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Search results 1 to 100 out of 101 for Doc2a

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Hits by Category

Hits by Strain

Type Details Score
Gene
8448 | DOC2A
Type: gene
Organism: human
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Gene
101730387 | doc2a
Type: gene
Organism: frog, western clawed
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Gene
65031 | Doc2a
Type: gene
Organism: rat
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Gene
489945 | DOC2A
Type: gene
Organism: dog, domestic
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Gene
467943 | DOC2A
Type: gene
Organism: chimpanzee
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Gene
528120 | DOC2A
Type: gene
Organism: cattle
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Gene
558815 | doc2a
Type: gene
Organism: zebrafish
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Gene
707895 | DOC2A
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:109446 | Doc2a
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
16515538 | J:108537
First Author: Groffen AJ
Year: 2006
Journal: J Neurochem
Title: DOC2A and DOC2B are sensors for neuronal activity with unique calcium-dependent and kinetic properties.
Volume: 97
Issue: 3
Pages: 818-33
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Publication
25005332 | J:218125
First Author: Li J
Year: 2014
Journal: Diabetologia
Title: DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake.
Volume: 57
Issue: 10
Pages: 2173-82
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Publication
20150444 | J:158605
First Author: Groffen AJ
Year: 2010
Journal: Science
Title: Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release.
Volume: 327
Issue: 5973
Pages: 1614-8
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Publication
22036572 | J:178686
First Author: Yao J
Year: 2011
Journal: Cell
Title: Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release.
Volume: 147
Issue: 3
Pages: 666-77
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Publication
31594980 | J:297992
First Author: Bourgeois-Jaarsma Q
Year: 2019
Journal: Sci Rep
Title: Doc2b Ca2+ binding site mutants enhance synaptic release at rest at the expense of sustained synaptic strength.
Volume: 9
Issue: 1
Pages: 14408
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Publication
38242640 | J:351576
First Author: Guiberson NGL
Year: 2024
Journal: Brain
Title: Disease-linked mutations in Munc18-1 deplete synaptic Doc2.
Volume: 147
Issue: 6
Pages: 2185-2202
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Publication
32098902 | J:286584
First Author: Díez-Arazola R
Year: 2020
Journal: J Neurosci
Title: Doc2 Proteins Are Not Required for the Increased Spontaneous Release Rate in Synaptotagmin-1-Deficient Neurons.
Volume: 40
Issue: 13
Pages: 2606-2617
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Publication
33753311 | J:317639
 
First Author: Bourgeois-Jaarsma Q
Year: 2021
Journal: Mol Cell Neurosci
Title: Ca2+ sensor proteins in spontaneous release and synaptic plasticity: Limited contribution of Doc2c, rabphilin-3a and synaptotagmin 7 in hippocampal glutamatergic neurons.
Volume: 112
Pages: 103613
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Protein Coding Gene
MGP_CAROLIEiJ_G0030469 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0033003 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032986 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032918 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032991 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0032701 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_109446 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0033497 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0032030 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0032674 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032826 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032779 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032920 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032811 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0033516 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031737 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0032142 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0013679 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0031583 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
9073161 | J:38862
First Author: Naito A
Year: 1997
Journal: Brain Res Mol Brain Res
Title: Molecular cloning of mouse Doc2alpha and distribution of its mRNA in adult mouse brain.
Volume: 44
Issue: 2
Pages: 198-204
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Publication
10594652 | J:89423
First Author: Sakaguchi G
Year: 1999
Journal: Eur J Neurosci
Title: Doc2alpha is an activity-dependent modulator of excitatory synaptic transmission.
Volume: 11
Issue: 12
Pages: 4262-8
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GXD Expression
GXD Expression
     
