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Search results 1 to 100 out of 597 for Eed

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Type Details Score
Gene
8726 | EED
Type: gene
Organism: human
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Gene
466901 | EED
Type: gene
Organism: chimpanzee
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Gene
404183 | EED
Type: gene
Organism: cattle
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Gene
426381 | EED
Type: gene
Organism: chicken
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Gene
550463 | eed
Type: gene
Organism: zebrafish
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Gene
703866 | EED
Type: gene
Organism: macaque, rhesus
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Gene
550079 | eed
Type: gene
Organism: frog, western clawed
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Gene
293104 | Eed
Type: gene
Organism: rat
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Gene
476779 | EED
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:95286 | Eed
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
266694 | EEDP1
Type: gene
Organism: human
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GXD Expression
GXD Expression
 
Probe: MGI:27136
Assay Type: RNA in situ
Annotation Date: 2020-02-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3116917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6391092
Age: embryonic day 10.5
Image: 6B Eed E10.5 (left) WT
Specimen Label: 6B Eed E10.5 (left) WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:27136
Assay Type: RNA in situ
Annotation Date: 2020-02-20
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3116917
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6391092
Age: embryonic day 10.5
Image: 6B Eed E10.5 (right) Pbx1-/-;Pbx1+/-
Note: Expression severely reduced posteriorly.
Specimen Label: 6B Eed E10.5 (right) Pbx1-/-;Pbx1+/-
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:27136
Assay Type: RNA in situ
Annotation Date: 2020-02-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1646917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6391092
Age: embryonic day 10.5
Image: 6B Eed E10.5 (left) WT
Note: Expression in neurectoderm.
Specimen Label: 6B Eed E10.5 (left) WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:27136
Assay Type: RNA in situ
Annotation Date: 2020-02-20
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1646917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6391092
Age: embryonic day 10.5
Image: 6B Eed E10.5 (left) Pbx1-/-;Pbx2+/-
Note: Expression severely reduced in neurectoderm.
Specimen Label: 6B Eed E10.5 (left) Pbx1-/-;Pbx2+/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:27136
Assay Type: RNA in situ
Annotation Date: 2020-02-20
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3116917
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6391092
Age: embryonic day 10.5
Image: 6B Eed E10.5 (left) Pbx1-/-;Pbx2+/-
Note: Expression severely reduced posteriorly.
Specimen Label: 6B Eed E10.5 (left) Pbx1-/-;Pbx2+/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:27136
Assay Type: RNA in situ
Annotation Date: 2020-02-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3116917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6391092
Age: embryonic day 10.5
Image: 6B Eed E10.5 (right) WT
Specimen Label: 6B Eed E10.5 (right) WT
Detected: true
Specimen Num: 3
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Publication
15916951 | J:99186
First Author: Montgomery ND
Year: 2005
Journal: Curr Biol
Title: The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation.
Volume: 15
Issue: 10
Pages: 942-7
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Publication
17997413 | J:166345
First Author: Montgomery ND
Year: 2007
Journal: J Mol Biol
Title: Molecular and functional mapping of EED motifs required for PRC2-dependent histone methylation.
Volume: 374
Issue: 5
Pages: 1145-57
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Publication
18201968 | J:137700
First Author: Ura H
Year: 2008
Journal: J Biol Chem
Title: STAT3 and Oct-3/4 control histone modification through induction of Eed in embryonic stem cells.
Volume: 283
Issue: 15
Pages: 9713-23
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Publication
12370779 | J:78736
First Author: Wang J
Year: 2002
Journal: Mamm Genome
Title: The mouse PcG gene eed is required for Hox gene repression and extraembryonic development.
Volume: 13
Issue: 9
Pages: 493-503
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Publication
17259173 | J:121147
First Author: Kim SY
Year: 2007
Journal: J Biol Chem
Title: Developmental regulation of Eed complex composition governs a switch in global histone modification in brain.
Volume: 282
Issue: 13
Pages: 9962-72
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Publication
16415857 | J:129406
First Author: Kalantry S
Year: 2006
Journal: Nat Cell Biol
Title: The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation.
Volume: 8
Issue: 2
Pages: 195-202
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Publication
9742080 | J:200345
First Author: Denisenko O
Year: 1998
Journal: Mol Cell Biol
Title: Point mutations in the WD40 domain of Eed block its interaction with Ezh2.
Volume: 18
Issue: 10
Pages: 5634-42
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Publication
20064375 | J:157630
First Author: Peng JC
Year: 2009
Journal: Cell
Title: Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells.
Volume: 139
Issue: 7
Pages: 1290-302
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Publication
30005706 | J:289621
First Author: Prokopuk L
Year: 2018
Journal: Clin Epigenetics
Title: Loss of maternal EED results in postnatal overgrowth.
Volume: 10
Issue: 1
Pages: 95
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Publication
7768172 | J:23134
First Author: Faust C
Year: 1995
Journal: Development
Title: The eed mutation disrupts anterior mesoderm production in mice.
Volume: 121
Issue: 2
Pages: 273-85
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Publication
27432459 | J:250153
 
