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Search results 1 to 100 out of 570 for Dll4

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0.039s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Zou M
Year: 2015
Journal: Dev Dyn
Title: Selective neuronal lineages derived from Dll4-expressing progenitors/precursors in the retina and spinal cord.
Volume: 244
Issue: 1
Pages: 86-97
GXD Expression  
Probe: MGI:6725776
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-23
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1876828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6725800
Age: postnatal day 10-11
Image: 3E R/R Dll4
Note: Expression dramatically reduced compared to wild type.
Specimen Num: 1
GXD Expression  
Probe: MGI:6725776
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6725800
Age: postnatal day 10-11
Image: 3E WT Dll4
Detected: true
Specimen Num: 2
Publication
First Author: Duarte A
Year: 2004
Journal: Genes Dev
Title: Dosage-sensitive requirement for mouse Dll4 in artery development.
Volume: 18
Issue: 20
Pages: 2474-8
Publication
First Author: Pitulescu ME
Year: 2017
Journal: Nat Cell Biol
Title: Dll4 and Notch signalling couples sprouting angiogenesis and artery formation.
Volume: 19
Issue: 8
Pages: 915-927
Publication
First Author: Benedito R
Year: 2005
Journal: Gene Expr Patterns
Title: Expression of Dll4 during mouse embryogenesis suggests multiple developmental roles.
Volume: 5
Issue: 6
Pages: 750-5
Publication
First Author: Preuße K
Year: 2015
Journal: PLoS Genet
Title: Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo.
Volume: 11
Issue: 6
Pages: e1005328
Allele
Name: transgene insertion, Mengqing Xiang
Allele Type: Transgenic
Attribute String: Recombinase
Publication categories: ProxyCollection
Genotype
Symbol: Tg(Dll4-cre)#Xia/?
Background: involves: C57BL/6 * CBA
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(CAG-Bgeo/GFP)21Lbe/? Tg(Dll4-cre)#Xia/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Dll4-cre)#Xia/?
Background: involves: 129X1/SvJ * C57BL/6J * CBA
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Dll4-cre)#Xia/?
Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Trindade A
Year: 2012
Journal: PLoS One
Title: Low-dosage inhibition of Dll4 signaling promotes wound healing by inducing functional neo-angiogenesis.
Volume: 7
Issue: 1
Pages: e29863
Publication    
First Author: Tveriakhina L
Year: 2018
Journal: Elife
Title: The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro.
Volume: 7
Publication
First Author: Lee SU
Year: 2013
Journal: Blood
Title: LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance.
Volume: 121
Issue: 6
Pages: 918-29
Publication
First Author: Hellström M
Year: 2007
Journal: Nature
Title: Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis.
Volume: 445
Issue: 7129
Pages: 776-80
Publication
First Author: Bernier-Latmani J
Year: 2015
Journal: J Clin Invest
Title: DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport.
Volume: 125
Issue: 12
Pages: 4572-86
Publication
First Author: Yu VW
Year: 2015
Journal: J Exp Med
Title: Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow.
Volume: 212
Issue: 5
Pages: 759-74
Publication
First Author: Jeurissen ML
Year: 2016
Journal: PLoS One
Title: Myeloid DLL4 Does Not Contribute to the Pathogenesis of Non-Alcoholic Steatohepatitis in Ldlr-/- Mice.
Volume: 11
Issue: 11
Pages: e0167199
Publication
First Author: Pedrosa AR
Year: 2015
Journal: Arterioscler Thromb Vasc Biol
Title: Endothelial Jagged1 antagonizes Dll4 regulation of endothelial branching and promotes vascular maturation downstream of Dll4/Notch1.
Volume: 35
Issue: 5
Pages: 1134-46
Publication
First Author: Cappellari O
Year: 2013
Journal: Dev Cell
Title: Dll4 and PDGF-BB convert committed skeletal myoblasts to pericytes without erasing their myogenic memory.
Volume: 24
Issue: 6
Pages: 586-99
Publication
First Author: Adam MG
Year: 2013
Journal: Circ Res
Title: Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis.
Volume: 113
Issue: 11
Pages: 1206-18
Publication
First Author: Benedito R
Year: 2009
Journal: Cell
Title: The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis.
Volume: 137
Issue: 6
Pages: 1124-35
Publication
First Author: Xiong H
Year: 2013
Journal: PLoS One
Title: Characterization of two distinct lymphoproliferative diseases caused by ectopic expression of the Notch ligand DLL4 on T cells.
Volume: 8
Issue: 12
Pages: e84841
Publication
First Author: Hayashi H
Year: 2008
Journal: PLoS One
Title: Foxc transcription factors directly regulate Dll4 and Hey2 expression by interacting with the VEGF-Notch signaling pathways in endothelial cells.
Volume: 3
Issue: 6
Pages: e2401
Publication  
First Author: Benedito R
Year: 2008
Journal: BMC Dev Biol
Title: Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli.
Volume: 8
Pages: 117
Publication
First Author: Mendonça L
Year: 2019
Journal: Clin Exp Metastasis
Title: Metastasis is impaired by endothelial-specific Dll4 loss-of-function through inhibition of epithelial-to-mesenchymal transition and reduction of cancer stem cells and circulating tumor cells.
Volume: 36
Issue: 4
Pages: 365-380
Publication
First Author: Rocha SF
Year: 2009
Journal: Dev Biol
Title: Dll1 and Dll4 function sequentially in the retina and pV2 domain of the spinal cord to regulate neurogenesis and create cell diversity.
Volume: 328
Issue: 1
Pages: 54-65
Publication      
First Author: Herman AM
Year: 2018
Journal: Biol Open
Title: A novel reporter allele for monitoring Dll4 expression within the embryonic and adult mouse.
Publication
First Author: Billiard F
Year: 2011
Journal: Eur J Immunol
Title: Ongoing Dll4-Notch signaling is required for T-cell homeostasis in the adult thymus.
Volume: 41
Issue: 8
Pages: 2207-16
Allele  
Name: delta like canonical Notch ligand 4; targeted mutation 1, Velocigene
Allele Type: Targeted
Publication categories: ProxyCollection
Publication
First Author: Shutter JR
Year: 2000
Journal: Genes Dev
Title: Dll4, a novel Notch ligand expressed in arterial endothelium.
Volume: 14
Issue: 11
Pages: 1313-8
Publication
First Author: Stewart KS
Year: 2011
Journal: Blood
Title: Delta-like ligand 4-Notch signaling regulates bone marrow-derived pericyte/vascular smooth muscle cell formation.
Volume: 117
Issue: 2
Pages: 719-26
Publication
First Author: Liu R
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Inhibition of Notch signaling by Dll4-Fc promotes reperfusion of acutely ischemic tissues.
Volume: 418
Issue: 1
Pages: 173-9
Publication
First Author: Yan XQ
Year: 2001
Journal: Blood
Title: A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer.
Volume: 98
Issue: 13
Pages: 3793-9
Publication
First Author: Stenzel D
Year: 2011
Journal: EMBO Rep
Title: Endothelial basement membrane limits tip cell formation by inducing Dll4/Notch signalling in vivo.
Volume: 12
Issue: 11
Pages: 1135-43
Publication
First Author: Tsukamoto N
Year: 2005
Journal: Cell Immunol
Title: Lack of Delta like 1 and 4 expressions in nude thymus anlages.
Volume: 234
Issue: 2
Pages: 77-80
Publication
First Author: Lobov IB
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting.
Volume: 104
Issue: 9
Pages: 3219-24
Publication
First Author: Hozumi K
Year: 2008
Journal: J Exp Med
Title: Delta-like 4 is indispensable in thymic environment specific for T cell development.
