|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 106 for Edc4

<< First    < Previous  |  Next >    Last >>
0.041s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
23644 | EDC4
Type: gene
Organism: human
•
•
•
•
•
Gene
454178 | EDC4
Type: gene
Organism: chimpanzee
•
•
•
•
•
Gene
513171 | EDC4
Type: gene
Organism: cattle
•
•
•
•
•
Gene
415656 | EDC4
Type: gene
Organism: chicken
•
•
•
•
•
Gene
565659 | edc4
Type: gene
Organism: zebrafish
•
•
•
•
•
Gene
701393 | EDC4
Type: gene
Organism: macaque, rhesus
•
•
•
•
•
Gene
100379843 | edc4
Type: gene
Organism: frog, western clawed
•
•
•
•
•
Gene
361399 | Edc4
Type: gene
Organism: rat
•
•
•
•
•
Gene
489751 | EDC4
Type: gene
Organism: dog, domestic
•
•
•
•
•
Protein Coding Gene
MGI:2446249 | Edc4
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CAROLIEiJ_G0031500 | -
Type: protein_coding_gene
Organism: Mus caroli
•
•
•
•
•
Protein Coding Gene
MGP_129S1SvImJ_G0034064 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AJ_G0034045 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AKRJ_G0033971 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_BALBcJ_G0034038 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C3HHeJ_G0033750 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI_C57BL6J_2446249 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C57BL6NJ_G0034558 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CASTEiJ_G0033076 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CBAJ_G0033723 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_DBA2J_G0033878 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_FVBNJ_G0033823 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_LPJ_G0033969 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NODShiLtJ_G0033867 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NZOHlLtJ_G0034576 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PWKPhJ_G0032777 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_WSBEiJ_G0033192 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PahariEiJ_G0023100 | -
Type: protein_coding_gene
Organism: Mus pahari
•
•
•
•
•
Protein Coding Gene
MGP_SPRETEiJ_G0032618 | -
Type: protein_coding_gene
Organism: Mus spretus
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3528468
Assay Type: RT-PCR
Annotation Date: 2005-03-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3528469
Age: postnatal
Specimen Label: liver
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3528468
Assay Type: RT-PCR
Annotation Date: 2005-03-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3528469
Age: postnatal
Specimen Label: spleen
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3528468
Assay Type: RT-PCR
Annotation Date: 2005-03-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3528469
Age: postnatal
Specimen Label: lung
Detected: false
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3528468
Assay Type: RT-PCR
Annotation Date: 2005-03-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3528469
Age: postnatal
Specimen Label: kidney
Detected: false
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3528468
Assay Type: RT-PCR
Annotation Date: 2005-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1738328
Stage: TS28
Assay Id: MGI:3528469
Age: postnatal
Specimen Label: gonad
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3528468
Assay Type: RT-PCR
Annotation Date: 2005-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3528469
Age: postnatal
Specimen Label: brain
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3528468
Assay Type: RT-PCR
Annotation Date: 2005-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3557728
Stage: TS28
Assay Id: MGI:3528469
Age: postnatal
Specimen Label: muscle
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3528468
Assay Type: RT-PCR
Annotation Date: 2005-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:3528469
Age: postnatal week 3
Specimen Label: 3wk adr
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3528468
Assay Type: RT-PCR
Annotation Date: 2005-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:3528469
Age: postnatal adult
Specimen Label: adult adr
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3528468
Assay Type: RT-PCR
Annotation Date: 2005-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1842627
Stage: TS27
Assay Id: MGI:3528469
Age: postnatal newborn
Specimen Label: P1 adr
Detected: true
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:5707839
Assay Type: Immunohistochemistry
Annotation Date: 2016-02-10
Strength: Present
Sex: Male
Emaps: EMAPS:1797528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5707859
Age: postnatal adult
Image: 3D
Note: Ge-1 described as a marker for chromatoid body and nuage, perinuclear structures related to the P-body of somatic cells.
