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Search results 1 to 100 out of 424 for Dot1l

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Liao J
Year: 2020
Journal: Sci Rep
Title: Maternal DOT1L is dispensable for mouse development.
Volume: 10
Issue: 1
Pages: 20636
Publication
First Author: Nguyen AT
Year: 2011
Journal: Genes Dev
Title: DOT1L regulates dystrophin expression and is critical for cardiac function.
Volume: 25
Issue: 3
Pages: 263-74
Publication
First Author: Jones B
Year: 2008
Journal: PLoS Genet
Title: The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure.
Volume: 4
Issue: 9
Pages: e1000190
Publication
First Author: Zhu B
Year: 2018
Journal: Nat Commun
Title: The protective role of DOT1L in UV-induced melanomagenesis.
Volume: 9
Issue: 1
Pages: 259
Publication  
First Author: Monteagudo S
Year: 2017
Journal: Nat Commun
Title: DOT1L safeguards cartilage homeostasis and protects against osteoarthritis.
Volume: 8
Pages: 15889
Publication
First Author: Feng Y
Year: 2010
Journal: Blood
Title: Early mammalian erythropoiesis requires the Dot1L methyltransferase.
Volume: 116
Issue: 22
Pages: 4483-91
Publication
First Author: Kealy L
Year: 2020
Journal: Cell Rep
Title: The Histone Methyltransferase DOT1L Is Essential for Humoral Immune Responses.
Volume: 33
Issue: 11
Pages: 108504
Publication
First Author: Aslam MA
Year: 2021
Journal: EMBO Rep
Title: Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation.
Volume: 22
Issue: 2
Pages: e51184
Publication  
First Author: Sutter PA
Year: 2021
Journal: Bone
Title: Mesenchyme-specific loss of Dot1L histone methyltransferase leads to skeletal dysplasia phenotype in mice.
Volume: 142
Pages: 115677
Publication
First Author: Jo SY
Year: 2011
Journal: Blood
Title: Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation.
Volume: 117
Issue: 18
Pages: 4759-68
Publication    
First Author: Yi D
Year: 2020
Journal: Elife
Title: Dot1l interacts with Zc3h10 to activate Ucp1 and other thermogenic genes.
Volume: 9
Publication
First Author: Rau RE
Year: 2016
Journal: Blood
Title: DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia.
Volume: 128
Issue: 7
Pages: 971-81
Publication
First Author: Kwesi-Maliepaard EM
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8+ T cells.
Volume: 117
Issue: 34
Pages: 20706-20716
Publication
First Author: Riedel SS
Year: 2016
Journal: J Clin Invest
Title: MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia.
Volume: 126
Issue: 4
Pages: 1438-50
Publication
First Author: Ooga M
Year: 2013
Journal: Biol Reprod
Title: Involvement of DOT1L in the remodeling of heterochromatin configuration during early preimplantation development in mice.
Volume: 89
Issue: 6
Pages: 145
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Scheer S
Year: 2020
Journal: Cell Rep
Title: The Methyltransferase DOT1L Controls Activation and Lineage Integrity in CD4+ T Cells during Infection and Inflammation.
Volume: 33
Issue: 11
Pages: 108505
Publication
First Author: Bovio PP
Year: 2019
Journal: Mol Neurobiol
Title: Differential Methylation of H3K79 Reveals DOT1L Target Genes and Function in the Cerebellum In Vivo.
Volume: 56
Issue: 6
Pages: 4273-4287
Publication
First Author: Xiao Z
Year: 2016
Journal: Exp Cell Res
Title: Dot1l deficiency leads to increased intercalated cells and upregulation of V-ATPase B1 in mice.
Volume: 344
Issue: 2
Pages: 167-75
Publication
First Author: Chen CW
Year: 2015
Journal: Nat Med
Title: DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.
Volume: 21
Issue: 4
Pages: 335-43
Publication
First Author: Franz H
Year: 2019
Journal: Nucleic Acids Res
Title: DOT1L promotes progenitor proliferation and primes neuronal layer identity in the developing cerebral cortex.
Volume: 47
Issue: 1
Pages: 168-183
Publication
First Author: Gray de Cristoforis A
Year: 2020
Journal: Mol Brain
Title: Differentiation and localization of interneurons in the developing spinal cord depends on DOT1L expression.
Volume: 13
Issue: 1
Pages: 85
Publication
First Author: FitzGerald J
Year: 2011
Journal: PLoS One
Title: Regulation of the DNA damage response and gene expression by the Dot1L histone methyltransferase and the 53Bp1 tumour suppressor.
Volume: 6
Issue: 2
Pages: e14714
Publication
First Author: Nguyen AT
Year: 2011
Journal: Blood
Title: DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis.
Volume: 117
Issue: 25
Pages: 6912-22
Publication
First Author: Deshpande AJ
Year: 2014
Journal: Cancer Cell
Title: AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes.
Volume: 26
Issue: 6
Pages: 896-908
Publication
First Author: Vlaming H
Year: 2019
Journal: EMBO J
Title: Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L-dose dependency in HDAC1-deficient thymic lymphoma.
Volume: 38
Issue: 14
Pages: e101564
Publication
First Author: Chen L
Year: 2013
Journal: Leukemia
Title: Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l.
Volume: 27
Issue: 4
Pages: 813-22
Publication
First Author: Steger DJ
Year: 2008
Journal: Mol Cell Biol
Title: DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells.
Volume: 28
Issue: 8
Pages: 2825-39
Publication
First Author: Bernt KM
Year: 2011
Journal: Cancer Cell
Title: MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.
Volume: 20
Issue: 1
Pages: 66-78
Publication
First Author: Chang MJ
Year: 2010
Journal: Cancer Res
Title: Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes.
Volume: 70
Issue: 24
Pages: 10234-42
Publication
First Author: Wu H
Year: 2013
Journal: J Am Soc Nephrol
Title: Aqp2-expressing cells give rise to renal intercalated cells.
Volume: 24
Issue: 2
Pages: 243-52
Publication
First Author: Deshpande AJ
Year: 2013
Journal: Blood
Title: Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l.
Volume: 121
Issue: 13
Pages: 2533-41
Publication
First Author: Ho LL
Year: 2013
Journal: Mol Cell Biol
Title: DOT1L-mediated H3K79 methylation in chromatin is dispensable for Wnt pathway-specific and other intestinal epithelial functions.
Volume: 33
Issue: 9
Pages: 1735-45
Publication
First Author: Zhang W
Year: 2013
Journal: Am J Physiol Renal Physiol
Title: An Af9 cis-element directly targets Dot1a to mediate transcriptional repression of the ╬▒ENaC gene.
Volume: 304
Issue: 4
Pages: F367-75
Publication
First Author: Wu H
Year: 2013
Journal: PLoS One
Title: Aqp5 is a new transcriptional target of Dot1a and a regulator of Aqp2.
Volume: 8
Issue: 1
Pages: e53342
Publication
First Author: Mahmoudi T
Year: 2010
Journal: PLoS Biol
Title: The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/╬▓-catenin coactivators essential for intestinal homeostasis.
Volume: 8
Issue: 11
Pages: e1000539
Publication
First Author: Okada Y
Year: 2005
Journal: Cell
Title: hDOT1L links histone methylation to leukemogenesis.
Volume: 121
Issue: 2
Pages: 167-78
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Zhang W
Year: 2004
Journal: Biochem J
Title: Structure and regulation of the mDot1 gene, a mouse histone H3 methyltransferase.
Volume: 377
Issue: Pt 3
Pages: 641-51
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2010-07-27
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1611815
Pattern: Ubiquitous
Stage: TS15
Assay Id: MGI:4462039
Age: embryonic day 9.5
Image: 2B
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3516422
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716122
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691622
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1760622
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737322
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3284222
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1666522
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619822
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754922
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Note: Expression was not detected in the corpus striatum (lateral ganglionic eminence).
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1697422
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3276322
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Note: Expression was not detected in the face/soft tissues.
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1783822
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1665922
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1706822
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1674822
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1670622
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738222
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1654222
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1777922
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684922
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716822
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619322
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1755022
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2010-07-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1626715
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4462039
Age: embryonic day 9.5
Image: 2C
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1733122
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1736622
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Note: Expression was not detected in the genito-urinary system.
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610422
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876922
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3276722
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1753622
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619422
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3290622
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1795022
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1745822
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3278022
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Note: Expression was not detected in the pallidum (medial ganglionic eminence).
Detected: false
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2010-07-27
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1653615
Pattern: Ubiquitous
Stage: TS15
Assay Id: MGI:4462039
Age: embryonic day 9.5
Image: 2B
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3286922
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:4423357
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1778722
Stage: TS22
Assay Id: MGI:5422128
Age: embryonic day 14.5
Detected: false
Specimen Num: 1