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Search results 1 to 100 out of 124 for Dock9

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: DOCK family members are evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases [[cite:PUB00014935]]. DOCK proteins are required during several cellular processes, such as cell motility and phagocytosis. The N-terminal SH3 domain of the DOCK proteins functions as an inhibitor of GEF, which can be relieved upon its binding to the ELMO1-3 adaptor proteins, after their binding to active RhoG at the plasma membrane [[cite:PUB00073863], [cite:PUB00073862]]. DOCK family proteins are categorised into four subfamilies based on their sequence homology: DOCK-A subfamily (DOCK1/180, 2, 5), DOCK-B subfamily (DOCK3, 4), DOCK-C subfamily (DOCK6, 7, 8), DOCK-D subfamily (DOCK9, 10, 11) [[cite:PUB00014935]]. This entry represents DOCK9 (also known as Zizimin). DOCK9 and DOCK11 activate Cdc42 [[cite:PUB00062242], [cite:PUB00062243]].
Publication
First Author: Nishikimi A
Year: 2005
Journal: FEBS Lett
Title: Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes.
Volume: 579
Issue: 5
Pages: 1039-46
Gene
Type: gene
Organism: Homo sapiens
Protein
Organism: Mus musculus
Length: 738  
Fragment?: false
Protein
Organism: Mus musculus
Length: 2058  
Fragment?: false
Protein
Organism: Mus musculus
Length: 2042  
Fragment?: false
Protein
Organism: Mus musculus
Length: 2088  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1920  
Fragment?: true
Gene
Type: gene
Organism: Homo sapiens
Protein
Organism: Mus musculus
Length: 166  
Fragment?: true
Publication
First Author: Meller N
Year: 2002
Journal: Nat Cell Biol
Title: Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins.
Volume: 4
Issue: 9
Pages: 639-47
Protein
Organism: Mus musculus
Length: 279  
Fragment?: true
Protein
Organism: Mus musculus
Length: 2055  
Fragment?: false
Protein
Organism: Mus musculus
Length: 2058  
Fragment?: false
Protein
Organism: Mus musculus
Length: 2113  
Fragment?: false
Protein
Organism: Mus musculus
Length: 2088  
Fragment?: false
Protein
Organism: Mus musculus
Length: 2042  
Fragment?: false
Publication
First Author: Côté JF
Year: 2002
Journal: J Cell Sci
Title: Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.
Volume: 115
Issue: Pt 24
Pages: 4901-13
Publication
First Author: Lu M
Year: 2005
Journal: Curr Biol
Title: A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs.
Volume: 15
Issue: 4
Pages: 371-7
Publication
First Author: Gadea G
Year: 2014
Journal: Eur J Cell Biol
Title: Dock-family exchange factors in cell migration and disease.
Volume: 93
Issue: 10-12
Pages: 466-77
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:1332096
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:1332097
Age: embryonic day 7.5
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:1332096
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:1332097
Age: embryonic day 7.5
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:1332096
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:1332097
Age: embryonic day 7.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:1332096
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:1332097
Age: embryonic day 7.5
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:1332096
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:1332097
Age: embryonic day 7.5
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:1332096
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:1332097
Age: embryonic day 7.5
Detected: true
Specimen Num: 4
Publication
First Author: Jaudon F
Year: 2015
Journal: Mol Biol Cell
Title: The RhoGEF DOCK10 is essential for dendritic spine morphogenesis.
Volume: 26
Issue: 11
Pages: 2112-27
Publication
First Author: Hu JK
Year: 2012
Journal: Genes Dev
Title: Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation.
Volume: 26
Issue: 18
Pages: 2088-102
Publication
First Author: Ko MS
Year: 1998
Journal: Hum Mol Genet
Title: Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome.
Volume: 7
Issue: 12
Pages: 1967-78
Publication      
First Author: The Jackson Laboratory DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX Interspecific Backcross BSS and BSB Public Mapping Data
Publication
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 1
Pages: 35-48
Publication
First Author: Cobellis G
Year: 2005
Journal: Nucleic Acids Res
Title: Tagging genes with cassette-exchange sites.
Volume: 33
Issue: 4
Pages: e44
Publication      
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
Publication
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication          
First Author: MGD Nomenclature Committee
Year: 1995
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics, the Protein Information Resource and the Protein Ontology Consortium
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Protein Domain
Type: Domain
Description: Rho guanosine triphosphatases (GTPases) are critical regulators of cellmotility, polarity, adhesion, cytoskeletal organisation, proliferation, geneexpression, and apoptosis. Conversion of these biomolecular switches to theactivated GTP-bound state is controlled by two families of guanine nucleotideexchanges factors (GEFs). DH-PH proteins are a large group of Rho GEFscomprising a catalytic Dbl homology (DH) domain with anadjacent pleckstrin homology (PH) domain within the contextof functionally diverse signalling modules. The evolutionarily distinct andsmaller family of DOCK (dedicator of cytokinesis) or CDM (CED-5, DOCK1180,Myoblast city) proteins activate either Rac or Cdc42 to control cellmigration, morphogenesis, and phagocytosis. DOCK proteins share the DOCK-homology region (DHR)-1 or CDM-zizimin homology 1 (CZH1) domain and the DHR-2domain (also termed the CZH2 or DOCKER domain), [[cite:PUB00057260], [cite:PUB00062242], [cite:PUB00014935], [cite:PUB00062238], [cite:PUB00059763], [cite:PUB00061816]].The ~200 residue DHR-1 domain is located toward the N terminus. It adopts aC2-like architecture and interacts with phosphatidylinositol3,4,5-trisphosphate [[cite:PUB00059763]]to mediate signalling and membranelocalization. The central core of the DHR-1 domain adopts an antiparallelbeta-sandwich with the "type II" C2 domain fold (a circular permutation of themore common "type I" topology), in which two 4-stranded sheets with strandorder 6-5-2-3 and 7-8-1-4 create convex- and concave-exposed faces,respectively [[cite:PUB00062238]].Some DOCK proteins are listed below:Mammalian Mammalian dedicator of cytokinesis 180 (DOCK180 or DOCK1),important for cell migration.Mammalian DOCK2, important for lymphocyte development, homong, activation,adhesion, polarization and migration processes.Mammalian DOCK3 (also known as MOCA), is expressed predominantly in neuronsand resides in growth cones and membrane ruffles.Mammalian DOCK4, possesses tumor suppressor properties.Mammalian DOCK9 (zizimin1), plays an important role in dendrite growth inhippocampal neurons through activation of Cdc42.Drosophila melanogaster Myoblast city.Caenorhabditis elegans CED-5.
Protein
Organism: Mus musculus
Length: 46  
Fragment?: true
Publication
First Author: Zhang D
Year: 2010
Journal: Gene
Title: Identification of novel families and classification of the C2 domain superfamily elucidate the origin and evolution of membrane targeting activities in eukaryotes.
Volume: 469
Issue: 1-2
Pages: 18-30
Publication
First Author: Kulkarni K
Year: 2011
Journal: J Biol Chem
Title: Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis (DOCK) nucleotide exchange factors.
Volume: 286
Issue: 28
Pages: 25341-51
Publication
First Author: Yang J
Year: 2009
Journal: Science
Title: Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor.
Volume: 325
Issue: 5946
Pages: 1398-402
Protein
Organism: Mus musculus
Length: 477  
Fragment?: true
Protein
Organism: Mus musculus
Length: 811  
Fragment?: true
Protein
Organism: Mus musculus
Length: 2080  
Fragment?: false
Protein
Organism: Mus musculus
Length: 2130  
Fragment?: false
Protein
Organism: Mus musculus
Length: 2100  
Fragment?: false
Protein
Organism: Mus musculus
Length: 2100  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1816  
Fragment?: true
Protein
Organism: Mus musculus
Length: 2111  
Fragment?: false
Protein
Organism: Mus musculus
Length: 2098  
Fragment?: false
Protein
Organism: Mus musculus
Length: 2130  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1601  
Fragment?: true
Protein
Organism: Mus musculus
Length: 2128  
Fragment?: false
Protein
Organism: Mus musculus
Length: 2100  
Fragment?: false
Protein
Organism: Mus musculus
Length: 2080  
Fragment?: false