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Search results 1 to 100 out of 160 for Dock3

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: DOCK family members are evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases [[cite:PUB00014935]]. DOCK proteins are required during several cellular processes, such as cell motility and phagocytosis. The N-terminal SH3 domain of the DOCK proteins functions as an inhibitor of GEF, which can be relieved upon its binding to the ELMO1-3 adaptor proteins, after their binding to active RhoG at the plasma membrane [[cite:PUB00073863], [cite:PUB00073862]]. DOCK family proteins are categorised into four subfamilies based on their sequence homology: DOCK-A subfamily (DOCK1/180, 2, 5), DOCK-B subfamily (DOCK3, 4), DOCK-C subfamily (DOCK6, 7, 8), DOCK-D subfamily (DOCK9, 10, 11) [[cite:PUB00014935]]. This entry represents DOCK3. DOCK3 is linked to Alzheimer disease due to its interaction with presenilin proteins and ability to stimulate Tau/MAPT phosphorylation [[cite:PUB00061817]].
Publication
First Author: Namekata K
Year: 2012
Journal: J Neurosci
Title: Dock3 stimulates axonal outgrowth via GSK-3β-mediated microtubule assembly.
Volume: 32
Issue: 1
Pages: 264-74
Publication  
First Author: Semba K
Year: 2014
Journal: Neurosci Lett
Title: Dock3 overexpression and p38 MAPK inhibition synergistically stimulate neuroprotection and axon regeneration after optic nerve injury.
Volume: 581
Pages: 89-93
Publication
First Author: Namekata K
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex.
Volume: 107
Issue: 16
Pages: 7586-91
Publication
First Author: Namekata K
Year: 2012
Journal: Genes Cells
Title: Dock3 regulates BDNF-TrkB signaling for neurite outgrowth by forming a ternary complex with Elmo and RhoG.
Volume: 17
Issue: 8
Pages: 688-97
Publication
First Author: Namekata K
Year: 2013
Journal: Cell Death Differ
Title: Dock3 attenuates neural cell death due to NMDA neurotoxicity and oxidative stress in a mouse model of normal tension glaucoma.
Volume: 20
Issue: 9
Pages: 1250-6
Publication
First Author: de Silva MG
Year: 2003
Journal: J Med Genet
Title: Disruption of a novel member of a sodium/hydrogen exchanger family and DOCK3 is associated with an attention deficit hyperactivity disorder-like phenotype.
Volume: 40
Issue: 10
Pages: 733-40
Publication
First Author: Chen Q
Year: 2002
Journal: J Cell Biol
Title: A novel mechanism for the regulation of amyloid precursor protein metabolism.
Volume: 158
Issue: 1
Pages: 79-89
Protein
Organism: Mus musculus
Length: 241  
Fragment?: true
Protein
Organism: Mus musculus
Length: 552  
Fragment?: true
Protein
Organism: Mus musculus
Length: 241  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1601  
Fragment?: true
Protein
Organism: Mus musculus
Length: 2027  
Fragment?: false
Protein
Organism: Mus musculus
Length: 2030  
Fragment?: false
Publication
First Author: Côté JF
Year: 2002
Journal: J Cell Sci
Title: Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.
Volume: 115
Issue: Pt 24
Pages: 4901-13
Protein
Organism: Mus musculus
Length: 333  
Fragment?: true
Publication
First Author: Lu M
Year: 2005
Journal: Curr Biol
Title: A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs.
Volume: 15
Issue: 4
Pages: 371-7
Publication
First Author: Gadea G
Year: 2014
Journal: Eur J Cell Biol
Title: Dock-family exchange factors in cell migration and disease.
Volume: 93
Issue: 10-12
Pages: 466-77
Publication
First Author: Alexander MS
Year: 2014
Journal: J Clin Invest
Title: MicroRNA-486-dependent modulation of DOCK3/PTEN/AKT signaling pathways improves muscular dystrophy-associated symptoms.
Volume: 124
Issue: 6
Pages: 2651-67
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Chen Q
Year: 2009
Journal: J Neurosci
Title: Loss of modifier of cell adhesion reveals a pathway leading to axonal degeneration.
Volume: 29
Issue: 1
Pages: 118-30
Publication
First Author: Sanz-Moreno V
Year: 2008
Journal: Cell
Title: Rac activation and inactivation control plasticity of tumor cell movement.
