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Search results 1 to 100 out of 102 for Dph2

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0.048s
Type Details Score
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression  
Probe: MGI:1700852
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824380
Age: embryonic day 14.5
Image: euxassay_001242_01
Specimen Label: euxassay_001242_01
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:1700852
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824380
Age: embryonic day 14.5
Image: euxassay_001242_02
Specimen Label: euxassay_001242_02
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:1700852
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824380
Age: embryonic day 14.5
Image: euxassay_001242_04
Specimen Label: euxassay_001242_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:1700852
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824380
Age: embryonic day 14.5
Image: euxassay_001242_05
Specimen Label: euxassay_001242_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:1700852
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824380
Age: embryonic day 14.5
Image: euxassay_001242_07
Specimen Label: euxassay_001242_07
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:1700852
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824380
Age: embryonic day 14.5
Image: euxassay_001242_08
Specimen Label: euxassay_001242_08
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:1700852
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824380
Age: embryonic day 14.5
Image: euxassay_001242_17
Specimen Label: euxassay_001242_17
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:1700852
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824380
Age: embryonic day 14.5
Image: euxassay_001242_18
Specimen Label: euxassay_001242_18
Detected: true
Specimen Num: 11
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
GXD Expression  
Probe: MGI:1700852
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824380
Age: embryonic day 14.5
Image: euxassay_001242_03
Specimen Label: euxassay_001242_03
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:1700852
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824380
Age: embryonic day 14.5
Image: euxassay_001242_06
Specimen Label: euxassay_001242_06
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:1700852
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1830623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824380
Age: embryonic day 14.5
Image: euxassay_001242_09
Specimen Label: euxassay_001242_09
Detected: true
Specimen Num: 9
Publication
First Author: Liu S
Year: 2004
Journal: Mol Cell Biol
Title: Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2.
Volume: 24
Issue: 21
Pages: 9487-97
Publication      
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniPathway vocabulary mapping
Publication
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Allele    
Name: DPH2 homolog; wild type
Allele
Name: DPH2 homolog; targeted mutation 1, Velocigene
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Publication
First Author: Mattheakis LC
Year: 1993
Journal: Gene
Title: Diphthamide synthesis in Saccharomyces cerevisiae: structure of the DPH2 gene.
Volume: 132
Issue: 1
Pages: 149-54
Protein
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
Allele
Name: DPH2 homolog; targeted mutation 2, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Strain
Attribute String: mutant strain, coisogenic, targeted mutation
Strain
Attribute String: targeted mutation, mutant strain, coisogenic
Allele  
Name: DPH2 homolog; gene trap IST13756E3, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
Genotype
Symbol: Dph2/Dph2
Background: C57BL/6N-A Dph2/WtsiH
Zygosity: hm
Has Mutant Allele: true
DO Term
Strain
Attribute String: coisogenic, targeted mutation
Genotype
Symbol: Dph2/Dph2<+>
Background: C57BL/6N-A Dph2/WtsiH
Zygosity: ht
Has Mutant Allele: true
Protein Domain
Type: Family
Description: Archaeal and eukaryotic translation elongation factor 2 contain a unique posttranslationally modified histidine residue called diphthamide, the target of the diphtheria toxin []. This family represents Dph2 from Archaea. This iron-sulphur cluster enzyme is involved in the first step of diphthamide biosynthesis [].
Publication
First Author: Chen CM
Year: 2005
Journal: Curr Opin Genet Dev
Title: OVCA1: tumor suppressor gene.
Volume: 15
Issue: 1
Pages: 49-54
Publication
First Author: Dong M
Year: 2019
Journal: J Biol Inorg Chem
Title: The asymmetric function of Dph1-Dph2 heterodimer in diphthamide biosynthesis.
Volume: 24
Issue: 6
Pages: 777-782
Protein Domain
Type: Family
Description: Archaeal and eukaryotic translation elongation factor 2 contain a unique posttranslationally modified histidine residue called diphthamide, the target of the diphtheria toxin. Diphtheria toxin inhibits eukaryotic protein synthesis by ADP-ribosylating diphthamide in EF2 [].Members of this family include 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1/2 (also known as Diphtheria toxin resistance protein 1/2, DPH 1/2), which are involved in the first step of diphthamide synthesis [, ]. Archaeal DPHs are more similar to eukaryotic DPH1 than to DPH2 [].
Publication
First Author: Chen CM
Year: 2004
Journal: Genes Dev
Title: Ovca1 regulates cell proliferation, embryonic development, and tumorigenesis.
Volume: 18
Issue: 3
Pages: 320-32
Protein Domain
Type: Family
Description: This entry includes diphthamide synthesis DPH1 from eukaryotes and archaea and DPH2 from archaea.Archaeal and eukaryotic translation elongation factor 2 (EF-2) contain a unique posttranslationally modified histidine residue called diphthamide, which become the target for ADP-ribosylation by diphtheria toxin []. DPH1 catalyzes the first step of diphthamide biosynthesis and is required for the modification of EF-2 []. The human DPH1 is also known as OVCA1 (for ovarian cancer gene 1), a tumour suppressor gene that plays a crucial role in the regulation of cell proliferation, embryonic development, and tumorigenesis [].
Publication
First Author: Webb TR
Year: 2008
Journal: J Cell Sci
Title: Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development.
Volume: 121
Issue: Pt 19
Pages: 3140-5
Publication
First Author: Zhang Y
Year: 2010
Journal: Nature
Title: Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme.
Volume: 465
Issue: 7300
Pages: 891-6
Protein
Organism: Mus musculus/domesticus
Length: 438  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 275  
Fragment?: true
Protein Domain
Type: Homologous_superfamily
Description: Diphthamide is the name given to a unique post-translationally modified histidine residue in archaeal and eukaryotic translation elongation factor 2. Thismodified histidine is target of diphtheria toxin, which inhibits eukaryotic protein synthesis by ADP-ribosylating diphthamide in EF2 [].The diphthamide synthesis DPH1/DPH2 enzymes which catalyse the first step in diphthamide biosynthesis. Archaeal DPHs are more similar to eukaryotic DPH1 than to DPH2 [].Available structural information on PhDph2 reveals that this enzyme is a homodimer and that each monomer comprises three domains which share the same overall fold. The basic domain fold is a four-stranded parallel β-sheet with three flanking α-helices (or two α-helices and one 3(10) helix in the case of domain 2). The two β-sheets in domain 1 and 2 each contain an additional β-strand that is antiparallel to the rest of the β-sheet. Domains 2 and 3 have two additional α-helices. Domain 1 of one monomer and domain 3 of the adjacent monomer form the dimer interface, creating an extended nine-stranded β-sheet. The domain folds and their arrangement resemble the structure of quinolinate synthase but the orientations of the domains with respect to each other are different in the two enzymes. Three conserved cysteine residues (Cys59, Cys163 and Cys287), each coming from a different structural domain, are clustered together in the centre of the PhDph2 monomers. All three cysteine residues are conserved in eukaryotic DPH1s. The first and third cysteine residues are conserved in eukaryotic DPH2s [].This superfamily represents the domain 2 found in diphthamide synthesis DPH1/DPH2 enzymes.