Volume: 205
Issue: 11
Pages: 2507-13
Publication
First Author: Schaller MA
Year: 2007
Journal: J Exp Med
Title: Notch ligand Delta-like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokines.
Volume: 204
Issue: 12
Pages: 2925-34
Publication
First Author: Real C
Year: 2011
Journal: PLoS One
Title: Bone marrow-derived endothelial progenitors expressing Delta-like 4 (Dll4) regulate tumor angiogenesis.
Volume: 6
Issue: 4
Pages: e18323
Publication
First Author: Bassil R
Year: 2011
Journal: J Immunol
Title: Notch ligand delta-like 4 blockade alleviates experimental autoimmune encephalomyelitis by promoting regulatory T cell development.
Volume: 187
Issue: 5
Pages: 2322-8
Publication
First Author: Reynolds ND
Year: 2011
Journal: J Immunol
Title: Delta-like ligand 4 regulates central nervous system T cell accumulation during experimental autoimmune encephalomyelitis.
Volume: 187
Issue: 5
Pages: 2803-13
Publication
First Author: Shen Z
Year: 2016
Journal: Am J Pathol
Title: Delta-Like Ligand 4 Modulates Liver Damage by Down-Regulating Chemokine Expression.
Volume: 186
Issue: 7
Pages: 1874-89
Publication  
First Author: Riahi R
Year: 2015
Journal: Nat Commun
Title: Notch1-Dll4 signalling and mechanical force regulate leader cell formation during collective cell migration.
Volume: 6
Pages: 6556
Publication    
First Author: Hirano KI
Year: 2020
Journal: Elife
Title: Delta-like 1 and Delta-like 4 differently require their extracellular domains for triggering Notch signaling in mice.
Volume: 9
Publication
First Author: Rostama B
Year: 2015
Journal: Arterioscler Thromb Vasc Biol
Title: DLL4/Notch1 and BMP9 Interdependent Signaling Induces Human Endothelial Cell Quiescence via P27KIP1 and Thrombospondin-1.
Volume: 35
Issue: 12
Pages: 2626-37
Publication
First Author: Laranjeiro R
Year: 2012
Journal: PLoS One
Title: The notch ligand delta-like 4 regulates multiple stages of early hemato-vascular development.
Volume: 7
Issue: 4
Pages: e34553
Publication
First Author: Laky K
Year: 2015
Journal: Immunity
Title: Notch signaling regulates antigen sensitivity of naive CD4+ T cells by tuning co-stimulation.
Volume: 42
Issue: 1
Pages: 80-94
Publication
First Author: Scehnet JS
Year: 2007
Journal: Blood
Title: Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion.
Volume: 109
Issue: 11
Pages: 4753-60
Publication
First Author: Feyerabend TB
Year: 2009
Journal: Immunity
Title: Deletion of Notch1 converts pro-T cells to dendritic cells and promotes thymic B cells by cell-extrinsic and cell-intrinsic mechanisms.
Volume: 30
Issue: 1
Pages: 67-79
Publication    
First Author: Ubezio B
Year: 2016
Journal: Elife
Title: Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion.
Volume: 5
UniProt Feature
Begin: 469
Description: Interaction with DLL4
Type: site
End: 469
Publication
First Author: Guarani V
Year: 2011
Journal: Nature
Title: Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase.
Volume: 473
Issue: 7346
Pages: 234-8
Publication
First Author: Gale NW
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.
Volume: 101
Issue: 45
Pages: 15949-54
Publication
First Author: Cristofaro B
Year: 2013
Journal: Development
Title: Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models.
Volume: 140
Issue: 8
Pages: 1720-9
Publication
First Author: Ito T
Year: 2009
Journal: J Clin Invest
Title: TLR9 regulates the mycobacteria-elicited pulmonary granulomatous immune response in mice through DC-derived Notch ligand delta-like 4.
