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Search results 1 to 100 out of 107 for Dlgap3

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
58512 | DLGAP3
Type: gene
Organism: human
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Gene
516070 | DLGAP3
Type: gene
Organism: cattle
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Gene
100612766 | DLGAP3
Type: gene
Organism: chimpanzee
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Gene
419638 | DLGAP3
Type: gene
Organism: chicken
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Gene
557556 | dlgap3
Type: gene
Organism: zebrafish
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Gene
711238 | DLGAP3
Type: gene
Organism: macaque, rhesus
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Gene
100127639 | dlgap3
Type: gene
Organism: frog, western clawed
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Gene
286923 | Dlgap3
Type: gene
Organism: rat
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Gene
475342 | DLGAP3
Type: gene
Organism: dog, domestic
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Protein Domain
IPR030526 | DLGAP3
Type: Family
Description: Disks large-associated protein 3 (DLGAP3, SAPAP3) belongs to the SAPAP family. DLGAP3 regulates excitatory neurotransmission by inhibiting mGluR5-driven endocytosis of AMPA-type glutamate receptors (AMPARs) []. It has been linked to obsessive-compulsive disorder (OCD) [].SAPAP family members are PSD-95/SAP90-associated proteins localised at postsynaptic density []. Postsynaptic density (PSD) is a specialised submembranous structure within which synaptic membrane proteins are linked to cytoskeleton and signalling proteins. PSD-95/SAP90 is one of the major components of PSD, and functions as a scaffold protein for various ion channels and associated signalling molecules.
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Protein Coding Gene
MGI:3039563 | Dlgap3
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
17713528 | J:125181
First Author: Welch JM
Year: 2007
Journal: Nature
Title: Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice.
Volume: 448
Issue: 7156
Pages: 894-900
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Publication
22090495 | J:177909
First Author: Wan Y
Year: 2011
Journal: J Neurosci
Title: Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses.
Volume: 31
Issue: 46
Pages: 16685-91
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Protein
Q6PFD5
Organism: Mus musculus/domesticus
Length: 977  
Fragment?: false
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Protein
B1AS06
Organism: Mus musculus/domesticus
Length: 966  
Fragment?: false
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Protein
Q3TY61
Organism: Mus musculus/domesticus
Length: 977  
Fragment?: false
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Publication
9115257 | -
First Author: Takeuchi M
Year: 1997
Journal: J Biol Chem
Title: SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density.
Volume: 272
Issue: 18
Pages: 11943-51
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Protein Coding Gene
MGP_CAROLIEiJ_G0026491 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0028794 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0028753 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0028706 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0028776 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0028490 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_3039563 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0029218 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0027923 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0028456 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0028605 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0028572 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0028706 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0028598 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0029256 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0027644 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0028003 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0028822 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0027471 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
37934666 | J:343598
First Author: Malgady JM
Year: 2023
Journal: Cell Rep
Title: Pathway-specific alterations in striatal excitability and cholinergic modulation in a SAPAP3 mouse model of compulsive motor behavior.
Volume: 42
Issue: 11
Pages: 113384
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Publication
32234806 | J:288367
 
First Author: Ehmer I
Year: 2020
Journal: eNeuro
Title: Evidence for Distinct Forms of Compulsivity in the SAPAP3 Mutant-Mouse Model for Obsessive-Compulsive Disorder.
Volume: 7
Issue: 2
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Publication
34417544 | J:333856
First Author: Ramírez-Armenta KI
Year: 2022
Journal: Neuropsychopharmacology
Title: Optogenetic inhibition of indirect pathway neurons in the dorsomedial striatum reduces excessive grooming in Sapap3-knockout mice.
Volume: 47
Issue: 2
Pages: 477-487
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Publication
31427755 | J:284844
First Author: Hadjas LC
Year: 2019
Journal: Sci Rep
Title: Aberrant habit formation in the Sapap3-knockout mouse model of obsessive-compulsive disorder.
Volume: 9
Issue: 1
Pages: 12061
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Publication
36717540 | J:344579
First Author: Lamothe H
Year: 2023
Journal: Transl Psychiatry
Title: The Sapap3(-/-) mouse reconsidered as a comorbid model expressing a spectrum of pathological repetitive behaviours.
Volume: 13
Issue: 1
Pages: 26
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Publication
35661523 | J:334598
 
