Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Disrupted-In-Schizophrenia 1 (DISC1) was identified as a novel gene disrupted by a (1;11)(q42.1;q14.3) translocation segregating with schizophrenia, bipolar disorder and other major mental illnesses in a Scottish family [, ]. Human DISC1 is multifunctional with several interacting proteins, including components of the dynein motor protein complex, such as nuclear distribution element-like (NDEL1/NUDEL) and lissencephaly 1 protein (LIS1). DISC1 is also required for regulation of microtubule dynamics, neurite outgrowth and neuronal migration in vivo []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Takahashi Y |
Year: |
2022 |
Journal: |
Int J Mol Sci |
Title: |
Polysialylation in a DISC1 Mutant Mouse. |
Volume: |
23 |
Issue: |
9 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Clapcote SJ |
Year: |
2007 |
Journal: |
Neuron |
Title: |
Behavioral phenotypes of Disc1 missense mutations in mice. |
Volume: |
54 |
Issue: |
3 |
Pages: |
387-402 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chandran JS |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Disc1 variation leads to specific alterations in adult neurogenesis. |
Volume: |
9 |
Issue: |
10 |
Pages: |
e108088 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tomoda T |
Year: |
2016 |
Journal: |
Neuroscience |
Title: |
Utility and validity of DISC1 mouse models in biological psychiatry. |
Volume: |
321 |
|
Pages: |
99-107 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lipina TV |
Year: |
2012 |
Journal: |
Neuropharmacology |
Title: |
Synergistic interactions between PDE4B and GSK-3: DISC1 mutant mice. |
Volume: |
62 |
Issue: |
3 |
Pages: |
1252-62 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
852
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
789
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
852
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Blackwood DH |
Year: |
2001 |
Journal: |
Am J Hum Genet |
Title: |
Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. |
Volume: |
69 |
Issue: |
2 |
Pages: |
428-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Millar JK |
Year: |
2000 |
Journal: |
Hum Mol Genet |
Title: |
Disruption of two novel genes by a translocation co-segregating with schizophrenia. |
Volume: |
9 |
Issue: |
9 |
Pages: |
1415-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kamiya A |
Year: |
2006 |
Journal: |
Hum Mol Genet |
Title: |
DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1. |
Volume: |
15 |
Issue: |
22 |
Pages: |
3313-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Arime Y |
Year: |
2014 |
Journal: |
Behav Brain Funct |
Title: |
Effects of background mutations and single nucleotide polymorphisms (SNPs) on the Disc1 L100P behavioral phenotype associated with schizophrenia in mice. |
Volume: |
10 |
|
Pages: |
45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee FH |
Year: |
2011 |
Journal: |
J Neurosci |
Title: |
Disc1 point mutations in mice affect development of the cerebral cortex. |
Volume: |
31 |
Issue: |
9 |
Pages: |
3197-206 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lipina TV |
Year: |
2013 |
Journal: |
J Neurosci |
Title: |
Maternal immune activation during gestation interacts with Disc1 point mutation to exacerbate schizophrenia-related behaviors in mice. |
Volume: |
33 |
Issue: |
18 |
Pages: |
7654-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Haque FN |
Year: |
2012 |
Journal: |
Behav Brain Res |
Title: |
Social defeat interacts with Disc1 mutations in the mouse to affect behavior. |
Volume: |
233 |
Issue: |
2 |
Pages: |
337-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Park SJ |
Year: |
2017 |
Journal: |
Cell Rep |
Title: |
DISC1 Modulates Neuronal Stress Responses by Gate-Keeping ER-Mitochondria Ca2+ Transfer through the MAM. |
Volume: |
21 |
Issue: |
10 |
Pages: |
2748-2759 |
|
•
•
•
•
•
|
Publication |
First Author: |
Seshadri S |
Year: |
2015 |
Journal: |
Nat Commun |
Title: |
Interneuronal DISC1 regulates NRG1-ErbB4 signalling and excitatory-inhibitory synapse formation in the mature cortex. |
Volume: |
6 |
|
Pages: |
10118 |
|
•
•
•
•
•
|
Publication |
First Author: |
Singh KK |
Year: |
2011 |
Journal: |
Neuron |
Title: |
Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development. |
Volume: |
72 |
Issue: |
4 |
Pages: |
545-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shahani N |
Year: |
2015 |
Journal: |
Mol Psychiatry |
Title: |
DISC1 regulates trafficking and processing of APP and Aβ generation. |
Volume: |
20 |
Issue: |
7 |
Pages: |
874-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Terrillion CE |
Year: |
2017 |
Journal: |
Neuropsychopharmacology |
Title: |
DISC1 in Astrocytes Influences Adult Neurogenesis and Hippocampus-Dependent Behaviors in Mice. |
Volume: |
42 |
Issue: |
11 |
Pages: |
2242-2251 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shevelkin AV |
Year: |
2020 |
Journal: |
Hum Mol Genet |
Title: |
Astrocyte DISC1 contributes to cognitive function in a brain region-dependent manner. |
Volume: |
29 |
Issue: |
17 |
Pages: |
2936-2950 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ballinger MD |
Year: |
2015 |
Journal: |
Neurobiol Dis |
Title: |
Adolescent cannabis exposure interacts with mutant DISC1 to produce impaired adult emotional memory. |
Volume: |
82 |
|
Pages: |
176-184 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ibi D |
Year: |
2010 |
Journal: |
Behav Brain Res |
Title: |
Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood. |
Volume: |
206 |
Issue: |
1 |
Pages: |
32-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marley A |
Year: |
2010 |
Journal: |
PLoS One |
Title: |
DISC1 regulates primary cilia that display specific dopamine receptors. |
Volume: |
5 |
Issue: |
5 |
Pages: |
e10902 |
|
•
•
•
•
•
|
Publication |
First Author: |
Abazyan B |
Year: |
2010 |
Journal: |
Biol Psychiatry |
Title: |
Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology. |
Volume: |
68 |
Issue: |
12 |
Pages: |
1172-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shevelkin AV |
Year: |
2017 |
Journal: |
Neurobiol Dis |
Title: |
Expression of mutant DISC1 in Purkinje cells increases their spontaneous activity and impairs cognitive and social behaviors in mice. |
Volume: |
103 |
|
Pages: |
144-153 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meyer KD |
Year: |
2009 |
Journal: |
Hum Mol Genet |
Title: |
Disc1 regulates granule cell migration in the developing hippocampus. |
Volume: |
18 |
Issue: |
17 |
Pages: |
3286-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ren J |
Year: |
2016 |
Journal: |
Brain Res |
Title: |
Interaction between DISC1 and CHL1 in regulation of neurite outgrowth. |
Volume: |
1648 |
Issue: |
Pt A |
Pages: |
290-297 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koike H |
Year: |
2006 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice. |
Volume: |
103 |
Issue: |
10 |
Pages: |
3693-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li N |
Year: |
2018 |
Journal: |
Front Cell Neurosci |
Title: |
Adolescent Isolation Interacts With DISC1 Point Mutation to Impair Adult Social Memory and Synaptic Functions in the Hippocampus. |
Volume: |
12 |
|
Pages: |
238 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ma L |
Year: |
2002 |
Journal: |
Genomics |
Title: |
Cloning and characterization of Disc1, the mouse ortholog of DISC1 (Disrupted-in-Schizophrenia 1). |
Volume: |
80 |
Issue: |
6 |
Pages: |
662-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu X |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice. |
Volume: |
12 |
Issue: |
1 |
Pages: |
6810 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jaaro-Peled H |
Year: |
2013 |
Journal: |
Hum Mol Genet |
Title: |
Subcortical dopaminergic deficits in a DISC1 mutant model: a study in direct reference to human molecular brain imaging. |
Volume: |
22 |
Issue: |
8 |
Pages: |
1574-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tanaka M |
Year: |
2017 |
Journal: |
J Clin Invest |
Title: |
Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington's disease. |
Volume: |
127 |
Issue: |
4 |
Pages: |
1438-1450 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katsel P |
Year: |
2018 |
Journal: |
Schizophr Bull |
Title: |
Overexpression of Truncated Human DISC1 Induces Appearance of Hindbrain Oligodendroglia in the Forebrain During Development. |
Volume: |
44 |
Issue: |
3 |
Pages: |
515-524 |
|
•
•
•
•
•
|
Publication |
First Author: |
Clapcote SJ |
Year: |
2006 |
Journal: |
Genetics |
Title: |
Deletion polymorphism of Disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function. |
Volume: |
173 |
Issue: |
4 |
Pages: |
2407-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jacobi AA |
Year: |
2019 |
Journal: |
Neurosci Lett |
Title: |
Neuronal serine racemase associates with Disrupted-In-Schizophrenia-1 and DISC1 agglomerates: Implications for schizophrenia. |
Volume: |
692 |
|
Pages: |
107-114 |
|
•
•
•
•
•
|
Publication |
First Author: |
Singh KK |
Year: |
2010 |
Journal: |
Neuron |
Title: |
Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. |
Volume: |
67 |
Issue: |
1 |
Pages: |
33-48 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6171213 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
|
Stage: |
TS19 |
Assay Id: |
MGI:6190114 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Disc1 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6171213 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
|
Stage: |
TS21 |
Assay Id: |
MGI:6190114 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Disc1 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6171213 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
|
Stage: |
TS24 |
Assay Id: |
MGI:6190114 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Disc1 |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6171213 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
|
Stage: |
TS26 |
Assay Id: |
MGI:6190114 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Disc1 |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6171213 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6190114 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Disc1 |
Detected: |
false |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6171213 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6190114 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Disc1 |
Detected: |
false |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6171213 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6190114 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Disc1 |
Detected: |
false |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
RodrÃguez-Seoane C |
Year: |
2015 |
Journal: |
J Neurochem |
Title: |
DISC1 regulates expression of the neurotrophin VGF through the PI3K/AKT/CREB pathway. |
Volume: |
135 |
Issue: |
3 |
Pages: |
598-605 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lepagnol-Bestel AM |
Year: |
2013 |
Journal: |
Mol Cell Neurosci |
Title: |
A Disc1 mutation differentially affects neurites and spines in hippocampal and cortical neurons. |
Volume: |
54 |
|
Pages: |
84-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim NS |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
Pharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation. |
Volume: |
12 |
Issue: |
1 |
Pages: |
1398 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou M |
Year: |
2013 |
Journal: |
Neuron |
Title: |
mTOR Inhibition ameliorates cognitive and affective deficits caused by Disc1 knockdown in adult-born dentate granule neurons. |
Volume: |
77 |
Issue: |
4 |
Pages: |
647-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kang E |
Year: |
2011 |
Journal: |
Neuron |
Title: |
Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia. |
Volume: |
72 |
Issue: |
4 |
Pages: |
559-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meyer KD |
Year: |
2008 |
Journal: |
Gene Expr Patterns |
Title: |
Immunohistochemical analysis of Disc1 expression in the developing and adult hippocampus. |
Volume: |
8 |
Issue: |
7-8 |
Pages: |
494-501 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baskaran R |
Year: |
2020 |
Journal: |
J Comp Neurol |
Title: |
Characterization of striatal phenotypes in heterozygous Disc1 mutant mice, a model of haploinsufficiency. |
Volume: |
528 |
Issue: |
7 |
Pages: |
1157-1172 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kvajo M |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Altered axonal targeting and short-term plasticity in the hippocampus of Disc1 mutant mice. |
Volume: |
108 |
Issue: |
49 |
Pages: |
E1349-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dachtler J |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Missense mutation in DISC1 C-terminal coiled-coil has GSK3β signaling and sex-dependent behavioral effects in mice. |
Volume: |
6 |
|
Pages: |
18748 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kakuda K |
Year: |
2019 |
Journal: |
J Biochem |
Title: |
A DISC1 point mutation promotes oligomerization and impairs information processing in a mouse model of schizophrenia. |
Volume: |
165 |
Issue: |
4 |
Pages: |
369-378 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hayashi Y |
Year: |
2016 |
Journal: |
Neurosci Res |
Title: |
Impaired hippocampal activity at the goal zone on the place preference task in a DISC1 mouse model. |
Volume: |
106 |
|
Pages: |
70-3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Osbun N |
Year: |
2011 |
Journal: |
Am J Med Genet A |
Title: |
Genetic and functional analyses identify DISC1 as a novel callosal agenesis candidate gene. |
Volume: |
155A |
Issue: |
8 |
Pages: |
1865-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim JY |
Year: |
2009 |
Journal: |
Neuron |
Title: |
DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. |
Volume: |
63 |
Issue: |
6 |
Pages: |
761-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang S |
Year: |
2016 |
Journal: |
Development |
Title: |
DISC1 regulates astrogenesis in the embryonic brain via modulation of RAS/MEK/ERK signaling through RASSF7. |
Volume: |
143 |
Issue: |
15 |
Pages: |
2732-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou X |
Year: |
2021 |
Journal: |
Neurosci Bull |
Title: |
Reduced Firing of Nucleus Accumbens Parvalbumin Interneurons Impairs Risk Avoidance in DISC1 Transgenic Mice. |
Volume: |
37 |
Issue: |
9 |
Pages: |
1325-1338 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ramsey AJ |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner. |
Volume: |
108 |
Issue: |
14 |
Pages: |
5795-800 |
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Publication |
First Author: |
Ritchie DJ |
Year: |
2013 |
Journal: |
Lab Anim |
Title: |
Disc1 deletion is present in Swiss-derived inbred mouse strains: implications for transgenic studies of learning and memory. |
Volume: |
47 |
Issue: |
3 |
Pages: |
162-7 |
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Publication |
First Author: |
Xu X |
Year: |
2021 |
Journal: |
Cereb Cortex |
Title: |
Knock-Down of Hippocampal DISC1 in Immune-Challenged Mice Impairs the Prefrontal-Hippocampal Coupling and the Cognitive Performance Throughout Development. |
Volume: |
31 |
Issue: |
2 |
Pages: |
1240-1258 |
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Publication |
First Author: |
Kuroda K |
Year: |
2011 |
Journal: |
Hum Mol Genet |
Title: |
Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse. |
Volume: |
20 |
Issue: |
23 |
Pages: |
4666-83 |
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Publication |
First Author: |
Gómez-Sintes R |
Year: |
2014 |
Journal: |
Front Behav Neurosci |
Title: |
Mice with a naturally occurring DISC1 mutation display a broad spectrum of behaviors associated to psychiatric disorders. |
Volume: |
8 |
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Pages: |
253 |
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Publication |
First Author: |
Chen CY |
Year: |
2017 |
Journal: |
EMBO Rep |
Title: |
TLR3 downregulates expression of schizophrenia gene Disc1 via MYD88 to control neuronal morphology. |
Volume: |
18 |
Issue: |
1 |
Pages: |
169-183 |
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Publication |
First Author: |
Xu X |
Year: |
2019 |
Journal: |
J Neurosci |
Title: |
Transient Knock-Down of Prefrontal DISC1 in Immune-Challenged Mice Causes Abnormal Long-Range Coupling and Cognitive Dysfunction throughout Development. |
Volume: |
39 |
Issue: |
7 |
Pages: |
1222-1235 |
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Publication |
First Author: |
Kvajo M |
Year: |
2008 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition. |
Volume: |
105 |
Issue: |
19 |
Pages: |
7076-81 |
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Publication |
First Author: |
Kamiya A |
Year: |
2008 |
Journal: |
Arch Gen Psychiatry |
Title: |
Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses. |
Volume: |
65 |
Issue: |
9 |
Pages: |
996-1006 |
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Publication |
First Author: |
Kubo K |
Year: |
2010 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Migration defects by DISC1 knockdown in C57BL/6, 129X1/SvJ, and ICR strains via in utero gene transfer and virus-mediated RNAi. |
Volume: |
400 |
Issue: |
4 |
Pages: |
631-7 |
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Publication |
First Author: |
Okamoto M |
Year: |
2015 |
Journal: |
J Neurosci |
Title: |
DBZ regulates cortical cell positioning and neurite development by sustaining the anterograde transport of Lis1 and DISC1 through control of Ndel1 dual-phosphorylation. |
Volume: |
35 |
Issue: |
7 |
Pages: |
2942-58 |
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Publication |
First Author: |
Cui L |
Year: |
2016 |
Journal: |
Mol Brain |
Title: |
Disrupted-in-schizophrenia1 (DISC1) L100P mutation alters synaptic transmission and plasticity in the hippocampus and causes recognition memory deficits. |
Volume: |
9 |
Issue: |
1 |
Pages: |
89 |
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Publication |
First Author: |
Lipina TV |
Year: |
2010 |
Journal: |
Genes Brain Behav |
Title: |
Enhanced dopamine function in DISC1-L100P mutant mice: implications for schizophrenia. |
Volume: |
9 |
Issue: |
7 |
Pages: |
777-89 |
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Publication |
First Author: |
Tropea D |
Year: |
2016 |
Journal: |
Transl Psychiatry |
Title: |
Disrupted in schizophrenia 1 (DISC1) L100P mutants have impaired activity-dependent plasticity in vivo and in vitro. |
Volume: |
6 |
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Pages: |
e712 |
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Publication |
First Author: |
Walsh J |
Year: |
2012 |
Journal: |
J Neurosci Res |
Title: |
Disruption of exploratory and habituation behavior in mice with mutation of DISC1: an ethologically based analysis. |
Volume: |
90 |
Issue: |
7 |
Pages: |
1445-53 |
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Publication |
First Author: |
Delevich K |
Year: |
2020 |
Journal: |
eNeuro |
Title: |
Parvalbumin Interneuron Dysfunction in a Thalamo-Prefrontal Cortical Circuit in Disc1 Locus Impairment Mice. |
Volume: |
7 |
Issue: |
2 |
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Publication |
First Author: |
Lipina TV |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Prophylactic valproic acid treatment prevents schizophrenia-related behaviour in Disc1-L100P mutant mice. |
Volume: |
7 |
Issue: |
12 |
Pages: |
e51562 |
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Publication |
First Author: |
Fukuda T |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
CAMDI, a novel disrupted in schizophrenia 1 (DISC1)-binding protein, is required for radial migration. |
Volume: |
285 |
Issue: |
52 |
Pages: |
40554-61 |
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Publication |
First Author: |
Walsh J |
Year: |
2010 |
Journal: |
Brain Res |
Title: |
Disruption of thermal nociceptive behaviour in mice mutant for the schizophrenia-associated genes NRG1, COMT and DISC1. |
Volume: |
1348 |
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Pages: |
114-9 |
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Publication |
First Author: |
Su P |
Year: |
2014 |
Journal: |
Neuron |
Title: |
A dopamine D2 receptor-DISC1 protein complex may contribute to antipsychotic-like effects. |
Volume: |
84 |
Issue: |
6 |
Pages: |
1302-16 |
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Publication |
First Author: |
O'Tuathaigh CM |
Year: |
2017 |
Journal: |
Schizophr Bull |
Title: |
Epistatic and Independent Effects on Schizophrenia-Related Phenotypes Following Co-disruption of the Risk Factors Neuregulin-1 × DISC1. |
Volume: |
43 |
Issue: |
1 |
Pages: |
214-225 |
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Publication |
First Author: |
Desbonnet L |
Year: |
2017 |
Journal: |
Behav Brain Res |
Title: |
Altered cytokine profile, pain sensitivity, and stress responsivity in mice with co-disruption of the developmental genes Neuregulin-1×DISC1. |
Volume: |
320 |
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Pages: |
113-118 |
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Publication |
First Author: |
Borkowska M |
Year: |
2016 |
Journal: |
PLoS One |
Title: |
Altered Disrupted-in-Schizophrenia-1 Function Affects the Development of Cortical Parvalbumin Interneurons by an Indirect Mechanism. |
Volume: |
11 |
Issue: |
5 |
Pages: |
e0156082 |
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Publication |
First Author: |
Clapcote SJ |
Year: |
2007 |
Journal: |
MGI Direct Data Submission |
Title: |
Inbred mouse strains 101/RI, BTBR T tf/J and LP/J have a deletion in Disc1 |
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Publication |
First Author: |
Shoji H |
Year: |
2012 |
Journal: |
BMC Res Notes |
Title: |
Comprehensive behavioral analysis of ENU-induced Disc1-Q31L and -L100P mutant mice. |
Volume: |
5 |
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Pages: |
108 |
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Publication |
First Author: |
Lai CC |
Year: |
2022 |
Journal: |
Int J Mol Sci |
Title: |
Chronic N-Acetylcysteine Treatment Prevents Amphetamine-Induced Hyperactivity in Heterozygous Disc1 Mutant Mice, a Putative Prodromal Schizophrenia Animal Model. |
Volume: |
23 |
Issue: |
16 |
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Publication |
First Author: |
Lee FH |
Year: |
2013 |
Journal: |
Mol Brain |
Title: |
Abnormal interneuron development in disrupted-in-schizophrenia-1 L100P mutant mice. |
Volume: |
6 |
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Pages: |
20 |
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Publication |
First Author: |
Sultana R |
Year: |
2020 |
Journal: |
Front Cell Neurosci |
Title: |
Disc1 Carrier Mice Exhibit Alterations in Neural pIGF-1Rβ and Related Kinase Expression. |
Volume: |
14 |
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Pages: |
94 |
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