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Search results 1 to 100 out of 140 for Dna2

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Saccharomyces cerevisiae
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: Dna2 and its plant homologue JHS1 are DNA replication factors with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, (5'-flap endonuclease) and helicase activities. It is required for Okazaki fragment processing and is involved in DNA repair pathways [, ]. The helicase activity is weak and its function remains unclear [, , , ].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein
Organism: Mus musculus
Length: 1062  
Fragment?: false
Publication
First Author: Liu Q
Year: 2000
Journal: J Biol Chem
Title: Identification of the Xenopus laevis homolog of Saccharomyces cerevisiae DNA2 and its role in DNA replication.
Volume: 275
Issue: 3
Pages: 1615-24
Publication
First Author: Kim JH
Year: 2006
Journal: Nucleic Acids Res
Title: Isolation of human Dna2 endonuclease and characterization of its enzymatic properties.
Volume: 34
Issue: 6
Pages: 1854-64
Publication
First Author: Balakrishnan L
Year: 2010
Journal: J Biol Chem
Title: Acetylation of Dna2 endonuclease/helicase and flap endonuclease 1 by p300 promotes DNA stability by creating long flap intermediates.
Volume: 285
Issue: 7
Pages: 4398-404
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Kang HY
Year: 2000
Journal: Genetics
Title: Genetic analyses of Schizosaccharomyces pombe dna2(+) reveal that dna2 plays an essential role in Okazaki fragment metabolism.
Volume: 155
Issue: 3
Pages: 1055-67
Publication
First Author: Gloor JW
Year: 2012
Journal: Nucleic Acids Res
Title: Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1.
Volume: 40
Issue: 14
Pages: 6774-86
Publication
First Author: Lin W
Year: 2013
Journal: EMBO J
Title: Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity.
Volume: 32
Issue: 10
Pages: 1425-39
Protein
Organism: Mus musculus
Length: 349  
Fragment?: true
Publication
First Author: Masuda-Sasa T
Year: 2006
Journal: Nucleic Acids Res
Title: Biochemical analysis of human Dna2.
Volume: 34
Issue: 6
Pages: 1865-75
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 4
Pages: 167-80
Publication
First Author: Kiyama T
Year: 2018
Journal: Mol Neurodegener
Title: Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis.
Volume: 13
Issue: 1
Pages: 56
Publication
First Author: Zhou L
Year: 2017
Journal: FASEB J
Title: Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development.
Volume: 31
Issue: 1
Pages: 132-147
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication          
First Author: MGD Nomenclature Committee
Year: 1995
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
UniProt Feature
Begin: 1
Description: DNA replication ATP-dependent helicase/nuclease DNA2
Type: chain
End: 1062
Protein
Organism: Mus musculus
Length: 966  
Fragment?: false
Publication
First Author: Hoa NN
Year: 2015
Journal: PLoS One
Title: BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination.
Volume: 10
Issue: 4
Pages: e0124495
DO Term
Interaction Experiment
Description: Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity.
Interaction Experiment
Description: Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity.
Interaction Experiment
Description: Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity.
DO Term
Protein Domain
Type: Domain
Description: This domain contains the ATP-binding region of DNA2. DNA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Proteins containing this domain also include Nam7 and other helicases. Dna2 is a DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, (5'-flap endonuclease) and helicase activities [, ]. Nam7 (also known as Upf1) is an ATP-dependent RNA helicase involved in the nonsense-mediated mRNA decay (NMD) pathway []. This domain is known as AAA_11 in Pfam.
Publication  
First Author: Bannwarth S
Year: 2016
Journal: Mitochondrion
Title: Inactivation of Pif1 helicase causes a mitochondrial myopathy in mice.
Volume: 30
Pages: 126-37
Publication  
First Author: M Plank TD
Year: 2018
Journal: Bioessays
Title: RNA Decay Factor UPF1 Promotes Protein Decay: A Hidden Talent.