First Author: Kajs BL
Year: 2022
Journal: J Psychiatr Res
Title: Valence processing alterations in SAPAP3 knockout mice and human OCD.
Volume: 151
Pages: 657-666
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Publication
33941812 | J:316335
First Author: Manning EE
Year: 2021
Journal: Sci Rep
Title: Disruption of prepulse inhibition is associated with compulsive behavior severity and nucleus accumbens dopamine receptor changes in Sapap3 knockout mice.
Volume: 11
Issue: 1
Pages: 9442
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Publication
37597609 | J:340609
 
First Author: Gattuso JJ
Year: 2023
Journal: Neuropharmacology
Title: Acute administration of the NMDA receptor antagonists ketamine and MK-801 reveals dysregulation of glutamatergic signalling and sensorimotor gating in the Sapap3 knockout mouse model of compulsive-like behaviour.
Volume: 239
Pages: 109689
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Publication
37046092 | J:339991
First Author: Soto JS
Year: 2023
Journal: Nature
Title: Astrocyte-neuron subproteomes and obsessive-compulsive disorder mechanisms.
Volume: 616
Issue: 7958
Pages: 764-773
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Publication
33188744 | J:328620
First Author: Yang Z
Year: 2021
Journal: Curr Biol
Title: Dysfunction of Orbitofrontal GABAergic Interneurons Leads to Impaired Reversal Learning in a Mouse Model of Obsessive-Compulsive Disorder.
Volume: 31
Issue: 2
Pages: 381-393.e4
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Publication
29035974 | J:272123
First Author: Tesdahl NS
Year: 2017
Journal: Neuroreport
Title: Altered ultrasonic vocalization in neonatal SAPAP3-deficient mice.
Volume: 28
Issue: 17
Pages: 1115-1118
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Publication
30688005 | J:294973
First Author: van den Boom BJG
Year: 2019
Journal: Genes Brain Behav
Title: Behavioral flexibility in a mouse model for obsessive-compulsive disorder: Impaired Pavlovian reversal learning in SAPAP3 mutants.
Volume: 18
Issue: 4
Pages: e12557
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Publication
33479495 | J:308380
First Author: Benzina N
Year: 2021
Journal: Commun Biol
Title: A cross-species assessment of behavioral flexibility in compulsive disorders.
Volume: 4
Issue: 1
Pages: 96
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Publication
23744950 | J:199175
First Author: Burguière E
Year: 2013
Journal: Science
Title: Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors.
Volume: 340
Issue: 6137
Pages: 1243-6
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Publication
32454126 | J:314878
 
First Author: Glorie D
Year: 2020
Journal: Neuropharmacology
Title: Progression of obsessive compulsive disorder-like grooming in Sapap3 knockout mice: A longitudinal [11C]ABP688 PET study.
Volume: 177
Pages: 108160
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Publication
- | J:339639
     
First Author: Malgady JM
Year: 2022
Journal: bioRxiv
Title: Non-synaptic alterations in striatal excitability and cholinergic modulation in a SAPAP3 mouse model of compulsive motor behavior
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Publication
30587851 | J:295104
First Author: Manning EE
Year: 2019
Journal: Neuropsychopharmacology
Title: Impaired instrumental reversal learning is associated with increased medial prefrontal cortex activity in Sapap3 knockout mouse model of compulsive behavior.
Volume: 44
Issue: 8
Pages: 1494-1504
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GXD Expression
GXD Expression
   
Probe: MGI:7278718
Assay Type: Western blot
Annotation Date: 2022-05-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754928
Stage: TS28
Assay Id: MGI:7278752
Age: postnatal adult
Image: 5
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7278718
Assay Type: Western blot
Annotation Date: 2022-05-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754928
Stage: TS28
Assay Id: MGI:7278752
Age: postnatal adult
Image: 5
Specimen Label: WT
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7278718
Assay Type: Western blot
Annotation Date: 2022-05-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754928
Stage: TS28
Assay Id: MGI:7278752
Age: postnatal adult
Image: 5
Specimen Label: WT
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7278718
Assay Type: Western blot
Annotation Date: 2022-05-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754928
Stage: TS28
Assay Id: MGI:7278752
Age: postnatal adult
Image: 5
Specimen Label: KO
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7278718
Assay Type: Western blot
Annotation Date: 2022-05-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754928
Stage: TS28
Assay Id: MGI:7278752
Age: postnatal adult
Image: 5
Specimen Label: KO
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:7278718
Assay Type: Western blot
Annotation Date: 2022-05-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754928
Stage: TS28
Assay Id: MGI:7278752
Age: postnatal adult
Image: 5
Specimen Label: KO
Detected: true
Specimen Num: 6
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Publication
21715621 | J:174059
First Author: Chen M
Year: 2011
Journal: J Neurosci
Title: Sapap3 deletion anomalously activates short-term endocannabinoid-mediated synaptic plasticity.
Volume: 31
Issue: 26
Pages: 9563-73
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Publication
27436084 | J:281836
First Author: Ade KK
Year: 2016
Journal: Biol Psychiatry
Title: Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice.
Volume: 80
Issue: 7
Pages: 522-33
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Publication
30737313 | J:273602
First Author: Corbit VL
Year: 2019
Journal: J Neurosci
Title: Strengthened Inputs from Secondary Motor Cortex to Striatum in a Mouse Model of Compulsive Behavior.
Volume: 39
Issue: 15
Pages: 2965-2975
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Publication
23414593 | J:248416
First Author: Wan Y
Year: 2014
Journal: Biol Psychiatry
Title: Circuit-selective striatal synaptic dysfunction in the Sapap3 knockout mouse model of obsessive-compulsive disorder.
Volume: 75
Issue: 8
Pages: 623-30
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Publication
17380122 | J:200411
First Author: Willard MD
Year: 2007
Journal: EMBO J
Title: Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth factor-mediated differentiation.
Volume: 26
Issue: 8
Pages: 2029-40
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Publication
15024750 | J:90432
First Author: Welch JM
Year: 2004
Journal: J Comp Neurol
Title: Differential mRNA expression and protein localization of the SAP90/PSD-95-associated proteins (SAPAPs) in the nervous system of the mouse.
Volume: 472
Issue: 1
Pages: 24-39
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Publication
12034499 | J:77078
First Author: Yamaki M
Year: 2002
Journal: Gene
Title: The mouse Edr2 (Mph2) gene has two forms of mRNA encoding 90- and 36-kDa polypeptides.
Volume: 288
Issue: 1-2
Pages: 103-10
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Publication
33086039 | J:300547
First Author: Yu X
Year: 2020
Journal: Neuron
Title: Context-Specific Striatal Astrocyte Molecular Responses Are Phenotypically Exploitable.
Volume: 108
Issue: 6
Pages: 1146-1162.e10
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Publication
26562431 | J:232355
 
First Author: Ahmari SE
Year: 2016
Journal: Neuroscience
Title: Using mice to model Obsessive Compulsive Disorder: From genes to circuits.
Volume: 321
Pages: 121-137
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Publication
23754400 | J:197974
First Author: Xu P
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Double deletion of melanocortin 4 receptors and SAPAP3 corrects compulsive behavior and obesity in mice.
Volume: 110
Issue: 26
Pages: 10759-64
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Publication
10721728 | J:60243
First Author: Ye TZ
Year: 2000
Journal: Gene
Title: Ermap, a gene coding for a novel erythroid specific adhesion/receptor membrane protein.
Volume: 242
Issue: 1-2
Pages: 337-45
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Publication
19640847 | J:156357
First Author: Schütt J
Year: 2009
Journal: J Biol Chem
Title: Fragile X mental retardation protein regulates the levels of scaffold proteins and glutamate receptors in postsynaptic densities.
Volume: 284
Issue: 38
Pages: 25479-87
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Publication
9173930 | J:39869
First Author: Yehiely F
Year: 1997
Journal: Neurobiol Dis
Title: Identification of candidate proteins binding to prion protein.
Volume: 3
Issue: 4
Pages: 339-55
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Publication
20519520 | J:160811
First Author: McDowell KA
Year: 2010
Journal: J Neurosci
Title: Reduced cortical BDNF expression and aberrant memory in Carf knock-out mice.
Volume: 30
Issue: 22
Pages: 7453-65
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Publication
28288114 | J:240674
First Author: Lu HC
Year: 2017
Journal: Nat Genet
Title: Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans.
Volume: 49
Issue: 4
Pages: 527-536
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:101977
     
First Author: The Jackson Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from The Jackson Laboratory, Bar Harbor, ME
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Publication
- | J:66660
       
First Author: Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration
Year: 2001
Title: LocusLink Collaboration
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:72247
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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