First Author: Ikeda K
Year: 2016
Journal: Sci Rep
Title: Maintenance of the functional integrity of mouse hematopoiesis by EED and promotion of leukemogenesis by EED haploinsufficiency.
Volume: 6
Pages: 29454
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Publication
28394251 | J:256950
   
First Author: Ai S
Year: 2017
Journal: Elife
Title: EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent.
Volume: 6
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Publication
11803473 | J:74380
First Author: Richie ER
Year: 2002
Journal: Oncogene
Title: The Polycomb-group gene eed regulates thymocyte differentiation and suppresses the development of carcinogen-induced T-cell lymphomas.
Volume: 21
Issue: 2
Pages: 299-306
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Publication
31204298 | J:295277
First Author: Liu PP
Year: 2019
Journal: Stem Cell Reports
Title: Polycomb Protein EED Regulates Neuronal Differentiation through Targeting SOX11 in Hippocampal Dentate Gyrus.
Volume: 13
Issue: 1
Pages: 115-131
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Publication
18511907 | J:137619
First Author: Shibata S
Year: 2008
Journal: EMBO J
Title: Synergy of Eed and Tsix in the repression of Xist gene and X-chromosome inactivation.
Volume: 27
Issue: 13
Pages: 1816-26
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Publication
9778508 | J:50351
First Author: Faust C
Year: 1998
Journal: Development
Title: The Polycomb-group gene eed is required for normal morphogenetic movements during gastrulation in the mouse embryo.
Volume: 125
Issue: 22
Pages: 4495-506
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Publication
29415247 | J:259671
First Author: Sun B
Year: 2018
Journal: Cereb Cortex
Title: Polycomb Protein Eed is Required for Neurogenesis and Cortical Injury Activation in the Subventricular Zone.
Volume: 28
Issue: 4
Pages: 1369-1382
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Publication
26118502 | J:230773
First Author: Danis E
Year: 2015
Journal: Exp Hematol
Title: Inactivation of Eed impedes MLL-AF9-mediated leukemogenesis through Cdkn2a-dependent and Cdkn2a-independent mechanisms in a murine model.
Volume: 43
Issue: 11
Pages: 930-935.e6
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Publication
10541555 | J:58294
First Author: Lessard J
Year: 1999
Journal: Genes Dev
Title: Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation.
Volume: 13
Issue: 20
Pages: 2691-703
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Publication
20080539 | J:245374
First Author: Philipp S
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase.
Volume: 107
Issue: 3
Pages: 1112-7
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Publication
35679863 | J:326056
First Author: Lowe MG
Year: 2022
Journal: Dev Cell
Title: EED is required for mouse primordial germ cell differentiation in the embryonic gonad.
Volume: 57
Issue: 12
Pages: 1482-1495.e5
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Publication
29310022 | J:318489
 
First Author: Naito T
Year: 2018
Journal: Mol Immunol
Title: Loss of Eed leads to lineage instability and increased CD8 expression of mouse CD4+ T cells upon TGFβ signaling.
Volume: 94
Pages: 140-152
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Publication
28406475 | J:253374
First Author: Yu W
Year: 2017
Journal: Cell Death Dis
Title: Depletion of polycomb repressive complex 2 core component EED impairs fetal hematopoiesis.
Volume: 8
Issue: 4
Pages: e2744
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Publication
16680199 | J:115851
First Author: Kalantry S
Year: 2006
Journal: PLoS Genet
Title: The Polycomb group protein EED is dispensable for the initiation of random X-chromosome inactivation.
Volume: 2
Issue: 5
Pages: e66
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Publication
23671187 | J:204480
First Author: Saha B
Year: 2013
Journal: Mol Cell Biol
Title: EED and KDM6B coordinate the first mammalian cell lineage commitment to ensure embryo implantation.
Volume: 33
Issue: 14
Pages: 2691-705
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Publication
27578866 | J:238281
First Author: Ueda T
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Propagation of trimethylated H3K27 regulated by polycomb protein EED is required for embryogenesis, hematopoietic maintenance, and tumor suppression.
Volume: 113
Issue: 37
Pages: 10370-5
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Publication
9234727 | J:41659
First Author: Denisenko ON
Year: 1997
Journal: Mol Cell Biol
Title: The product of the murine homolog of the Drosophila extra sex combs gene displays transcriptional repressor activity.
Volume: 17
Issue: 8
Pages: 4707-17
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GXD Expression
GXD Expression
Probe: MGI:7495820
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-06
Strength: Trace
Sex: Not Specified
Emaps: EMAPS:318643
Pattern: Not Specified
Stage: TS03
Assay Id: MGI:7495828
Age: embryonic day 2.0
Image: 2-S1B 4-cell m-/-
Note: Zygotic Eed transcription initiated (summarized in 2C and 2E).
Specimen Label: 2-S1B 4-cell m-/-
Detected: true
Specimen Num: 13
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Publication
11479595 | J:70724
First Author: Wang J
Year: 2001
Journal: Nat Genet
Title: Imprinted X inactivation maintained by a mouse Polycomb group gene.
Volume: 28
Issue: 4
Pages: 371-5
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Publication
8805699 | J:35419
First Author: Shumacher A
Year: 1996
Journal: Nature
Title: Positional cloning of a global regulator of anterior-posterior patterning in mice.
Volume: 383
Issue: 6597
Pages: 250-3
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Publication
12627233 | J:82790
First Author: Mager J
Year: 2003
Journal: Nat Genet
Title: Genome imprinting regulated by the mouse Polycomb group protein Eed.
Volume: 33
Issue: 4
Pages: 502-7
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Publication
12649488 | J:82788
First Author: Plath K
Year: 2003
Journal: Science
Title: Role of histone H3 lysine 27 methylation in X inactivation.
Volume: 300
Issue: 5616
Pages: 131-5
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Publication
18480470 | J:139777
First Author: Monk D
Year: 2008
Journal: Genome Res
Title: Comparative analysis of human chromosome 7q21 and mouse proximal chromosome 6 reveals a placental-specific imprinted gene, TFPI2/Tfpi2, which requires EHMT2 and EED for allelic-silencing.
Volume: 18
Issue: 8
Pages: 1270-81
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Publication
17937919 | J:247419
First Author: Han Z
Year: 2007
Journal: Structure
Title: Structural basis of EZH2 recognition by EED.
Volume: 15
Issue: 10
Pages: 1306-15
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GXD Expression
GXD Expression
Probe: MGI:7495820
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Pattern: Not Specified
Stage: TS03
Assay Id: MGI:7495828
Age: embryonic day 2.0
Image: 2-S1B 4-cell fl/- or -/-
Note: A subset of embryos displayed reduced Eed and H3K27me3 levels (summarized in 2C and 2E).
Specimen Label: 2-S1B 4-cell fl/- or -/-
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
   
Probe: MGI:7495820
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-06
Strength: Absent
Sex: Male
Emaps: EMAPS:360354
Stage: TS04
Assay Id: MGI:7495828
Age: embryonic day 3.0-3.5
Note: No enrichment of Eed or H3K27me3 in the nucleus, as in the WT male embryos.
Specimen Label: not shown
Detected: false
Specimen Num: 6
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GXD Expression
GXD Expression
Probe: MGI:7495820
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160404
Pattern: Not Specified
Stage: TS04
Assay Id: MGI:7495828
Age: embryonic day 3.0
Image: 2B 16-cell fl/-
Note: Statistically indistinguishable from Eed fl/fl embryos (summarized in 2C and 2E).
Specimen Label: 2B 16-cell fl/-
Detected: true
Specimen Num: 20
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GXD Expression
GXD Expression
Probe: MGI:7495820
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160404
Pattern: Not Specified
Stage: TS04
Assay Id: MGI:7495828
Age: embryonic day 3.0
Image: 2B 16-cell -/-
Note: Expressed at a lower levels compared with the Eed fl/fl controls (summarized in 2C and 2E).
Specimen Label: 2B 16-cell -/-
Detected: true
Specimen Num: 21
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GXD Expression
GXD Expression
Probe: MGI:7495820
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Not Specified
Stage: TS02
Assay Id: MGI:7495828
Age: embryonic day 1.0
Image: 2A 2-cell fl/- or -/-
Note: Exhibited similar levels of Eed and H3K27me3 as in the control (summarized in 2C and 2E).
Specimen Label: 2A 2-cell fl/- or -/-
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:7495820
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-06
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:7495828
Age: embryonic day 1.0
Image: 2A 2-cell m-/-
Note: Devoid of both Eed and H3K27me3 (summarized in 2C and 2E).
Specimen Label: 2A 2-cell m-/-
Detected: false
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:7495820
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-06
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160362
Stage: TS02
Assay Id: MGI:7495828
Age: embryonic day 1.0
Image: 2A 2-cell mz-/-
Note: Devoid of both Eed and H3K27me3 (summarized in 2C and 2E).
Specimen Label: 2A 2-cell mz-/-
Detected: false
Specimen Num: 10
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Publication
14671313 | J:93084
First Author: Okamoto I
Year: 2004
Journal: Science
Title: Epigenetic dynamics of imprinted X inactivation during early mouse development.
Volume: 303
Issue: 5658
Pages: 644-9
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GXD Expression
GXD Expression
Probe: MGI:7495820
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318653
Pattern: Not Specified
Stage: TS03
Assay Id: MGI:7495828
Age: embryonic day 2.5
Image: 2-S1B 8-cell fl/- or -/-
Note: Highly variable Eed and H3K27me3 levels, suggesting further differentiation of the two genotypes (summarized in 2C and 2E).
Specimen Label: 2-S1B 8-cell fl/- or -/-
Detected: true
Specimen Num: 16
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GXD Expression
GXD Expression
 
Probe: MGI:7495820
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-06
Strength: Absent
Sex: Female
Emaps: EMAPS:360354
Stage: TS04
Assay Id: MGI:7495828
Age: embryonic day 3.0-3.5
Image: 1B -/-
Note: Devoid of Eed or H3K27me3 enrichment overlapping with the Xist RNA coat (9 out of 41 female embryos).
Specimen Label: 1B -/-
Detected: false
Specimen Num: 4
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Publication
30463900 | J:272571
First Author: Inoue A
Year: 2018
Journal: Genes Dev
Title: Maternal Eed knockout causes loss of H3K27me3 imprinting and random X inactivation in the extraembryonic cells.
Volume: 32
Issue: 23-24
Pages: 1525-1536
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GXD Expression
GXD Expression
Probe: MGI:7495820
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-06
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:318653
Pattern: Not Specified
Stage: TS03
Assay Id: MGI:7495828
Age: embryonic day 2.5
Image: 2-S1B 8-cell m-/-
Note: In agreement with increasing zygotic Eed expression, Eed m-/- embryos displayed higher levels of Eed and H3K27me3 than the corresponding Eed mz-/- embryos (summarized in 2C and 2E).
Specimen Label: 2-S1B 8-cell m-/-
Detected: true
Specimen Num: 17
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GXD Expression
GXD Expression
Probe: MGI:7495820
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-06
Strength: Present
Sex: Female
Emaps: EMAPS:360354
Pattern: Not Specified
Stage: TS04
Assay Id: MGI:7495828
Age: embryonic day 3.0-3.5
Image: 1B +/-
Note: Coincident accumulation of Eed and/or H3K27me3 with Xist RNA in over 70% of the nuclei (9 out of 41 female embryos), similar as in the wild-type female.
Specimen Label: 1B +/-
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:7495820
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-06
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:160404
Pattern: Not Specified
Stage: TS04
Assay Id: MGI:7495828
Age: embryonic day 3.0
Image: 2B 16-cell m-/-
Note: Continued to display higher levels of Eed and H3K27me3 than the Eed mz-/- embryos, but lower levels than Eed fl/fl embryos (summarized in 2C and 2E).
Specimen Label: 2B 16-cell m-/-
Detected: true
Specimen Num: 22
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GXD Expression
GXD Expression
 
Probe: MGI:7495820
Assay Type: Immunohistochemistry
Annotation Date: 2023-07-06
Strength: Present
Sex: Female
Emaps: EMAPS:360354
Pattern: Not Specified
Stage: TS04
Assay Id: MGI:7495828
Age: embryonic day 3.0-3.5
Note: 23 out of 41 female embryos displayed 2-70% of nuclei with Eed and/or H3K27me3 enrichment, likely representing Eed+/- or Eed-/- embryos that had not yet fully depleted maternally-inherited Eed protein or Eed+/- embryos which had not yet robustly expressed zygotic Eed.
Specimen Label: not shown
Detected: true
Specimen Num: 5
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Protein
A0A140LIN6
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: true
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Protein
Q921E6
Organism: Mus musculus/domesticus
Length: 441  
Fragment?: false
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Protein
A0A5F8MPX8
Organism: Mus musculus/domesticus
Length: 500  
Fragment?: false
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Protein
A0A140LIG5
Organism: Mus musculus/domesticus
Length: 220  
Fragment?: true
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Publication
20144788 | J:157068
First Author: Walker E
Year: 2010
Journal: Cell Stem Cell
Title: Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation.
Volume: 6
Issue: 2
Pages: 153-66
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Publication
29945864 | J:264141
 
First Author: Zhang L
Year: 2018
Journal: Development
Title: EED, a member of the polycomb group, is required for nephron differentiation and the maintenance of nephron progenitor cells.
Volume: 145
Issue: 14
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Publication
30306639 | J:267339
First Author: Ma KH
Year: 2018
Journal: Glia
Title: Polycomb repression regulates Schwann cell proliferation and axon regeneration after nerve injury.
Volume: 66
Issue: 11
Pages: 2487-2502
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Publication
26041929 | J:222233
First Author: Ma KH
Year: 2015
Journal: J Neurosci
Title: Regulation of Peripheral Nerve Myelin Maintenance by Gene Repression through Polycomb Repressive Complex 2.
Volume: 35
Issue: 22
Pages: 8640-52
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Publication
28468635 | J:244701
First Author: Maclary E
Year: 2017
Journal: Genome Biol
Title: PRC2 represses transcribed genes on the imprinted inactive X chromosome in mice.
Volume: 18
Issue: 1
Pages: 82
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Publication
17906077 | J:130038
First Author: Sauvageau M
Year: 2008
Journal: Blood
Title: Quantitative expression profiling guided by common retroviral insertion sites reveals novel and cell type specific cancer genes in leukemia.
Volume: 111
Issue: 2
Pages: 790-9
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Publication
12095683 | J:77932
First Author: Showell C
Year: 2002
Journal: Gene
Title: Identification of putative interaction partners for the Xenopus Polycomb-group protein Xeed.
Volume: 291
Issue: 1-2
Pages: 95-104
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Publication
17804093 | J:127066
First Author: Roy N
Year: 2007
Journal: Biochim Biophys Acta
Title: The transcriptional repression by NIPP1 is mediated by Polycomb group proteins.
Volume: 1769
Issue: 9-10
Pages: 541-5
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Publication
1684331 | J:2961
First Author: Sharan SK
Year: 1991
Journal: Genetics
Title: The albino-deletion complex of the mouse: molecular mapping of deletion breakpoints that define regions necessary for development of the embryonic and extraembryonic ectoderm.
Volume: 129
Issue: 3
Pages: 825-32
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Publication
30938678 | J:275851
   
First Author: Harris C
Year: 2019
Journal: Elife
Title: Conversion of random X-inactivation to imprinted X-inactivation by maternal PRC2.
Volume: 8
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Publication
32851157 | J:314186
First Author: Wang J
Year: 2020
Journal: Sci Adv
Title: EED-mediated histone methylation is critical for CNS myelination and remyelination by inhibiting WNT, BMP, and senescence pathways.
Volume: 6
Issue: 33
Pages: eaaz6477
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Publication
8358168 | J:12917
First Author: Rinchik EM
Year: 1993
Journal: Mamm Genome
Title: N-ethyl-N-nitrosourea-induced prenatally lethal mutations define at least two complementation groups within the embryonic ectoderm development (eed) locus in mouse chromosome 7.
Volume: 4
Issue: 7
Pages: 349-53
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Publication
25228648 | J:213769
First Author: Mu W
Year: 2014
Journal: Genes Dev
Title: Repression of the soma-specific transcriptome by Polycomb-repressive complex 2 promotes male germ cell development.
Volume: 28
Issue: 18
Pages: 2056-69
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Publication
15385962 | J:93307
First Author: Pasini D
Year: 2004
Journal: EMBO J
Title: Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity.
Volume: 23
Issue: 20
Pages: 4061-71
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Publication
24239285 | J:205522
First Author: Xie H
Year: 2014
Journal: Cell Stem Cell
Title: Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner.
Volume: 14
Issue: 1
Pages: 68-80
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Publication
28223321 | J:241294
First Author: Vasanthakumar A
Year: 2017
Journal: EMBO Rep
Title: A non-canonical function of Ezh2 preserves immune homeostasis.
Volume: 18
Issue: 4
Pages: 619-631
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Publication
35731926 | J:327858
First Author: Yi J
Year: 2022
Journal: Cancer Res
Title: PRC2 Heterogeneity Drives Tumor Growth in Medulloblastoma.
Volume: 82
Issue: 16
Pages: 2874-2886
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Publication
21540835 | J:173167
First Author: Ura H
Year: 2011
Journal: EMBO J
Title: Eed/Sox2 regulatory loop controls ES cell self-renewal through histone methylation and acetylation.
Volume: 30
Issue: 11
Pages: 2190-204
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Publication
26766588 | J:231322
First Author: Serresi M
Year: 2016
Journal: Cancer Cell
Title: Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer.
Volume: 29
Issue: 1
Pages: 17-31
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Publication
15733677 | J:96532
First Author: Nolen LD
Year: 2005
Journal: Dev Biol
Title: X chromosome reactivation and regulation in cloned embryos.
Volume: 279
Issue: 2
Pages: 525-40
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Publication
35245348 | J:321834
 
First Author: Yaghmaeian Salmani B
Year: 2022
Journal: Development
Title: Selective requirement for polycomb repressor complex 2 in the generation of specific hypothalamic neuronal subtypes.
Volume: 149
Issue: 5
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Publication
27329220 | J:240073
 
First Author: Mirzamohammadi F
Year: 2016
Journal: Nat Commun
Title: Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling.
Volume: 7
Pages: 12047
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Publication
28072869 | -
First Author: Li L
Year: 2017
Journal: PLoS One
Title: Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED.
Volume: 12
Issue: 1
Pages: e0169855
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Publication
12408863 | -
First Author: Czermin B
Year: 2002
Journal: Cell
Title: Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites.
Volume: 111
Issue: 2
Pages: 185-96
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Publication
12408864 | -
First Author: Müller J
Year: 2002
Journal: Cell
Title: Histone methyltransferase activity of a Drosophila Polycomb group repressor complex.
Volume: 111
Issue: 2
Pages: 197-208
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Publication
18276122 | -
First Author: Ohno K
Year: 2008
Journal: Mech Dev
Title: ESC, ESCL and their roles in Polycomb Group mechanisms.
Volume: 125
Issue: 5-6
Pages: 527-41
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Protein Domain
IPR037352 | Polycomb_EED
Type: Family
Description: The WD40 domain-containing protein EED is the regulatory subunit of Polycomb repressive complex 2 (PRC2) [, ], which mediates gene silencing primarily through methylation of lysine-27 of histone H3 []. The core subunits of the complex in mammals include EED, EZH2, SUZ12 and RBBP4. PRC2 is well conserved throughout evolution. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12 [, ]. Drosophila has two copies of the Eed homologue, Esc and Esc-like [].
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Publication
7558026 | J:27749
First Author: Holdener BC
Year: 1995
Journal: Genomics
Title: Physical localization of eed: a region of mouse chromosome 7 required for gastrulation.
Volume: 27
Issue: 3
Pages: 447-56
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UniProt Feature
UniProt Feature
Begin: 2
Description: Polycomb protein EED
Type: chain
End: 441
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Publication
7767008 | J:22809
First Author: Potter MD
Year: 1995
Journal: Mamm Genome
Title: Genetic and physical mapping of the fitness 1 (fit1) locus within the Fes-Hbb region of mouse chromosome 7.
Volume: 6
Issue: 2
Pages: 70-5
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