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Search results 1 to 80 out of 80 for Dnph1

0.029s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Protein Domain
Type: Family
Description: DNPH1 (also known as Rcl) is an enzyme involved in nucleotide metabolism. It catalyses the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base []. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases. This enzyme is over-expressed in several cancers [], which may be a potential molecular target for cancer treatment [].
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Ghiorghi YK
Year: 2007
Journal: J Biol Chem
Title: The c-Myc target gene Rcl (C6orf108) encodes a novel enzyme, deoxynucleoside 5'-monophosphate N-glycosidase.
Volume: 282
Issue: 11
Pages: 8150-6
Publication
First Author: Yang Y
Year: 2009
Journal: J Mol Biol
Title: Structural characterization of the mammalian deoxynucleotide N-hydrolase Rcl and its stabilizing interactions with two inhibitors.
Volume: 394
Issue: 3
Pages: 435-47
Publication  
First Author: Amiable C
Year: 2014
Journal: Eur J Med Chem
Title: 6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities.
Volume: 85
Pages: 418-37
Protein
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: false
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression    
Probe: MGI:5000872
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2760523
Stage: TS23
Assay Id: MGI:5541430
Age: embryonic day 15.5
Image: GUDMAP:9650
Specimen Label: GUDMAP:9650
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5000872
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2769723
Stage: TS23
Assay Id: MGI:5541430
Age: embryonic day 15.5
Image: GUDMAP:9650
Specimen Label: GUDMAP:9650
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5000872
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2851823
Stage: TS23
Assay Id: MGI:5541430
Age: embryonic day 15.5
Image: GUDMAP:9650
Specimen Label: GUDMAP:9650
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:5000872
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2762123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541430
Age: embryonic day 15.5
Image: GUDMAP:9650
Specimen Label: GUDMAP:9650
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5000872
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2850023
Stage: TS23
Assay Id: MGI:5541430
Age: embryonic day 15.5
Image: GUDMAP:9650
Specimen Label: GUDMAP:9650
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5000872
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2852723
Stage: TS23
Assay Id: MGI:5541430
Age: embryonic day 15.5
Image: GUDMAP:9650
Specimen Label: GUDMAP:9650
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5000872
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2845723
Stage: TS23
Assay Id: MGI:5541430
Age: embryonic day 15.5
Image: GUDMAP:9650
Specimen Label: GUDMAP:9650
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5000872
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1795023
Stage: TS23
Assay Id: MGI:5541430
Age: embryonic day 15.5
Image: GUDMAP:9650
Specimen Label: GUDMAP:9650
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5000872
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1869223
Stage: TS23
Assay Id: MGI:5541430
Age: embryonic day 15.5
Image: GUDMAP:9650
Specimen Label: GUDMAP:9650
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5000872
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1832123
Stage: TS23
Assay Id: MGI:5541430
Age: embryonic day 15.5
Image: GUDMAP:9650
Specimen Label: GUDMAP:9650
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5000872
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1797223
Stage: TS23
Assay Id: MGI:5541430
Age: embryonic day 15.5
Image: GUDMAP:9650
Specimen Label: GUDMAP:9650
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:5000872
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2853323
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5541430
Age: embryonic day 15.5
Image: GUDMAP:9650
Specimen Label: GUDMAP:9650
Detected: true
Specimen Num: 1
Publication        
First Author: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health
Year: 2001
Title: GenBank Record Derived Information
Publication        
First Author: Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration
Year: 2001
Title: LocusLink Collaboration
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
Publication
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication      
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication
First Author: Anand R
Year: 2004
Journal: Biochemistry
Title: Structures of purine 2'-deoxyribosyltransferase, substrate complexes, and the ribosylated enzyme intermediate at 2.0 A resolution.
Volume: 43
Issue: 9
Pages: 2384-93
Publication
First Author: Armstrong SR
Year: 1996
Journal: Structure
Title: Crystal structures of nucleoside 2-deoxyribosyltransferase in native and ligand-bound forms reveal architecture of the active site.
Volume: 4
Issue: 1
Pages: 97-107
Publication  
First Author: Aas-Valleriani N
Year: 2018
Journal: Biochimie
Title: Deoxynucleoside 5-monophosphate N-glycosidase from a phylogenetically distant metazoa, sponge.
Volume: 146
Pages: 113-118
Publication
First Author: Schuldiner O
Year: 2001
Journal: Oncogene
Title: A DNA microarray screen for genes involved in c-MYC and N-MYC oncogenesis in human tumors.
Volume: 20
Issue: 36
Pages: 4984-94
Protein Domain
Type: Family
Description: Nucleoside 2-deoxyribosyltransferase (NDT) () catalyses the cleavage of the glycosidic bonds of 2-deoxyribonucleosides. Nucleoside 2-deoxyribosyltransferases can be divided into two groups based on their substrate specificity: class I enzymes are specific for the transfer of deoxyribose between two purines, while class II enzymes will transfer the deoxyribose between either purines or pyrimidines. The structure of the class I []and class II []enzymes are very similar. In class I enzymes, the purine base shields the active site from solvent, which the smaller pyrimidine base cannot do, while in class II enzymes the active site is shielded by a loop (residues 48-62). Both classes of enzymes are found in various Lactobacillus species and participate in nucleoside recycling in these microorganisms. This entry represents both classes of enzymes.This entry also includes the related enzyme deoxynucleoside 5-monophosphate N-glycosidase (DNPH1), a nucleotide hydrolase (). DNPH1 is related to NDT in structure and enzymatic activity, but in contrast to NDT catalyzes the hydrolysis of 2'-deoxyribonucleoside 5'-monophosphate to yield a free nucleobase and 2-deoxyribose 5-phosphate [, ]. DNPH1 is a potential proto-oncogene [].