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Search results 1 to 100 out of 579 for Dppa3

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Type Details Score
Gene
Type: gene
Organism: Not Specified
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: macaque, rhesus
Protein Domain
Type: Family
Description: Dppa3 (developmental pluripotency-associated protein 3), also known as Stella or PGC7, belongs to family known only in placental mammals [, , ]. The PGC7/Stella/Dppa3 protein protects imprinted regions from demethylation post-fertilization []. This suggests that it might bind methylated DNA sequences directly []. Dppa3 also seems to be involved in the demethylation process during reprogramming of embryonic germ cell precursors []. Most placental mammals contain 3-6 paralogues of this family.The conserved core of Dppa3 includes a positively charged helical segment and a C-terminal CXCXXC motif that is predicted to chelate a metal ion []. The CXCXXC motif is also conserved in a subset of fungal MBD4-like proteins [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Nakashima H
Year: 2013
Journal: Biol Reprod
Title: Effects of dppa3 on DNA methylation dynamics during primordial germ cell development in mice.
Volume: 88
Issue: 5
Pages: 125
Publication
First Author: Nakamura T
Year: 2007
Journal: Nat Cell Biol
Title: PGC7/Stella protects against DNA demethylation in early embryogenesis.
Volume: 9
Issue: 1
Pages: 64-71
Publication
First Author: Payer B
Year: 2003
Journal: Curr Biol
Title: Stella is a maternal effect gene required for normal early development in mice.
Volume: 13
Issue: 23
Pages: 2110-7
GXD Expression
Probe: MGI:6435789
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160331
Pattern: Regionally restricted
Stage: TS01
Assay Id: MGI:7482800
Age: embryonic day 0.5
Image: S7a DPPA3 WT
Note: Expression in cytoplasm and pronuclei.
Specimen Label: S7a DPPA3 WT
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6435789
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160331
Stage: TS01
Assay Id: MGI:7482800
Age: embryonic day 0.5
Image: S7A DPPA3 -/-
Specimen Label: S7A DPPA3 -/-
Detected: false
Specimen Num: 6
GXD Expression
Probe: MGI:6435789
Assay Type: Immunohistochemistry
Annotation Date: 2023-05-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160331
Pattern: Regionally restricted
Stage: TS01
Assay Id: MGI:7482800
Age: embryonic day 0.5
Image: S7A DPPA3 R60A/-
Note: Expression strongly localized in both pronuclei, but absent from cytoplasm.
Specimen Label: S7A DPPA3 R60A/-
Detected: true
Specimen Num: 5
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Liu YJ
Year: 2012
Journal: Biol Reprod
Title: Essential role of DPPA3 for chromatin condensation in mouse oocytogenesis.
Volume: 86
Issue: 2
Pages: 40
Protein
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 141  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 204  
Fragment?: false
Publication
First Author: Clark AT
Year: 2004
Journal: Stem Cells
Title: Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma.
Volume: 22
Issue: 2
Pages: 169-79
Publication  
First Author: Iyer LM
Year: 2011
Journal: Prog Mol Biol Transl Sci
Title: Natural history of eukaryotic DNA methylation systems.
Volume: 101
Pages: 25-104
Publication  
First Author: Xu X
Year: 2015
Journal: Nat Commun
Title: Dppa3 expression is critical for generation of fully reprogrammed iPS cells and maintenance of Dlk1-Dio3 imprinting.
Volume: 6
Pages: 6008
Publication  
First Author: Bortvin A
Year: 2004
Journal: BMC Dev Biol
Title: Dppa3 / Pgc7 / stella is a maternal factor and is not required for germ cell specification in mice.
Volume: 4
Pages: 2
Publication
First Author: Shin SW
Year: 2017
Journal: Nat Commun
Title: Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice.
Volume: 8
Issue: 1
Pages: 1643
Publication
First Author: Bowles J
Year: 2003
Journal: Cytogenet Genome Res
Title: Dppa3 is a marker of pluripotency and has a human homologue that is expressed in germ cell tumours.
