Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
Homo sapiens |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
Rattus norvegicus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
DOCK family members are evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases []. DOCK proteins are required during several cellular processes, such as cell motility and phagocytosis. The N-terminal SH3 domain of the DOCK proteins functions as an inhibitor of GEF, which can be relieved upon its binding to the ELMO1-3 adaptor proteins, after their binding to active RhoG at the plasma membrane [, ]. DOCK family proteins are categorised into four subfamilies based on their sequence homology: DOCK-A subfamily (DOCK1/180, 2, 5), DOCK-B subfamily (DOCK3, 4), DOCK-C subfamily (DOCK6, 7, 8), DOCK-D subfamily (DOCK9, 10, 11) []. This entry represents DOCK9 (also known as Zizimin). DOCK9 and DOCK11 activate Cdc42 [, ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Nishikimi A |
Year: |
2005 |
Journal: |
FEBS Lett |
Title: |
Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes. |
Volume: |
579 |
Issue: |
5 |
Pages: |
1039-46 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
Homo sapiens |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
738
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
2042
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
2058
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
2088
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
1920
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
Homo sapiens |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
166
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
133
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Meller N |
Year: |
2002 |
Journal: |
Nat Cell Biol |
Title: |
Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins. |
Volume: |
4 |
Issue: |
9 |
Pages: |
639-47 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
279
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
2055
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
2042
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
2058
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
2113
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
2088
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus |
Length: |
2055
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Côté JF |
Year: |
2002 |
Journal: |
J Cell Sci |
Title: |
Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity. |
Volume: |
115 |
Issue: |
Pt 24 |
Pages: |
4901-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lu M |
Year: |
2005 |
Journal: |
Curr Biol |
Title: |
A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs. |
Volume: |
15 |
Issue: |
4 |
Pages: |
371-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gadea G |
Year: |
2014 |
Journal: |
Eur J Cell Biol |
Title: |
Dock-family exchange factors in cell migration and disease. |
Volume: |
93 |
Issue: |
10-12 |
Pages: |
466-77 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus musculus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1332096 |
Assay Type: |
RT-PCR |
Annotation Date: |
1999-03-18 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603911 |
|
Stage: |
TS11 |
Assay Id: |
MGI:1332097 |
Age: |
embryonic day 7.5 |
|
|
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1332096 |
Assay Type: |
RT-PCR |
Annotation Date: |
1999-03-18 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603911 |
|
Stage: |
TS11 |
Assay Id: |
MGI:1332097 |
Age: |
embryonic day 7.5 |
|
|
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1332096 |
Assay Type: |
RT-PCR |
Annotation Date: |
1999-03-18 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603911 |
|
Stage: |
TS11 |
Assay Id: |
MGI:1332097 |
Age: |
embryonic day 7.5 |
|
|
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1332096 |
Assay Type: |
RT-PCR |
Annotation Date: |
1999-03-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1604211 |
|
Stage: |
TS11 |
Assay Id: |
MGI:1332097 |
Age: |
embryonic day 7.5 |
|
|
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1332096 |
Assay Type: |
RT-PCR |
Annotation Date: |
1999-03-18 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1604211 |
|
Stage: |
TS11 |
Assay Id: |
MGI:1332097 |
Age: |
embryonic day 7.5 |
|
|
Detected: |
false |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1332096 |
Assay Type: |
RT-PCR |
Annotation Date: |
1999-03-18 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1604211 |
|
Stage: |
TS11 |
Assay Id: |
MGI:1332097 |
Age: |
embryonic day 7.5 |
|
|
Detected: |
false |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6358424 |
Assay Type: |
RNA in situ |
Annotation Date: |
2019-09-06 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640618 |
Pattern: |
Regionally restricted |
Stage: |
TS18 |
Assay Id: |
MGI:6358586 |
Age: |
embryonic day 11.0 |
Image: |
S8K |
Note: |
Expression was detected in the dorsal and ventral muscle masses. |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6358424 |
Assay Type: |
RNA in situ |
Annotation Date: |
2019-09-06 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640618 |
Pattern: |
Regionally restricted |
Stage: |
TS18 |
Assay Id: |
MGI:6358586 |
Age: |
embryonic day 11.0 |
Image: |
S8M |
Note: |
Expression was detected in the dorsal and ventral muscle masses. |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6358424 |
Assay Type: |
RNA in situ |
Annotation Date: |
2019-09-06 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640618 |
Pattern: |
Regionally restricted |
Stage: |
TS18 |
Assay Id: |
MGI:6358586 |
Age: |
embryonic day 11.0 |
Image: |
S8N |
Note: |
Expression was downregulated in the dorsal and ventral muscle masses in the conditional knockout mutant. |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6358424 |
Assay Type: |
RNA in situ |
Annotation Date: |
2019-09-06 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640618 |
Pattern: |
Regionally restricted |
Stage: |
TS18 |
Assay Id: |
MGI:6358586 |
Age: |
embryonic day 11.0 |
Image: |
S8L |
Note: |
Expression was downregulated in the dorsal and ventral muscle masses in the conditional knockout mutant. |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6358424 |
Assay Type: |
RNA in situ |
Annotation Date: |
2019-09-06 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640818 |
Pattern: |
Regionally restricted |
Stage: |
TS18 |
Assay Id: |
MGI:6358586 |
Age: |
embryonic day 11.0 |
Image: |
S8K |
Note: |
Expression was detected in condensing mesenchyme. |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6358424 |
Assay Type: |
RNA in situ |
Annotation Date: |
2019-09-06 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640818 |
Pattern: |
Regionally restricted |
Stage: |
TS18 |
Assay Id: |
MGI:6358586 |
Age: |
embryonic day 11.0 |
Image: |
S8L |
Note: |
Expression was unaffected in condensing mesenchyme in the conditional knockout mutant. |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6358424 |
Assay Type: |
RNA in situ |
Annotation Date: |
2019-09-06 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640818 |
Pattern: |
Regionally restricted |
Stage: |
TS18 |
Assay Id: |
MGI:6358586 |
Age: |
embryonic day 11.0 |
Image: |
S8M |
Note: |
Expression was detected in condensing mesenchyme. |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6358424 |
Assay Type: |
RNA in situ |
Annotation Date: |
2019-09-06 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640818 |
Pattern: |
Regionally restricted |
Stage: |
TS18 |
Assay Id: |
MGI:6358586 |
Age: |
embryonic day 11.0 |
Image: |
S8N |
Note: |
Expression was unaffected in condensing mesenchyme in the conditional knockout mutant. |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jaudon F |
Year: |
2015 |
Journal: |
Mol Biol Cell |
Title: |
The RhoGEF DOCK10 is essential for dendritic spine morphogenesis. |
Volume: |
26 |
Issue: |
11 |
Pages: |
2112-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hu JK |
Year: |
2012 |
Journal: |
Genes Dev |
Title: |
Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation. |
Volume: |
26 |
Issue: |
18 |
Pages: |
2088-102 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakano Y |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. |
Volume: |
27 |
Issue: |
3 |
Pages: |
860-871.e8 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory DNA Panel Mapping Resource |
Year: |
1999 |
Journal: |
Database Release |
Title: |
JAX Interspecific Backcross BSS and BSB Public Mapping Data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ko MS |
Year: |
1998 |
Journal: |
Hum Mol Genet |
Title: |
Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. |
Volume: |
7 |
Issue: |
12 |
Pages: |
1967-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki N |
Year: |
2003 |
Journal: |
DNA Res |
Title: |
Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. |
Volume: |
10 |
Issue: |
1 |
Pages: |
35-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cobellis G |
Year: |
2005 |
Journal: |
Nucleic Acids Res |
Title: |
Tagging genes with cassette-exchange sites. |
Volume: |
33 |
Issue: |
4 |
Pages: |
e44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ko MS |
Year: |
2000 |
Journal: |
Development |
Title: |
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. |
Volume: |
127 |
Issue: |
8 |
Pages: |
1737-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory |
Year: |
2012 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by The Jackson Laboratory |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lennon G |
Year: |
1999 |
Journal: |
Database Download |
Title: |
WashU-HHMI Mouse EST Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
|
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
|
Title: |
Gene Ontology Annotation by the MGI Curatorial Staff |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2000 |
|
Title: |
Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Namekata K |
Year: |
2020 |
Journal: |
J Biol Chem |
Title: |
Roles of the DOCK-D family proteins in a mouse model of neuroinflammation. |
Volume: |
295 |
Issue: |
19 |
Pages: |
6710-6720 |
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Protein Domain |
Type: |
Domain |
Description: |
Rho guanosine triphosphatases (GTPases) are critical regulators of cellmotility, polarity, adhesion, cytoskeletal organisation, proliferation, geneexpression, and apoptosis. Conversion of these biomolecular switches to theactivated GTP-bound state is controlled by two families of guanine nucleotideexchanges factors (GEFs). DH-PH proteins are a large group of Rho GEFscomprising a catalytic Dbl homology (DH) domain with anadjacent pleckstrin homology (PH) domain within the contextof functionally diverse signalling modules. The evolutionarily distinct andsmaller family of DOCK (dedicator of cytokinesis) or CDM (CED-5, DOCK1180,Myoblast city) proteins activate either Rac or Cdc42 to control cellmigration, morphogenesis, and phagocytosis. DOCK proteins share the DOCK-homology region (DHR)-1 or CDM-zizimin homology 1 (CZH1) domain and the DHR-2domain (also termed the CZH2 or DOCKER domain), [, , , , , ].The ~200 residue DHR-1 domain is located toward the N terminus. It adopts aC2-like architecture and interacts with phosphatidylinositol3,4,5-trisphosphate []to mediate signalling and membranelocalization. The central core of the DHR-1 domain adopts an antiparallelbeta-sandwich with the "type II"C2 domain fold (a circular permutation of themore common "type I"topology), in which two 4-stranded sheets with strandorder 6-5-2-3 and 7-8-1-4 create convex- and concave-exposed faces,respectively [].Some DOCK proteins are listed below:Mammalian Mammalian dedicator of cytokinesis 180 (DOCK180 or DOCK1),important for cell migration.Mammalian DOCK2, important for lymphocyte development, homong, activation,adhesion, polarization and migration processes.Mammalian DOCK3 (also known as MOCA), is expressed predominantly in neuronsand resides in growth cones and membrane ruffles.Mammalian DOCK4, possesses tumor suppressor properties.Mammalian DOCK9 (zizimin1), plays an important role in dendrite growth inhippocampal neurons through activation of Cdc42.Drosophila melanogaster Myoblast city.Caenorhabditis elegans CED-5. |
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Protein |
Organism: |
Mus musculus |
Length: |
46
 |
Fragment?: |
true |
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Publication |
First Author: |
Zhang D |
Year: |
2010 |
Journal: |
Gene |
Title: |
Identification of novel families and classification of the C2 domain superfamily elucidate the origin and evolution of membrane targeting activities in eukaryotes. |
Volume: |
469 |
Issue: |
1-2 |
Pages: |
18-30 |
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Publication |
First Author: |
Yang J |
Year: |
2009 |
Journal: |
Science |
Title: |
Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor. |
Volume: |
325 |
Issue: |
5946 |
Pages: |
1398-402 |
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Protein |
Organism: |
Mus musculus |
Length: |
477
 |
Fragment?: |
true |
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Protein |
Organism: |
Mus musculus |
Length: |
811
 |
Fragment?: |
true |
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Publication |
First Author: |
Kulkarni K |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis (DOCK) nucleotide exchange factors. |
Volume: |
286 |
Issue: |
28 |
Pages: |
25341-51 |
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