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Search results 1 to 100 out of 119 for Dock5

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0.268s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: DOCK family members are evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases []. DOCK proteins are required during several cellular processes, such as cell motility and phagocytosis. The N-terminal SH3 domain of the DOCK proteins functions as an inhibitor of GEF, which can be relieved upon its binding to the ELMO1-3 adaptor proteins, after their binding to active RhoG at the plasma membrane [, ]. DOCK family proteins are categorised into four subfamilies based on their sequence homology: DOCK-A subfamily (DOCK1/180, 2, 5), DOCK-B subfamily (DOCK3, 4), DOCK-C subfamily (DOCK6, 7, 8), DOCK-D subfamily (DOCK9, 10, 11) []. This entry includes DOCK5, which, along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on collagen IV [].
Publication
First Author: Lai Y
Year: 2020
Journal: EMBO Rep
Title: DOCK5 regulates energy balance and hepatic insulin sensitivity by targeting mTORC1 signaling.
Volume: 21
Issue: 2
Pages: e49473
Publication  
First Author: Vives V
Year: 2015
Journal: Nat Commun
Title: Pharmacological inhibition of Dock5 prevents osteolysis by affecting osteoclast podosome organization while preserving bone formation.
Volume: 6
Pages: 6218
Publication
First Author: Touaitahuata H
Year: 2016
Journal: J Cell Sci
Title: Tensin 3 is a new partner of Dock5 that controls osteoclast podosome organization and activity.
Volume: 129
Issue: 18
Pages: 3449-61
Publication
First Author: Ogawa K
Year: 2014
Journal: J Exp Med
Title: DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation.
Volume: 211
Issue: 7
Pages: 1407-19
Publication
First Author: Laurin M
Year: 2013
Journal: Small GTPases
Title: The Rac-specific exchange factors Dock1 and Dock5 are dispensable for the establishment of the glomerular filtration barrier in vivo.
Volume: 4
Issue: 4
Pages: 221-30
Publication
First Author: Sanders MA
Year: 2009
Journal: J Biol Chem
Title: DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV.
Volume: 284
Issue: 1
Pages: 27-35
Protein
Organism: Mus musculus
Length: 1868  
Fragment?: false
Protein
Organism: Mus musculus
Length: 682  
Fragment?: false
Protein
Organism: Mus musculus
Length: 212  
Fragment?: false
Publication
First Author: Côté JF
Year: 2002
Journal: J Cell Sci
Title: Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.
Volume: 115
Issue: Pt 24
Pages: 4901-13
Publication
First Author: Lu M
Year: 2005
Journal: Curr Biol
Title: A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs.
Volume: 15
Issue: 4
Pages: 371-7
Publication
First Author: Gadea G
Year: 2014
Journal: Eur J Cell Biol
Title: Dock-family exchange factors in cell migration and disease.
Volume: 93
Issue: 10-12
Pages: 466-77
Publication  
First Author: Li H
Year: 2013
Journal: Nat Commun
Title: Association between Gαi2 and ELMO1/Dock180 connects chemokine signalling with Rac activation and metastasis.
Volume: 4
Pages: 1706
Publication
First Author: Grimsley CM
Year: 2004
Journal: J Biol Chem
Title: Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration.
Volume: 279
Issue: 7
Pages: 6087-97
Publication
First Author: Tachibana M
Year: 2009
Journal: Exp Cell Res
Title: Ankyrin repeat domain 28 (ANKRD28), a novel binding partner of DOCK180, promotes cell migration by regulating focal adhesion formation.
Volume: 315
Issue: 5
Pages: 863-76
Publication
First Author: Feng H
Year: 2015
Journal: Neuro Oncol
Title: Protein kinase A-dependent phosphorylation of Dock180 at serine residue 1250 is important for glioma growth and invasion stimulated by platelet derived-growth factor receptor α.
Volume: 17
Issue: 6
Pages: 832-42
Publication
First Author: Omi N
Year: 2008
Journal: Exp Eye Res
Title: Mutation of Dock5, a member of the guanine exchange factor Dock180 superfamily, in the rupture of lens cataract mouse.
Volume: 86
Issue: 5
Pages: 828-34
Publication
First Author: Qu H
Year: 2021
Journal: Diabetes
Title: Dedicator of Cytokinesis 5 Regulates Keratinocyte Function and Promotes Diabetic Wound Healing.
Volume: 70
Issue: 5
Pages: 1170-1184
Publication
First Author: Laurin M
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo.
Volume: 105
Issue: 40
Pages: 15446-51
Publication
First Author: Sanematsu F
Year: 2013
Journal: J Biol Chem
Title: Phosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation.
Volume: 288
Issue: 12
Pages: 8092-100
Publication
First Author: Touaitahuata H
Year: 2014
Journal: Dev Biol
Title: The mineral dissolution function of osteoclasts is dispensable for hypertrophic cartilage degradation during long bone development and growth.
Volume: 393
Issue: 1
Pages: 57-70
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Iida F
Year: 1997
Journal: Exp Eye Res
Title: Rupture of lens cataract: a novel hereditary recessive cataract model in the mouse.
Volume: 64
Issue: 1
Pages: 107-13
Publication
First Author: Song CW
Year: 1997
Journal: Lab Anim
Title: A new hereditary cataract mouse with lens rupture.
Volume: 31
Issue: 3
Pages: 248-53
Publication
First Author: Matsushima Y
Year: 1996
Journal: Genomics
Title: Mapping of rupture of lens cataract (rlc) on mouse chromosome 14.
