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Search results 1 to 100 out of 285 for Dnm2

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
1785 | DNM2
Type: gene
Organism: human
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Gene
496487 | dnm2
Type: gene
Organism: frog, western clawed
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Gene
25751 | Dnm2
Type: gene
Organism: rat
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Gene
455718 | DNM2
Type: gene
Organism: chimpanzee
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Gene
484949 | DNM2
Type: gene
Organism: dog, domestic
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Gene
511691 | DNM2
Type: gene
Organism: cattle
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Gene
713558 | DNM2
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:109547 | Dnm2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR027188 | DNM2
Type: Family
Description: Dynamin-2 () is a microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. It most probably involved in vesicular trafficking processes, in particular endocytosis. It is also involved in cytokinesis [, , ].
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Publication
- | J:306120
     
First Author: Birling M-C
Year: 2021
Journal: MGI Direct Data Submission
Title: Dnm2 mutation.
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Protein
Q91Z39
Organism: Mus musculus/domesticus
Length: 454  
Fragment?: false
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GXD Expression
GXD Expression
 
Probe: MGI:4365628
Assay Type: Immunohistochemistry
Annotation Date: 2009-10-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752826
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:4365632
Age: embryonic day 19.5
Note: Staining was more intense in the basal and suprabasal layers, and accumulates in the subcorneum.
Specimen Label: 8B DNM2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4365628
Assay Type: Immunohistochemistry
Annotation Date: 2009-10-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752526
Pattern: Widespread
Stage: TS26
Assay Id: MGI:4365632
Age: embryonic day 19.5
Note: Expression was cytoplasmic in all layers.
Specimen Label: 8B DNM2
Detected: true
Specimen Num: 1
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Publication
28589938 | J:251686
 
First Author: Tasfaout H
Year: 2017
Journal: Nat Commun
Title: Antisense oligonucleotide-mediated Dnm2 knockdown prevents and reverts myotubular myopathy in mice.
Volume: 8
Pages: 15661
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Publication
9143510 | J:39830
First Author: Klocke R
Year: 1997
Journal: Genomics
Title: Dynamin genes Dnm1 and Dnm2 are located on proximal mouse chromosomes 2 and 9, respectively.
Volume: 41
Issue: 2
Pages: 290-2
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Publication
30925452 | J:285494
 
First Author: Rabai A
Year: 2019
Journal: Mol Ther Nucleic Acids
Title: Allele-Specific CRISPR/Cas9 Correction of a Heterozygous DNM2 Mutation Rescues Centronuclear Myopathy Cell Phenotypes.
Volume: 16
Pages: 246-256
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Publication
18923138 | -
First Author: Liu YW
Year: 2008
Journal: Mol Biol Cell
Title: Isoform and splice-variant specific functions of dynamin-2 revealed by analysis of conditional knock-out cells.
Volume: 19
Issue: 12
Pages: 5347-59
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Protein
P39054
Organism: Mus musculus/domesticus
Length: 870  
Fragment?: false
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Protein
Q3TCR7
Organism: Mus musculus/domesticus
Length: 869  
Fragment?: false
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Protein
G3UZZ3
Organism: Mus musculus/domesticus
Length: 807  
Fragment?: true
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Protein
G3UXX2
Organism: Mus musculus/domesticus
Length: 248  
Fragment?: true
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Protein
Q9CUM4
Organism: Mus musculus/domesticus
Length: 493  
Fragment?: true
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Protein
Q3TBU6
Organism: Mus musculus/domesticus
Length: 869  
Fragment?: false
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Protein
G3X9G4
Organism: Mus musculus/domesticus
Length: 870  
Fragment?: false
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Protein
F8WIV5
Organism: Mus musculus/domesticus
Length: 870  
Fragment?: false
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Protein
Q3T9X3
Organism: Mus musculus/domesticus
Length: 860  
Fragment?: false
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Publication
12498685 | -
First Author: Thompson HM
Year: 2002
Journal: Curr Biol
Title: The large GTPase dynamin associates with the spindle midzone and is required for cytokinesis.
Volume: 12
Issue: 24
Pages: 2111-7
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Publication
21195118 | -
First Author: Chircop M
Year: 2011
Journal: Biochim Biophys Acta
Title: Phosphorylation of dynamin II at serine-764 is associated with cytokinesis.
Volume: 1813
Issue: 10
Pages: 1689-99
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Publication
23092955 | J:211544
First Author: Koutsopoulos OS
Year: 2013
Journal: Eur J Hum Genet
Title: Dynamin 2 homozygous mutation in humans with a lethal congenital syndrome.
Volume: 21
Issue: 6
Pages: 637-42
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Publication
32129442 | J:288372
First Author: Pereira JA
Year: 2020
Journal: Hum Mol Genet
Title: Mice carrying an analogous heterozygous dynamin 2 K562E mutation that causes neuropathy in humans develop predominant characteristics of a primary myopathy.
Volume: 29
Issue: 8
Pages: 1253-1273
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Publication
35217605 | J:321638
 