Specimen Label: 3D
Detected: true
Specimen Num: 1
•
•
•
•
•
Publication
24858563 | J:217575
First Author: Ling YH
Year: 2014
Journal: Exp Cell Res
Title: CCHCR1 interacts with EDC4, suggesting its localization in P-bodies.
Volume: 327
Issue: 1
Pages: 12-23
•
•
•
•
•
Publication
20639877 | J:162534
First Author: Glasmacher E
Year: 2010
Journal: Nat Immunol
Title: Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression.
Volume: 11
Issue: 8
Pages: 725-33
•
•
•
•
•
Publication
20826699 | J:168659
First Author: Marnef A
Year: 2010
Journal: RNA
Title: Distinct functions of maternal and somatic Pat1 protein paralogs.
Volume: 16
Issue: 11
Pages: 2094-107
•
•
•
•
•
Publication
35803934 | J:345293
First Author: Wei W
Year: 2022
Journal: Nat Commun
Title: TRIM24 is an insulin-responsive regulator of P-bodies.
Volume: 13
Issue: 1
Pages: 3972
•
•
•
•
•
Publication
19114715 | J:147897
First Author: Unhavaithaya Y
Year: 2009
Journal: J Biol Chem
Title: MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation.
Volume: 284
Issue: 10
Pages: 6507-19
•
•
•
•
•
Publication
28254886 | J:243444
First Author: Tarabay Y
Year: 2017
Journal: J Cell Sci
Title: Tex19 paralogs are new members of the piRNA pathway controlling retrotransposon suppression.
Volume: 130
Issue: 8
Pages: 1463-1474
•
•
•
•
•
Publication
23583643 | J:196136
First Author: Vogel KU
Year: 2013
Journal: Immunity
Title: Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation.
Volume: 38
Issue: 4
Pages: 655-68
•
•
•
•
•
Publication
26120033 | J:239655
First Author: Zhou Z
Year: 2015
Journal: Dev Cell
Title: RNA Binding Protein Nanos2 Organizes Post-transcriptional Buffering System to Retain Primitive State of Mouse Spermatogonial Stem Cells.
Volume: 34
Issue: 1
Pages: 96-107
•
•
•
•
•
Publication
15537664 | J:95686
First Author: Keegan CE
Year: 2005
Journal: Hum Mol Genet
Title: Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator.
Volume: 14
Issue: 1
Pages: 113-23
•
•
•
•
•
Publication
29078390 | J:249035
First Author: Kannan M
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy.
Volume: 114
Issue: 44
Pages: E9308-E9317
•
•
•
•
•
Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
•
•
•
•
•
Publication
12477932 | J:82808
First Author: Strausberg RL
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Volume: 99
Issue: 26
Pages: 16899-903
•
•
•
•
•
Publication
- | J:175295
     
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
•
•
•
•
•
Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
•
•
•
•
•
Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
•
•
•
•
•
Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
•
•
•
•
•
Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
•
•
•
•
•
Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
•
•
•
•
•
Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
•
•
•
•
•
Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
•
•
•
•
•
Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
•
•
•
•
•
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
•
•
•
•
•
Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
•
•
•
•
•
Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
22982864 | -
First Author: Gudkova D
Year: 2012
Journal: FEBS Lett
Title: EDC4 interacts with and regulates the dephospho-CoA kinase activity of CoA synthase.
Volume: 586
Issue: 20
Pages: 3590-5
•
•
•
•
•
Publication
25514416 | -
First Author: Rahman H
Year: 2014
Journal: Int J Mol Sci
Title: Crosstalk between Edc4 and mammalian target of rapamycin complex 1 (mTORC1) signaling in mRNA decapping.
Volume: 15
Issue: 12
Pages: 23179-95
•
•
•
•
•
Publication
32510323 | -
   
First Author: Brothers WR
Year: 2020
Journal: Elife
Title: A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay.
Volume: 9
•
•
•
•
•
Publication
25970328 | -
First Author: Seto E
Year: 2015
Journal: PLoS One
Title: The Assembly of EDC4 and Dcp1a into Processing Bodies Is Critical for the Translational Regulation of IL-6.
Volume: 10
Issue: 5
Pages: e0123223
•
•
•
•
•
Allele
Edc4<em1Smoc> | MGI:7289442
Name: enhancer of mRNA decapping 4; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
•
•
•
•
•
Publication
24510189 | -
First Author: Chang CT
Year: 2014
Journal: Nucleic Acids Res
Title: The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1.
Volume: 42
Issue: 8
Pages: 5217-33
•
•
•
•
•
Publication
21655181 | -
First Author: Fan SJ
Year: 2011
Journal: PLoS One
Title: Drosophila Ge-1 promotes P body formation and oskar mRNA localization.
Volume: 6
Issue: 5
Pages: e20612
•
•
•
•
•
Protein Domain
IPR032401 | EDC4_WD40
Type: Domain
Description: This entry represents the N-terminal region of Ge-1, also known as EDC4 (enhancer of mRNA-decapping protein 4). This WD40-repeat region is involved in protein-protein interactions [].
•
•
•
•
•
Protein
F6ZJ27
Organism: Mus musculus/domesticus
Length: 427  
Fragment?: true
•
•
•
•
•
Protein
F6V5I7
Organism: Mus musculus/domesticus
Length: 265  
Fragment?: true
•
•
•
•
•
Publication
17513503 | -
First Author: Goeres DC
Year: 2007
Journal: Plant Cell
Title: Components of the Arabidopsis mRNA decapping complex are required for early seedling development.
Volume: 19
Issue: 5
Pages: 1549-64
•
•
•
•
•
Protein Domain
IPR045152 | EDC4-like
Type: Family
Description: Ge-1, also known as EDC4 (enhancer of mRNA-decapping protein 4), is a regulator of mRNA decapping to function in the mRNA P-bodies within the cytoplasm. It has been shown to interact with mTORC1 [], coenzyme A synthase []and MARF1 []. It is also involved in the regulation of immune system [].This entry also includes EDC4 homologues from fungi and plants [].
•
•
•
•
•
Publication
32366357 | -
   
First Author: Borbolis F
Year: 2020
Journal: Elife
Title: mRNA decapping is an evolutionarily conserved modulator of neuroendocrine signaling that controls development and ageing.
Volume: 9
•
•
•
•
•
Protein Domain
IPR010334 | Dcp1
Type: Family
Description: An essential step in mRNA turnover is decapping. In yeast, two proteins have been identified that are essential for decapping, Dcp1 (this family) and Dcp2. Dcp1 is a coactivator that binds to the decapping enzyme Dcp2 and forms a decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation []. Yeast Dcp1 interact directly with Dcp2, however, the Dcp1-Dcp2 interaction is promoted by an additional factor, EDC4 []. In the nervous system, it promotes neurons' lifespan through the negative regulation of the insulin-like peptide ins-7 expression [].
•
•
•
•
•
Publication
23637887 | J:200561
First Author: Chiang PY
Year: 2013
Journal: PLoS One
Title: Phosphorylation of mRNA decapping protein Dcp1a by the ERK signaling pathway during early differentiation of 3T3-L1 preadipocytes.
Volume: 8
Issue: 4
Pages: e61697
•
•
•
•
•
Protein
D6RE33
Organism: Mus musculus/domesticus
Length: 1318  
Fragment?: false
•
•
•
•
•
Protein
Q3UJB9
Organism: Mus musculus/domesticus
Length: 1406  
Fragment?: false
•
•
•
•
•
Protein
G5E896
Organism: Mus musculus/domesticus
Length: 1406  
Fragment?: false
•
•
•
•
•
Protein
A0A0R4J1Q0
Organism: Mus musculus/domesticus
Length: 1390  
Fragment?: false
•
•
•
•
•
Protein
A0A286YCN4
Organism: Mus musculus/domesticus
Length: 177  
Fragment?: true
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom