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Search results 1 to 100 out of 104 for Edem1

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0.079s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Hosokawa N
Year: 2010
Journal: Glycobiology
Title: EDEM1 accelerates the trimming of alpha1,2-linked mannose on the C branch of N-glycans.
Volume: 20
Issue: 5
Pages: 567-75
Publication
First Author: Calì T
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Segregation and rapid turnover of EDEM1 by an autophagy-like mechanism modulates standard ERAD and folding activities.
Volume: 371
Issue: 3
Pages: 405-10
Publication
First Author: Shenkman M
Year: 2013
Journal: J Biol Chem
Title: A shared endoplasmic reticulum-associated degradation pathway involving the EDEM1 protein for glycosylated and nonglycosylated proteins.
Volume: 288
Issue: 4
Pages: 2167-78
Publication
First Author: Słomińska-Wojewódzka M
Year: 2014
Journal: Biochem J
Title: The role of EDEM2 compared with EDEM1 in ricin transport from the endoplasmic reticulum to the cytosol.
Volume: 457
Issue: 3
Pages: 485-96
Publication
First Author: Hagiwara M
Year: 2011
Journal: Mol Cell
Title: Structural basis of an ERAD pathway mediated by the ER-resident protein disulfide reductase ERdj5.
Volume: 41
Issue: 4
Pages: 432-44
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Hosokawa N
Year: 2001
Journal: EMBO Rep
Title: A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation.
Volume: 2
Issue: 5
Pages: 415-22
Publication
First Author: Molinari M
Year: 2003
Journal: Science
Title: Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle.
Volume: 299
Issue: 5611
Pages: 1397-400
Publication
First Author: Oda Y
Year: 2003
Journal: Science
Title: EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin.
Volume: 299
Issue: 5611
Pages: 1394-7
Publication
First Author: Gnann A
Year: 2004
Journal: Mol Biol Cell
Title: Cystic fibrosis transmembrane conductance regulator degradation depends on the lectins Htm1p/EDEM and the Cdc48 protein complex in yeast.
Volume: 15
Issue: 9
Pages: 4125-35
Publication
First Author: Slominska-Wojewodzka M
Year: 2006
Journal: Mol Biol Cell
Title: EDEM is involved in retrotranslocation of ricin from the endoplasmic reticulum to the cytosol.
Volume: 17
Issue: 4
Pages: 1664-75
GXD Expression    
Probe: MGI:4835320
Assay Type: RT-PCR
Annotation Date: 2010-10-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:4835410
Age: embryonic day 12.5
Image: 2
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4835320
Assay Type: RT-PCR
Annotation Date: 2010-10-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:4835410
Age: embryonic day 12.5
Image: 2
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6274243
Assay Type: RT-PCR
Annotation Date: 2019-01-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6274249
Age: postnatal month 3
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6274243
Assay Type: RT-PCR
Annotation Date: 2019-01-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6274255
Age: postnatal month 3
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6274243
Assay Type: RT-PCR
Annotation Date: 2019-01-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6274261
Age: postnatal month 3
Detected: true
Specimen Num: 1
Publication
First Author: Zhang K
Year: 2006
Journal: Cell
Title: Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response.
Volume: 124
Issue: 3
Pages: 587-99
Publication
First Author: Francisco AB
Year: 2010
Journal: J Biol Chem
Title: Deficiency of suppressor enhancer Lin12 1 like (SEL1L) in mice leads to systemic endoplasmic reticulum stress and embryonic lethality.
Volume: 285
Issue: 18
Pages: 13694-703
Publication
First Author: Posey KL
Year: 2012
Journal: Am J Pathol
Title: Chop (Ddit3) is essential for D469del-COMP retention and cell death in chondrocytes in an inducible transgenic mouse model of pseudoachondroplasia.
Volume: 180
Issue: 2
Pages: 727-37
Publication
First Author: Iwawaki T
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability.
Volume: 106
Issue: 39
Pages: 16657-62
Publication
First Author: Kaneko K
Year: 2016
Journal: Cell Rep
Title: Neuronal Rap1 Regulates Energy Balance, Glucose Homeostasis, and Leptin Actions.
Volume: 16
Issue: 11
Pages: 3003-3015
Publication
First Author: Zhang B
Year: 2011
Journal: Blood
Title: Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin.
Volume: 118
Issue: 12
Pages: 3384-91
Publication
First Author: Tao J
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: SEC23B is required for the maintenance of murine professional secretory tissues.
Volume: 109
Issue: 29
Pages: E2001-9
Publication  
First Author: Zhu M
Year: 2015
Journal: Sci Rep
Title: Neural tube opening and abnormal extraembryonic membrane development in SEC23A deficient mice.
Volume: 5
Pages: 15471
Publication  
First Author: Tian E
Year: 2012
Journal: Nat Commun
Title: O-glycosylation modulates integrin and FGF signalling by influencing the secretion of basement membrane components.
Volume: 3
Pages: 869
Publication
First Author: Song B
Year: 2008
Journal: J Clin Invest
Title: Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes.
Volume: 118
Issue: 10
Pages: 3378-89
Publication
First Author: Wang B
Year: 2018
Journal: J Clin Invest
Title: The COPII cargo adapter SEC24C is essential for neuronal homeostasis.
Volume: 128
Issue: 8
Pages: 3319-3332
Publication
First Author: Sasaki M
Year: 2012
Journal: Genes Dev
Title: D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function.
Volume: 26
Issue: 18
Pages: 2038-49
Publication
First Author: Chu VT
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line.
Volume: 113
Issue: 44
Pages: 12514-12519
Publication
First Author: Flodby P
Year: 2016
Journal: Am J Respir Cell Mol Biol
Title: The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development.
Volume: 55
Issue: 1
Pages: 135-49
Publication      
First Author: The RIKEN BioResource Center
Year: 2006
Journal: Unpublished
Title: Information obtained from The RIKEN BioResource Center
Publication
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 4
Pages: 167-80
Publication      
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
Publication      
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication
First Author: Groisman B
Year: 2011
Journal: J Biol Chem
Title: Mannose trimming is required for delivery of a glycoprotein from EDEM1 to XTP3-B and to late endoplasmic reticulum-associated degradation steps.
Volume: 286
Issue: 2
Pages: 1292-300
Publication
First Author: Cormier JH
Year: 2009
Journal: Mol Cell
Title: EDEM1 recognition and delivery of misfolded proteins to the SEL1L-containing ERAD complex.
Volume: 34
Issue: 5
Pages: 627-33
Interaction Experiment
Description: Tyrosinase Degradation Is Prevented when EDEM1 Lacks the Intrinsically Disordered Region.
Publication  
First Author: Sokołowska I
Year: 2015
Journal: BMC Cell Biol
Title: Hydrophobicity of protein determinants influences the recognition of substrates by EDEM1 and EDEM2 in human cells.
Volume: 16
Pages: 1
Publication
First Author: Marin MB
Year: 2012
Journal: PLoS One
Title: Tyrosinase degradation is prevented when EDEM1 lacks the intrinsically disordered region.
Volume: 7
Issue: 8
Pages: e42998
Publication
First Author: Pfeiffer A
Year: 2016
Journal: J Biol Chem
Title: A Complex of Htm1 and the Oxidoreductase Pdi1 Accelerates Degradation of Misfolded Glycoproteins.
Volume: 291
Issue: 23
Pages: 12195-207
Publication
First Author: Hüttner S
Year: 2014
Journal: Plant Cell
Title: Arabidopsis Class I α-Mannosidases MNS4 and MNS5 Are Involved in Endoplasmic Reticulum-Associated Degradation of Misfolded Glycoproteins.
Volume: 26
Issue: 4
Pages: 1712-1728
Protein Domain
Type: Family
Description: This entry represents a group of alpha-1,2-specific exomannosidases that are involved in endoplasmic reticulum-associated degradation (ERAD), including EDEM1/2/3 from humans, Mnl1 from yeasts and MNS4/5 from Arabidopsis. Mnl1 forms a complex with Pdi1 to process unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response []. In humans, mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 is performed mainly by EDEM3 and to a lesser extent by EDEM1, while EDEM2 catalyses the first mannose trimming step from Man9GlcNAc2 []. EDEM1 has been shown to recognise and deliver misfolded proteins to the SEL1L-containing ERAD complex []. MNS4/5 function in the formation of unique N-glycan structures that are specifically recognized by components of the endoplasmic reticulum-associated degradation (ERAD) machinery, which leads to the degradation of misfolded glycoproteins [].
Publication
First Author: Das I
Year: 2013
Journal: J Exp Med
Title: Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins.
Volume: 210
Issue: 6
Pages: 1201-16
Publication
First Author: Ninagawa S
Year: 2014
Journal: J Cell Biol
Title: EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step.
Volume: 206
Issue: 3
Pages: 347-56
Protein
Organism: Mus musculus
Length: 931  
Fragment?: false
Protein
Organism: Mus musculus
Length: 577  
Fragment?: false
Protein
Organism: Mus musculus
Length: 652  
Fragment?: false
Protein
Organism: Mus musculus
Length: 917  
Fragment?: false
Protein
Organism: Mus musculus
Length: 913  
Fragment?: false
Protein
Organism: Mus musculus
Length: 674  
Fragment?: true
Protein
Organism: Mus musculus
Length: 947  
Fragment?: false
Protein
Organism: Mus musculus
Length: 539  
Fragment?: false
Protein
Organism: Mus musculus
Length: 306  
Fragment?: true