Volume: 119
Issue: 1
Pages: 33-46
Publication
First Author: Jang S
Year: 2010
Journal: J Immunol
Title: Notch ligand delta-like 4 regulates development and pathogenesis of allergic airway responses by modulating IL-2 production and Th2 immunity.
Volume: 185
Issue: 10
Pages: 5835-44
Publication
First Author: Mohtashami M
Year: 2006
Journal: J Immunol
Title: Three-dimensional architecture of the thymus is required to maintain delta-like expression necessary for inducing T cell development.
Volume: 176
Issue: 2
Pages: 730-4
Publication
First Author: Mohtashami M
Year: 2013
Journal: Int Immunol
Title: Induction of T-cell development by Delta-like 4-expressing fibroblasts.
Volume: 25
Issue: 10
Pages: 601-11
Publication
First Author: Deng J
Year: 2014
Journal: J Pathol
Title: IFNγ-responsiveness of endothelial cells leads to efficient angiostasis in tumours involving down-regulation of Dll4.
Volume: 233
Issue: 2
Pages: 170-82
Publication
First Author: Krebs LT
Year: 2004
Journal: Genes Dev
Title: Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants.
Volume: 18
Issue: 20
Pages: 2469-73
Publication  
First Author: Gama-Norton L
Year: 2015
Journal: Nat Commun
Title: Notch signal strength controls cell fate in the haemogenic endothelium.
Volume: 6
Pages: 8510
Publication  
First Author: Wu ZQ
Year: 2014
Journal: Nat Commun
Title: A Snail1/Notch1 signalling axis controls embryonic vascular development.
Volume: 5
Pages: 3998
Publication
First Author: Zarkada G
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: VEGFR3 does not sustain retinal angiogenesis without VEGFR2.
Volume: 112
Issue: 3
Pages: 761-6
Publication
First Author: Chung J
Year: 2017
Journal: J Clin Invest
Title: Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands.
Volume: 127
Issue: 4
Pages: 1574-1588
Publication
First Author: Anderson GA
Year: 2015
Journal: PLoS One
Title: Cardiovascular Patterning as Determined by Hemodynamic Forces and Blood Vessel Genetics.
Volume: 10
Issue: 9
Pages: e0137175
Publication
First Author: Ting HA
Year: 2017
Journal: J Immunol
Title: Notch Ligand Delta-like 4 Promotes Regulatory T Cell Identity in Pulmonary Viral Infection.
Volume: 198
Issue: 4
Pages: 1492-1502
Publication
First Author: Mukherjee S
Year: 2009
Journal: J Immunol
Title: Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activation.
Volume: 182
Issue: 12
Pages: 7381-8
Publication
First Author: Hainaud P
Year: 2006
Journal: Cancer Res
Title: The role of the vascular endothelial growth factor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vessel remodeling and endothelial cell functions.
Volume: 66
Issue: 17
Pages: 8501-10
Publication
First Author: Badenes M
Year: 2017
Journal: BMC Cancer
Title: Delta-like 4/Notch signaling promotes Apc Min/+ tumor initiation through angiogenic and non-angiogenic related mechanisms.
Volume: 17
Issue: 1
Pages: 50
Publication
First Author: Wythe JD
Year: 2013
Journal: Dev Cell
Title: ETS factors regulate Vegf-dependent arterial specification.
Volume: 26
Issue: 1
Pages: 45-58
Publication
First Author: Corada M
Year: 2010
Journal: Dev Cell
Title: The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling.
Volume: 18
Issue: 6
Pages: 938-49
Publication
First Author: Velardi E
Year: 2014
Journal: J Exp Med
Title: Sex steroid blockade enhances thymopoiesis by modulating Notch signaling.
Volume: 211
Issue: 12
Pages: 2341-9
Publication
First Author: Radojcic V
Year: 2018
Journal: Blood
Title: Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice.
Volume: 132
Issue: 20
Pages: 2188-2200
Publication
First Author: Billiard F
Year: 2012
Journal: J Exp Med
Title: Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.
