Publication
27892953 | J:250663
First Author: Chun S
Year: 2017
Journal: Nat Med
Title: Thalamic miR-338-3p mediates auditory thalamocortical disruption and its late onset in models of 22q11.2 microdeletion.
Volume: 23
Issue: 1
Pages: 39-48
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Publication
21368174 | J:170822
First Author: Fénelon K
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Deficiency of Dgcr8, a gene disrupted by the 22q11.2 microdeletion, results in altered short-term plasticity in the prefrontal cortex.
Volume: 108
Issue: 11
Pages: 4447-52
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Publication
18469815 | J:136969
First Author: Stark KL
Year: 2008
Journal: Nat Genet
Title: Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model.
Volume: 40
Issue: 6
Pages: 751-60
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Publication
25881298 | J:233486
 
First Author: Bartram MP
Year: 2015
Journal: BMC Nephrol
Title: Loss of Dgcr8-mediated microRNA expression in the kidney results in hydronephrosis and renal malformation.
Volume: 16
Pages: 55
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Publication
27641147 | J:246331
First Author: Brandl A
Year: 2016
Journal: Eur J Immunol
Title: The microprocessor component, DGCR8, is essential for early B-cell development in mice.
Volume: 46
Issue: 12
Pages: 2710-2718
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Publication
24904170 | J:211625
First Author: Chun S
Year: 2014
Journal: Science
Title: Specific disruption of thalamic inputs to the auditory cortex in schizophrenia models.
Volume: 344
Issue: 6188
Pages: 1178-82
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Publication
20054295 | J:156757
First Author: Melton C
Year: 2010
Journal: Nature
Title: Opposing microRNA families regulate self-renewal in mouse embryonic stem cells.
Volume: 463
Issue: 7281
Pages: 621-6
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Publication
26748703 | J:277596
First Author: Swahari V
Year: 2016
Journal: Cell Rep
Title: Essential Function of Dicer in Resolving DNA Damage in the Rapidly Dividing Cells of the Developing and Malignant Cerebellum.
Volume: 14
Issue: 2
Pages: 216-24
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Publication
22728723 | J:203596
First Author: Hsu R
Year: 2012
Journal: Mol Cell Neurosci
Title: Loss of microRNAs in pyramidal neurons leads to specific changes in inhibitory synaptic transmission in the prefrontal cortex.
Volume: 50
Issue: 3-4
Pages: 283-92
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Publication
26833131 | J:251593
 
First Author: Kim YS
Year: 2016
Journal: Sci Rep
Title: Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice.
Volume: 6
Pages: 20242
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Publication
29146941 | J:257286
First Author: Amin H
Year: 2017
Journal: Sci Rep
Title: Developmental excitatory-to-inhibitory GABA-polarity switch is disrupted in 22q11.2 deletion syndrome: a potential target for clinical therapeutics.
Volume: 7
Issue: 1
Pages: 15752
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Publication
22897173 | J:190566
First Author: Lugli G
Year: 2012
Journal: J Neurochem
Title: Primary microRNA precursor transcripts are localized at post-synaptic densities in adult mouse forebrain.
Volume: 123
Issue: 4
Pages: 459-66
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Publication
19759829 | J:223635
First Author: Shenoy A
Year: 2009
Journal: PLoS One
Title: Genomic analysis suggests that mRNA destabilization by the microprocessor is specialized for the auto-regulation of Dgcr8.
Volume: 4
Issue: 9
Pages: e6971
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Publication
27090781 | J:319576
 
