|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 169 for Dock1

<< First    < Previous  |  Next >    Last >>
0.022s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Sanematsu F
Year: 2013
Journal: J Biol Chem
Title: Phosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation.
Volume: 288
Issue: 12
Pages: 8092-100
Publication
First Author: Laurin M
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis.
Volume: 110
Issue: 18
Pages: 7434-9
Publication
First Author: Laurin M
Year: 2013
Journal: Small GTPases
Title: The Rac-specific exchange factors Dock1 and Dock5 are dispensable for the establishment of the glomerular filtration barrier in vivo.
Volume: 4
Issue: 4
Pages: 221-30
Gene
Type: gene
Organism: Saccharomyces cerevisiae
Publication
First Author: Tajiri H
Year: 2017
Journal: Cell Rep
Title: Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1.
Volume: 19
Issue: 5
Pages: 969-980
Publication
First Author: Laurin M
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo.
Volume: 105
Issue: 40
Pages: 15446-51
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression  
Probe: MGI:5635581
Assay Type: Immunohistochemistry
Annotation Date: 2015-05-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1657020
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:5635660
Age: embryonic day 12.5
Note: There was co-localization of expression with Cxcr4 in the vascular endothelial cell lineage.
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5635581
Assay Type: Immunohistochemistry
Annotation Date: 2015-05-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1669620
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:5635660
Age: embryonic day 12.5
Note: There was co-localization of expression with Cxcr4 in the cardiac cell lineage.
Detected: true
Specimen Num: 2
Publication
First Author: Li X
Year: 2008
Journal: Nat Neurosci
Title: Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling.
Volume: 11
Issue: 1
Pages: 28-35
Publication
First Author: He X
Year: 2010
Journal: Mol Cell Biol
Title: Rac1 is essential for basement membrane-dependent epiblast survival.
Volume: 30
Issue: 14
Pages: 3569-81
Publication
First Author: Park D
Year: 2007
Journal: Nature
Title: BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module.
Volume: 450
Issue: 7168
Pages: 430-4
Publication
First Author: Lei Y
Year: 2009
Journal: Eur J Immunol
Title: Role of DOCK2 and DOCK180 in fetal thymus colonization.
Volume: 39
Issue: 10
Pages: 2695-702
Publication
First Author: Kashiwa A
Year: 2000
Journal: J Neurochem
Title: Isolation and characterization of novel presenilin binding protein.
Volume: 75
Issue: 1
Pages: 109-16
Publication
First Author: Sanematsu F
Year: 2010
Journal: Circ Res
Title: DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4.
Volume: 107
Issue: 9
Pages: 1102-5
Publication
First Author: Deramaudt TB
Year: 2011
Journal: Mol Biol Cell
Title: FAK phosphorylation at Tyr-925 regulates cross-talk between focal adhesion turnover and cell protrusion.
Volume: 22
Issue: 7
Pages: 964-75
Publication
First Author: Pratt SJ
Year: 2005
Journal: J Cell Biol
Title: The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration.
Volume: 168
Issue: 5
Pages: 813-24
Publication
First Author: Seo JH
Year: 2009
Journal: Mol Cell Biol
Title: Structural and functional basis of a role for CRKL in a fibroblast growth factor 8-induced feed-forward loop.
Volume: 29
Issue: 11
Pages: 3076-87
Publication  
First Author: Teo ZL
Year: 2014
Journal: Exp Eye Res
Title: Integrin linked kinase (ILK) is required for lens epithelial cell survival, proliferation and differentiation.
Volume: 121
Pages: 130-42
Publication
First Author: Nagamachi A
Year: 2013
Journal: Cancer Cell
Title: Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.
Volume: 24
Issue: 3
Pages: 305-17
Publication
First Author: Li Y
Year: 2015
Journal: Nature
Title: Global genetic analysis in mice unveils central role for cilia in congenital heart disease.
Volume: 521
Issue: 7553
Pages: 520-4
Publication      
First Author: Lo C
Year: 2011
Journal: MGI Direct Data Submission (B2B/CvDC)
Title: Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC)
Publication
First Author: Papin J
Year: 2004
Journal: Curr Opin Biotechnol
Title: Bioinformatics and cellular signaling.
Volume: 15
Issue: 1
Pages: 78-81
Publication
First Author: Araki K
Year: 1999
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Exchangeable gene trap using the Cre/mutated lox system.
Volume: 45
Issue: 5
Pages: 737-50
Publication
First Author: Taniwaki T
Year: 2005
Journal: Dev Growth Differ
Title: Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.
Volume: 47
Issue: 3
Pages: 163-72
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
Publication      
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
GXD Expression  
Probe: MGI:5635579
Assay Type: Immunohistochemistry
Annotation Date: 2015-05-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1657020
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:5635647
Age: embryonic day 12.5
Note: There was co-localization of expression with Dock1 in the vascular endothelial cell lineage.
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:5635579
Assay Type: Immunohistochemistry
Annotation Date: 2015-05-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1669620
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:5635647
Age: embryonic day 12.5
Note: There was co-localization of expression with Dock1 in the cardiac cell lineage.
Detected: true
Specimen Num: 5
Publication
First Author: Sanders MA
Year: 2009
Journal: J Biol Chem
Title: DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV.
Volume: 284
Issue: 1
Pages: 27-35
Publication
First Author: Goicoechea SM
Year: 2002
Journal: Int J Biochem Cell Biol
Title: Nck-2 interacts with focal adhesion kinase and modulates cell motility.
Volume: 34
Issue: 7
Pages: 791-805
Publication
First Author: Tu Y
Year: 1998
Journal: Mol Biol Cell
Title: Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways.
Volume: 9
Issue: 12
Pages: 3367-82
Protein Domain
Type: Family
Description: Cytoplasmic protein NCK2 (NCK2) is a non-enzymatic adaptor protein composed of three SH3 (Src homology 3) domains and a C-terminal SH2 domain. There are two vertebrate NCK proteins, NCK1 and NCK2. NCK2 mediates Slit-induced cortical neurite outgrowth []. NCK2 interacts with focal adhesion kinase (FAK) and this interaction suggests a role of NCK2 in the modulation of cell motility []. It also interacts with DOCK1 [], LIMS1 [].
Protein Domain
Type: Domain
Description: This entry represents the ELMO (EnguLfment and Cell MOtility) domain, which is found in a number of eukaryotic proteins involved in the cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility, including CED-12, ELMO-1 and ELMO-2. ELMO-1 and ELMO-2 are components of signalling pathways that regulate phagocytosis and cell migration and are mammalian orthologues of the Caenorhabditis elegans gene, ced-12 that is required for the engulfment of dying cells and cell migration. ELMO-1/2 act in association with DOCK1 and CRK. ELMO-1/2 interact with the SH3-domain of DOCK1 via an SH3-binding site to enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. ELMO-1/2 could be part of a complex with DOCK1 and Rac1 that could be required to activate Rac Rho small GTPases. Regulatory GTPases in the Ras superfamily employ a cycle of alternating GTP binding and hydrolysis, controlled by guanine nucleotide exchange factors and GTPase-activating proteins (GAPs), as essential features of their actions in cells. Within the Ras superfamily, the Arf family is composed of 30 members, including 22 Arf-like (Arl) proteins. The ELMO domain has been proposed to be a GAP domain for ARL2 and other members of the Arf family [].
Protein
Organism: Mus musculus
Length: 326  
Fragment?: false
Protein
Organism: Mus musculus
Length: 381  
Fragment?: false
Protein
Organism: Mus musculus
Length: 293  
Fragment?: false
Protein
Organism: Mus musculus
Length: 326  
Fragment?: false
Protein
Organism: Mus musculus
Length: 164  
Fragment?: false
Protein
Organism: Mus musculus
Length: 295  
Fragment?: true
Protein
Organism: Mus musculus
Length: 213  
Fragment?: true
Protein
Organism: Mus musculus
Length: 189  
Fragment?: true
Protein
Organism: Mus musculus
Length: 295  
Fragment?: true
Protein
Organism: Mus musculus
Length: 269  
Fragment?: false
Protein
Organism: Mus musculus
Length: 164  
Fragment?: true
Protein
Organism: Mus musculus
Length: 216  
Fragment?: false
Publication
First Author: Elliott MR
Year: 2010
Journal: Nature
Title: Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivo.
Volume: 467
Issue: 7313
Pages: 333-7
Protein
Organism: Mus musculus
Length: 193  
Fragment?: true
Publication
First Author: Miyamoto Y
Year: 2010
Journal: Cell Signal
Title: Cellular signaling of Dock family proteins in neural function.
Volume: 22
Issue: 2
Pages: 175-82