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Search results 1 to 100 out of 302 for Dnm1l

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0.078s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Protein Domain
Type: Family
Description: Human dynamin-1-like protein (DNM1L, also known as Drp1) belongs to the dynamin superfamily. It is a large GTPase involved in segregating mitochondria and peroxisomes []. During mitochondrial fission, Drp1 is recruited from the cytosol onto the mitochondrial outer membrane, where it assembles into puncta. These puncta consist of oligomeric Drp1 complexes that wrap around and constrict the mitochondrial tubule to mediate fission []. Drp1 is required for normal brain development, including that of cerebellum []. It maintains the integrity of mitochondrial structure and function in mouse heart and brain [].Dynamin superfamily members are large GTPases [], including dynamins, dynamin-like proteins, OPA1, Mx proteins, mitofusins and guanylate-binding proteins/atlastins [, , , ]. They are involved in the scission of a wide range of vesicles and organelles and play a role in many processes including budding of transport vesicles, division of organelles, cytokinesis and pathogen resistance. The minimal distinguishing architectural features that are common to all dynamins, and are distinct from other GTPases, are the structure of the large GTPase domain (300 amino acids) and the presence of two additional domains, the middle domain and the GTPase effector domain (GED), which are involved in oligomerisation and regulation of the GTPase activity.
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Kageyama Y
Year: 2014
Journal: EMBO J
Title: Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain.
Volume: 33
Issue: 23
Pages: 2798-813
Publication
First Author: Wakabayashi J
Year: 2009
Journal: J Cell Biol
Title: The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice.
Volume: 186
Issue: 6
Pages: 805-16
Publication
First Author: Ashrafian H
Year: 2010
Journal: PLoS Genet
Title: A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy.
Volume: 6
Issue: 6
Pages: e1001000
Protein
Organism: Mus musculus/domesticus
Length: 742  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 587  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 712  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 714  
Fragment?: true
Publication  
First Author: Vallee RB
Year: 1990
Journal: Annu Rev Biochem
Title: Motor proteins of cytoplasmic microtubules.
Volume: 59
Pages: 909-32
Publication
First Author: Rothman JH
Year: 1990
Journal: Cell
Title: A putative GTP binding protein homologous to interferon-inducible Mx proteins performs an essential function in yeast protein sorting.
Volume: 61
Issue: 6
Pages: 1063-74
Publication
First Author: Jones BA
Year: 1992
Journal: Genes Dev
Title: Mitochondrial DNA maintenance in yeast requires a protein containing a region related to the GTP-binding domain of dynamin.
Volume: 6
Issue: 3
Pages: 380-9
Publication
First Author: Weitz G
Year: 1989
Journal: J Interferon Res
Title: Purification and characterization of a human Mx protein.
Volume: 9
Issue: 6
Pages: 679-89
Publication
First Author: Praefcke GJ
Year: 2004
Journal: Nat Rev Mol Cell Biol
Title: The dynamin superfamily: universal membrane tubulation and fission molecules?
Volume: 5
Issue: 2
Pages: 133-47
Publication
First Author: Wenger J
Year: 2013
Journal: PLoS One
Title: Functional mapping of human dynamin-1-like GTPase domain based on x-ray structure analyses.
Volume: 8
Issue: 8
Pages: e71835
Publication
First Author: MacLean MR
Year: 1990
Journal: Br J Pharmacol
Title: Effect of neuropeptide Y on cardiac output, its distribution, regional blood flow and organ vascular resistances in the pithed rat.
Volume: 99
Issue: 2
Pages: 340-2
Publication
First Author: Losón OC
Year: 2013
Journal: Mol Biol Cell
Title: Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission.
Volume: 24
Issue: 5
Pages: 659-67
Publication
First Author: Jokinen R
Year: 2016
Journal: Hum Mol Genet
Title: Tissue-specific modulation of mitochondrial DNA segregation by a defect in mitochondrial division.
Volume: 25
Issue: 4
Pages: 706-14
Publication
First Author: Bouche L
Year: 2021
Journal: PLoS One
Title: DRP1 haploinsufficiency attenuates cardiac ischemia/reperfusion injuries.
Volume: 16
Issue: 3
Pages: e0248554
Publication
First Author: Gerber S
Year: 2017
Journal: Brain
Title: Mutations in DNM1L, as in OPA1, result in dominant optic atrophy despite opposite effects on mitochondrial fusion and fission.
Volume: 140
Issue: 10
Pages: 2586-2596
Publication
First Author: Wang Q
Year: 2017
Journal: Autophagy
Title: Deletion of PRKAA triggers mitochondrial fission by inhibiting the autophagy-dependent degradation of DNM1L.
Volume: 13
Issue: 2
Pages: 404-422
Publication  
First Author: Zhao Q
Year: 2022
Journal: J Cell Sci
Title: Drp1 regulates transcription of ribosomal protein genes in embryonic hearts.
Volume: 135
Issue: 4
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Kamimoto T
Year: 1998
Journal: J Biol Chem
Title: Dymple, a novel dynamin-like high molecular weight GTPase lacking a proline-rich carboxyl-terminal domain in mammalian cells.
Volume: 273
Issue: 2
Pages: 1044-51
Publication
First Author: Manczak M
Year: 2016
Journal: Hum Mol Genet
Title: Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.
Volume: 25
Issue: 23
Pages: 5148-5166
Publication
First Author: Adhikari D
Year: 2022
Journal: Sci Adv
Title: Depletion of oocyte dynamin-related protein 1 shows maternal-effect abnormalities in embryonic development.
Volume: 8
Issue: 24
Pages: eabl8070
Publication
First Author: Oettinghaus B
Year: 2016
Journal: Cell Death Differ
Title: Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons.
Volume: 23
Issue: 1
Pages: 18-28
Publication  
First Author: Kiryu-Seo S
Year: 2016
Journal: Sci Rep
Title: Mitochondrial fission is an acute and adaptive response in injured motor neurons.
Volume: 6
Pages: 28331
Publication
First Author: Tamada H
Year: 2017
Journal: J Comp Neurol
Title: Three-dimensional analysis of somatic mitochondrial dynamics in fission-deficient injured motor neurons using FIB/SEM.
Volume: 525
Issue: 11
Pages: 2535-2548
Publication  
First Author: Shields LY
Year: 2015
Journal: Cell Death Dis
Title: Dynamin-related protein 1 is required for normal mitochondrial bioenergetic and synaptic function in CA1 hippocampal neurons.
Volume: 6
Pages: e1725
Publication
First Author: Li X
Year: 2020
Journal: FASEB J
Title: Novel role of dynamin-related-protein 1 in dynamics of ER-lipid droplets in adipose tissue.
Volume: 34
Issue: 6
Pages: 8265-8282
Publication
First Author: Galloway CA
Year: 2012
Journal: Diabetes
Title: Transgenic control of mitochondrial fission induces mitochondrial uncoupling and relieves diabetic oxidative stress.
Volume: 61
Issue: 8
Pages: 2093-104
Publication
First Author: Anzell AR
Year: 2021
Journal: Cell Death Dis
Title: Mitochondrial fission and mitophagy are independent mechanisms regulating ischemia/reperfusion injury in primary neurons.
Volume: 12
Issue: 5
Pages: 475
Publication    
First Author: Itoh K
Year: 2019
Journal: Elife
Title: Brain-specific Drp1 regulates postsynaptic endocytosis and dendrite formation independently of mitochondrial division.
Volume: 8
Publication
First Author: Baek SH
Year: 2017
Journal: J Neurosci
Title: Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition, and Cognitive Impairment in an Alzheimer's Disease Model.
Volume: 37
Issue: 20
Pages: 5099-5110
Publication
First Author: Tagaya M
Year: 2022
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Inhibition of mitochondrial fission protects podocytes from albumin-induced cell damage in diabetic kidney disease.
Volume: 1868
Issue: 5
Pages: 166368
Publication  
First Author: Kugler BA
Year: 2023
Journal: Mol Metab
Title: Partial skeletal muscle-specific Drp1 knockout enhances insulin sensitivity in diet-induced obese mice, but not in lean mice.
Volume: 77
Pages: 101802
Publication
First Author: Adachi Y
Year: 2020
Journal: Mol Cell
Title: Drp1 Tubulates the ER in a GTPase-Independent Manner.
Volume: 80
Issue: 4
Pages: 621-632.e6
Publication  
First Author: Yang X
Year: 2017
Journal: Redox Biol
Title: Inhibition of Drp1 protects against senecionine-induced mitochondria-mediated apoptosis in primary hepatocytes and in mice.
Volume: 12
Pages: 264-273
Publication
First Author: Udagawa O
Year: 2014
Journal: Curr Biol
Title: Mitochondrial fission factor Drp1 maintains oocyte quality via dynamic rearrangement of multiple organelles.
Volume: 24
Issue: 20
Pages: 2451-8
Publication
First Author: Wang L
Year: 2015
Journal: Diabetologia
Title: Disruption of mitochondrial fission in the liver protects mice from diet-induced obesity and metabolic deterioration.
Volume: 58
Issue: 10
Pages: 2371-80
Publication
First Author: Restelli LM
Year: 2018
Journal: Cell Rep
Title: Neuronal Mitochondrial Dysfunction Activates the Integrated Stress Response to Induce Fibroblast Growth Factor 21.
Volume: 24
Issue: 6
Pages: 1407-1414
Publication
First Author: Wang L
Year: 2021
Journal: Commun Biol
Title: Dynamin-related protein 1 deficiency accelerates lipopolysaccharide-induced acute liver injury and inflammation in mice.
Volume: 4
Issue: 1
Pages: 894
Publication      
First Author: Rogers MA
Year: 2021
Journal: Cardiovasc Res
Title: Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion.
Publication
First Author: Duan C
Year: 2020
Journal: Aging (Albany NY)
Title: Activated Drp1-mediated mitochondrial ROS influence the gut microbiome and intestinal barrier after hemorrhagic shock.
Volume: 12
Issue: 2
Pages: 1397-1416
Publication  
First Author: Zhu Y
Year: 2021
Journal: Front Pharmacol
Title: Protective Effects of Inhibition of Mitochondrial Fission on Organ Function After Sepsis.
Volume: 12
Pages: 712489
Publication
First Author: Valera-Alberni M
Year: 2021
Journal: Cell Rep
Title: Crosstalk between Drp1 phosphorylation sites during mitochondrial remodeling and their impact on metabolic adaptation.
Volume: 36
Issue: 8
Pages: 109565
Publication
First Author: Manczak M
Year: 2012
Journal: Biochim Biophys Acta
Title: Dynamin-related protein 1 heterozygote knockout mice do not have synaptic and mitochondrial deficiencies.
Volume: 1822
Issue: 6
Pages: 862-74
Publication
First Author: Kandimalla R
Year: 2016
Journal: Hum Mol Genet
Title: Reduced dynamin-related protein 1 protects against phosphorylated Tau-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.
Volume: 25
Issue: 22
Pages: 4881-4897
Publication
First Author: Itoh K
Year: 2018
Journal: J Biol Chem
Title: A brain-enriched Drp1 isoform associates with lysosomes, late endosomes, and the plasma membrane.
Volume: 293
Issue: 30
Pages: 11809-11822
Publication
First Author: Valenti D
Year: 2017
Journal: Biochim Biophys Acta
Title: Inhibition of Drp1-mediated mitochondrial fission improves mitochondrial dynamics and bioenergetics stimulating neurogenesis in hippocampal progenitor cells from a Down syndrome mouse model.
Volume: 1863
Issue: 12
Pages: 3117-3127
Publication
First Author: Strack S
Year: 2013
Journal: J Cell Biol
Title: Cyclin-dependent kinases regulate splice-specific targeting of dynamin-related protein 1 to microtubules.
Volume: 201
Issue: 7
Pages: 1037-51
Publication
First Author: Gomez-Lazaro M
Year: 2008
Journal: Free Radic Biol Med
Title: 6-Hydroxydopamine (6-OHDA) induces Drp1-dependent mitochondrial fragmentation in SH-SY5Y cells.
Volume: 44
Issue: 11
Pages: 1960-9
Publication
First Author: Brooks C
Year: 2009
Journal: J Clin Invest
Title: Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models.
Volume: 119
Issue: 5
Pages: 1275-85
Publication
First Author: Jain P
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Helicobacter pylori vacuolating cytotoxin A (VacA) engages the mitochondrial fission machinery to induce host cell death.
Volume: 108
Issue: 38
Pages: 16032-7
Publication
First Author: Ban-Ishihara R
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Dynamics of nucleoid structure regulated by mitochondrial fission contributes to cristae reformation and release of cytochrome c.
Volume: 110
Issue: 29
Pages: 11863-8
Publication
First Author: Kim B
Year: 2013
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Inhibition of Drp1-dependent mitochondrial division impairs myogenic differentiation.
Volume: 305
Issue: 8
Pages: R927-38
Publication
First Author: Zhang C
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Downregualtion of dynamin-related protein 1 attenuates glutamate-induced excitotoxicity via regulating mitochondrial function in a calcium dependent manner in HT22 cells.
Volume: 443
Issue: 1
Pages: 138-43
Publication
First Author: Serasinghe MN
Year: 2015
Journal: Mol Cell
Title: Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors.
Volume: 57
Issue: 3
Pages: 521-36
Publication
First Author: Galloway CA
Year: 2014
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Decreasing mitochondrial fission alleviates hepatic steatosis in a murine model of nonalcoholic fatty liver disease.
Volume: 307
Issue: 6
Pages: G632-41
Publication  
First Author: Fukumitsu K
Year: 2016
Journal: Mol Cell Neurosci
Title: Mitochondrial fission protein Drp1 regulates mitochondrial transport and dendritic arborization in cerebellar Purkinje cells.
Volume: 71
Pages: 56-65
Publication
First Author: Kabra UD
Year: 2017
Journal: Diabetes
Title: Direct Substrate Delivery Into Mitochondrial Fission-Deficient Pancreatic Islets Rescues Insulin Secretion.
Volume: 66
Issue: 5
Pages: 1247-1257
Publication
First Author: Kim DI
Year: 2016
Journal: Biochim Biophys Acta
Title: Aβ-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis.
Volume: 1863
Issue: 11
Pages: 2820-2834
Publication  
First Author: Li C
Year: 2018
Journal: Aging Cell
Title: DLP1-dependent mitochondrial fragmentation and redistribution mediate prion-associated mitochondrial dysfunction and neuronal death.
Volume: 17
Issue: 1
Publication
First Author: Galvan DL
Year: 2019
Journal: J Clin Invest
Title: Drp1S600 phosphorylation regulates mitochondrial fission and progression of nephropathy in diabetic mice.
Volume: 129
Issue: 7
Pages: 2807-2823
Publication
First Author: Haileselassie B
Year: 2020
Journal: J Neuroinflammation
Title: Mitochondrial dysfunction mediated through dynamin-related protein 1 (Drp1) propagates impairment in blood brain barrier in septic encephalopathy.
Volume: 17
Issue: 1
Pages: 36
Publication    
First Author: Shields LY
Year: 2021
Journal: J Biol Chem
Title: Mitochondrial fission is a critical modulator of mutant APP-induced neural toxicity.
Pages: 100469
Publication
First Author: Luo TT
Year: 2020
Journal: Mol Brain
Title: Drp1 is widely, yet heterogeneously, distributed in the mouse central nervous system.
Volume: 13
Issue: 1
Pages: 90
Publication
First Author: Hu Q
Year: 2020
Journal: Circ Res
Title: Increased Drp1 Acetylation by Lipid Overload Induces Cardiomyocyte Death and Heart Dysfunction.
Volume: 126
Issue: 4
Pages: 456-470
Publication
First Author: Singh M
Year: 2018
Journal: J Physiol
Title: Presynaptic loss of dynamin-related protein 1 impairs synaptic vesicle release and recycling at the mouse calyx of Held.
Volume: 596
Issue: 24
Pages: 6263-6287
Publication
First Author: Park G
Year: 2021
Journal: Cell Death Dis
Title: Ablation of dynamin-related protein 1 promotes diabetes-induced synaptic injury in the hippocampus.
Volume: 12
Issue: 5
Pages: 445
Publication
First Author: Yu T
Year: 2014
Journal: J Biol Chem
Title: Decreasing mitochondrial fission prevents cholestatic liver injury.
Volume: 289
Issue: 49
Pages: 34074-88
Publication
First Author: Yamamori T
Year: 2015
Journal: Mol Biol Cell
Title: Inhibition of the mitochondrial fission protein dynamin-related protein 1 (Drp1) impairs mitochondrial fission and mitotic catastrophe after x-irradiation.
Volume: 26
Issue: 25
Pages: 4607-17