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Search results 1 to 100 out of 774 for Dmp1

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Hits by Category

Type Details Score
Gene
key_979901 | Dmp1
Type: gene
Organism: Not Specified
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Gene
487849 | DMP1
Type: gene
Organism: dog, domestic
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Gene
404539 | DMP1
Type: gene
Organism: chicken
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Gene
701692 | DMP1
Type: gene
Organism: macaque, rhesus
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Gene
100271748 | dmp1
Type: gene
Organism: frog, western clawed
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Gene
281118 | DMP1
Type: gene
Organism: cattle
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Gene
1758 | DMP1
Type: gene
Organism: human
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Gene
25312 | Dmp1
Type: gene
Organism: rat
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Gene
741526 | DMP1
Type: gene
Organism: chimpanzee
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Protein Domain
IPR009889 | DMP1
Type: Family
Description: This family consists of several mammalian dentin matrix protein 1 (DMP1) sequences. The dentin matrix acidic phosphoprotein 1 (DMP1) gene has been mapped to human chromosome 4q21 []. DMP1 is a bone and teeth specific protein initially identified from mineralised dentin. DMP1 is primarily localised in the nuclear compartment of undifferentiated osteoblasts. In the nucleus, DMP1 acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the early phase of osteoblast maturation, Ca2+surges into the nucleus from the cytoplasm, triggering the phosphorylation of DMP1 by a nuclear isoform of casein kinase II. This phosphorylated DMP1 is then exported out into the extracellular matrix, where it regulates nucleation of hydroxyapatite. DMP1 is a unique molecule that initiates osteoblast differentiation by transcription in the nucleus and orchestrates mineralised matrix formation extracellularly, at later stages of osteoblast maturation []. The DMP1 gene has been found to be ectopically expressed in lung cancer although the reason for this is unknown [].
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Protein Coding Gene
MGI:94910 | Dmp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q2HJ09
Organism: Mus musculus/domesticus
Length: 503  
Fragment?: false
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Publication
9177774 | J:40731
First Author: Hirst KL
Year: 1997
Journal: Genomics
Title: Elucidation of the sequence and the genomic organization of the human dentin matrix acidic phosphoprotein 1 (DMP1) gene: exclusion of the locus from a causative role in the pathogenesis of dentinogenesis imperfecta type II.
Volume: 42
Issue: 1
Pages: 38-45
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Publication
32256524 | J:308930
 
First Author: Xia X
Year: 2020
Journal: Front Genet
Title: The Long Non-coding RNA lnc-DMP1 Regulates Dmp1 Expression Through H3K27Ac Modification.
Volume: 11
Pages: 233
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Protein
O55188
Organism: Mus musculus/domesticus
Length: 503  
Fragment?: false
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Publication
12615915 | -
First Author: Narayanan K
Year: 2003
Journal: J Biol Chem
Title: Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store.
Volume: 278
Issue: 19
Pages: 17500-8
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Publication
12929940 | -
First Author: Chaplet M
Year: 2003
Journal: J Bone Miner Res
Title: Dentin matrix protein 1 is expressed in human lung cancer.
Volume: 18
Issue: 8
Pages: 1506-12
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Publication
31461788 | J:288181
     
