|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 130 for Eef2

<< First    < Previous  |  Next >    Last >>
0.021s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Danio rerio
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Demeulder B
Year: 2013
Journal: Biochim Biophys Acta
Title: Differential regulation of eEF2 and p70S6K by AMPKalpha2 in heart.
Volume: 1832
Issue: 6
Pages: 780-90
Publication  
First Author: Gosrani SP
Year: 2020
Journal: Neurobiol Aging
Title: Repression of eEF2 kinase improves deficits in novel object recognition memory in aged mice.
Volume: 95
Pages: 154-160
Publication
First Author: Webb TR
Year: 2008
Journal: J Cell Sci
Title: Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development.
Volume: 121
Issue: Pt 19
Pages: 3140-5
Publication
First Author: Gerashchenko MV
Year: 2020
Journal: Sci Rep
Title: Translation elongation factor 2 depletion by siRNA in mouse liver leads to mTOR-independent translational upregulation of ribosomal protein genes.
Volume: 10
Issue: 1
Pages: 15473
Publication
First Author: Liu S
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development.
Volume: 109
Issue: 34
Pages: 13817-22
Publication
First Author: Chen PJ
Year: 2012
Journal: EMBO J
Title: CPEB2-eEF2 interaction impedes HIF-1α RNA translation.
Volume: 31
Issue: 4
Pages: 959-71
Publication
First Author: Takei N
Year: 2009
Journal: J Biol Chem
Title: Brain-derived neurotrophic factor enhances the basal rate of protein synthesis by increasing active eukaryotic elongation factor 2 levels and promoting translation elongation in cortical neurons.
Volume: 284
Issue: 39
Pages: 26340-8
Publication
First Author: González-Terán B
Year: 2013
Journal: J Clin Invest
Title: Eukaryotic elongation factor 2 controls TNF-α translation in LPS-induced hepatitis.
Volume: 123
Issue: 1
Pages: 164-78
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Ishiura M
Year: 1989
Journal: Gene
Title: Simplified cosmid vectors for gene transfer to cultured mammalian cells: isolation of the gene for elongation factor 2 from the mouse.
Volume: 85
Issue: 2
Pages: 427-33
Publication
First Author: Brown TL
Year: 1994
Journal: Arch Biochem Biophys
Title: Identification of a 100-kDa phosphoprotein in developing murine embryos as elongation factor 2.
Volume: 309
Issue: 1
Pages: 105-10
Publication
First Author: Satyamoorthy K
Year: 1997
Journal: DNA Cell Biol
Title: The mouse elongation factor-2 gene: isolation and characterization of the promoter.
Volume: 16
Issue: 4
Pages: 401-12
GXD Expression      
Probe: MGI:3836759
Assay Type: Northern blot
Annotation Date: 2009-03-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:3836766
Age: embryonic day 13.0
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3836759
Assay Type: Northern blot
Annotation Date: 2009-03-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:3836766
Age: embryonic day 15.0
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3836759
Assay Type: Northern blot
Annotation Date: 2009-03-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:3836766
Age: embryonic day 18.0
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3836759
Assay Type: Northern blot
Annotation Date: 2009-03-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3836766
Age: postnatal day 5
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3836759
Assay Type: Northern blot
Annotation Date: 2009-03-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3836766
Age: postnatal day 10
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3836759
Assay Type: Northern blot
Annotation Date: 2009-03-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3836766
Age: postnatal day 15
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3836759
Assay Type: Northern blot
Annotation Date: 2009-03-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3836766
Age: postnatal day 20
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3836759
Assay Type: Northern blot
Annotation Date: 2009-03-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3836766
Age: postnatal day 50
Detected: true
Specimen Num: 8
Publication
First Author: Sakagami H
Year: 2002
Journal: Neurosci Lett
Title: Transient up-regulation of elongation factor-2 kinase (Ca2+/calmodulin-dependent protein kinase III) messenger RNA in developing mouse brain.
Volume: 330
Issue: 1
Pages: 41-4
Publication
First Author: Im HI
Year: 2009
Journal: PLoS One
Title: Post-training dephosphorylation of eEF-2 promotes protein synthesis for memory consolidation.
Volume: 4
Issue: 10
Pages: e7424
Publication
First Author: Bohnsack MT
Year: 2002
Journal: EMBO J
Title: Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.
Volume: 21
Issue: 22
Pages: 6205-15
Publication
First Author: Liu S
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Solid tumor therapy by selectively targeting stromal endothelial cells.
Volume: 113
Issue: 28
Pages: E4079-87
Publication
First Author: Burnicka-Turek O
Year: 2009
Journal: Endocrinology
Title: Inactivation of insulin-like factor 6 disrupts the progression of spermatogenesis at late meiotic prophase.
Volume: 150
Issue: 9
Pages: 4348-57
Publication
First Author: Fakruddin M
Year: 2018
Journal: Cell Rep
Title: Defective Mitochondrial tRNA Taurine Modification Activates Global Proteostress and Leads to Mitochondrial Disease.
Volume: 22
Issue: 2
Pages: 482-496
Publication
First Author: Chu CC
Year: 1998
Journal: Mol Immunol
Title: Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis.
Volume: 35
Issue: 8
Pages: 487-502
Publication
First Author: Kraushar ML
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Temporally defined neocortical translation and polysome assembly are determined by the RNA-binding protein Hu antigen R.
Volume: 111
Issue: 36
Pages: E3815-24
Publication
First Author: Maggi LB Jr
Year: 2008
Journal: Mol Cell Biol
Title: Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome.
Volume: 28
Issue: 23
Pages: 7050-65
Publication
First Author: Cai J
Year: 2005
Journal: Hum Mol Genet
Title: Gene expression in pharyngeal arch 1 during human embryonic development.
Volume: 14
Issue: 7
Pages: 903-12
Publication
First Author: Trinidad JC
Year: 2006
Journal: Mol Cell Proteomics
Title: Comprehensive identification of phosphorylation sites in postsynaptic density preparations.
Volume: 5
Issue: 5
Pages: 914-22
Publication
First Author: Guo Y
Year: 2009
Journal: PLoS One
Title: Relationships between hematopoiesis and hepatogenesis in the midtrimester fetal liver characterized by dynamic transcriptomic and proteomic profiles.
Volume: 4
Issue: 10
Pages: e7641
Publication
First Author: Nagamachi A
Year: 2013
Journal: Cancer Cell
Title: Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.
Volume: 24
Issue: 3
Pages: 305-17
Publication
First Author: Lo JC
Year: 2012
Journal: PLoS Genet
Title: RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly.
Volume: 8
Issue: 10
Pages: e1002969
Publication
First Author: Ko MS
Year: 1998
Journal: Hum Mol Genet
Title: Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome.
Volume: 7
Issue: 12
Pages: 1967-78
Publication      
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication          
First Author: MGD Nomenclature Committee
Year: 1995
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Protein
Organism: Mus musculus
Length: 287  
Fragment?: true
Protein
Organism: Mus musculus
Length: 843  
Fragment?: true
Publication
First Author: Beckelman BC
Year: 2019
Journal: J Clin Invest
Title: Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer's disease model mice.
Volume: 129
Issue: 2
Pages: 820-833
Publication
First Author: Delaidelli A
Year: 2017
Journal: Cell Death Differ
Title: MYCN amplified neuroblastoma requires the mRNA translation regulator eEF2 kinase to adapt to nutrient deprivation.
Volume: 24
Issue: 9
Pages: 1564-1576
Publication
First Author: Hayes H
Year: 1996
Journal: Cytogenet Cell Genet
Title: Localization of ZNF164, ZNF146, GGTA1, SOX2, PRLR and EEF2 on homoeologous cattle, sheep and goat chromosomes by fluorescent in situ hybridization and comparison with the human gene map.
Volume: 72
Issue: 4
Pages: 342-6
Publication
First Author: Spahn CM
Year: 2004
Journal: EMBO J
Title: Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation.
Volume: 23
Issue: 5
Pages: 1008-19
DO Term
GO Term
Publication
First Author: Um JW
Year: 2013
Journal: Neuron
Title: Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein.
Volume: 79
Issue: 5
Pages: 887-902
Protein Domain
Type: Family
Description: Eukaryotic eIF-5A was initially thought to function as a translation initiation factor, based on its ability to stimulate methionyl-puromycin synthesis. However, subsequent work revealed a role for eIF5A in translation elongation [, ]. Depletion or inactivation of eIF-5A in the yeast Saccharomyces cerevisiae (Baker's yeast) resulted in the accumulation of polysomes and an increase in ribosomal transit times. Addition of recombinant eIF-5A from yeast, but not a derivative lacking hypusine, enhanced the rate of tripeptide synthesis in vitro. Moreover, inactivation of eIF-5A mimicked the effects of the eEF2 inhibitor sordarin, indicating that eIF-5A might function together with eEF2 to promote ribosomal translocation. Finally, it was shown that eIF5A is specifically required to promote peptide-bond formation between consecutive proline residues. It has been proposed to stimulate the peptidyl-transferase activity of the ribosome and facilitate the reactivity of poor substrates like proline [].eIF-5A is a cofactor for the Rev and Rex transactivator proteins of human immunodeficiency virus-1 and T-cell leukaemia virus I, respectively [, , ]. IF-5A is the sole protein in eukaryotes and archaea to contain the unusual amino acid hypusine (Ne-(4-amino-2-hydroxybutyl)lysine) that is an absolute functional requirement. The first step in the post-translational modification of lysine to hypusine is catalyzed by the enzyme deoxyhypusine synthase, the structure of which has been reported []. The archaeal IF-5A proteins have not been studied as comprehensively as their eukaryotic homologues, though the crystal structure of the Pyrobaculum aerophilum protein has been determined. Unmodified P. aerophilum IF-5A is found to be a beta structure with two domains and three separate hydrophobic cores. The lysine (Lys42) that is post-translationally modified by deoxyhypusine synthase is found at one end of the IF-5A molecule in a turn between beta strands beta4 and beta5; this lysine residue is freely solvent accessible. The C-terminal domain is found to be homologous to the cold-shock protein CspA of E. coli, which has a well characterised RNA-binding fold, suggesting that IF-5A is involved in RNA binding [].This entry represents the archaeal IF-5A proteins.
HT Experiment
Series Id: GSE80633
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Protein Domain
Type: Family
Description: Eukaryotic eIF-5A was initially thought to function as a translation initiation factor, based on its ability to stimulate methionyl-puromycin synthesis. However, subsequent work revealed a role for eIF5A in translation elongation [, ]. Depletion or inactivation of eIF-5A in the yeast Saccharomyces cerevisiae (Baker's yeast) resulted in the accumulation of polysomes and an increase in ribosomal transit times. Addition of recombinant eIF-5A from yeast, but not a derivative lacking hypusine, enhanced the rate of tripeptide synthesis in vitro. Moreover, inactivation of eIF-5A mimicked the effects of the eEF2 inhibitor sordarin, indicating that eIF-5A might function together with eEF2 to promote ribosomal translocation. Finally, it was shown that eIF5A is specifically required to promote peptide-bond formation between consecutive proline residues. It has been proposed to stimulate the peptidyl-transferase activity of the ribosome and facilitate the reactivity of poor substrates like proline [].eIF-5A is a cofactor for the Rev and Rex transactivator proteins of human immunodeficiency virus-1 and T-cell leukaemia virus I, respectively [, , ]. IF-5A is the sole protein in eukaryotes and archaea to contain the unusual amino acid hypusine (Ne-(4-amino-2-hydroxybutyl)lysine) that is an absolute functional requirement. The first step in the post-translational modification of lysine to hypusine is catalyzed by the enzyme deoxyhypusine synthase, the structure of which has been reported []. The archaeal IF-5A proteins have not been studied as comprehensively as their eukaryotic homologues, though the crystal structure of the Pyrobaculum aerophilum protein has been determined. Unmodified P. aerophilum IF-5A is found to be a beta structure with two domains and three separate hydrophobic cores. The lysine (Lys42) that is post-translationally modified by deoxyhypusine synthase is found at one end of the IF-5A molecule in a turn between beta strands beta4 and beta5; this lysine residue is freely solvent accessible. The C-terminal domain is found to be homologous to the cold-shock protein CspA of E. coli, which has a well characterised RNA-binding fold, suggesting that IF-5A is involved in RNA binding [].This family also includes the Woronin body major protein Hex1, whose sequence and structure are similar to eukaryotic initiation factor 5A(eIF5A), suggesting they share a common ancestor during evolution [].
Publication  
First Author: Yang W
Year: 2021
Journal: Neurobiol Aging
Title: Suppression of the kinase for elongation factor 2 alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease.
Volume: 98
Pages: 225-230
Publication
First Author: Moore CE
Year: 2015
Journal: Mol Cell Biol
Title: Elongation Factor 2 Kinase Is Regulated by Proline Hydroxylation and Protects Cells during Hypoxia.
Volume: 35
Issue: 10
Pages: 1788-804