|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 380 for Ehmt2

<< First    < Previous  |  Next >    Last >>
0.035s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: Histone-lysine N-methyltransferase EHMT2 () mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin []. H3K9me is a specific tag for repression of epigenetic transcription, recruiting HP1 proteins to methylated histones. EHMT2 also monomethylates 'Lys-56' of histone H3 (H3K56me1) during the G1 phase of the cell cycle [], and methylates 'Lys-27' of histone H3 (H3K27me) []. EHMT2 also dimethylates other proteins [], including 'Lys-373' of p53 []. EHMT2 forms a heterdimer with EHMT1 [], and is a component of the E2F6.com-1 complex in G0 phase []. EHMT2 contains seven ankyrin repeats which bind the monomethylated RELA subunit of NF-kappa-B, a SET domain which interacts with WIZ [], and a pre-SET domain that binds three zinc ions via cysteine residues [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Yu Y
Year: 2012
Journal: Mol Cell
Title: Histone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNA.
Volume: 46
Issue: 1
Pages: 7-17
Publication
First Author: Ueda J
Year: 2006
Journal: J Biol Chem
Title: Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP.
Volume: 281
Issue: 29
Pages: 20120-8
Publication
First Author: Tachibana M
Year: 2001
Journal: J Biol Chem
Title: Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3.
Volume: 276
Issue: 27
Pages: 25309-17
Protein
Organism: Mus musculus
Length: 441  
Fragment?: true
Protein
Organism: Mus musculus
Length: 155  
Fragment?: true
Protein
Organism: Mus musculus
Length: 194  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1263  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1229  
Fragment?: false
Publication
First Author: Rathert P
Year: 2008
Journal: Nat Chem Biol
Title: Protein lysine methyltransferase G9a acts on non-histone targets.
Volume: 4
Issue: 6
Pages: 344-6
Publication
First Author: Collins RE
Year: 2008
Journal: Nat Struct Mol Biol
Title: The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules.
Volume: 15
Issue: 3
Pages: 245-50
Publication
First Author: Huang J
Year: 2010
Journal: J Biol Chem
Title: G9a and Glp methylate lysine 373 in the tumor suppressor p53.
Volume: 285
Issue: 13
Pages: 9636-41
Publication
First Author: Zeng TB
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: EHMT2 and SETDB1 protect the maternal pronucleus from 5mC oxidation.
Volume: 116
Issue: 22
Pages: 10834-10841
Protein
Organism: Mus musculus
Length: 615  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1229  
Fragment?: false
Publication
First Author: Auclair G
Year: 2016
Journal: Genome Res
Title: EHMT2 directs DNA methylation for efficient gene silencing in mouse embryos.
Volume: 26
Issue: 2
Pages: 192-202
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Ogawa H
Year: 2002
Journal: Science
Title: A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells.
Volume: 296
Issue: 5570
Pages: 1132-6
Publication
First Author: Monk D
Year: 2008
Journal: Genome Res
Title: Comparative analysis of human chromosome 7q21 and mouse proximal chromosome 6 reveals a placental-specific imprinted gene, TFPI2/Tfpi2, which requires EHMT2 and EED for allelic-silencing.
Volume: 18
Issue: 8
Pages: 1270-81
Publication
First Author: Tachibana M
Year: 2002
Journal: Genes Dev
Title: G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis.
Volume: 16
Issue: 14
Pages: 1779-91
Publication
First Author: Tachibana M
Year: 2008
Journal: EMBO J
Title: G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription.
Volume: 27
Issue: 20
Pages: 2681-90
Publication
First Author: Tachibana M
Year: 2005
Journal: Genes Dev
Title: Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9.
Volume: 19
Issue: 7
Pages: 815-26
Publication
First Author: Iacono G
Year: 2018
Journal: Nucleic Acids Res
Title: Increased H3K9 methylation and impaired expression of Protocadherins are associated with the cognitive dysfunctions of the Kleefstra syndrome.
Volume: 46
Issue: 10
Pages: 4950-4965
Publication  
First Author: Li Z
Year: 2017
Journal: Sci Signal
Title: The transcription factor C/EBPβ in the dorsal root ganglion contributes to peripheral nerve trauma-induced nociceptive hypersensitivity.
Volume: 10
Issue: 487
Publication
First Author: Thienpont B
Year: 2017
Journal: J Clin Invest
Title: The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy.
Volume: 127
Issue: 1
Pages: 335-348
Publication  
First Author: Liu W
Year: 2017
Journal: Nat Commun
Title: BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis.
Volume: 8
Pages: 14182
Publication
First Author: Zhang Y
Year: 2016
Journal: J Biol Chem
Title: Nerve Injury Diminishes Opioid Analgesia through Lysine Methyltransferase-mediated Transcriptional Repression of μ-Opioid Receptors in Primary Sensory Neurons.
Volume: 291
Issue: 16
Pages: 8475-85
Publication
First Author: Sridharan R
Year: 2013
Journal: Nat Cell Biol
Title: Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1γ in reprogramming to pluripotency.
Volume: 15
Issue: 7
Pages: 872-82
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Maze I
Year: 2010
Journal: Science
Title: Essential role of the histone methyltransferase G9a in cocaine-induced plasticity.
Volume: 327
Issue: 5962
Pages: 213-6
Publication
First Author: Lehnertz B
Year: 2010
Journal: J Exp Med
Title: Activating and inhibitory functions for the histone lysine methyltransferase G9a in T helper cell differentiation and function.
Volume: 207
Issue: 5
Pages: 915-22
Publication
First Author: Antignano F
Year: 2016
Journal: J Exp Med
Title: G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program.
Volume: 213
Issue: 7
Pages: 1153-62
Publication
First Author: Ohhata T
Year: 2004
Journal: Genesis
Title: X-inactivation is stably maintained in mouse embryos deficient for histone methyl transferase G9a.
Volume: 40
Issue: 3
Pages: 151-6
Publication
First Author: Maze I
Year: 2014
Journal: Nat Neurosci
Title: G9a influences neuronal subtype specification in striatum.
Volume: 17
Issue: 4
Pages: 533-9
Publication
First Author: Verbaro DJ
Year: 2018
Journal: J Immunol
Title: Cutting Edge: The Histone Methyltransferase G9a Is Required for Silencing of Helper T Lineage-Associated Genes in Proliferating CD8 T Cells.
Volume: 200
Issue: 12
Pages: 3891-3896
Publication
First Author: Sampath SC
Year: 2007
Journal: Mol Cell
Title: Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assembly.
Volume: 27
Issue: 4
Pages: 596-608
Publication
First Author: Ikegami K
Year: 2007
Journal: Genes Cells
Title: Genome-wide and locus-specific DNA hypomethylation in G9a deficient mouse embryonic stem cells.
Volume: 12
Issue: 1
Pages: 1-11
Publication
First Author: Chin HG
Year: 2007
Journal: Nucleic Acids Res
Title: Automethylation of G9a and its implication in wider substrate specificity and HP1 binding.
Volume: 35
Issue: 21
Pages: 7313-23
Publication
First Author: Lee JS
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Hypoxia-induced methylation of a pontin chromatin remodeling factor.
Volume: 108
Issue: 33
Pages: 13510-5
Publication
First Author: Dong C
Year: 2012
Journal: J Clin Invest
Title: G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer.
Volume: 122
Issue: 4
Pages: 1469-86
Publication
First Author: Bittencourt D
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: G9a functions as a molecular scaffold for assembly of transcriptional coactivators on a subset of glucocorticoid receptor target genes.
Volume: 109
Issue: 48
Pages: 19673-8
Publication  
First Author: Subbanna S
Year: 2013
Journal: Neurobiol Dis
Title: G9a-mediated histone methylation regulates ethanol-induced neurodegeneration in the neonatal mouse brain.
Volume: 54
Pages: 475-85
Publication  
First Author: Subbanna S
Year: 2014
Journal: Neuroscience
Title: Ethanol induced acetylation of histone at G9a exon1 and G9a-mediated histone H3 dimethylation leads to neurodegeneration in neonatal mice.
Volume: 258
Pages: 422-32
Publication
First Author: Maeda K
Year: 2017
Journal: PLoS One
Title: Inhibition of H3K9 methyltransferase G9a ameliorates methylglyoxal-induced peritoneal fibrosis.
Volume: 12
Issue: 3
Pages: e0173706
Publication
First Author: Rao VK
Year: 2016
Journal: Nucleic Acids Res
Title: G9a promotes proliferation and inhibits cell cycle exit during myogenic differentiation.