First Author: Cai M
Year: 2019
Journal: J Oral Rehabil
Title: Glycosylation of DMP1 maintains cranial sutures in mice.
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Publication
21297011 | J:222362
First Author: Sun Y
Year: 2011
Journal: J Dent Res
Title: DMP1 processing is essential to dentin and jaw formation.
Volume: 90
Issue: 5
Pages: 619-24
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Publication
22879941 | J:189832
First Author: Rangiani A
Year: 2012
Journal: PLoS One
Title: Protective roles of DMP1 in high phosphate homeostasis.
Volume: 7
Issue: 8
Pages: e42329
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Publication
25105818 | J:326940
First Author: Lin SX
Year: 2014
Journal: Int J Oral Sci
Title: Nucleus-targeted Dmp1 transgene fails to rescue dental defects in Dmp1 null mice.
Volume: 6
Issue: 3
Pages: 133-41
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Publication
18257058 | J:135314
First Author: Feng JQ
Year: 2008
Journal: Genesis
Title: Generation of a conditional null allele for Dmp1 in mouse.
Volume: 46
Issue: 2
Pages: 87-91
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Publication
20499360 | J:233129
First Author: Jiang B
Year: 2010
Journal: J Bone Miner Res
Title: DMP1 C-terminal mutant mice recapture the human ARHR tooth phenotype.
Volume: 25
Issue: 10
Pages: 2155-64
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Publication
18573980 | J:241769
First Author: Ye L
Year: 2008
Journal: J Dent Res
Title: Periodontal breakdown in the Dmp1 null mouse model of hypophosphatemic rickets.
Volume: 87
Issue: 7
Pages: 624-9
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Publication
32331833 | J:298511
First Author: Xue H
Year: 2020
Journal: Biochem Biophys Res Commun
Title: Glycosylation of DMP1 promotes bone reconstruction in long bone defects.
Volume: 526
Issue: 4
Pages: 1125-1130
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Publication
36175851 | J:330235
First Author: Liu Y
Year: 2022
Journal: BMC Mol Cell Biol
Title: The role of proteoglycan form of DMP1 in cranial repair.
Volume: 23
Issue: 1
Pages: 43
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Publication
28005411 | J:245199
First Author: Ichikawa S
Year: 2017
Journal: Endocrinology
Title: A Mutation in the Dmp1 Gene Alters Phosphate Responsiveness in Mice.
Volume: 158
Issue: 3
Pages: 470-476
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Publication
23938323 | J:201887
First Author: Zhu S
Year: 2013
Journal: Am J Pathol
Title: Cooperation between Dmp1 loss and cyclin D1 overexpression in breast cancer.
Volume: 183
Issue: 4
Pages: 1339-50
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Publication
17033621 | J:115339
First Author: Feng JQ
Year: 2006
Journal: Nat Genet
Title: Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism.
Volume: 38
Issue: 11
Pages: 1310-5
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Publication
20877695 | J:310072
First Author: Lv K
Year: 2010
Journal: Int J Biol Sci
Title: Circling behavior developed in Dmp1 null mice is due to bone defects in the vestibular apparatus.
Volume: 6
Issue: 6
Pages: 537-45
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Publication
18728349 | J:151283
First Author: Lu Y
Year: 2009
Journal: Cells Tissues Organs
Title: Studies of the DMP1 57-kDa functional domain both in vivo and in vitro.
Volume: 189
Issue: 1-4
Pages: 175-85
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Publication
22813642 | J:186228
First Author: Siyam A
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Nuclear localization of DMP1 proteins suggests a role in intracellular signaling.
Volume: 424
Issue: 3
Pages: 641-6
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Publication
29775615 | J:271454
First Author: Zhang S
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Extracellular matrix protein DMP1 suppresses osteogenic differentiation of Mesenchymal Stem Cells.
Volume: 501
Issue: 4
Pages: 968-973
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Publication
25978185 | J:311146
 
First Author: Murata H
Year: 2015
Journal: Ann Anat
Title: Expression of DMP1 in the developing mouse tongue embryo.
Volume: 200
Pages: 136-48
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Publication
16294270 | J:128131
First Author: Ling Y
Year: 2005
Journal: J Bone Miner Res
Title: DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis.
Volume: 20
Issue: 12
Pages: 2169-77
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Publication
22331460 | J:184938
First Author: Frazier DP
Year: 2012
Journal: Cancer Res
Title: Dmp1 physically interacts with p53 and positively regulates p53's stability, nuclear localization, and function.
Volume: 72
Issue: 7
Pages: 1740-50
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Publication
11711428 | J:72617
First Author: Inoue K
Year: 2001
Journal: Genes Dev
Title: Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas.
Volume: 15
Issue: 22
Pages: 2934-9
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Publication
17196192 | J:118796
First Author: Lu Y
Year: 2007
Journal: Dev Biol
Title: Rescue of odontogenesis in Dmp1-deficient mice by targeted re-expression of DMP1 reveals roles for DMP1 in early odontogenesis and dentin apposition in vivo.
Volume: 303
Issue: 1
Pages: 191-201
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Publication
25537728 | J:220608
First Author: Maglic D
Year: 2015
Journal: J Pathol
Title: DMP1β, a splice isoform of the tumour suppressor DMP1 locus, induces proliferation and progression of breast cancer.
Volume: 236
Issue: 1
Pages: 90-102
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Publication
22930691 | J:225089
First Author: Martin A
Year: 2012
Journal: Mol Endocrinol
Title: Overexpression of the DMP1 C-terminal fragment stimulates FGF23 and exacerbates the hypophosphatemic rickets phenotype in Hyp mice.
Volume: 26
Issue: 11
Pages: 1883-95
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Publication
23349460 | J:197747
First Author: Gibson MP
Year: 2013
Journal: J Biol Chem
Title: The rescue of dentin matrix protein 1 (DMP1)-deficient tooth defects by the transgenic expression of dentin sialophosphoprotein (DSPP) indicates that DSPP is a downstream effector molecule of DMP1 in dentinogenesis.
Volume: 288
Issue: 10
Pages: 7204-14
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Publication
27766035 | J:286235
First Author: Zhang Q
Year: 2016
Journal: Int J Biol Sci
Title: Dmp1 Null Mice Develop a Unique Osteoarthritis-like Phenotype.
Volume: 12
Issue: 10
Pages: 1203-1212
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ncRNA Gene
MGI:6765971 | Lncdmp1
Type: lncRNA_gene
Organism: mouse, laboratory
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Publication
17384025 | J:133758
First Author: Lu Y
Year: 2007
Journal: J Dent Res
Title: DMP1-targeted Cre expression in odontoblasts and osteocytes.
Volume: 86
Issue: 4
Pages: 320-5
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Publication
37036533 | J:338540
First Author: Nakamura T
Year: 2023
Journal: J Bone Miner Metab
Title: Generation of bicistronic Dmp1-Cre knock-in mice using a self-cleaving 2A peptide.
Volume: 41
Issue: 4
Pages: 470-480
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Allele
Dmp1<tm1Mis> | MGI:3040629
Name: dentin matrix protein 1; targeted mutation 1, Yuji Mishina
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Publication
37943605 | J:345899
 
First Author: Courbon G
Year: 2023
Journal: JCI Insight
Title: FGF23 directly inhibits osteoprogenitor differentiation in Dmp1-knockout mice.
Volume: 8
Issue: 24
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Publication
17237816 | J:122908
First Author: Inoue K
Year: 2007
Journal: Oncogene
Title: Dmp1 and tumor suppression.
Volume: 26
Issue: 30
Pages: 4329-35
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Publication
15207743 | J:91252
First Author: Kalajzic I
Year: 2004
Journal: Bone
Title: Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene.
Volume: 35
Issue: 1
Pages: 74-82
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Publication
34326685 | J:323276
First Author: Wang K
Year: 2021
Journal: Int J Biol Sci
Title: Osteocytes but not osteoblasts directly build mineralized bone structures.
Volume: 17
Issue: 10
Pages: 2430-2448
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Publication
14514755 | J:85859
First Author: Feng JQ
Year: 2003
Journal: J Dent Res
Title: The Dentin matrix protein 1 (Dmp1) is specifically expressed in mineralized, but not soft, tissues during development.
Volume: 82
Issue: 10
Pages: 776-80
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Publication
21542006 | J:184352
First Author: Zhang R
Year: 2011
Journal: J Bone Miner Res
Title: Unique roles of phosphorus in endochondral bone formation and osteocyte maturation.
Volume: 26
Issue: 5
Pages: 1047-56
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Publication
9525343 | J:46696
First Author: MacDougall M
Year: 1998
Journal: J Bone Miner Res
Title: Identification of a novel isoform of mouse dentin matrix protein 1: spatial expression in mineralized tissues.
Volume: 13
Issue: 3
Pages: 422-31
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Publication
15590631 | J:96955
First Author: Ye L
Year: 2005
Journal: J Biol Chem
Title: Dmp1-deficient mice display severe defects in cartilage formation responsible for a chondrodysplasia-like phenotype.
Volume: 280
Issue: 7
Pages: 6197-203
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Publication
26303287 | J:228436
 
First Author: Maginot M
Year: 2015
Journal: Bone
Title: The in vivo role of DMP-1 and serum phosphate on bone mineral composition.
Volume: 81
Pages: 602-13
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Publication
26721590 | J:237008
 