First Author: Bartram MP
Year: 2016
Journal: BMC Mol Biol
Title: Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure.
Volume: 17
Pages: 11
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Publication
20805417 | J:164317
First Author: Bezman NA
Year: 2010
Journal: J Immunol
Title: Distinct requirements of microRNAs in NK cell activation, survival, and function.
Volume: 185
Issue: 7
Pages: 3835-46
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Publication
30295958 | J:268793
First Author: Gökbuget D
Year: 2018
Journal: Glia
Title: The miRNA biogenesis pathway prevents inappropriate expression of injury response genes in developing and adult Schwann cells.
Volume: 66
Issue: 12
Pages: 2632-2644
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Publication
25707934 | J:317047
First Author: Kobayashi T
Year: 2015
Journal: Osteoarthritis Cartilage
Title: Early postnatal ablation of the microRNA-processing enzyme, Drosha, causes chondrocyte death and impairs the structural integrity of the articular cartilage.
Volume: 23
Issue: 7
Pages: 1214-20
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Publication
26272614 | J:225866
First Author: Lin HP
Year: 2015
Journal: J Biol Chem
Title: Microprocessor complex subunit DiGeorge syndrome critical region gene 8 (Dgcr8) is required for schwann cell myelination and myelin maintenance.
Volume: 290
Issue: 40
Pages: 24294-307
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Publication
22511778 | J:186203
First Author: Chen Z
Year: 2012
Journal: J Biol Chem
Title: DiGeorge syndrome critical region 8 (DGCR8) protein-mediated microRNA biogenesis is essential for vascular smooth muscle cell development in mice.
Volume: 287
Issue: 23
Pages: 19018-28
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Publication
24449888 | J:206433
First Author: Chakravarti D
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Induced multipotency in adult keratinocytes through down-regulation of ΔNp63 or DGCR8.
Volume: 111
Issue: 5
Pages: E572-81
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Publication
24101523 | J:201966
First Author: Toritsuka M
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model.
Volume: 110
Issue: 43
Pages: 17552-7
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Publication
26062936 | J:224079
First Author: Ohana R
Year: 2015
Journal: Development
Title: MicroRNAs are essential for differentiation of the retinal pigmented epithelium and maturation of adjacent photoreceptors.
Volume: 142
Issue: 14
Pages: 2487-98
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Publication
36197846 | J:329565
First Author: Kim J
Year: 2022
Journal: PLoS Genet
Title: The RNA helicase DDX6 controls early mouse embryogenesis by repressing aberrant inhibition of BMP signaling through miRNA-mediated gene silencing.
Volume: 18
Issue: 10
Pages: e1009967
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Protein Coding Gene
MGP_CAROLIEiJ_G0020542 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0022607 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0022568 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0022545 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0022573 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0022340 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2151114 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0023022 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0021867 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0022309 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0022441 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0022416 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0022508 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0022438 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0023033 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0021609 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0021913 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0016247 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0021437 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
19679836 | J:161342
First Author: Rao PK
Year: 2009
Journal: Circ Res
Title: Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure.
Volume: 105
Issue: 6
Pages: 585-94
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Publication
21820330 | J:175847
First Author: Steiner DF
Year: 2011
Journal: Immunity
Title: MicroRNA-29 regulates T-box transcription factors and interferon-γ production in helper T cells.
Volume: 35
Issue: 2
Pages: 169-81
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Publication
34678162 | J:319882
First Author: Zick JL
Year: 2022
Journal: Curr Biol
Title: Disparate insults relevant to schizophrenia converge on impaired spike synchrony and weaker synaptic interactions in prefrontal local circuits.
Volume: 32
Issue: 1
Pages: 14-25.e4
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Publication
25519956 | J:217873
First Author: Ma Y
Year: 2015
Journal: EMBO J
Title: Functional screen reveals essential roles of miR-27a/24 in differentiation of embryonic stem cells.
Volume: 34
Issue: 3
Pages: 361-78
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GXD Expression
GXD Expression
   
Probe: MGI:3028100
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689517
Stage: TS17
Assay Id: MGI:3028161
Age: embryonic day 10.5
Image: 1
Specimen Label: fnm/fb
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3028100
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611717
Stage: TS17
Assay Id: MGI:3028161
Age: embryonic day 10.5
Image: 1
Specimen Label: ba
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3028100
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610417
Stage: TS17
Assay Id: MGI:3028161
Age: embryonic day 10.5
Image: 1
Specimen Label: aah
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:3028100
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640617
Stage: TS17
Assay Id: MGI:3028161
Age: embryonic day 10.5
Image: 1
Specimen Label: flb
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:3028100
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603916
Stage: TS16
Assay Id: MGI:3028201
Age: embryonic day 10.0
Image: 2
Specimen Label: E10 Whole
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3028100
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:3028201
Age: embryonic day 14.0
Image: 2
Specimen Label: E14 Whole
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3028100
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689420
Stage: TS20
Assay Id: MGI:3028201
Age: embryonic day 12.0
Image: 2
Specimen Label: E12 Brain
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:3028100
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689422
Stage: TS22
Assay Id: MGI:3028201
Age: embryonic day 14.0
Image: 2
Specimen Label: E14 Brain
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3028100
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:3028201
Age: embryonic day 18.0
Image: 2
Specimen Label: E18 Brain
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3028100
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:3028201
Age: postnatal day 0
Image: 2
Specimen Label: P0 Brain
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3028100
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3028201
Age: postnatal day 7
Image: 2
Specimen Label: P7 Brain
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3028100
Assay Type: RT-PCR
Annotation Date: 2004-02-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3028201
Age: postnatal day 25
Image: 2
Specimen Label: P25 Brain
Detected: true
Specimen Num: 8
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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