First Author: Lionello VM
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: BIN1 modulation in vivo rescues dynamin-related myopathy.
Volume: 119
Issue: 9
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Publication
29246969 | J:261350
First Author: Trochet D
Year: 2018
Journal: EMBO Mol Med
Title: Allele-specific silencing therapy for Dynamin 2-related dominant centronuclear myopathy.
Volume: 10
Issue: 2
Pages: 239-253
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Publication
30648534 | J:283104
   
First Author: Gerber D
Year: 2019
Journal: Elife
Title: Schwann cells, but not Oligodendrocytes, Depend Strictly on Dynamin 2 Function.
Volume: 8
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Publication
20858595 | J:166364
First Author: Durieux AC
Year: 2010
Journal: Hum Mol Genet
Title: A centronuclear myopathy-dynamin 2 mutation impairs skeletal muscle structure and function in mice.
Volume: 19
Issue: 24
Pages: 4820-36
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Publication
32809972 | J:329580
 
First Author: Massana Muñoz X
Year: 2020
Journal: JCI Insight
Title: Physiological impact and disease reversion for the severe form of centronuclear myopathy linked to dynamin.
Volume: 5
Issue: 18
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Publication
23813975 | J:202266
First Author: Tinelli E
Year: 2013
Journal: Hum Mol Genet
Title: Muscle-specific function of the centronuclear myopathy and Charcot-Marie-Tooth neuropathy-associated dynamin 2 is required for proper lipid metabolism, mitochondria, muscle fibers, neuromuscular junctions and peripheral nerves.
Volume: 22
Issue: 21
Pages: 4417-29
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Publication
22451505 | J:283439
First Author: Sidiropoulos PN
Year: 2012
Journal: Brain
Title: Dynamin 2 mutations in Charcot-Marie-Tooth neuropathy highlight the importance of clathrin-mediated endocytosis in myelination.
Volume: 135
Issue: Pt 5
Pages: 1395-411
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Publication
27725702 | J:250193
 
First Author: Redgrove KA
Year: 2016
Journal: Sci Rep
Title: Dynamin 2 is essential for mammalian spermatogenesis.
Volume: 6
Pages: 35084
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Publication
25468568 | J:221386
First Author: Bender M
Year: 2015
Journal: Blood
Title: Dynamin 2-dependent endocytosis is required for normal megakaryocyte development in mice.
Volume: 125
Issue: 6
Pages: 1014-24
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Publication
30733559 | J:275393
First Author: Fongy A
Year: 2019
Journal: Sci Rep
Title: Nuclear defects in skeletal muscle from a Dynamin 2-linked centronuclear myopathy mouse model.
Volume: 9
Issue: 1
Pages: 1580
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Publication
30291191 | J:266517
First Author: Buono S
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Reducing dynamin 2 (DNM2) rescues DNM2-related dominant centronuclear myopathy.
Volume: 115
Issue: 43
Pages: 11066-11071
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Publication
22369075 | J:310375
First Author: Durieux AC
Year: 2012
Journal: Traffic
Title: A centronuclear myopathy--dynamin 2 mutation impairs autophagy in mice.
Volume: 13
Issue: 6
Pages: 869-79
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Publication
21514436 | J:171584
First Author: Cowling BS
Year: 2011
Journal: Am J Pathol
Title: Increased expression of wild-type or a centronuclear myopathy mutant of dynamin 2 in skeletal muscle of adult mice leads to structural defects and muscle weakness.
Volume: 178
Issue: 5
Pages: 2224-35
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Publication
24706848 | J:208622
First Author: Joshi HP
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Dynamin 2 along with microRNA-199a reciprocally regulate hypoxia-inducible factors and ovarian cancer metastasis.
Volume: 111
Issue: 14
Pages: 5331-6
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Publication
24598168 | J:221290
First Author: Lee MY
Year: 2014
Journal: Development
Title: Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis.
Volume: 141
Issue: 7
Pages: 1465-72
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Publication
28466468 | J:330452
First Author: Brown FC
Year: 2017
Journal: Br J Haematol
Title: Loss of Dynamin 2 GTPase function results in microcytic anaemia.
Volume: 178
Issue: 4
Pages: 616-628
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Publication
32065700 | J:304939
First Author: Mihalas BP
Year: 2020
Journal: FASEB J
Title: Dynamin 2-dependent endocytosis is essential for mouse oocyte development and fertility.
Volume: 34
Issue: 4
Pages: 5162-5177
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Publication
24569376 | J:209721
First Author: Cowling BS
Year: 2014
Journal: J Clin Invest
Title: Reducing dynamin 2 expression rescues X-linked centronuclear myopathy.
Volume: 124
Issue: 3
Pages: 1350-63
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Publication
34371181 | J:341143
First Author: Silva-Rojas R
Year: 2022
Journal: Mol Ther
Title: Mice with muscle-specific deletion of Bin1 recapitulate centronuclear myopathy and acute downregulation of dynamin 2 improves their phenotypes.
Volume: 30
Issue: 2
Pages: 868-880
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Publication
35763354 | J:330841
 
First Author: Li Q
Year: 2022
Journal: JCI Insight
Title: Dynamin-2 reduction rescues the skeletal myopathy of a SPEG-deficient mouse model.
Volume: 7
Issue: 15
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Publication
27118408 | J:236123
First Author: Tremblay CS
Year: 2016
Journal: Leukemia
Title: Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling.
Volume: 30
Issue: 10
Pages: 1993-2001
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Publication
23187129 | J:194200
First Author: Soda K
Year: 2012
Journal: J Clin Invest
Title: Role of dynamin, synaptojanin, and endophilin in podocyte foot processes.
Volume: 122
Issue: 12
Pages: 4401-11
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Publication
29130937 | J:272180
First Author: Cowling BS
Year: 2017
Journal: J Clin Invest
Title: Amphiphysin (BIN1) negatively regulates dynamin 2 for normal muscle maturation.
Volume: 127
Issue: 12
Pages: 4477-4487
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Protein Coding Gene
MGP_CAROLIEiJ_G0031873 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0034453 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0034431 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0034358 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0034422 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0034134 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_109547 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0034943 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0033457 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0034107 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0034266 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0034209 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0034351 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0034252 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0034963 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0033163 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0033572 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0014739 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0032997 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
25831514 | J:220817
First Author: Willinger T
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Dynamin 2-dependent endocytosis sustains T-cell receptor signaling and drives metabolic reprogramming in T lymphocytes.
Volume: 112
Issue: 14
Pages: 4423-8
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Publication
27870637 | J:237196
First Author: Fraysse B
Year: 2016
Journal: Biol Open
Title: Calcium homeostasis alterations in a mouse model of the Dynamin 2-related centronuclear myopathy.
Volume: 5
Issue: 11
Pages: 1691-1696
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Publication
26413867 | J:227493
First Author: Fan F
Year: 2015
Journal: J Clin Invest
Title: Dynamin 2 regulates biphasic insulin secretion and plasma glucose homeostasis.
Volume: 125
Issue: 11
Pages: 4026-41
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Publication
29071728 | J:328781
First Author: Kutchukian C
Year: 2017
Journal: J Physiol
Title: Impaired excitation-contraction coupling in muscle fibres from the dynamin2R465W mouse model of centronuclear myopathy.
Volume: 595
Issue: 24
Pages: 7369-7382
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Publication
28676641 | J:257238
First Author: González-Jamett AM
Year: 2017
Journal: Sci Rep
Title: Dynamin-2 mutations linked to Centronuclear Myopathy impair actin-dependent trafficking in muscle cells.
Volume: 7
Issue: 1
Pages: 4580
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Publication
27840081 | J:239103
First Author: Wang R
Year: 2017
Journal: Am J Pathol
Title: Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate-Induced Cell Migration.
Volume: 187
Issue: 1
Pages: 134-145
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Publication
18003703 | J:128506
First Author: Cao H
Year: 2007
Journal: J Cell Sci
Title: Dynamin 2 mediates fluid-phase micropinocytosis in epithelial cells.
Volume: 120
Issue: Pt 23
Pages: 4167-77
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Publication
19032944 | J:143063
First Author: Otsuka A
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Dynamin 2 is required for actin assembly in phagocytosis in Sertoli cells.
Volume: 378
Issue: 3
Pages: 478-82
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Publication
25336256 | J:218403
First Author: Verma SK
Year: 2014
Journal: Biochem J
Title: Late stages of the synchronized macrophage fusion in osteoclast formation depend on dynamin.
Volume: 464
Issue: 3
Pages: 293-300
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Publication
26199319 | J:226050
First Author: Chin YH
Year: 2015
Journal: Hum Mol Genet
Title: Dynamin-2 mutations associated with centronuclear myopathy are hypermorphic and lead to T-tubule fragmentation.
Volume: 24
Issue: 19
Pages: 5542-54
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Publication
32354746 | J:297159
First Author: Chen X
Year: 2020
Journal: J Biol Chem
Title: The intragenic microRNA miR199A1 in the dynamin 2 gene contributes to the pathology of X-linked centronuclear myopathy.
Volume: 295
Issue: 26
Pages: 8656-8667
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Publication
33113375 | J:343214
First Author: Lin SS
Year: 2020
Journal: Cell Rep
Title: Dynamin-2 Regulates Postsynaptic Cytoskeleton Organization and Neuromuscular Junction Development.
Volume: 33
Issue: 4
Pages: 108310
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GXD Expression
GXD Expression
   
Probe: MGI:6401116
Assay Type: RT-PCR
Annotation Date: 2020-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609217
Stage: TS17
Assay Id: MGI:6401222
Age: embryonic day 10.5
Image: 3
Specimen Label: E10
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6401116
Assay Type: RT-PCR
Annotation Date: 2020-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757721
Stage: TS21
Assay Id: MGI:6401222
Age: embryonic day 13.5
Image: 3
Specimen Label: E13
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6401116
Assay Type: RT-PCR
Annotation Date: 2020-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757727
Stage: TS27
Assay Id: MGI:6401222
Age: postnatal day 0
Image: 3
Specimen Label: P0
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:7428979
Assay Type: RT-PCR
Annotation Date: 2023-01-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754426
Stage: TS26
Assay Id: MGI:7429004
Age: embryonic day 18.5
Specimen Label: +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7428979
Assay Type: RT-PCR
Annotation Date: 2023-01-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754426
Stage: TS26
Assay Id: MGI:7429004
Age: embryonic day 18.5
Specimen Label: +/delta7-8
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7428979
Assay Type: RT-PCR
Annotation Date: 2023-01-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754426
Stage: TS26
Assay Id: MGI:7429004
Age: embryonic day 18.5
Specimen Label: delta7-8/delta7-8
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7482727
Assay Type: RT-PCR
Annotation Date: 2023-05-22
Strength: Present
Sex: Female
Emaps: EMAPS:3570528
Stage: TS28
Assay Id: MGI:7482761
Age: postnatal adult
Image: S5
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7482727
Assay Type: RT-PCR
Annotation Date: 2023-05-22
Strength: Present
Sex: Female
Emaps: EMAPS:3570528
Stage: TS28
Assay Id: MGI:7482761
Age: postnatal adult
Image: S5
Specimen Label: KO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7482717
Assay Type: Western blot
Annotation Date: 2023-05-22
Strength: Present
Sex: Female
Emaps: EMAPS:3575528
Stage: TS28
Assay Id: MGI:7482789
Age: postnatal adult
Image: S5
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7482717
Assay Type: Western blot
Annotation Date: 2023-05-22
Strength: Present
Sex: Female
Emaps: EMAPS:3575528
Stage: TS28
Assay Id: MGI:7482789
Age: postnatal adult
Image: S5
Specimen Label: KO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7529964
Assay Type: RT-PCR
Annotation Date: 2023-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684623
Stage: TS23
Assay Id: MGI:7529983
Age: embryonic day 15.5
Image: S4
Specimen Label: FL (E15.5)
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7529964
Assay Type: RT-PCR
Annotation Date: 2023-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:7529983
Age: embryonic day 17.5
Image: S4
Specimen Label: FL (E17.5)
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:7529964
Assay Type: RT-PCR
Annotation Date: 2023-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283427
Stage: TS27
Assay Id: MGI:7529983
Age: postnatal newborn
Image: S4
Specimen Label: S.I.
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:7529964
Assay Type: RT-PCR
Annotation Date: 2023-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7529983
Age: postnatal adult
Image: S4
Specimen Label: Adult brain
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4882357
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691619
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4944786
Age: embryonic day 11.5
Image: g00206 E11.5
Specimen Label: g00206 E11.5
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4882357
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4944786
Age: embryonic day 15.5
Image: g00206 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g00206 E15.5
Detected: true
Specimen Num: 2
•
•
•
•
•




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