First Author: Ren Y
Year: 2016
Journal: Matrix Biol
Title: Sclerostin antibody (Scl-Ab) improves osteomalacia phenotype in dentin matrix protein 1(Dmp1) knockout mice with little impact on serum levels of phosphorus and FGF23.
Volume: 52-54
Pages: 151-161
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Publication
28603080 | J:257073
 
First Author: Lv K
Year: 2017
Journal: Bone
Title: A novel auditory ossicles membrane and the development of conductive hearing loss in Dmp1-null mice.
Volume: 103
Pages: 39-46
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Publication
20663874 | J:166806
First Author: Sun Y
Year: 2010
Journal: J Biol Chem
Title: Failure to process dentin matrix protein 1 (DMP1) into fragments leads to its loss of function in osteogenesis.
Volume: 285
Issue: 41
Pages: 31713-22
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Publication
16612089 | J:133879
First Author: Lu Y
Year: 2005
Journal: Cells Tissues Organs
Title: Differential regulation of dentin matrix protein 1 expression during odontogenesis.
Volume: 181
Issue: 3-4
Pages: 241-7
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Publication
26634432 | J:278186
 
First Author: Sun Y
Year: 2015
Journal: Sci Rep
Title: Glycosylation of Dentin Matrix Protein 1 is critical for osteogenesis.
Volume: 5
Pages: 17518
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Publication
31065929 | J:294514
First Author: Xue H
Year: 2019
Journal: Front Med
Title: Glycosylation of dentin matrix protein 1 is critical for fracture healing via promoting chondrogenesis.
Volume: 13
Issue: 5
Pages: 575-589
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Publication
10654257 | J:59261
First Author: Toyosawa S
Year: 2000
Journal: J Mol Evol
Title: Expression of the dentin matrix protein 1 gene in birds.
Volume: 50
Issue: 1
Pages: 31-8
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Publication
24987156 | J:321080
First Author: Prasadam I
Year: 2014
Journal: Rheumatology (Oxford)
Title: Role of dentin matrix protein 1 in cartilage redifferentiation and osteoarthritis.
Volume: 53
Issue: 12
Pages: 2280-7
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Publication
27242547 | J:236938
 
First Author: Wacker MJ
Year: 2016
Journal: Front Physiol
Title: Skeletal Muscle, but not Cardiovascular Function, Is Altered in a Mouse Model of Autosomal Recessive Hypophosphatemic Rickets.
Volume: 7
Pages: 173
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Publication
18559986 | J:140067
First Author: Liu S
Year: 2008
Journal: Am J Physiol Endocrinol Metab
Title: Pathogenic role of Fgf23 in Dmp1-null mice.
Volume: 295
Issue: 2
Pages: E254-61
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Publication
9421236 | J:44807
First Author: D'Souza RN
Year: 1997
Journal: J Bone Miner Res
Title: Gene expression patterns of murine dentin matrix protein 1 (Dmp1) and dentin sialophosphoprotein (DSPP) suggest distinct developmental functions in vivo.
Volume: 12
Issue: 12
Pages: 2040-9
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Publication
28647374 | J:251108
First Author: Pan M
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Overexpression of Dentin matrix protein 1 in Nestin+ cells causes bone loss in mouse long bone.
Volume: 490
Issue: 2
Pages: 356-363
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Publication
26686820 | J:237010
 
First Author: Jani PH
Year: 2016
Journal: Matrix Biol
Title: Transgenic expression of Dspp partially rescued the long bone defects of Dmp1-null mice.
Volume: 52-54
Pages: 95-112
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Publication
23258378 | J:315262
First Author: Rangiani A
Year: 2012
Journal: Int J Oral Sci
Title: Dentin matrix protein 1 and phosphate homeostasis are critical for postnatal pulp, dentin and enamel formation.
Volume: 4
Issue: 4
Pages: 189-95
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Publication
33059101 | J:301203
 
