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Search results 1 to 100 out of 150 for Dna2

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
1763 | DNA2
Type: gene
Organism: human
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Gene
100170166 | dna2
Type: gene
Organism: frog, western clawed
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Gene
309762 | Dna2
Type: gene
Organism: rat
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Gene
489015 | DNA2
Type: gene
Organism: dog, domestic
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Gene
450496 | DNA2
Type: gene
Organism: chimpanzee
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Gene
540969 | DNA2
Type: gene
Organism: cattle
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Gene
423688 | DNA2
Type: gene
Organism: chicken
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Gene
559535 | dna2
Type: gene
Organism: zebrafish
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Gene
694401 | DNA2
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR026851 | Dna2
Type: Family
Description: Dna2 and its plant homologue JHS1 are DNA replication factors with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, (5'-flap endonuclease) and helicase activities. It is required for Okazaki fragment processing and is involved in DNA repair pathways [, ]. The helicase activity is weak and its function remains unclear [, , , ].
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Protein Coding Gene
MGI:2443732 | Dna2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q6ZQJ5
Organism: Mus musculus/domesticus
Length: 1062  
Fragment?: false
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Publication
10636853 | -
First Author: Liu Q
Year: 2000
Journal: J Biol Chem
Title: Identification of the Xenopus laevis homolog of Saccharomyces cerevisiae DNA2 and its role in DNA replication.
Volume: 275
Issue: 3
Pages: 1615-24
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Publication
16595799 | -
First Author: Kim JH
Year: 2006
Journal: Nucleic Acids Res
Title: Isolation of human Dna2 endonuclease and characterization of its enzymatic properties.
Volume: 34
Issue: 6
Pages: 1854-64
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Gene
107648864 | LOC107648864
Type: gene
Organism: human
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Publication
20019387 | -
First Author: Balakrishnan L
Year: 2010
Journal: J Biol Chem
Title: Acetylation of Dna2 endonuclease/helicase and flap endonuclease 1 by p300 promotes DNA stability by creating long flap intermediates.
Volume: 285
Issue: 7
Pages: 4398-404
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Publication
10880469 | -
First Author: Kang HY
Year: 2000
Journal: Genetics
Title: Genetic analyses of Schizosaccharomyces pombe dna2(+) reveal that dna2 plays an essential role in Okazaki fragment metabolism.
Volume: 155
Issue: 3
Pages: 1055-67
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Publication
22570407 | -
First Author: Gloor JW
Year: 2012
Journal: Nucleic Acids Res
Title: Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1.
Volume: 40
Issue: 14
Pages: 6774-86
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Publication
23604072 | J:198831
First Author: Lin W
Year: 2013
Journal: EMBO J
Title: Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity.
Volume: 32
Issue: 10
Pages: 1425-39
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Publication
16595800 | -
First Author: Masuda-Sasa T
Year: 2006
Journal: Nucleic Acids Res
Title: Biochemical analysis of human Dna2.
Volume: 34
Issue: 6
Pages: 1865-75
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Protein
Q8K2P5
Organism: Mus musculus/domesticus
Length: 349  
Fragment?: true
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Protein Coding Gene
MGP_CAROLIEiJ_G0015394 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0017308 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0017286 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0017246 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0017246 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0017069 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2443732 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0017704 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0016640 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0017041 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0017146 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0017140 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0017220 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0017168 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0017742 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0016423 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0016704 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0030810 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0016205 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:7711811
Assay Type: RT-PCR
Annotation Date: 2024-08-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610526
Stage: TS26
Assay Id: MGI:7711912
Age: embryonic day 19.5
Specimen Label: WT E19.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7711811
Assay Type: RT-PCR
Annotation Date: 2024-08-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610526
Stage: TS26
Assay Id: MGI:7711912
Age: embryonic day 19.5
Specimen Label: S187A E19.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7711811
Assay Type: RT-PCR
Annotation Date: 2024-08-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:7711912
Age: postnatal day 1
Specimen Label: WT P1
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:7711811
Assay Type: RT-PCR
Annotation Date: 2024-08-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:7711912
Age: postnatal day 1
Specimen Label: S187A P1
Detected: true
Specimen Num: 4
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Publication
14621295 | J:86686
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 4
Pages: 167-80
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Publication
30333037 | J:267504
First Author: Kiyama T
Year: 2018
Journal: Mol Neurodegener
Title: Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis.
Volume: 13
Issue: 1
Pages: 56
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Publication
27694478 | J:268403
First Author: Zhou L
Year: 2017
Journal: FASEB J
Title: Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development.
Volume: 31
Issue: 1
Pages: 132-147
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 1
Description: DNA replication ATP-dependent helicase/nuclease DNA2
Type: chain
End: 1062
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Protein
Q6ZQJ5-2
Organism: Mus musculus/domesticus
Length: 966  
Fragment?: false
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Publication
25909997 | -
First Author: Hoa NN
Year: 2015
Journal: PLoS One
Title: BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination.
Volume: 10
Issue: 4
Pages: e0124495
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DO Term
DOID:0070009 | Seckel syndrome 8
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DO Term
DOID:0111519 | autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 6
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Protein Domain
IPR041677 | DNA2/NAM7_AAA_11
Type: Domain
Description: This domain contains the ATP-binding region of DNA2. DNA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Proteins containing this domain also include Nam7 and other helicases. Dna2 is a DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, (5'-flap endonuclease) and helicase activities [, ]. Nam7 (also known as Upf1) is an ATP-dependent RNA helicase involved in the nonsense-mediated mRNA decay (NMD) pathway []. This domain is known as AAA_11 in Pfam.
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Publication
26923168 | J:299554
 
First Author: Bannwarth S
Year: 2016
Journal: Mitochondrion
Title: Inactivation of Pif1 helicase causes a mitochondrial myopathy in mice.
Volume: 30
Pages: 126-37
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Protein Domain
IPR041679 | DNA2/NAM7-like_C
Type: Domain
Description: This domain contains a P-loop motif that is characteristic of the AAA superfamily. Proteins containing this domain are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA [, , ].Proteins containing this domain include helicases, such as Dna2 an Nam7. Dna2 is a DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, (5'-flap endonuclease) and helicase activities [, ]. Nam7 (also known as Upf1) is an ATP-dependent RNA helicase involved in the nonsense-mediated mRNA decay (NMD) pathway []. This domain can also be found in some virus polyproteins. This domain is also known as HelicC.
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Publication
29236296 | -
 
First Author: M Plank TD
Year: 2018
Journal: Bioessays
Title: RNA Decay Factor UPF1 Promotes Protein Decay: A Hidden Talent.
Volume: 40
Issue: 1
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Publication
35416772 | J:338334
   
First Author: Balasubramanian S
Year: 2022
Journal: Elife
Title: Protection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region.
Volume: 11
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Publication
28860160 | J:245949
First Author: Xu S
Year: 2017
Journal: Genes Dev
Title: Abro1 maintains genome stability and limits replication stress by protecting replication fork stability.
Volume: 31
Issue: 14
Pages: 1469-1482
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Publication
31337767 | J:281163
First Author: Mukherjee C
Year: 2019
Journal: Nat Commun
Title: RIF1 promotes replication fork protection and efficient restart to maintain genome stability.
Volume: 10
Issue: 1
Pages: 3287
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Publication
16935882 | -
First Author: Fuller-Pace FV
Year: 2006
Journal: Nucleic Acids Res
Title: DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation.
Volume: 34
Issue: 15
Pages: 4206-15
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Publication
10322435 | -
First Author: de la Cruz J
Year: 1999
Journal: Trends Biochem Sci
Title: Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families.
Volume: 24
Issue: 5
Pages: 192-8
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Protein
Q99MV5
Organism: Mus musculus/domesticus
Length: 1187  
Fragment?: false
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Protein
G3UYS5
Organism: Mus musculus/domesticus
Length: 310  
Fragment?: true
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Protein
G3X8T0
Organism: Mus musculus/domesticus
Length: 1187  
Fragment?: false
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Protein
F2YMC1
Organism: Mus musculus/domesticus
Length: 1239  
Fragment?: false
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Protein
Q05AH2
Organism: Mus musculus/domesticus
Length: 1165  
Fragment?: false
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Protein
D3YWG8
Organism: Mus musculus/domesticus
Length: 1239  
Fragment?: false
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Publication
27058754 | J:252618
First Author: Reczek CR
Year: 2016
Journal: Oncotarget
Title: The DNA resection protein CtIP promotes mammary tumorigenesis.
Volume: 7
Issue: 22
Pages: 32172-83
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Publication
23712259 | J:197743
First Author: Reczek CR
Year: 2013
Journal: J Cell Biol
Title: The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression.
Volume: 201
Issue: 5
Pages: 693-707
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Publication
25558984 | -
First Author: Davies OR
Year: 2015
Journal: Nat Struct Mol Biol
Title: CtIP tetramer assembly is required for DNA-end resection and repair.
Volume: 22
Issue: 2
Pages: 150-157
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Protein Domain
IPR033594 | RBBP8
Type: Family
Description: Retinoblastoma-binding protein 8 (RBBP8), also known as CtIP, is an endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends [, ]. CtIP interacts with the BRCA1 tumour suppressor []. BRCA1 and CtIP are required to recruit Dna2 at DSBs in homologous recombination, ensuring robust DSB resection []. CtIP it is not a tumuor suppressor itself, instead, it can promote tumourigenesis. This is probably related to its role in the formation of chromosomal rearrangements through the microhomology-mediated end joining (MMEJ) pathway, a relatively error-prone pathway of DSB repair [].
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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Cambridge CB2 3EH, United Kingdom