Volume: 135
Issue: 3
Pages: 510-23
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753628
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945895
Age: postnatal day 42
Image: g01926 Adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753628
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945895
Age: postnatal day 7
Image: g01926 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753623
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945895
Age: embryonic day 15.5
Image: g01926 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609219
Pattern: Scattered
Stage: TS19
Assay Id: MGI:4945895
Age: embryonic day 11.5
Image: g01926 E11.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945895
Age: postnatal day 42
Image: g01926 Adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945895
Age: postnatal day 7
Image: g01926 P7
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3280923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945895
Age: embryonic day 15.5
Image: g01926 E15.5
Note: Expression was region specific and scattered.
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3284223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945895
Age: embryonic day 15.5
Image: g01926 E15.5
Note: Expression was region specific and scattered.
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945895
Age: postnatal day 42
Image: g01926 Adult
Note: Expression was region specific and scattered.
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945895
Age: postnatal day 7
Image: g01926 P7
Note: Expression was region specific and scattered.
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284523
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945895
Age: embryonic day 15.5
Image: g01926 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945895
Age: postnatal day 42
Image: g01926 Adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945895
Age: postnatal day 7
Image: g01926 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945895
Age: postnatal day 42
Image: g01926 Adult
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945895
Age: postnatal day 7
Image: g01926 P7
Note: Expression was region specific and scattered.
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945895
Age: embryonic day 15.5
Image: g01926 E15.5
Note: Expression was region specific and scattered.
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945895
Age: postnatal day 42
Image: g01926 Adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945895
Age: postnatal day 7
Image: g01926 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945895
Age: postnatal day 42
Image: g01926 Adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945895
Age: postnatal day 7
Image: g01926 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697423
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945895
Age: embryonic day 15.5
Image: g01926 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697419
Pattern: Scattered
Stage: TS19
Assay Id: MGI:4945895
Age: embryonic day 11.5
Image: g01926 E11.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267328
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945895
Age: postnatal day 42
Image: g01926 Adult
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267328
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945895
Age: postnatal day 7
Image: g01926 P7
Note: Expression was region specific and scattered.
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691623
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945895
Age: embryonic day 15.5
Image: g01926 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691619
Pattern: Scattered
Stage: TS19
Assay Id: MGI:4945895
Age: embryonic day 11.5
Image: g01926 E11.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266523
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945895
Age: embryonic day 15.5
Image: g01926 E15.5
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945895
Age: postnatal day 42
Image: g01926 Adult
Note: Expression was region specific and scattered.
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1754428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945895
Age: postnatal day 7
Image: g01926 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267228
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945895
Age: postnatal day 42
Image: g01926 Adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267228
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945895
Age: postnatal day 7
Image: g01926 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945895
Age: postnatal day 42
Image: g01926 Adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945895
Age: postnatal day 7
Image: g01926 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945895
Age: postnatal day 42
Image: g01926 Adult
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945895
Age: postnatal day 7
Image: g01926 P7
Note: Expression was region specific and scattered.
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778723
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945895
Age: embryonic day 15.5
Image: g01926 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945895
Age: postnatal day 42
Image: g01926 Adult
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3274128
Stage: TS28
Assay Id: MGI:4945895
Age: postnatal day 7
Image: g01926 P7
Detected: false
Specimen Num: 3
GXD Expression  
Probe: MGI:4884965
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691019
Pattern: Scattered
Stage: TS19
Assay Id: MGI:4945895
Age: embryonic day 11.5
Image: g01926 E11.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3836565
Assay Type: RNA in situ
Annotation Date: 2009-03-20
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689420
Pattern: Widespread
Stage: TS20
Assay Id: MGI:3836570
Age: embryonic day 12.5
Note: Low level generalised expression was detected in the developing brain.
Detected: true
Specimen Num: 1
Publication
First Author: Kashiwa A
Year: 2000
Journal: J Neurochem
Title: Isolation and characterization of novel presenilin binding protein.
Volume: 75
Issue: 1
Pages: 109-16
Publication
First Author: Potts RC
Year: 2011
Journal: PLoS One
Title: CHD5, a brain-specific paralog of Mi2 chromatin remodeling enzymes, regulates expression of neuronal genes.
Volume: 6
Issue: 9
Pages: e24515
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).