Volume: 101
Issue: 3-4
Pages: 261-5
GXD Expression  
Probe: MGI:6438133
Assay Type: Immunohistochemistry
Annotation Date: 2020-07-08
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:160403
Pattern: Not Specified
Stage: TS03
Assay Id: MGI:6438140
Age: embryonic day 2.5
Note: Mutant embryos with only maternal expression do not show much staining from E2.5 onwards. Maternally inherited Dppa3 was degraded by the early morula stage.
Specimen Label: 5G/H
Detected: true
Specimen Num: 9
Publication
First Author: Hirota T
Year: 2011
Journal: Biol Reprod
Title: Drug-inducible gene recombination by the Dppa3-MER Cre MER transgene in the developmental cycle of the germ cell lineage in mice.
Volume: 85
Issue: 2
Pages: 367-77
Publication
First Author: Han L
Year: 2018
Journal: Nat Genet
Title: Embryonic defects induced by maternal obesity in mice derive from Stella insufficiency in oocytes.
Volume: 50
Issue: 3
Pages: 432-442
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Sato M
Year: 2002
Journal: Mech Dev
Title: Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells.
Volume: 113
Issue: 1
Pages: 91-4
Publication    
First Author: Huang Y
Year: 2017
Journal: Elife
Title: Stella modulates transcriptional and endogenous retrovirus programs during maternal-to-zygotic transition.
Volume: 6
Publication
First Author: Hou C
Year: 2022
Journal: Int J Biol Sci
Title: Stella Regulates the Development of Female Germline Stem Cells by Modulating Chromatin Structure and DNA Methylation.
Volume: 18
Issue: 7
Pages: 3006-3018
Publication
First Author: Mikedis MM
Year: 2012
Journal: Dev Biol
Title: STELLA-positive subregions of the primitive streak contribute to posterior tissues of the mouse gastrula.
Volume: 363
Issue: 1
Pages: 201-18
GXD Expression    
Probe: MGI:3703340
Assay Type: RT-PCR
Annotation Date: 2007-04-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160414
Stage: TS04
Assay Id: MGI:3703542
Age: embryonic day 3.5
Image: 5
Specimen Label: -/-, 3.5dpc
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3703340
Assay Type: RT-PCR
Annotation Date: 2007-04-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160415
Stage: TS05
Assay Id: MGI:3703542
Age: embryonic day 4.5
Image: 5
Specimen Label: -/-, 4.5dpc
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3783505
Assay Type: Northern blot
Annotation Date: 2008-05-01
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3783509
Age: postnatal adult
Image: 1
Specimen Label: Brain
Specimen Num: 2
GXD Expression      
Probe: MGI:3783505
Assay Type: Northern blot
Annotation Date: 2008-05-01
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3783509
Age: postnatal adult
Image: 1
Specimen Label: Heart
Specimen Num: 3
GXD Expression      
Probe: MGI:3783505
Assay Type: Northern blot
Annotation Date: 2008-05-01
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3783509
Age: postnatal adult
Image: 1
Specimen Label: Kidney
Specimen Num: 4
GXD Expression      
Probe: MGI:3783505
Assay Type: Northern blot
Annotation Date: 2008-05-01
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3783509
Age: postnatal adult
Image: 1
Specimen Label: Liver
Specimen Num: 5
GXD Expression      
Probe: MGI:3783505
Assay Type: Northern blot
Annotation Date: 2008-05-01
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3783509
Age: postnatal adult
Image: 1
Specimen Label: Spleen
Specimen Num: 6
GXD Expression      
Probe: MGI:3783505
Assay Type: Northern blot
Annotation Date: 2008-05-01
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:3783509
Age: postnatal adult
Image: 1
Specimen Label: Thymus
Specimen Num: 7
GXD Expression      
Probe: MGI:3783505
Assay Type: Northern blot
Annotation Date: 2008-05-01
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3783509
Age: postnatal adult
Image: 1
Specimen Label: Lung
Specimen Num: 8
GXD Expression      
Probe: MGI:3783505
Assay Type: Northern blot
Annotation Date: 2008-05-01
Strength: Not Specified
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3783509
Age: postnatal adult
Image: 1
Specimen Label: Testis
Specimen Num: 9
GXD Expression    
Probe: MGI:3783505
Assay Type: Northern blot
Annotation Date: 2008-05-01
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:3783509
Age: postnatal adult
Image: 1
Specimen Label: Ovary
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:3851971
Assay Type: RT-PCR
Annotation Date: 2009-08-06
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:3852188
Age: postnatal newborn
Image: 8
Specimen Label: Brain
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3851971
Assay Type: RT-PCR
Annotation Date: 2009-08-06
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:3852188
Age: postnatal newborn
Image: 8
Specimen Label: Heart
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3851971
Assay Type: RT-PCR
Annotation Date: 2009-08-06
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3287427
Stage: TS27
Assay Id: MGI:3852188
Age: postnatal newborn
Image: 8
Specimen Label: Intestine
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:3851971
Assay Type: RT-PCR
Annotation Date: 2009-08-06
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737327
Stage: TS27
Assay Id: MGI:3852188
Age: postnatal newborn
Image: 8
Specimen Label: Kidney
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:3851971
Assay Type: RT-PCR
Annotation Date: 2009-08-06
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:3852188
Age: postnatal newborn
Image: 8
Specimen Label: Liver
Detected: false
Specimen Num: 5
GXD Expression    
Probe: MGI:3851971
Assay Type: RT-PCR
Annotation Date: 2009-08-06
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672827
Stage: TS27
Assay Id: MGI:3852188
Age: postnatal newborn
Image: 8
Specimen Label: Lung
Detected: false
Specimen Num: 6
GXD Expression    
Probe: MGI:3851971
Assay Type: RT-PCR
Annotation Date: 2009-08-06
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3557727
Stage: TS27
Assay Id: MGI:3852188
Age: postnatal newborn
Image: 8
Specimen Label: Muscle
Detected: false
Specimen Num: 7
GXD Expression    
Probe: MGI:3851971
Assay Type: RT-PCR
Annotation Date: 2009-08-06
Strength: Present
Sex: Female
Emaps: EMAPS:1796227
Stage: TS27
Assay Id: MGI:3852188
Age: postnatal newborn
Image: 8
Specimen Label: Ovary
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:3851971
Assay Type: RT-PCR
Annotation Date: 2009-08-06
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876727
Stage: TS27
Assay Id: MGI:3852188
Age: postnatal newborn
Image: 8
Specimen Label: Spleen
Detected: false
Specimen Num: 9
GXD Expression    
Probe: MGI:3851971
Assay Type: RT-PCR
Annotation Date: 2009-08-06
Strength: Absent
Sex: Male
Emaps: EMAPS:1797227
Stage: TS27
Assay Id: MGI:3852188
Age: postnatal newborn
Image: 8
Specimen Label: Testis
Detected: false
Specimen Num: 10
GXD Expression    
Probe: MGI:3851971
Assay Type: RT-PCR
Annotation Date: 2009-08-06
Strength: Absent
Sex: Female
Emaps: EMAPS:2991527
Stage: TS27
Assay Id: MGI:3852188
Age: postnatal newborn
Image: 8
Specimen Label: Uterus
Detected: false
Specimen Num: 11
GXD Expression    
Probe: MGI:3851971
Assay Type: RT-PCR
Annotation Date: 2009-08-06
Strength: Absent
Sex: Female
Emaps: EMAPS:1796220
Stage: TS20
Assay Id: MGI:3852197
Age: embryonic day 12.5
Image: 8
Specimen Label: E12.5
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3851971
Assay Type: RT-PCR
Annotation Date: 2009-08-06
Strength: Absent
Sex: Female
Emaps: EMAPS:1796220
Stage: TS20
Assay Id: MGI:3852197
Age: embryonic day 12.5
Image: 8
Specimen Label: E12.5
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3851971
Assay Type: RT-PCR
Annotation Date: 2009-08-06
Strength: Absent
Sex: Female
Emaps: EMAPS:1796221
Stage: TS21
Assay Id: MGI:3852197
Age: embryonic day 13.5
Image: 8
Specimen Label: E13.5
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:3851971
Assay Type: RT-PCR
Annotation Date: 2009-08-06
Strength: Absent
Sex: Female
Emaps: EMAPS:1796221
Stage: TS21
Assay Id: MGI:3852197
Age: embryonic day 13.5
Image: 8
Specimen Label: E13.5
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:3851971
Assay Type: RT-PCR
Annotation Date: 2009-08-06
Strength: Present
Sex: Female
Emaps: EMAPS:1796223
Stage: TS23
Assay Id: MGI:3852197
Age: embryonic day 15.5
Image: 8
Specimen Label: E15.5
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:3851971
Assay Type: RT-PCR
Annotation Date: 2009-08-06
Strength: Absent
Sex: Female
Emaps: EMAPS:1796223
Stage: TS23
Assay Id: MGI:3852197
Age: embryonic day 15.5
Image: 8
Specimen Label: E15.5
Detected: false
Specimen Num: 6
GXD Expression    
Probe: MGI:3851971
Assay Type: RT-PCR
Annotation Date: 2009-08-06
Strength: Present
Sex: Female
Emaps: EMAPS:1796225
Stage: TS25
Assay Id: MGI:3852197
Age: embryonic day 17.5
Image: 8
Specimen Label: E17.5
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:3851971
Assay Type: RT-PCR
Annotation Date: 2009-08-06
Strength: Absent
Sex: Female
Emaps: EMAPS:1796225
Stage: TS25
Assay Id: MGI:3852197
Age: embryonic day 17.5
Image: 8
Specimen Label: E17.5
Detected: false
Specimen Num: 8
GXD Expression    
Probe: MGI:3851971
Assay Type: RT-PCR
Annotation Date: 2009-08-06
Strength: Present
Sex: Female
Emaps: EMAPS:1796226
Stage: TS26
Assay Id: MGI:3852197
Age: embryonic day 19.5
Image: 8
Specimen Label: E19.5
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:3851971
Assay Type: RT-PCR
Annotation Date: 2009-08-06
Strength: Absent
Sex: Female
Emaps: EMAPS:1796226
Stage: TS26
Assay Id: MGI:3852197
Age: embryonic day 19.5
Image: 8
Specimen Label: E19.5
Detected: false
Specimen Num: 10
GXD Expression    
Probe: MGI:3851971
Assay Type: RT-PCR
Annotation Date: 2009-08-06
Strength: Present
Sex: Female
Emaps: EMAPS:1796227
Stage: TS27
Assay Id: MGI:3852197
Age: postnatal newborn
Image: 8
Specimen Label: Newborn
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:3851971
Assay Type: RT-PCR
Annotation Date: 2009-08-06
Strength: Absent
Sex: Female
Emaps: EMAPS:1796227
Stage: TS27
Assay Id: MGI:3852197
Age: postnatal newborn
Image: 8
Specimen Label: Newborn
Detected: false
Specimen Num: 12
GXD Expression    
Probe: MGI:3851971
Assay Type: RT-PCR
Annotation Date: 2009-08-06
Strength: Present
Sex: Female
Emaps: EMAPS:1796227
Stage: TS27
Assay Id: MGI:3852197
Age: postnatal day 2
Image: 8
Specimen Label: 2d
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:3851971
Assay Type: RT-PCR
Annotation Date: 2009-08-06
Strength: Absent
Sex: Female
Emaps: EMAPS:1796227
Stage: TS27
Assay Id: MGI:3852197
Age: postnatal day 2
Image: 8
Specimen Label: 2d
Detected: false
Specimen Num: 14
GXD Expression    
Probe: MGI:3851971
Assay Type: RT-PCR
Annotation Date: 2009-08-06
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:3852197
Age: postnatal day 7
Image: 8
Specimen Label: 7d
Detected: true
Specimen Num: 15
GXD Expression    
Probe: MGI:3851971
Assay Type: RT-PCR
Annotation Date: 2009-08-06
Strength: Absent
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:3852197
Age: postnatal day 7
Image: 8
Specimen Label: 7d
Detected: false
Specimen Num: 16