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Search results 1 to 100 out of 496 for Disc1

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: Disrupted-In-Schizophrenia 1 (DISC1) was identified as a novel gene disrupted by a (1;11)(q42.1;q14.3) translocation segregating with schizophrenia, bipolar disorder and other major mental illnesses in a Scottish family [, ]. Human DISC1 is multifunctional with several interacting proteins, including components of the dynein motor protein complex, such as nuclear distribution element-like (NDEL1/NUDEL) and lissencephaly 1 protein (LIS1). DISC1 is also required for regulation of microtubule dynamics, neurite outgrowth and neuronal migration in vivo [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Clapcote SJ
Year: 2007
Journal: Neuron
Title: Behavioral phenotypes of Disc1 missense mutations in mice.
Volume: 54
Issue: 3
Pages: 387-402
Publication  
First Author: Tomoda T
Year: 2016
Journal: Neuroscience
Title: Utility and validity of DISC1 mouse models in biological psychiatry.
Volume: 321
Pages: 99-107
Publication
First Author: Chandran JS
Year: 2014
Journal: PLoS One
Title: Disc1 variation leads to specific alterations in adult neurogenesis.
Volume: 9
Issue: 10
Pages: e108088
Publication
First Author: Lipina TV
Year: 2012
Journal: Neuropharmacology
Title: Synergistic interactions between PDE4B and GSK-3: DISC1 mutant mice.
Volume: 62
Issue: 3
Pages: 1252-62
Protein
Organism: Mus musculus
Length: 852  
Fragment?: false
Protein
Organism: Mus musculus
Length: 789  
Fragment?: false
Protein
Organism: Mus musculus
Length: 852  
Fragment?: false
Publication
First Author: Blackwood DH
Year: 2001
Journal: Am J Hum Genet
Title: Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family.
Volume: 69
Issue: 2
Pages: 428-33
Publication
First Author: Millar JK
Year: 2000
Journal: Hum Mol Genet
Title: Disruption of two novel genes by a translocation co-segregating with schizophrenia.
Volume: 9
Issue: 9
Pages: 1415-23
Publication
First Author: Kamiya A
Year: 2006
Journal: Hum Mol Genet
Title: DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1.
Volume: 15
Issue: 22
Pages: 3313-23
Publication
First Author: Lee FH
Year: 2011
Journal: J Neurosci
Title: Disc1 point mutations in mice affect development of the cerebral cortex.
Volume: 31
Issue: 9
Pages: 3197-206
Publication  
First Author: Arime Y
Year: 2014
Journal: Behav Brain Funct
Title: Effects of background mutations and single nucleotide polymorphisms (SNPs) on the Disc1 L100P behavioral phenotype associated with schizophrenia in mice.
Volume: 10
Pages: 45
Publication
First Author: Lipina TV
Year: 2013
Journal: J Neurosci
Title: Maternal immune activation during gestation interacts with Disc1 point mutation to exacerbate schizophrenia-related behaviors in mice.
Volume: 33
Issue: 18
Pages: 7654-66
Publication
First Author: Haque FN
Year: 2012
Journal: Behav Brain Res
Title: Social defeat interacts with Disc1 mutations in the mouse to affect behavior.
Volume: 233
Issue: 2
Pages: 337-44
Publication
First Author: Park SJ
Year: 2017
Journal: Cell Rep
Title: DISC1 Modulates Neuronal Stress Responses by Gate-Keeping ER-Mitochondria Ca2+ Transfer through the MAM.
Volume: 21
Issue: 10
Pages: 2748-2759
Publication
First Author: Singh KK
Year: 2011
Journal: Neuron
Title: Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development.
Volume: 72
Issue: 4
Pages: 545-58
Publication  
First Author: Seshadri S
Year: 2015
Journal: Nat Commun
Title: Interneuronal DISC1 regulates NRG1-ErbB4 signalling and excitatory-inhibitory synapse formation in the mature cortex.
Volume: 6
Pages: 10118
Publication
First Author: Shevelkin AV
Year: 2020
Journal: Hum Mol Genet
Title: Astrocyte DISC1 contributes to cognitive function in a brain region-dependent manner.
Volume: 29
Issue: 17
Pages: 2936-2950
Publication
First Author: Terrillion CE
Year: 2017
Journal: Neuropsychopharmacology
Title: DISC1 in Astrocytes Influences Adult Neurogenesis and Hippocampus-Dependent Behaviors in Mice.
Volume: 42
Issue: 11
Pages: 2242-2251
Publication
First Author: Ibi D
Year: 2010
Journal: Behav Brain Res
Title: Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood.
Volume: 206
Issue: 1
Pages: 32-7
Publication  
First Author: Ballinger MD
Year: 2015
Journal: Neurobiol Dis
Title: Adolescent cannabis exposure interacts with mutant DISC1 to produce impaired adult emotional memory.
Volume: 82
Pages: 176-184
Publication
First Author: Abazyan B
Year: 2010
Journal: Biol Psychiatry
Title: Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology.
Volume: 68
Issue: 12
Pages: 1172-81
Publication
First Author: Marley A
Year: 2010
Journal: PLoS One
Title: DISC1 regulates primary cilia that display specific dopamine receptors.
Volume: 5
Issue: 5
Pages: e10902
Publication  
First Author: Shevelkin AV
Year: 2017
Journal: Neurobiol Dis
Title: Expression of mutant DISC1 in Purkinje cells increases their spontaneous activity and impairs cognitive and social behaviors in mice.
Volume: 103
Pages: 144-153
Publication
First Author: Ren J
Year: 2016
Journal: Brain Res
Title: Interaction between DISC1 and CHL1 in regulation of neurite outgrowth.
Volume: 1648
Issue: Pt A
Pages: 290-297
Publication
First Author: Meyer KD
Year: 2009
Journal: Hum Mol Genet
Title: Disc1 regulates granule cell migration in the developing hippocampus.
Volume: 18
Issue: 17
Pages: 3286-97
Publication
First Author: Jaaro-Peled H
Year: 2013
Journal: Hum Mol Genet
Title: Subcortical dopaminergic deficits in a DISC1 mutant model: a study in direct reference to human molecular brain imaging.
Volume: 22
Issue: 8
Pages: 1574-80
Publication
First Author: Koike H
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice.
Volume: 103
Issue: 10
Pages: 3693-7
Publication
First Author: Katsel P
Year: 2018
Journal: Schizophr Bull
Title: Overexpression of Truncated Human DISC1 Induces Appearance of Hindbrain Oligodendroglia in the Forebrain During Development.
Volume: 44
Issue: 3
Pages: 515-524
Publication  
First Author: Li N
Year: 2018
Journal: Front Cell Neurosci
Title: Adolescent Isolation Interacts With DISC1 Point Mutation to Impair Adult Social Memory and Synaptic Functions in the Hippocampus.
Volume: 12
Pages: 238
Publication
First Author: Ma L
Year: 2002
Journal: Genomics
Title: Cloning and characterization of Disc1, the mouse ortholog of DISC1 (Disrupted-in-Schizophrenia 1).
Volume: 80
Issue: 6
Pages: 662-72
Publication
First Author: Tanaka M
Year: 2017
Journal: J Clin Invest
Title: Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington's disease.
Volume: 127
Issue: 4
Pages: 1438-1450
Publication
First Author: Clapcote SJ
Year: 2006
Journal: Genetics
Title: Deletion polymorphism of Disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function.
Volume: 173
Issue: 4
Pages: 2407-10
Publication  
First Author: Lepagnol-Bestel AM
Year: 2013
Journal: Mol Cell Neurosci
Title: A Disc1 mutation differentially affects neurites and spines in hippocampal and cortical neurons.
Volume: 54
Pages: 84-92
Publication
First Author: Zhou M
Year: 2013
Journal: Neuron
Title: mTOR Inhibition ameliorates cognitive and affective deficits caused by Disc1 knockdown in adult-born dentate granule neurons.
Volume: 77
Issue: 4
Pages: 647-54
Publication  
First Author: Jacobi AA
Year: 2019
Journal: Neurosci Lett
Title: Neuronal serine racemase associates with Disrupted-In-Schizophrenia-1 and DISC1 agglomerates: Implications for schizophrenia.
Volume: 692
Pages: 107-114
Publication
First Author: Singh KK
Year: 2010
Journal: Neuron
Title: Dixdc1 is a critical regulator of DISC1 and embryonic cortical development.
Volume: 67
Issue: 1
Pages: 33-48
Publication
First Author: Rodríguez-Seoane C
Year: 2015
Journal: J Neurochem
Title: DISC1 regulates expression of the neurotrophin VGF through the PI3K/AKT/CREB pathway.
Volume: 135
Issue: 3
Pages: 598-605
Publication
First Author: Kang E
Year: 2011
Journal: Neuron
Title: Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia.
Volume: 72
Issue: 4
Pages: 559-71
Publication
First Author: Kvajo M
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Altered axonal targeting and short-term plasticity in the hippocampus of Disc1 mutant mice.
Volume: 108
Issue: 49
Pages: E1349-58
Publication
First Author: Baskaran R
Year: 2020
Journal: J Comp Neurol
Title: Characterization of striatal phenotypes in heterozygous Disc1 mutant mice, a model of haploinsufficiency.
Volume: 528
Issue: 7
Pages: 1157-1172
Publication  
First Author: Dachtler J
Year: 2016
Journal: Sci Rep
Title: Missense mutation in DISC1 C-terminal coiled-coil has GSK3β signaling and sex-dependent behavioral effects in mice.
Volume: 6
Pages: 18748
Publication  
First Author: Hayashi Y
Year: 2016
Journal: Neurosci Res
Title: Impaired hippocampal activity at the goal zone on the place preference task in a DISC1 mouse model.
Volume: 106
Pages: 70-3
Publication
First Author: Meyer KD
Year: 2008
Journal: Gene Expr Patterns
Title: Immunohistochemical analysis of Disc1 expression in the developing and adult hippocampus.
Volume: 8
Issue: 7-8
Pages: 494-501
Publication
First Author: Kim JY
Year: 2009
Journal: Neuron
Title: DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212.
Volume: 63
Issue: 6
Pages: 761-73
Publication
First Author: Osbun N
Year: 2011
Journal: Am J Med Genet A
Title: Genetic and functional analyses identify DISC1 as a novel callosal agenesis candidate gene.
Volume: 155A
Issue: 8
Pages: 1865-76
Publication
First Author: Wang S
Year: 2016
Journal: Development
Title: DISC1 regulates astrogenesis in the embryonic brain via modulation of RAS/MEK/ERK signaling through RASSF7.
Volume: 143
Issue: 15
Pages: 2732-40
Publication
First Author: Ramsey AJ
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner.
Volume: 108
Issue: 14
Pages: 5795-800
Publication
First Author: Kuroda K
Year: 2011
Journal: Hum Mol Genet
Title: Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse.
Volume: 20
Issue: 23
Pages: 4666-83
Publication  
First Author: Gómez-Sintes R
Year: 2014
Journal: Front Behav Neurosci
Title: Mice with a naturally occurring DISC1 mutation display a broad spectrum of behaviors associated to psychiatric disorders.
Volume: 8
Pages: 253
Publication
First Author: Xu X
Year: 2021
Journal: Cereb Cortex
Title: Knock-Down of Hippocampal DISC1 in Immune-Challenged Mice Impairs the Prefrontal-Hippocampal Coupling and the Cognitive Performance Throughout Development.
Volume: 31
Issue: 2
Pages: 1240-1258
Publication
First Author: Ritchie DJ
Year: 2013
Journal: Lab Anim
Title: Disc1 deletion is present in Swiss-derived inbred mouse strains: implications for transgenic studies of learning and memory.
Volume: 47
Issue: 3
Pages: 162-7
Publication
First Author: Xu X
Year: 2019
Journal: J Neurosci
Title: Transient Knock-Down of Prefrontal DISC1 in Immune-Challenged Mice Causes Abnormal Long-Range Coupling and Cognitive Dysfunction throughout Development.
Volume: 39
Issue: 7
Pages: 1222-1235
Publication
First Author: Chen CY
Year: 2017
Journal: EMBO Rep
Title: TLR3 downregulates expression of schizophrenia gene Disc1 via MYD88 to control neuronal morphology.
Volume: 18
Issue: 1
Pages: 169-183
Publication
First Author: Kvajo M
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition.
Volume: 105
Issue: 19
Pages: 7076-81
Publication
First Author: Kamiya A
Year: 2008
Journal: Arch Gen Psychiatry
Title: Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses.
Volume: 65
Issue: 9
Pages: 996-1006
Publication
First Author: Kubo K
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Migration defects by DISC1 knockdown in C57BL/6, 129X1/SvJ, and ICR strains via in utero gene transfer and virus-mediated RNAi.
Volume: 400
Issue: 4
Pages: 631-7
Publication
First Author: Okamoto M
Year: 2015
Journal: J Neurosci
Title: DBZ regulates cortical cell positioning and neurite development by sustaining the anterograde transport of Lis1 and DISC1 through control of Ndel1 dual-phosphorylation.
Volume: 35
Issue: 7
Pages: 2942-58
Publication
First Author: Cui L
Year: 2016
Journal: Mol Brain
Title: Disrupted-in-schizophrenia1 (DISC1) L100P mutation alters synaptic transmission and plasticity in the hippocampus and causes recognition memory deficits.
Volume: 9
Issue: 1
Pages: 89
Publication
First Author: Lipina TV
Year: 2010
Journal: Genes Brain Behav
Title: Enhanced dopamine function in DISC1-L100P mutant mice: implications for schizophrenia.
Volume: 9
Issue: 7
Pages: 777-89
Publication
First Author: Walsh J
Year: 2012
Journal: J Neurosci Res
Title: Disruption of exploratory and habituation behavior in mice with mutation of DISC1: an ethologically based analysis.
Volume: 90
Issue: 7
Pages: 1445-53
Publication  
First Author: Tropea D
Year: 2016
Journal: Transl Psychiatry
Title: Disrupted in schizophrenia 1 (DISC1) L100P mutants have impaired activity-dependent plasticity in vivo and in vitro.
Volume: 6
Pages: e712
Publication  
First Author: Delevich K
Year: 2020
Journal: eNeuro
Title: Parvalbumin Interneuron Dysfunction in a Thalamo-Prefrontal Cortical Circuit in Disc1 Locus Impairment Mice.
Volume: 7
Issue: 2
Publication
First Author: Lipina TV
Year: 2012
Journal: PLoS One
Title: Prophylactic valproic acid treatment prevents schizophrenia-related behaviour in Disc1-L100P mutant mice.
Volume: 7
Issue: 12
Pages: e51562
Publication
First Author: Fukuda T
Year: 2010
Journal: J Biol Chem
Title: CAMDI, a novel disrupted in schizophrenia 1 (DISC1)-binding protein, is required for radial migration.
Volume: 285
Issue: 52
Pages: 40554-61
Publication
First Author: Su P
Year: 2014
Journal: Neuron
Title: A dopamine D2 receptor-DISC1 protein complex may contribute to antipsychotic-like effects.
Volume: 84
Issue: 6
Pages: 1302-16
Publication  
First Author: Walsh J
Year: 2010
Journal: Brain Res
Title: Disruption of thermal nociceptive behaviour in mice mutant for the schizophrenia-associated genes NRG1, COMT and DISC1.
Volume: 1348
Pages: 114-9
Publication
First Author: O'Tuathaigh CM
Year: 2017
Journal: Schizophr Bull
Title: Epistatic and Independent Effects on Schizophrenia-Related Phenotypes Following Co-disruption of the Risk Factors Neuregulin-1 × DISC1.
Volume: 43
Issue: 1
Pages: 214-225
Publication  
First Author: Desbonnet L
Year: 2017
Journal: Behav Brain Res
Title: Altered cytokine profile, pain sensitivity, and stress responsivity in mice with co-disruption of the developmental genes Neuregulin-1×DISC1.
Volume: 320
Pages: 113-118
Publication
First Author: Borkowska M
Year: 2016
Journal: PLoS One
Title: Altered Disrupted-in-Schizophrenia-1 Function Affects the Development of Cortical Parvalbumin Interneurons by an Indirect Mechanism.
Volume: 11
Issue: 5
Pages: e0156082
Publication  
First Author: Shoji H
Year: 2012
Journal: BMC Res Notes
Title: Comprehensive behavioral analysis of ENU-induced Disc1-Q31L and -L100P mutant mice.
Volume: 5
Pages: 108
Publication      
First Author: Clapcote SJ
Year: 2007
Journal: MGI Direct Data Submission
Title: Inbred mouse strains 101/RI, BTBR T tf/J and LP/J have a deletion in Disc1
Publication  
First Author: Lee FH
Year: 2013
Journal: Mol Brain
Title: Abnormal interneuron development in disrupted-in-schizophrenia-1 L100P mutant mice.
Volume: 6
Pages: 20
Publication  
First Author: Sultana R
Year: 2020
Journal: Front Cell Neurosci
Title: Disc1 Carrier Mice Exhibit Alterations in Neural pIGF-1Rβ and Related Kinase Expression.
Volume: 14
Pages: 94
Publication
First Author: Booth CA
Year: 2014
Journal: Eur J Neurosci
Title: Neurophysiological modification of CA1 pyramidal neurons in a transgenic mouse expressing a truncated form of disrupted-in-schizophrenia 1.
Volume: 39
Issue: 7
Pages: 1074-90
Publication
First Author: Shen S
Year: 2008
Journal: J Neurosci
Title: Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1.
Volume: 28
Issue: 43
Pages: 10893-904
Publication
First Author: Johnson AW
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Cognitive and motivational deficits together with prefrontal oxidative stress in a mouse model for neuropsychiatric illness.
Volume: 110
Issue: 30
Pages: 12462-7
Publication
First Author: Abazyan S
Year: 2014
Journal: J Neurosci Res
Title: Mutant disrupted-in-schizophrenia 1 in astrocytes: focus on glutamate metabolism.
Volume: 92
Issue: 12
Pages: 1659-68
Publication
First Author: Ji B
Year: 2014
Journal: Hum Mol Genet
Title: Inhibition of protein translation by the DISC1-Boymaw fusion gene from a Scottish family with major psychiatric disorders.
Volume: 23
Issue: 21
Pages: 5683-705
Publication
First Author: Li W
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice.
Volume: 104
Issue: 46
Pages: 18280-5
Publication
First Author: Ma TM
Year: 2013
Journal: Mol Psychiatry
Title: Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion.
Volume: 18
Issue: 5
Pages: 557-67
Publication
First Author: Jurczyk A
Year: 2016
Journal: FASEB J
Title: Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β.
Volume: 30
Issue: 2
Pages: 983-93
Publication
First Author: Taylor MS
Year: 2003
Journal: Genomics
Title: Evolutionary constraints on the Disrupted in Schizophrenia locus.
Volume: 81
Issue: 1
Pages: 67-77
Publication
First Author: Onishi T
Year: 2018
Journal: Sci Rep
Title: The Altered Supramolecular Structure of Dopamine D2 Receptors in Disc1-deficient Mice.
Volume: 8
Issue: 1
Pages: 1692
Publication  
First Author: Kvajo M
Year: 2012
Journal: Neuroscience
Title: Avoiding mouse traps in schizophrenia genetics: lessons and promises from current and emerging mouse models.
Volume: 211
Pages: 136-64
Publication
First Author: Wulaer B
Year: 2018
Journal: Genes Brain Behav
Title: Repetitive and compulsive-like behaviors lead to cognitive dysfunction in Disc1Δ2-3/Δ2-3 mice.
Volume: 17
Issue: 8
Pages: e12478
Publication
First Author: Wang ZT
Year: 2019
Journal: Aging Cell
Title: Disrupted-in-schizophrenia-1 protects synaptic plasticity in a transgenic mouse model of Alzheimer's disease as a mitophagy receptor.
Volume: 18
Issue: 1
Pages: e12860
Publication
First Author: Dittrich L
Year: 2017
Journal: Sci Rep
Title: The natural Disc1-deletion present in several inbred mouse strains does not affect sleep.
Volume: 7
Issue: 1
Pages: 5665
Publication
First Author: Chen SY
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Disrupted-in-Schizophrenia 1-mediated axon guidance involves TRIO-RAC-PAK small GTPase pathway signaling.
Volume: 108
Issue: 14
Pages: 5861-6
Publication
First Author: Austin CP
Year: 2004
Journal: Neuroscience
Title: Expression of Disrupted-In-Schizophrenia-1, a schizophrenia-associated gene, is prominent in the mouse hippocampus throughout brain development.
Volume: 124
Issue: 1
Pages: 3-10
Publication
First Author: Tomita K
Year: 2011
Journal: Hum Mol Genet
Title: Disrupted-in-Schizophrenia-1 (Disc1) is necessary for migration of the pyramidal neurons during mouse hippocampal development.
Volume: 20
Issue: 14
Pages: 2834-45
Publication
First Author: Duan X
Year: 2007
Journal: Cell
Title: Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain.
Volume: 130
Issue: 6
Pages: 1146-58
Publication  
First Author: Owczarek S
Year: 2015
Journal: Neural Plast
Title: Neurexin-Neuroligin Synaptic Complex Regulates Schizophrenia-Related DISC1/Kal-7/Rac1 "Signalosome".
Volume: 2015
Pages: 167308