Volume: 44
Issue: 17
Pages: 8129-43
GXD Expression    
Probe: MGI:5468109
Assay Type: Western blot
Annotation Date: 2013-03-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3570528
Stage: TS28
Assay Id: MGI:5468124
Age: postnatal adult
Image: 1
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289647
Age: embryonic day 2.0
Detected: true
Specimen Num: 36
GXD Expression      
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289647
Age: embryonic day 2.0
Detected: true
Specimen Num: 35
GXD Expression      
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289647
Age: embryonic day 2.0
Detected: true
Specimen Num: 34
GXD Expression      
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289647
Age: embryonic day 2.0
Detected: true
Specimen Num: 33
GXD Expression      
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289647
Age: embryonic day 2.0
Detected: true
Specimen Num: 32
GXD Expression      
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289647
Age: embryonic day 2.0
Detected: true
Specimen Num: 31
GXD Expression      
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289647
Age: embryonic day 2.0
Detected: true
Specimen Num: 30
GXD Expression      
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289647
Age: embryonic day 2.0
Detected: true
Specimen Num: 29
GXD Expression      
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289647
Age: embryonic day 2.0
Detected: true
Specimen Num: 28
GXD Expression      
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289647
Age: embryonic day 2.0
Detected: true
Specimen Num: 27
GXD Expression      
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289647
Age: embryonic day 2.0
Detected: true
Specimen Num: 26
GXD Expression      
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289647
Age: embryonic day 2.0
Detected: true
Specimen Num: 25
GXD Expression      
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289647
Age: embryonic day 2.0
Detected: true
Specimen Num: 24
GXD Expression      
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289647
Age: embryonic day 2.0
Detected: true
Specimen Num: 23
GXD Expression      
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289647
Age: embryonic day 2.0
Detected: true
Specimen Num: 22
GXD Expression      
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289647
Age: embryonic day 2.0
Detected: true
Specimen Num: 21
GXD Expression      
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289647
Age: embryonic day 2.0
Detected: true
Specimen Num: 20
GXD Expression      
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289647
Age: embryonic day 2.0
Detected: true
Specimen Num: 19
GXD Expression      
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289647
Age: embryonic day 2.0
Detected: true
Specimen Num: 18
GXD Expression      
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289647
Age: embryonic day 2.0
Detected: true
Specimen Num: 17
GXD Expression      
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289647
Age: embryonic day 2.0
Detected: true
Specimen Num: 16
GXD Expression      
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289647
Age: embryonic day 2.0
Detected: true
Specimen Num: 15
GXD Expression      
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289647
Age: embryonic day 2.0
Detected: true
Specimen Num: 14
GXD Expression      
Probe: MGI:5288958
Assay Type: RT-PCR
Annotation Date: 2011-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:5289647
Age: embryonic day 2.0
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:6194776
Assay Type: Western blot
Annotation Date: 2018-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3535024
Stage: TS24
Assay Id: MGI:6194891
Age: embryonic day 16.5
Image: 5
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6194776
Assay Type: Western blot
Annotation Date: 2018-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3535024
Stage: TS24
Assay Id: MGI:6194891
Age: embryonic day 16.5
Image: 5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6194776
Assay Type: Western blot
Annotation Date: 2018-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3535024
Stage: TS24
Assay Id: MGI:6194891
Age: embryonic day 16.5
Image: 5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6194776
Assay Type: Western blot
Annotation Date: 2018-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3535024
Stage: TS24
Assay Id: MGI:6194891
Age: embryonic day 16.5
Image: 5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6194848
Assay Type: RT-PCR
Annotation Date: 2018-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3535024
Stage: TS24
Assay Id: MGI:6194868
Age: embryonic day 16.5
Image: 4
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6194848
Assay Type: RT-PCR
Annotation Date: 2018-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3535024
Stage: TS24
Assay Id: MGI:6194868
Age: embryonic day 16.5
Image: 4
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6194848
Assay Type: RT-PCR
Annotation Date: 2018-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3535024
Stage: TS24
Assay Id: MGI:6194868
Age: embryonic day 16.5
Image: 4
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6194848
Assay Type: RT-PCR
Annotation Date: 2018-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3535024
Stage: TS24
Assay Id: MGI:6194868
Age: embryonic day 16.5
Image: 4
Detected: true
Specimen Num: 1