Volume: 36
Issue: 3
Pages: 553-4
Publication
First Author: Hiai H
Year: 1997
Journal: Lab Anim
Title: Hereditary cataract mouse with lens rupture: disputed priority.
Volume: 31
Issue: 4
Pages: 389-90
Publication
First Author: Song CW
Year: 1997
Journal: Mamm Genome
Title: Mapping of new recessive cataract gene (lr2) in the mouse.
Volume: 8
Issue: 12
Pages: 927-31
GXD Expression    
Probe: MGI:5002259
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2769723
Stage: TS23
Assay Id: MGI:5542813
Age: embryonic day 15.5
Image: GUDMAP:11667
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5002259
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2769723
Stage: TS23
Assay Id: MGI:5542813
Age: embryonic day 15.5
Image: GUDMAP:11668
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5002259
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2853323
Stage: TS23
Assay Id: MGI:5542813
Age: embryonic day 15.5
Image: GUDMAP:11668
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5002259
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2845723
Stage: TS23
Assay Id: MGI:5542813
Age: embryonic day 15.5
Image: GUDMAP:11667
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5002259
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2845723
Stage: TS23
Assay Id: MGI:5542813
Age: embryonic day 15.5
Image: GUDMAP:11668
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5002259
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1795023
Stage: TS23
Assay Id: MGI:5542813
Age: embryonic day 15.5
Image: GUDMAP:11667
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5002259
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1795023
Stage: TS23
Assay Id: MGI:5542813
Age: embryonic day 15.5
Image: GUDMAP:11668
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5002259
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1869223
Stage: TS23
Assay Id: MGI:5542813
Age: embryonic day 15.5
Image: GUDMAP:11668
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:4426282
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1795223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824370
Age: embryonic day 14.5
Image: euxassay_014244_05
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4426282
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1795223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824370
Age: embryonic day 14.5
Image: euxassay_014244_06
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4426282
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1795223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824370
Age: embryonic day 14.5
Image: euxassay_014244_07
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4426282
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1795223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824370
Age: embryonic day 14.5
Image: euxassay_014244_13
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4426282
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1795223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824370
Age: embryonic day 14.5
Image: euxassay_014244_14
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4426282
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1795223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824370
Age: embryonic day 14.5
Image: euxassay_014244_15
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:4426282
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1795223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824370
Age: embryonic day 14.5
Image: euxassay_014244_16
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:5002259
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2854023
Stage: TS23
Assay Id: MGI:5542813
Age: embryonic day 15.5
Image: GUDMAP:11667
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:5002259
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2762123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542813
Age: embryonic day 15.5
Image: GUDMAP:11667
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5002259
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2762123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542813
Age: embryonic day 15.5
Image: GUDMAP:11668
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5002259
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1797223
Stage: TS23
Assay Id: MGI:5542813
Age: embryonic day 15.5
Image: GUDMAP:11668
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5002259
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1832123
Stage: TS23
Assay Id: MGI:5542813
Age: embryonic day 15.5
Image: GUDMAP:11667
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5002259
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1832123
Stage: TS23
Assay Id: MGI:5542813
Age: embryonic day 15.5
Image: GUDMAP:11668
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5002259
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2851823
Stage: TS23
Assay Id: MGI:5542813
Age: embryonic day 15.5
Image: GUDMAP:11667
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5002259
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2851823
Stage: TS23
Assay Id: MGI:5542813
Age: embryonic day 15.5
Image: GUDMAP:11668
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5002259
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2760523
Stage: TS23
Assay Id: MGI:5542813
Age: embryonic day 15.5
Image: GUDMAP:11667
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5002259
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2760523
Stage: TS23
Assay Id: MGI:5542813
Age: embryonic day 15.5
Image: GUDMAP:11668
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5002259
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2852723
Stage: TS23
Assay Id: MGI:5542813
Age: embryonic day 15.5
Image: GUDMAP:11667
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5002259
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2852723
Stage: TS23
Assay Id: MGI:5542813
Age: embryonic day 15.5
Image: GUDMAP:11668
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5002259
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2874723
Stage: TS23
Assay Id: MGI:5542813
Age: embryonic day 15.5
Image: GUDMAP:11667
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5002259
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2850023
Stage: TS23
Assay Id: MGI:5542813
Age: embryonic day 15.5
Image: GUDMAP:11667
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5002259
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2850023
Stage: TS23
Assay Id: MGI:5542813
Age: embryonic day 15.5
Image: GUDMAP:11668
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5002259
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1796223
Stage: TS23
Assay Id: MGI:5542813
Age: embryonic day 15.5
Image: GUDMAP:11667
Detected: false
Specimen Num: 1
Publication
First Author: Shvarts A
Year: 1997
Journal: Genomics
Title: Isolation and identification of the human homolog of a new p53-binding protein, Mdmx.
Volume: 43
Issue: 1
Pages: 34-42
Publication
First Author: Rhee SD
Year: 2004
Journal: Exp Anim
Title: Fine localization of Nefl and Nef3 and its exclusion as candidate gene for lens rupture 2(lr2).
Volume: 53
Issue: 4
Pages: 295-301
Publication
First Author: Kim E
Year: 2007
Journal: Cytogenet Genome Res
Title: Genomic organization of the region spanning D14Mit262 and D14Mit86 on mouse chromosome 14 and exclusion of Adam28 and Adamdec1 as the cataract-causing gene, lr2.
Volume: 116
Issue: 1-2
Pages: 12-7
Publication      
First Author: GemPharmatech
Year: 2020
Journal: website
Title: GemPharmatech website
Publication
First Author: Strausberg RL
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Volume: 99
Issue: 26
Pages: 16899-903
Publication
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication      
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS