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Search results 1 to 100 out of 124 for Dock9

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
23348 | DOCK9
Type: gene
Organism: Homo sapiens
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Gene
RGD:629617 | Dock9
Type: gene
Organism: Rattus norvegicus
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Protein Coding Gene
MGI:106321 | Dock9
Type: protein_coding_gene
Organism: Mus musculus
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Protein Domain
IPR026796 | DOCK9
Type: Family
Description: DOCK family members are evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases [[cite:PUB00014935]]. DOCK proteins are required during several cellular processes, such as cell motility and phagocytosis. The N-terminal SH3 domain of the DOCK proteins functions as an inhibitor of GEF, which can be relieved upon its binding to the ELMO1-3 adaptor proteins, after their binding to active RhoG at the plasma membrane [[cite:PUB00073863], [cite:PUB00073862]]. DOCK family proteins are categorised into four subfamilies based on their sequence homology: DOCK-A subfamily (DOCK1/180, 2, 5), DOCK-B subfamily (DOCK3, 4), DOCK-C subfamily (DOCK6, 7, 8), DOCK-D subfamily (DOCK9, 10, 11) [[cite:PUB00014935]]. This entry represents DOCK9 (also known as Zizimin). DOCK9 and DOCK11 activate Cdc42 [[cite:PUB00062242], [cite:PUB00062243]].
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Publication
15710388 | J:96146
First Author: Nishikimi A
Year: 2005
Journal: FEBS Lett
Title: Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes.
Volume: 579
Issue: 5
Pages: 1039-46
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Gene
100861541 | DOCK9-DT
Type: gene
Organism: Homo sapiens
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Protein
Q6PF84
Organism: Mus musculus
Length: 738  
Fragment?: false
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Protein
B2RY79
Organism: Mus musculus
Length: 2058  
Fragment?: false
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Protein
B2RY08
Organism: Mus musculus
Length: 2042  
Fragment?: false
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Protein
B2RXS7
Organism: Mus musculus
Length: 2088  
Fragment?: false
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Protein
Q7TN11
Organism: Mus musculus
Length: 1920  
Fragment?: true
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Gene
100874096 | DOCK9-AS1
Type: gene
Organism: Homo sapiens
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Protein
A0A1D5RLB8
Organism: Mus musculus
Length: 166  
Fragment?: true
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Publication
12172552 | -
First Author: Meller N
Year: 2002
Journal: Nat Cell Biol
Title: Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins.
Volume: 4
Issue: 9
Pages: 639-47
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Protein
Q3UYH1
Organism: Mus musculus
Length: 279  
Fragment?: true
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Protein
Q8BIK4
Organism: Mus musculus
Length: 2055  
Fragment?: false
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Protein
E9QMR2
Organism: Mus musculus
Length: 2058  
Fragment?: false
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Protein
F8VPN7
Organism: Mus musculus
Length: 2113  
Fragment?: false
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Protein
A0A1D5RMM1
Organism: Mus musculus
Length: 2088  
Fragment?: false
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Protein
A0A1D5RLE0
Organism: Mus musculus
Length: 2042  
Fragment?: false
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Publication
12432077 | -
First Author: Côté JF
Year: 2002
Journal: J Cell Sci
Title: Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.
Volume: 115
Issue: Pt 24
Pages: 4901-13
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Publication
15723800 | -
First Author: Lu M
Year: 2005
Journal: Curr Biol
Title: A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs.
Volume: 15
Issue: 4
Pages: 371-7
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Publication
25022758 | -
First Author: Gadea G
Year: 2014
Journal: Eur J Cell Biol
Title: Dock-family exchange factors in cell migration and disease.
Volume: 93
Issue: 10-12
Pages: 466-77
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Protein Coding Gene
MGP_CAROLIEiJ_G0019607 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0021663 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_AJ_G0021623 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_AKRJ_G0021599 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_BALBcJ_G0021629 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_C3HHeJ_G0021407 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGI_C57BL6J_106321 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_C57BL6NJ_G0022069 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_CASTEiJ_G0020922 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_CBAJ_G0021375 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_DBA2J_G0021498 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_FVBNJ_G0021476 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_LPJ_G0021566 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_NODShiLtJ_G0021503 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_NZOHlLtJ_G0022092 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_PWKPhJ_G0020666 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_WSBEiJ_G0020978 | -
Type: protein_coding_gene
Organism: Mus musculus
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Protein Coding Gene
MGP_PahariEiJ_G0030624 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0020504 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:1332096
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:1332097
Age: embryonic day 7.5
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:1332096
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:1332097
Age: embryonic day 7.5
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:1332096
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:1332097
Age: embryonic day 7.5
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:1332096
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:1332097
Age: embryonic day 7.5
Detected: false
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:1332096
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:1332097
Age: embryonic day 7.5
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:1332096
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:1332097
Age: embryonic day 7.5
Detected: true
Specimen Num: 4
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Publication
25851601 | J:239194
First Author: Jaudon F
Year: 2015
Journal: Mol Biol Cell
Title: The RhoGEF DOCK10 is essential for dendritic spine morphogenesis.
Volume: 26
Issue: 11
Pages: 2112-27
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Publication
22987639 | J:187741
First Author: Hu JK
Year: 2012
Journal: Genes Dev
Title: Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation.
Volume: 26
Issue: 18
Pages: 2088-102
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Publication
9811942 | J:50869
First Author: Ko MS
Year: 1998
Journal: Hum Mol Genet
Title: Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome.
Volume: 7
Issue: 12
Pages: 1967-78
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Publication
- | J:29126
     
First Author: The Jackson Laboratory DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX Interspecific Backcross BSS and BSB Public Mapping Data
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Publication
12693553 | J:83413
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 1
Pages: 35-48
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Publication
15741177 | J:126097
First Author: Cobellis G
Year: 2005
Journal: Nucleic Acids Res
Title: Tagging genes with cassette-exchange sites.
Volume: 33
Issue: 4
Pages: e44
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:23000
         
First Author: MGD Nomenclature Committee
Year: 1995
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:72247
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics, the Protein Information Resource and the Protein Ontology Consortium
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Protein Domain
IPR027007 | DHR-1_domain
Type: Domain
Description: Rho guanosine triphosphatases (GTPases) are critical regulators of cellmotility, polarity, adhesion, cytoskeletal organisation, proliferation, geneexpression, and apoptosis. Conversion of these biomolecular switches to theactivated GTP-bound state is controlled by two families of guanine nucleotideexchanges factors (GEFs). DH-PH proteins are a large group of Rho GEFscomprising a catalytic Dbl homology (DH) domain with anadjacent pleckstrin homology (PH) domain within the contextof functionally diverse signalling modules. The evolutionarily distinct andsmaller family of DOCK (dedicator of cytokinesis) or CDM (CED-5, DOCK1180,Myoblast city) proteins activate either Rac or Cdc42 to control cellmigration, morphogenesis, and phagocytosis. DOCK proteins share the DOCK-homology region (DHR)-1 or CDM-zizimin homology 1 (CZH1) domain and the DHR-2domain (also termed the CZH2 or DOCKER domain), [[cite:PUB00057260], [cite:PUB00062242], [cite:PUB00014935], [cite:PUB00062238], [cite:PUB00059763], [cite:PUB00061816]].The ~200 residue DHR-1 domain is located toward the N terminus. It adopts aC2-like architecture and interacts with phosphatidylinositol3,4,5-trisphosphate [[cite:PUB00059763]]to mediate signalling and membranelocalization. The central core of the DHR-1 domain adopts an antiparallelbeta-sandwich with the "type II" C2 domain fold (a circular permutation of themore common "type I" topology), in which two 4-stranded sheets with strandorder 6-5-2-3 and 7-8-1-4 create convex- and concave-exposed faces,respectively [[cite:PUB00062238]].Some DOCK proteins are listed below:Mammalian Mammalian dedicator of cytokinesis 180 (DOCK180 or DOCK1),important for cell migration.Mammalian DOCK2, important for lymphocyte development, homong, activation,adhesion, polarization and migration processes.Mammalian DOCK3 (also known as MOCA), is expressed predominantly in neuronsand resides in growth cones and membrane ruffles.Mammalian DOCK4, possesses tumor suppressor properties.Mammalian DOCK9 (zizimin1), plays an important role in dendrite growth inhippocampal neurons through activation of Cdc42.Drosophila melanogaster Myoblast city.Caenorhabditis elegans CED-5.
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Protein
A0A0U1RPH6
Organism: Mus musculus
Length: 46  
Fragment?: true
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Publication
20713135 | -
First Author: Zhang D
Year: 2010
Journal: Gene
Title: Identification of novel families and classification of the C2 domain superfamily elucidate the origin and evolution of membrane targeting activities in eukaryotes.
Volume: 469
Issue: 1-2
Pages: 18-30
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Publication
21613211 | -
First Author: Kulkarni K
Year: 2011
Journal: J Biol Chem
Title: Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis (DOCK) nucleotide exchange factors.
Volume: 286
Issue: 28
Pages: 25341-51
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Publication
19745154 | -
First Author: Yang J
Year: 2009
Journal: Science
Title: Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor.
Volume: 325
Issue: 5946
Pages: 1398-402
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Protein
A0A1L1STJ1
Organism: Mus musculus
Length: 477  
Fragment?: true
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Protein
A0A0U1RNY4
Organism: Mus musculus
Length: 811  
Fragment?: true
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Protein
Q8VDR9
Organism: Mus musculus
Length: 2080  
Fragment?: false
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Protein
Q8R1A4
Organism: Mus musculus
Length: 2130  
Fragment?: false
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Protein
Q8C147
Organism: Mus musculus
Length: 2100  
Fragment?: false
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Protein
B9EJ70
Organism: Mus musculus
Length: 2100  
Fragment?: false
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Protein
A0A0R4J2B7
Organism: Mus musculus
Length: 1816  
Fragment?: true
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Protein
A0A1L1SQR4
Organism: Mus musculus
Length: 2111  
Fragment?: false
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Protein
A0A0U1RNK7
Organism: Mus musculus
Length: 2098  
Fragment?: false
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Protein
A2A9M4
Organism: Mus musculus
Length: 2130  
Fragment?: false
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Protein
Q3UHH9
Organism: Mus musculus
Length: 1601  
Fragment?: true
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Protein
A2A9M5
Organism: Mus musculus
Length: 2128  
Fragment?: false
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Protein
E9PX48
Organism: Mus musculus
Length: 2100  
Fragment?: false
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Protein
E9QPN7
Organism: Mus musculus
Length: 2080  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom