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Search results 1 to 100 out of 1649 for Dnmt3a

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: In mammals, DNA methylation patterns are thought to be established during embryonic development by de novo DNA methyltransferases 3A and 3B (DNMT3A/3B) []. DNMT3A/3B work synergistically to propagate methylation patterns with DNMT3B stimulating DNMT3A activity by promoting its association with nucleosomes []. DNMT3A exists in an autoinhibitory form that can be activated by the histone H3 tail in a DNMT3L-independent manner []. DNMT3A has been linked to cancers [, , ].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Mayle A
Year: 2015
Journal: Blood
Title: Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation.
Volume: 125
Issue: 4
Pages: 629-38
Publication
First Author: Okano M
Year: 1999
Journal: Cell
Title: DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.
Volume: 99
Issue: 3
Pages: 247-57
Publication
First Author: Celik H
Year: 2015
Journal: Blood
Title: Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation.
Volume: 125
Issue: 4
Pages: 619-28
Protein
Organism: Mus musculus/domesticus
Length: 908  
Fragment?: false
GXD Expression    
Probe: MGI:7470897
Assay Type: RT-PCR
Annotation Date: 2023-05-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360355
Stage: TS05
Assay Id: MGI:7470906
Age: embryonic day 3.5
Image: 3
Specimen Label: E3.5 Dnmt3a
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:7470897
Assay Type: RT-PCR
Annotation Date: 2023-05-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:7470906
Age: embryonic day 7.5
Image: 3
Specimen Label: E7.5 Dnmt3a
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:7470897
Assay Type: RT-PCR
Annotation Date: 2023-05-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:7470906
Age: embryonic day 10.5
Image: 3
Specimen Label: E10.5 Dnmt3a
Detected: true
Specimen Num: 12
Protein
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: true
Publication
First Author: Guo X
Year: 2015
Journal: Nature
Title: Structural insight into autoinhibition and histone H3-induced activation of DNMT3A.
Volume: 517
Issue: 7536
Pages: 640-4
Publication
First Author: Santos GC Jr
Year: 2015
Journal: J Cell Biochem
Title: Epigenetic modifications, chromatin distribution and TP53 transcription in a model of breast cancer progression.
Volume: 116
Issue: 4
Pages: 533-41
Publication
First Author: Sharma S
Year: 2011
Journal: PLoS Genet
Title: Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance.
Volume: 7
Issue: 2
Pages: e1001286
Protein
Organism: Mus musculus/domesticus
Length: 332  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 107  
Fragment?: true
Publication  
First Author: Higo T
Year: 2022
Journal: Exp Hematol
Title: Heterozygous Dnmt3a R878C induces expansion of quiescent hematopoietic stem cell pool.
Volume: 109
Pages: 45-54
Publication
First Author: Challen GA
Year: 2011
Journal: Nat Genet
Title: Dnmt3a is essential for hematopoietic stem cell differentiation.
Volume: 44
Issue: 1
Pages: 23-31
Publication
First Author: Gowher H
Year: 2005
Journal: J Biol Chem
Title: Mechanism of stimulation of catalytic activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L.
Volume: 280
Issue: 14
Pages: 13341-8
Publication
First Author: Yang L
Year: 2016
Journal: Cancer Cell
Title: DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias.
Volume: 29
Issue: 6
Pages: 922-934
Publication    
First Author: You D
Year: 2017
Journal: Elife
Title: Dnmt3a is an epigenetic mediator of adipose insulin resistance.
Volume: 6
Publication
First Author: Raddatz G
Year: 2012
Journal: PLoS Genet
Title: Dnmt3a protects active chromosome domains against cancer-associated hypomethylation.
Volume: 8
Issue: 12
Pages: e1003146
Publication
First Author: Jeong M
Year: 2018
Journal: Cell Rep
Title: Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo.
Volume: 23
Issue: 1
Pages: 1-10
Publication  
First Author: Feng Y
Year: 2023
Journal: J Exp Med
Title: Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer.
Volume: 220
Issue: 11
Publication
First Author: Kramer AC
Year: 2017
Journal: Leukemia
Title: Dnmt3a regulates T-cell development and suppresses T-ALL transformation.
Volume: 31
Issue: 11
Pages: 2479-2490
Publication
First Author: Watanabe D
Year: 2002
Journal: Mech Dev
Title: Stage- and cell-specific expression of Dnmt3a and Dnmt3b during embryogenesis.
Volume: 118
Issue: 1-2
Pages: 187-90
Publication
First Author: Kohno D
Year: 2014
Journal: J Neurosci
Title: Dnmt3a in Sim1 neurons is necessary for normal energy homeostasis.
Volume: 34
Issue: 46
Pages: 15288-96
Publication
First Author: Pham D
Year: 2013
Journal: J Immunol
Title: Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation.
Volume: 191
Issue: 2
Pages: 902-11
Publication
First Author: Li N
Year: 2020
Journal: Curr Mol Med
Title: Uterine Dnmt3a is not Required for Mouse Embryo Implantation.
Volume: 20
Issue: 8
Pages: 633-642
Publication
First Author: Zhang X
Year: 2020
Journal: Blood
Title: Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis.
Volume: 135
Issue: 11
Pages: 845-856
Publication
First Author: Rajavelu A
Year: 2018
Journal: Nucleic Acids Res
Title: Chromatin-dependent allosteric regulation of DNMT3A activity by MeCP2.
Volume: 46
Issue: 17
Pages: 9044-9056
Publication
First Author: González-Rodríguez P
Year: 2021
Journal: Autophagy
Title: The DNA methyltransferase DNMT3A contributes to autophagy long-term memory.
Volume: 17
Issue: 5
Pages: 1259-1277
Publication
First Author: Naito M
Year: 2016
Journal: PLoS Genet
Title: Dnmt3a Regulates Proliferation of Muscle Satellite Cells via p57Kip2.
Volume: 12
Issue: 7
Pages: e1006167
Publication
First Author: Smith AM
Year: 2021
Journal: Nat Commun
Title: Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome.
Volume: 12
Issue: 1
Pages: 4549
Publication
First Author: Colquitt BM
Year: 2014
Journal: Neuron
Title: Dnmt3a regulates global gene expression in olfactory sensory neurons and enables odorant-induced transcription.
Volume: 83
Issue: 4
Pages: 823-38
Publication    
First Author: Tovy A
Year: 2022
Journal: Elife
Title: Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis.
Volume: 11
Publication
First Author: Guryanova OA
Year: 2016
Journal: Leukemia
Title: Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic stem and progenitor cells.
Volume: 30
Issue: 5
Pages: 1133-42
Publication
First Author: Minero AS
Year: 2012
Journal: FEBS J
Title: Probing murine methyltransfease Dnmt3a interactions with benzo[a]pyrene-modified DNA by fluorescence methods.
Volume: 279
Issue: 20
Pages: 3965-80
Publication
First Author: Jacquelin S
Year: 2018
Journal: Blood
Title: Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation.
Volume: 132
Issue: 26
Pages: 2707-2721
Publication
First Author: Liao J
Year: 2015
Journal: Nat Genet
Title: Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells.
Volume: 47
Issue: 5
Pages: 469-78
GXD Expression    
Probe: MGI:6171381
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190136
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Dnmt3a
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6171381
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190136
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Dnmt3a
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6171381
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190136
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Dnmt3a
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6171381
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190136
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Dnmt3a
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6171381
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190136
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Dnmt3a
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6171381
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190136
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Dnmt3a
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6171381
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190136
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Dnmt3a
Detected: true
Specimen Num: 7
Publication
First Author: Haney SL
Year: 2016
Journal: PLoS Genet
Title: Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma.
Volume: 12
Issue: 9
Pages: e1006334
Publication
First Author: Elliott E
Year: 2016
Journal: J Neurosci
Title: Dnmt3a in the Medial Prefrontal Cortex Regulates Anxiety-Like Behavior in Adult Mice.
Volume: 36
Issue: 3
Pages: 730-40
Publication
First Author: Gu T
Year: 2022
Journal: Nat Genet
Title: The disordered N-terminal domain of DNMT3A recognizes H2AK119ub and is required for postnatal development.
Volume: 54
Issue: 5
Pages: 625-636
Publication
First Author: Christian DL
Year: 2020
Journal: Cell Rep
Title: DNMT3A Haploinsufficiency Results in Behavioral Deficits and Global Epigenomic Dysregulation Shared across Neurodevelopmental Disorders.
Volume: 33
Issue: 8
Pages: 108416
Publication  
First Author: Zhao JY
Year: 2017
Journal: Nat Commun
Title: DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons.
Volume: 8
Pages: 14712
Publication
First Author: Dai YJ
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Conditional knockin of Dnmt3a R878H initiates acute myeloid leukemia with mTOR pathway involvement.
Volume: 114
Issue: 20
Pages: 5237-5242
Publication
First Author: Sendžikaitė G
Year: 2019
Journal: Nat Commun
Title: A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice.
Volume: 10
Issue: 1
Pages: 1884
Publication
First Author: Li X
Year: 2020
Journal: FASEB J
Title: LncRNA Dnmt3aos regulates Dnmt3a expression leading to aberrant DNA methylation in macrophage polarization.
Volume: 34
Issue: 4
Pages: 5077-5091
Publication
First Author: Zhang X
Year: 2016
Journal: Nat Genet
Title: DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells.
Volume: 48
Issue: 9
Pages: 1014-23
Publication  
First Author: Ramdas B
Year: 2022
Journal: JCI Insight
Title: Combined heterozygosity of FLT3 ITD, TET2, and DNMT3A results in aggressive leukemia.
Volume: 7
Issue: 17
Publication    
First Author: Li J
Year: 2022
Journal: Elife
Title: Dnmt3a knockout in excitatory neurons impairs postnatal synapse maturation and increases the repressive histone modification H3K27me3.
Volume: 11
Publication
First Author: Siddique AN
Year: 2011
Journal: FEBS J
Title: Auto-methylation of the mouse DNA-(cytosine C5)-methyltransferase Dnmt3a at its active site cysteine residue.
Volume: 278
Issue: 12
Pages: 2055-63
Publication  
First Author: Haney SL
Year: 2016
Journal: Sci Rep
Title: Loss of Dnmt3a induces CLL and PTCL with distinct methylomes and transcriptomes in mice.
Volume: 6
Pages: 34222
Publication
First Author: Guryanova OA
Year: 2016
Journal: Nat Med
Title: DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling.
Volume: 22
Issue: 12
Pages: 1488-1495
Publication
First Author: Kaneda M
Year: 2004
Journal: Nature
Title: Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting.
Volume: 429
Issue: 6994
Pages: 900-3
Publication
First Author: Jurkowska RZ
Year: 2008
Journal: Nucleic Acids Res
Title: Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L.
Volume: 36
Issue: 21
Pages: 6656-63
Publication
First Author: Feng J
Year: 2010
Journal: Nat Neurosci
Title: Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons.
Volume: 13
Issue: 4
Pages: 423-30
Publication
First Author: Yagi M
Year: 2020
Journal: Nat Commun
Title: Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development.
Volume: 11
Issue: 1
Pages: 3199
Publication
First Author: Gao Q
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression.
Volume: 108
Issue: 44
Pages: 18061-6
Publication  
First Author: Saunders J
Year: 2018
Journal: Front Mol Neurosci
Title: Negative Evidence for a Functional Role of Neuronal DNMT3a in Persistent Pain.
Volume: 11
Pages: 332
Publication
First Author: Challen GA
Year: 2014
Journal: Cell Stem Cell
Title: Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells.
Volume: 15
Issue: 3
Pages: 350-364
Publication    
First Author: Lavery LA
Year: 2020
Journal: Elife
Title: Losing Dnmt3a dependent methylation in inhibitory neurons impairs neural function by a mechanism impacting Rett syndrome.
Volume: 9
Publication  
First Author: Koya J
Year: 2016
Journal: Nat Commun
Title: DNMT3A R882 mutants interact with polycomb proteins to block haematopoietic stem and leukaemic cell differentiation.
Volume: 7
Pages: 10924
Publication
First Author: Scheller M
Year: 2021
Journal: Nat Cancer
Title: Hotspot DNMT3A mutations in clonal hematopoiesis and acute myeloid leukemia sensitize cells to azacytidine via viral mimicry response.
Volume: 2
Issue: 5
Pages: 527-544
Publication
First Author: Li X
Year: 2016
Journal: Nat Immunol
Title: Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity.
Volume: 17
Issue: 7
Pages: 806-15
Publication
First Author: Gowher H
Year: 2006
Journal: J Mol Biol
Title: Mutational analysis of the catalytic domain of the murine Dnmt3a DNA-(cytosine C5)-methyltransferase.
Volume: 357
Issue: 3
Pages: 928-41
Publication
First Author: Li YQ
Year: 2007
Journal: Nucleic Acids Res
Title: Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair.
Volume: 35
Issue: 2
Pages: 390-400
Publication
First Author: Takeshima H
Year: 2008
Journal: J Mol Biol
Title: Mouse Dnmt3a preferentially methylates linker DNA and is inhibited by histone H1.
Volume: 383
Issue: 4
Pages: 810-21
Publication
First Author: Chen CC
Year: 2012
Journal: J Biol Chem
Title: The mammalian de novo DNA methyltransferases DNMT3A and DNMT3B are also DNA 5-hydroxymethylcytosine dehydroxymethylases.
Volume: 287
Issue: 40
Pages: 33116-21
Publication
First Author: Gowher H
Year: 2002
Journal: J Biol Chem
Title: Molecular enzymology of the catalytic domains of the Dnmt3a and Dnmt3b DNA methyltransferases.
Volume: 277
Issue: 23
Pages: 20409-14
Publication
First Author: Haney SL
Year: 2015
Journal: Oncogene
Title: Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis.
Volume: 34
Issue: 43
Pages: 5436-5446
Publication  
First Author: Ktena YP
Year: 2022
Journal: J Clin Invest
Title: Donor T cell DNMT3a regulates alloreactivity in mouse models of hematopoietic stem cell transplantation.
Volume: 132
Issue: 13
Publication  
First Author: Chen DY
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype.
Volume: 118
Issue: 16
Publication
First Author: Poitras JL
Year: 2016
Journal: Oncotarget
Title: Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model.
Volume: 7
Issue: 43
Pages: 69124-69135
Publication
First Author: Chen T
Year: 2003
Journal: Mol Cell Biol
Title: Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b.
Volume: 23
Issue: 16
Pages: 5594-605
Publication
First Author: Sportoletti P
Year: 2021
Journal: Leukemia
Title: Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in acute erythroid leukemia onset in mice.
Volume: 35
Issue: 7
Pages: 1949-1963
Publication
First Author: Shi X
Year: 2019
Journal: BMC Cancer
Title: Cooperation of Dnmt3a R878H with Nras G12D promotes leukemogenesis in knock-in mice: a pilot study.
Volume: 19
Issue: 1
Pages: 1072
Publication
First Author: Sun W
Year: 2020
Journal: Biochem Biophys Res Commun
Title: Virus-mediated Dnmt1 and Dnmt3a deletion disrupts excitatory synaptogenesis and synaptic function in primary cultured hippocampal neurons.
Volume: 526
Issue: 2
Pages: 361-367
Publication    
First Author: Rinaldi L
Year: 2017
Journal: Elife
Title: Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ.
Volume: 6
Publication
First Author: Nguyen S
Year: 2007
Journal: Dev Dyn
Title: Ablation of de novo DNA methyltransferase Dnmt3a in the nervous system leads to neuromuscular defects and shortened lifespan.
Volume: 236
Issue: 6
Pages: 1663-76