Volume: 40
Issue: 1
Protein Domain
Type: Domain
Description: Dna2 and its plant homologue JHS1 are DNA replication factors with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, (5'-flap endonuclease) and helicase activities. It is required for Okazaki fragment processing and is involved in DNA repair pathways [, ]. The helicase activity is weak and its function remains unclear [, , , ].This entry represents N-terminal domain of the DNA replication factor Dna2.
Publication
First Author: de la Cruz J
Year: 1999
Journal: Trends Biochem Sci
Title: Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families.
Volume: 24
Issue: 5
Pages: 192-8
Publication
First Author: Fuller-Pace FV
Year: 2006
Journal: Nucleic Acids Res
Title: DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation.
Volume: 34
Issue: 15
Pages: 4206-15
Protein Domain
Type: Domain
Description: This domain contains a P-loop motif that is characteristic of the AAA superfamily. Proteins containing this domain are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA [, , ].Proteins containing this domain include helicases, such as Dna2 an Nam7. Dna2 is a DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, (5'-flap endonuclease) and helicase activities [, ]. Nam7 (also known as Upf1) is an ATP-dependent RNA helicase involved in the nonsense-mediated mRNA decay (NMD) pathway []. This domain can also be found in some virus polyproteins. This domain is also known as HelicC.
Publication
First Author: Xu S
Year: 2017
Journal: Genes Dev
Title: Abro1 maintains genome stability and limits replication stress by protecting replication fork stability.
Volume: 31
Issue: 14
Pages: 1469-1482
Publication
First Author: Mukherjee C
Year: 2019
Journal: Nat Commun
Title: RIF1 promotes replication fork protection and efficient restart to maintain genome stability.
Volume: 10
Issue: 1
Pages: 3287
Protein
Organism: Mus musculus
Length: 1187  
Fragment?: false
Protein
Organism: Mus musculus
Length: 2646  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1239  
Fragment?: false
Protein
Organism: Mus musculus
Length: 935  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1165  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1187  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1239  
Fragment?: false
Protein
Organism: Mus musculus
Length: 310  
Fragment?: true
Protein
Organism: Mus musculus
Length: 381  
Fragment?: true
Protein
Organism: Mus musculus
Length: 528  
Fragment?: true
Protein
Organism: Mus musculus
Length: 606  
Fragment?: true
Publication
First Author: Reczek CR
Year: 2016
Journal: Oncotarget
Title: The DNA resection protein CtIP promotes mammary tumorigenesis.
Volume: 7
Issue: 22
Pages: 32172-83
Publication
First Author: Reczek CR
Year: 2013
Journal: J Cell Biol
Title: The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression.
Volume: 201
Issue: 5
Pages: 693-707
Publication
First Author: Davies OR
Year: 2015
Journal: Nat Struct Mol Biol
Title: CtIP tetramer assembly is required for DNA-end resection and repair.
Volume: 22
Issue: 2
Pages: 150-157
Protein Domain
Type: Family
Description: Retinoblastoma-binding protein 8 (RBBP8), also known as CtIP, is an endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends [, ]. CtIP interacts with the BRCA1 tumour suppressor []. BRCA1 and CtIP are required to recruit Dna2 at DSBs in homologous recombination, ensuring robust DSB resection []. CtIP it is not a tumuor suppressor itself, instead, it can promote tumourigenesis. This is probably related to its role in the formation of chromosomal rearrangements through the microhomology-mediated end joining (MMEJ) pathway, a relatively error-prone pathway of DSB repair [].
Publication
First Author: Zhou ZW
Year: 2013
Journal: PLoS Genet
Title: An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence.
Volume: 9
Issue: 8
Pages: e1003702
Publication
First Author: Liu K
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin.
Volume: 114
Issue: 19
Pages: E3766-E3775
Protein
Organism: Mus musculus
Length: 1004  
Fragment?: false