Probe: MGI:3576311
Assay Type: Western blot
Annotation Date: 2005-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754426
Stage: TS26
Assay Id: MGI:3576321
Age: embryonic day 18.5
Specimen Label: +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3576311
Assay Type: Western blot
Annotation Date: 2005-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754426
Stage: TS26
Assay Id: MGI:3576321
Age: embryonic day 18.5
Specimen Label: -/-
Detected: true
Specimen Num: 2
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Publication
24133251 | J:202747
First Author: Pinheiro PS
Year: 2013
Journal: J Neurosci
Title: Doc2b synchronizes secretion from chromaffin cells by stimulating fast and inhibiting sustained release.
Volume: 33
Issue: 42
Pages: 16459-70
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Publication
37354460 | J:338430
First Author: Wang QW
Year: 2023
Journal: Cell Rep
Title: 16p11.2 CNV gene Doc2α functions in neurodevelopment and social behaviors through interaction with Secretagogin.
Volume: 42
Issue: 7
Pages: 112691
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Publication
18354201 | J:133380
First Author: Higashio H
Year: 2008
Journal: J Immunol
Title: Doc2 alpha and Munc13-4 regulate Ca(2+) -dependent secretory lysosome exocytosis in mast cells.
Volume: 180
Issue: 7
Pages: 4774-84
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Publication
29754754 | J:267944
First Author: Courtney NA
Year: 2018
Journal: Neuron
Title: Excitatory and Inhibitory Neurons Utilize Different Ca2+ Sensors and Sources to Regulate Spontaneous Release.
Volume: 98
Issue: 5
Pages: 977-991.e5
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Publication
29274147 | J:254968
   
First Author: Houy S
Year: 2017
Journal: Elife
Title: Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs.
Volume: 6
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Publication
21521611 | J:174823
First Author: Pang ZP
Year: 2011
Journal: Neuron
Title: Doc2 supports spontaneous synaptic transmission by a Ca(2+)-independent mechanism.
Volume: 70
Issue: 2
Pages: 244-51
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Publication
27091977 | J:232211
First Author: de Jong AP
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Phosphorylation of synaptotagmin-1 controls a post-priming step in PKC-dependent presynaptic plasticity.
Volume: 113
Issue: 18
Pages: 5095-100
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Publication
15145078 | J:91381
First Author: Bouwman J
Year: 2004
Journal: Neuroscience
Title: Quantification of synapse formation and maintenance in vivo in the absence of synaptic release.
Volume: 126
Issue: 1
Pages: 115-26
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Publication
15935055 | J:99424
First Author: Toonen RF
Year: 2005
Journal: J Neurochem
Title: Munc18-1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation.
Volume: 93
Issue: 6
Pages: 1393-400
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Doc2a<em1Smoc> | MGI:7289382
Name: double C2, alpha; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6475147 | C57BL/6JSmoc-Doc2a<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Tg(Doc2a-EGFP)IK151Gsat | MGI:4847001
Name: transgene insertion IK151, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:5004069 | STOCK Tg(Doc2a-EGFP)IK151Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Publication
8902635 | J:39762
First Author: Kojima T
Year: 1996
Journal: J Biochem
Title: Calcium-dependent phospholipid binding to the C2A domain of a ubiquitous form of double C2 protein (Doc2 beta).
Volume: 120
Issue: 3
Pages: 671-6
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Publication
19033398 | J:146942
First Author: Fukuda N
Year: 2009
Journal: Diabetes
Title: DOC2B: a novel syntaxin-4 binding protein mediating insulin-regulated GLUT4 vesicle fusion in adipocytes.
Volume: 58
Issue: 2
Pages: 377-84
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Publication
22698913 | J:208531
First Author: Ramalingam L
Year: 2012
Journal: Diabetes
Title: Doc2b is a key effector of insulin secretion and skeletal muscle insulin sensitivity.
Volume: 61
Issue: 10
Pages: 2424-32
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Publication
20403080 | -
First Author: Sato M
Year: 2010
Journal: J Neurochem
Title: Role of the polybasic sequence in the Doc2alpha C2B domain in dense-core vesicle exocytosis in PC12 cells.
Volume: 114
Issue: 1
Pages: 171-81
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Protein Domain
IPR030535 | Doc2a/b
Type: Family
Description: Doc2a (double C2-like domain-containing protein alpha) and Doc2b (double C2-like domain-containing protein beta) are members of the double C2 domain protein family. Doc2a is expressed in neuronal cells and has been implicated in Ca2+-dependent neurotransmitter release [, ]. Doc2a exhibits Ca2+-dependent phospholipid-binding activity through its C2A domain, which is thought to be important for the regulation of Ca2+-dependent exocytosis. The C2B domain is required for binding of syntaxin-1a/synaptosome-associated protein of 25kDa (SNAP-25) heterodimer []. Doc2a is also expressed in pancreatic islets, and has been implicated together with Doc2b in the synergistic regulation of glucose-stimulated insulin secretion [].Doc2b contains two calcium and phospholipid binding domains in its C terminus []. It interacts with the SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) complex composed of SNAP25, STX1A and VAMP2. Doc2b regulates SNARE-dependent fusion of vesicles with membranes in a calcium-dependent manner. It is involved in calcium-dependent spontaneous release of neurotransmitter, with a function analogous to synaptotagmin-1, but with a higher Ca2+ sensitivity []. Doc2b is a positive SNARE regulator for glucose transporter GLUT4 vesicle fusion and mediates insulin-stimulated glucose transport in adipocytes []. It is involved in both insulin-stimulated glucose uptake in adipocytes and glucose-stimulated insulin secretion in pancreatic cells, as well as insulin responsiveness in skeletal muscle [, ].
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Protein
D3Z126
Organism: Mus musculus/domesticus
Length: 83  
Fragment?: true
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Publication
11371549 | -
First Author: Fukuda M
Year: 2001
Journal: J Biol Chem
Title: The C2A domain of double C2 protein gamma contains a functional nuclear localization signal.
Volume: 276
Issue: 27
Pages: 24441-4
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Protein Domain
IPR030536 | Doc2g
Type: Family
Description: This entry represents double C2-like domain-containing protein gamma (Doc2g). The Doc2 (double C2) family members Doc2a and Doc2b are characterised by an N-terminal Munc13-1 interacting domain, and two C2 domains that interact with Ca(2+) and phospholipid at the C terminus. In contrast, the C2 domains of Doc2g impair Ca(2+)-dependent phospholipid binding activity. The Ca2+-independent C2A domain of Doc2g seems to have a nuclear localisation function []. Doc2g may also function as an effector for Munc13-1, and it may be involved in the regulation of vesicular trafficking [].
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Publication
32347796 | J:291939
   
First Author: Khan MM
Year: 2020
Journal: Elife
Title: Loss of Doc2b does not influence transmission at Purkinje cell to deep nuclei synapses under physiological conditions.
Volume: 9
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Publication
9115738 | J:39082
First Author: Verhage M
Year: 1997
Journal: Neuron
Title: DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion.
Volume: 18
Issue: 3
Pages: 453-61
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Protein
D3YZ51
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: true
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Protein
Q7TNF0
Organism: Mus musculus/domesticus
Length: 405  
Fragment?: false
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Protein
P70169
Organism: Mus musculus/domesticus
Length: 412  
Fragment?: false
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Publication
11027523 | J:64801
First Author: Fukuda M
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Doc2gamma, a third isoform of double C2 protein, lacking calcium-dependent phospholipid binding activity.
Volume: 276
Issue: 2
Pages: 626-32
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Protein
H3BJT3
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: true
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Protein
D3YYV2
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: true
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Protein
O35527
Organism: Mus musculus/domesticus
Length: 405  
Fragment?: true
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Protein
D3Z1K1
Organism: Mus musculus/domesticus
Length: 177  
Fragment?: true
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Protein
A0A494BAY3
Organism: Mus musculus/domesticus
Length: 196  
Fragment?: true
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Protein
Q9ESN1
Organism: Mus musculus/domesticus
Length: 387  
Fragment?: false
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Protein
A0A0R4J053
Organism: Mus musculus/domesticus
Length: 387  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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