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Search results 1 to 100 out of 138 for Dock4

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Categories

Hits by Pathway

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Hits by Strain

Type Details Score
Gene
9732 | DOCK4
Type: gene
Organism: human
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Gene
100490130 | dock4
Type: gene
Organism: frog, western clawed
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Gene
482407 | DOCK4
Type: gene
Organism: dog, domestic
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Gene
366608 | Dock4
Type: gene
Organism: rat
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Gene
463661 | DOCK4
Type: gene
Organism: chimpanzee
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Gene
534227 | DOCK4
Type: gene
Organism: cattle
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Gene
417779 | DOCK4
Type: gene
Organism: chicken
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Gene
566115 | dock4
Type: gene
Organism: zebrafish
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Gene
703726 | DOCK4
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1918006 | Dock4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR037014 | DOCK4
Type: Family
Description: DOCK family members are evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases []. DOCK proteins are required during several cellular processes, such as cell motility and phagocytosis. The N-terminal SH3 domain of the DOCK proteins functions as an inhibitor of GEF, which can be relieved upon its binding to the ELMO1-3 adaptor proteins, after their binding to active RhoG at the plasma membrane [, ]. DOCK family proteins are categorised into four subfamilies based on their sequence homology: DOCK-A subfamily (DOCK1/180, 2, 5), DOCK-B subfamily (DOCK3, 4), DOCK-C subfamily (DOCK6, 7, 8), DOCK-D subfamily (DOCK9, 10, 11) []. This entry represents DOCK4. DOCK4 plays a critical role in mediating TGF-beta's prometastatic effects in lungcancer [].
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Gene
100506413 | DOCK4-AS1
Type: gene
Organism: human
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Publication
33705839 | J:316850
 
First Author: Yang X
Year: 2021
Journal: Behav Brain Res
Title: Altered postnatal developmental patterns of ultrasonic vocalizations in Dock4 knockout mice.
Volume: 406
Pages: 113232
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Publication
25644601 | -
First Author: Yu JR
Year: 2015
Journal: Genes Dev
Title: TGF-β/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis.
Volume: 29
Issue: 3
Pages: 250-61
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Publication
31019307 | J:282954
First Author: Huang L
Year: 2019
Journal: Nature
Title: SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis.
Volume: 569
Issue: 7757
Pages: 565-569
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Publication
31388105 | J:316919
First Author: Guo D
Year: 2021
Journal: Mol Psychiatry
Title: Autism-like social deficit generated by Dock4 deficiency is rescued by restoration of Rac1 activity and NMDA receptor function.
Volume: 26
Issue: 5
Pages: 1505-1519
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Publication
16464467 | J:110328
First Author: Yan D
Year: 2006
Journal: J Mol Biol
Title: An isoform of GTPase regulator DOCK4 localizes to the stereocilia in the inner ear and binds to harmonin (USH1C).
Volume: 357
Issue: 3
Pages: 755-64
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Publication
32009906 | J:310713
 
First Author: Huang M
Year: 2019
Journal: Front Cell Neurosci
Title: Two Autism/Dyslexia Linked Variations of DOCK4 Disrupt the Gene Function on Rac1/Rap1 Activation, Neurite Outgrowth, and Synapse Development.
Volume: 13
Pages: 577
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Protein
Q3TQD2
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: true
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Publication
15723800 | -
First Author: Lu M
Year: 2005
Journal: Curr Biol
Title: A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs.
Volume: 15
Issue: 4
Pages: 371-7
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Publication
25022758 | -
First Author: Gadea G
Year: 2014
Journal: Eur J Cell Biol
Title: Dock-family exchange factors in cell migration and disease.
Volume: 93
Issue: 10-12
Pages: 466-77
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Protein
Q8BMP2
Organism: Mus musculus/domesticus
Length: 1134  
Fragment?: false
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Publication
12432077 | -
First Author: Côté JF
Year: 2002
Journal: J Cell Sci
Title: Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.
Volume: 115
Issue: Pt 24
Pages: 4901-13
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Protein
P59764
Organism: Mus musculus/domesticus
Length: 1978  
Fragment?: false
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Protein
Q3US86
Organism: Mus musculus/domesticus
Length: 557  
Fragment?: true
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Protein
A0A1Y7VLY2
Organism: Mus musculus/domesticus
Length: 1940  
Fragment?: false
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Publication
26129894 | J:224385
 
First Author: Abraham S
Year: 2015
Journal: Nat Commun
Title: A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis.
Volume: 6
Pages: 7286
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Protein Coding Gene
MGP_CAROLIEiJ_G0017721 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0019705 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0019671 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0019642 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0019649 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0019453 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1918006 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0020096 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0019006 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0019425 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0019538 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0019527 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0019608 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0019563 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0020136 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0018773 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0019056 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0029478 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0018563 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:6724236
Assay Type: RT-PCR
Annotation Date: 2021-07-20
Strength: Present
Sex: Female
Emaps: EMAPS:1796220
Stage: TS20
Assay Id: MGI:6724317
Age: embryonic day 12.5
Specimen Label: E12.5 XX
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6724236
Assay Type: RT-PCR
Annotation Date: 2021-07-20
Strength: Present
Sex: Male
Emaps: EMAPS:1797220
Stage: TS20
Assay Id: MGI:6724317
Age: embryonic day 12.5
Specimen Label: E12.5 XY
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6724236
Assay Type: RT-PCR
Annotation Date: 2021-07-20
Strength: Present
Sex: Female
Emaps: EMAPS:1796221
Stage: TS21
Assay Id: MGI:6724317
Age: embryonic day 13.5
Specimen Label: E13.5 XX
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:6724236
Assay Type: RT-PCR
Annotation Date: 2021-07-20
Strength: Present
Sex: Male
Emaps: EMAPS:1797221
Stage: TS21
Assay Id: MGI:6724317
Age: embryonic day 13.5
Specimen Label: E13.5 XY
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:5776245
Assay Type: Immunohistochemistry
Annotation Date: 2016-06-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1620421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5776249
Age: embryonic day 13.5
Image: S9c WT
Specimen Label: S9c WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5776245
Assay Type: Immunohistochemistry
Annotation Date: 2016-06-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1620421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:5776249
Age: embryonic day 13.5
Image: S9c Het
Specimen Label: S9c Het
Detected: true
Specimen Num: 2
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Publication
19528233 | J:151521
First Author: Kawada K
Year: 2009
Journal: Mol Cell Biol
Title: Cell migration is regulated by platelet-derived growth factor receptor endocytosis.
Volume: 29
Issue: 16
Pages: 4508-18
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Publication
15793261 | J:109430
First Author: Davis RC
Year: 2005
Journal: Diabetes
Title: Ultrafine mapping of SNPs from mouse strains C57BL/6J, DBA/2J, and C57BLKS/J for loci contributing to diabetes and atherosclerosis susceptibility.
Volume: 54
Issue: 4
Pages: 1191-9
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Publication
10810084 | J:62157
First Author: Thomas JW
Year: 2000
Journal: Genome Res
Title: Comparative genome mapping in the sequence-based era: early experience with human chromosome 7.
Volume: 10
Issue: 5
Pages: 624-33
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Publication
19864314 | J:156788
First Author: Bouma GJ
Year: 2010
Journal: Biol Reprod
Title: New candidate genes identified for controlling mouse gonadal sex determination and the early stages of granulosa and Sertoli cell differentiation.
Volume: 82
Issue: 2
Pages: 380-9
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Publication
19884258 | J:154029
First Author: Munger SC
Year: 2009
Journal: Genes Dev
Title: Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal.
Volume: 23
Issue: 21
Pages: 2521-36
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Publication
12693553 | J:83413
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 1
Pages: 35-48
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Publication
- | J:165964
     
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
23536706 | -
First Author: Ueda S
Year: 2013
Journal: Mol Biol Cell
Title: Rac GEF Dock4 interacts with cortactin to regulate dendritic spine formation.
Volume: 24
Issue: 10
Pages: 1602-13
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Protein Domain
IPR037811 | C2_Dock-B
Type: Domain
Description: DOCK family members are evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases []. DOCK proteins are required during several cellular processes, such as cell motility and phagocytosis. The N-terminal SH3 domain of the DOCK proteins functions as an inhibitor of GEF, which can be relieved upon its binding to the ELMO1-3 adaptor proteins, after their binding to active RhoG at the plasma membrane [, ]. DOCK family proteins are categorised into four subfamilies based on their sequence homology: DOCK-A subfamily (DOCK1/180, 2, 5), DOCK-B subfamily (DOCK3, 4), DOCK-C subfamily (DOCK6, 7, 8), DOCK-D subfamily (DOCK9, 10, 11) []. This entry represents the C2 domain of the Dock-B members. Most of these members have been shown to be GEFs specific for Rac, although Dock4 has also been shown to interact indirectly with the Ras family GTPase Rap1, probably through Rap regulatory proteins. In addition to the C2 domain (also known as DHR-1 domain) and the DHR-2 domain, Dock-B members contain a SH3 domain upstream of the C2 domain and a proline-rich region downstream. DHR-2 has the catalytic activity for Rac and/or Cdc42, but is structurally unrelated to the DH domain. The C2/DHR-1 domains of Dock1 (also known as Dock180) and Dock4 have been shown to bind phosphatidylinositol-3, 4, 5-triphosphate (PtdIns(3,4,5)P3)[, , ].
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Publication
19796679 | -
First Author: Miyamoto Y
Year: 2010
Journal: Cell Signal
Title: Cellular signaling of Dock family proteins in neural function.
Volume: 22
Issue: 2
Pages: 175-82
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Publication
19803396 | -
First Author: Katoh H
Year: 2009
Journal: Seikagaku
Title: [Regulation of cell morphology and motility by Dock family proteins].
Volume: 81
Issue: 8
Pages: 711-6
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Protein Domain
IPR035769 | DOCK4_SH3
Type: Domain
Description: DOCK family members are evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases []. DOCK proteins are required during several cellular processes, such as cell motility and phagocytosis. The N-terminal SH3 domain of the DOCK proteins functions as an inhibitor of GEF, which can be relieved upon its binding to the ELMO1-3 adaptor proteins, after their binding to active RhoG at the plasma membrane [, ]. DOCK family proteins are categorised into four subfamilies based on their sequence homology: DOCK-A subfamily (DOCK1/180, 2, 5), DOCK-B subfamily (DOCK3, 4), DOCK-C subfamily (DOCK6, 7, 8), DOCK-D subfamily (DOCK9, 10, 11) []. This entry represents the SH3 domain found in DOCK4. DOCK4 regulates dendritic spine formation and has been linked to autism, dyslexia, and schizophrenia []. It also plays a critical role in mediating TGF-beta's prometastatic effects in lung cancer [].
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Publication
36425784 | J:355541
 
First Author: Liu Y
Year: 2022
Journal: Front Cell Infect Microbiol
Title: Reprogrammed fecal and mucosa-associated intestinal microbiota and weakened mucus layer in intestinal goblet cell- specific Piezo1-deficient mice.
Volume: 12
Pages: 1035386
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