First Author: Ma C
Year: 2021
Journal: Bone
Title: ScxLin cells directly form a subset of chondrocytes in temporomandibular joint that are sharply increased in Dmp1-null mice.
Volume: 142
Pages: 115687
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Publication
7983353 | J:22787
First Author: George A
Year: 1994
Journal: J Histochem Cytochem
Title: In situ localization and chromosomal mapping of the AG1 (Dmp1) gene.
Volume: 42
Issue: 12
Pages: 1527-31
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Publication
8955126 | J:37297
First Author: George A
Year: 1996
Journal: J Biol Chem
Title: The carboxyl-terminal domain of phosphophoryn contains unique extended triplet amino acid repeat sequences forming ordered carboxyl-phosphate interaction ridges that may be essential in the biomineralization process.
Volume: 271
Issue: 51
Pages: 32869-73
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Publication
27143110 | J:235518
 
First Author: Kang KS
Year: 2016
Journal: Bone
Title: Postnatal β-catenin deletion from Dmp1-expressing osteocytes/osteoblasts reduces structural adaptation to loading, but not periosteal load-induced bone formation.
Volume: 88
Pages: 138-145
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Publication
31505764 | J:290475
 
First Author: Lewis KJ
Year: 2019
Journal: Int J Mol Sci
Title: Twist1 Inactivation in Dmp1-Expressing Cells Increases Bone Mass but Does Not Affect the Anabolic Response to Sclerostin Neutralization.
Volume: 20
Issue: 18
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Publication
26428891 | J:227060
First Author: Fujikawa K
Year: 2015
Journal: Eur J Histochem
Title: An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage.
Volume: 59
Issue: 3
Pages: 2553
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Publication
26310138 | J:316653
First Author: Chen Z
Year: 2016
Journal: Cell Tissue Res
Title: Klf10 regulates odontoblast differentiation and mineralization via promoting expression of dentin matrix protein 1 and dentin sialophosphoprotein genes.
Volume: 363
Issue: 2
Pages: 385-98
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Publication
32529635 | J:330754
First Author: Lim KE
Year: 2020
Journal: J Cell Physiol
Title: Pten deletion in Dmp1-expressing cells does not rescue the osteopenic effects of Wnt/β-catenin suppression.
Volume: 235
Issue: 12
Pages: 9785-9794
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Publication
28822114 | J:279157
First Author: Jing B
Year: 2018
Journal: Protein Cell
Title: Glycosylation of dentin matrix protein 1 is a novel key element for astrocyte maturation and BBB integrity.
Volume: 9
Issue: 3
Pages: 298-309
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Publication
21678127 | J:197592
First Author: Kyono A
Year: 2012
Journal: J Bone Miner Metab
Title: FGF and ERK signaling coordinately regulate mineralization-related genes and play essential roles in osteocyte differentiation.
Volume: 30
Issue: 1
Pages: 19-30
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Publication
31751752 | J:285828
 
First Author: Li H
Year: 2020
Journal: Bone
Title: Hypophosphatemic rickets accelerate chondrogenesis and cell trans-differentiation from TMJ chondrocytes into bone cells via a sharp increase in β-catenin.
Volume: 131
Pages: 115151
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Publication
24710520 | J:215016
First Author: Miyagawa K
Year: 2014
Journal: PLoS One
Title: Dysregulated gene expression in the primary osteoblasts and osteocytes isolated from hypophosphatemic Hyp mice.
Volume: 9
Issue: 4
Pages: e93840
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Publication
12369786 | J:111429
First Author: Fen JQ
Year: 2002
Journal: J Bone Miner Res
Title: Dentin matrix protein 1, a target molecule for Cbfa1 in bone, is a unique bone marker gene.
Volume: 17
Issue: 10
Pages: 1822-31
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Publication
24917674 | J:314657
First Author: Lin S
Year: 2014
Journal: J Biol Chem
Title: Constitutive nuclear expression of dentin matrix protein 1 fails to rescue the Dmp1-null phenotype.
Volume: 289
Issue: 31
Pages: 21533-43
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Protein Coding Gene
MGP_CAROLIEiJ_G0027477 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0029811 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0029775 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0029723 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0029787 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0029509 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_94910 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0030242 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0028921 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0029480 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0029624 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0029583 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0029712 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0029612 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0030275 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0028638 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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•
•
•
•
Protein Coding Gene
MGP_WSBEiJ_G0028999 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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•
•
•
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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