Volume: 209
Issue: 5
Pages: 1011-28
Publication
First Author: Fukuda D
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders.
Volume: 109
Issue: 27
Pages: E1868-77
Publication
First Author: Abe N
Year: 2010
Journal: Eur J Immunol
Title: Notch ligands transduce different magnitudes of signaling critical for determination of T-cell fate.
Volume: 40
Issue: 9
Pages: 2608-17
Publication
First Author: Yasuda D
Year: 2019
Journal: J Clin Invest
Title: Lysophosphatidic acid-induced YAP/TAZ activation promotes developmental angiogenesis by repressing Notch ligand Dll4.
Volume: 129
Issue: 10
Pages: 4332-4349
Publication    
First Author: Travisano SI
Year: 2019
Journal: Elife
Title: Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade.
Volume: 8
Publication
First Author: D'Amato G
Year: 2016
Journal: Nat Cell Biol
Title: Sequential Notch activation regulates ventricular chamber development.
Volume: 18
Issue: 1
Pages: 7-20
Publication
First Author: Pellegrinet L
Year: 2011
Journal: Gastroenterology
Title: Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells.
Volume: 140
Issue: 4
Pages: 1230-1240.e1-7
Publication
First Author: Ramasamy SK
Year: 2014
Journal: Nature
Title: Endothelial Notch activity promotes angiogenesis and osteogenesis in bone.
Volume: 507
Issue: 7492
Pages: 376-380
Publication
First Author: Benedito R
Year: 2012
Journal: Nature
Title: Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling.
Volume: 484
Issue: 7392
Pages: 110-4
Publication
First Author: Schwarting GA
Year: 2007
Journal: J Mol Histol
Title: Notch1 expression and ligand interactions in progenitor cells of the mouse olfactory epithelium.
Volume: 38
Issue: 6
Pages: 543-53
Publication
First Author: Krebs LT
Year: 2000
Journal: Genes Dev
Title: Notch signaling is essential for vascular morphogenesis in mice.
Volume: 14
Issue: 11
Pages: 1343-52
Publication
First Author: Del Barrio MG
Year: 2007
Journal: Development
Title: A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool.
Volume: 134
Issue: 19
Pages: 3427-36
Publication
First Author: Francius C
Year: 2015
Journal: Dev Neurobiol
Title: Genetic dissection of Gata2 selective functions during specification of V2 interneurons in the developing spinal cord.
Volume: 75
Issue: 7
Pages: 721-37
Publication  
First Author: De Zoysa P
Year: 2020
Journal: Development
Title: Delta-like ligand 4-mediated Notch signaling controls proliferation of second heart field progenitor cells by regulating Fgf8 expression.
Volume: 147
Issue: 17
Publication
First Author: Suchting S
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching.
Volume: 104
Issue: 9
Pages: 3225-30
Publication
First Author: Gasperowicz M
Year: 2013
Journal: Gene Expr Patterns
Title: Spatiotemporal expression of Notch receptors and ligands in developing mouse placenta.
Volume: 13
Issue: 7
Pages: 249-54
Publication
First Author: Misra K
Year: 2014
Journal: Development
Title: Asymmetric activation of Dll4-Notch signaling by Foxn4 and proneural factors activates BMP/TGFβ signaling to specify V2b interneurons in the spinal cord.
Volume: 141
Issue: 1
Pages: 187-98
Publication
First Author: Seo S
Year: 2006
Journal: Dev Biol
Title: The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development.
Volume: 294
Issue: 2
Pages: 458-70
Publication
First Author: Trindade A
Year: 2008
Journal: Blood
Title: Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos.
Volume: 112
Issue: 5
Pages: 1720-9
Publication
First Author: Luo H
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Forkhead box N4 (Foxn4) activates Dll4-Notch signaling to suppress photoreceptor cell fates of early retinal progenitors.
Volume: 109
Issue: 9
Pages: E553-62
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli