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Search results 1 to 100 out of 255 for Eif2ak3

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0.04s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Gene
Type: gene
Organism: Homo sapiens
GXD Expression  
Probe: MGI:3820987
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3564922
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3826164
Age: embryonic day 14.5
Image: Additional file 4 Eif2ak3
Detected: true
Specimen Num: 1
Publication
First Author: Zhang W
Year: 2006
Journal: Cell Metab
Title: PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis.
Volume: 4
Issue: 6
Pages: 491-7
Publication
First Author: Lin W
Year: 2013
Journal: J Neurosci
Title: Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis.
Volume: 33
Issue: 14
Pages: 5980-91
Publication
First Author: Yuan SH
Year: 2018
Journal: Hum Mol Genet
Title: Tauopathy-associated PERK alleles are functional hypomorphs that increase neuronal vulnerability to ER stress.
Volume: 27
Issue: 22
Pages: 3951-3963
Publication
First Author: Delépine M
Year: 2000
Journal: Nat Genet
Title: EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome.
Volume: 25
Issue: 4
Pages: 406-9
Publication
First Author: Stockwell SR
Year: 2012
Journal: PLoS One
Title: Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling.
Volume: 7
Issue: 1
Pages: e28568
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Gupta S
Year: 2009
Journal: PLoS One
Title: PERK regulates the proliferation and development of insulin-secreting beta-cell tumors in the endocrine pancreas of mice.
Volume: 4
Issue: 11
Pages: e8008
Publication
First Author: Lin Y
Year: 2014
Journal: Am J Pathol
Title: PERK activation preserves the viability and function of remyelinating oligodendrocytes in immune-mediated demyelinating diseases.
Volume: 184
Issue: 2
Pages: 507-19
Publication
First Author: Gallot YS
Year: 2019
Journal: FASEB J
Title: PERK regulates skeletal muscle mass and contractile function in adult mice.
Volume: 33
Issue: 2
Pages: 1946-1962
Publication
First Author: Latorre-Muro P
Year: 2021
Journal: Cell Metab
Title: A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation.
Volume: 33
Issue: 3
Pages: 598-614.e7
Publication
First Author: Zhang P
Year: 2002
Journal: Mol Cell Biol
Title: The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas.
Volume: 22
Issue: 11
Pages: 3864-74
Publication
First Author: Lin W
Year: 2007
Journal: J Clin Invest
Title: The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage.
Volume: 117
Issue: 2
Pages: 448-56
Publication  
First Author: Musner N
Year: 2016
Journal: ASN Neuro
Title: Perk Ablation Ameliorates Myelination in S63del-Charcot-Marie-Tooth 1B Neuropathy.
Volume: 8
Issue: 2
Publication  
First Author: Chen Y
Year: 2016
Journal: Neurobiol Dis
Title: Calcineurin β protects brain after injury by activating the unfolded protein response.
Volume: 94
Pages: 139-56
Publication
First Author: Gass JN
Year: 2008
Journal: Mol Immunol
Title: The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cells.
Volume: 45
Issue: 4
Pages: 1035-43
Publication  
First Author: Kato H
Year: 2020
Journal: Life Sci Alliance
Title: ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue.
Volume: 3
Issue: 3
Publication
First Author: Wang R
Year: 2014
Journal: PLoS One
Title: Perk gene dosage regulates glucose homeostasis by modulating pancreatic β-cell functions.
Volume: 9
Issue: 6
Pages: e99684
Publication
First Author: Bu Y
Year: 2018
Journal: Nat Cell Biol
Title: A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival.
Volume: 20
Issue: 1
Pages: 104-115
Publication
First Author: Gannon PJ
Year: 2017
Journal: Am J Pathol
Title: HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via β-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation.
Volume: 187
Issue: 1
Pages: 91-109
Publication
First Author: Zhu S
Year: 2016
Journal: PLoS One
Title: PERK Regulates Working Memory and Protein Synthesis-Dependent Memory Flexibility.
Volume: 11
Issue: 9
Pages: e0162766
Publication
First Author: Shimizu T
Year: 2020
Journal: iScience
Title: PERK-Mediated Suppression of microRNAs by Sildenafil Improves Mitochondrial Dysfunction in Heart Failure.
Volume: 23
Issue: 8
Pages: 101410
Publication
First Author: Shimizu T
Year: 2020
Journal: Sci Rep
Title: PERK participates in cardiac valve development via fatty acid oxidation and endocardial-mesenchymal transformation.
Volume: 10
Issue: 1
Pages: 20094
Publication
First Author: Pavio N
Year: 2003
Journal: J Virol
Title: Protein synthesis and endoplasmic reticulum stress can be modulated by the hepatitis C virus envelope protein E2 through the eukaryotic initiation factor 2alpha kinase PERK.
Volume: 77
Issue: 6
Pages: 3578-85
Publication
First Author: Wang Y
Year: 2012
Journal: Cancer Res
Title: The unfolded protein response induces the angiogenic switch in human tumor cells through the PERK/ATF4 pathway.
Volume: 72
Issue: 20
Pages: 5396-406
Publication
First Author: Zhou J
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response.
Volume: 103
Issue: 39
Pages: 14343-8
Publication
First Author: Suragani RN
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases.
Volume: 338
Issue: 4
Pages: 1766-72
Publication  
First Author: Egan PA
Year: 2013
Journal: Open Virol J
Title: Hepatitis C Virus Envelope Protein E1 Binds PERK and Represses the Unfolded Protein Response.
Volume: 7
Pages: 37-40
Publication
First Author: Mak BC
Year: 2008
Journal: J Biol Chem
Title: Novel function of PERK as a mediator of force-induced apoptosis.
Volume: 283
Issue: 34
Pages: 23462-72
Publication
First Author: Gao N
Year: 2011
Journal: Mol Biol Cell
Title: Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides.
Volume: 22
Issue: 17
Pages: 2994-3009
Publication
First Author: Verfaillie T
Year: 2012
Journal: Cell Death Differ
Title: PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress.
Volume: 19
Issue: 11
Pages: 1880-91
Publication
First Author: Carrara M
Year: 2015
Journal: EMBO J
Title: Crystal structures reveal transient PERK luminal domain tetramerization in endoplasmic reticulum stress signaling.
Volume: 34
Issue: 11
Pages: 1589-600
Publication
First Author: Sharma V
Year: 2018
Journal: J Neurosci
Title: Local Inhibition of PERK Enhances Memory and Reverses Age-Related Deterioration of Cognitive and Neuronal Properties.
Volume: 38
Issue: 3
Pages: 648-658
Publication
First Author: Philippe C
Year: 2016
Journal: Sci Signal
Title: PERK mediates the IRES-dependent translational activation of mRNAs encoding angiogenic growth factors after ischemic stress.
Volume: 9
Issue: 426
Pages: ra44
Publication
First Author: Chen S
Year: 2019
Journal: Cell Metab
Title: Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction.
Volume: 30
Issue: 6
Pages: 1141-1151.e5
GXD Expression      
Probe: MGI:3759588
Assay Type: RT-PCR
Annotation Date: 2007-10-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:3759639
Age: postnatal adult
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:3759588
Assay Type: RT-PCR
Annotation Date: 2007-10-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3759639
Age: postnatal adult
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3759588
Assay Type: RT-PCR
Annotation Date: 2007-10-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:3759639
Age: embryonic day 14.5
Detected: false
Specimen Num: 5
GXD Expression    
Probe: MGI:5300967
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423458
Age: postnatal month 1
Image: 7
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5300967
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423458
Age: postnatal month 1
Image: 7
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5300967
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423458
Age: postnatal month 1
Image: 7
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:5300967
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423458
Age: postnatal month 1
Image: 7
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:5300967
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423458
Age: postnatal month 1
Image: 7
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:5300967
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423458
Age: postnatal month 1
Image: 7
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6505999
Assay Type: RT-PCR
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3289727
Stage: TS27
Assay Id: MGI:6506020
Age: postnatal day 0
Image: 1
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3759588
Assay Type: RT-PCR
Annotation Date: 2007-10-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3759639
Age: postnatal adult
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:6509660
Assay Type: RT-PCR
Annotation Date: 2021-03-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6510256
Age: postnatal month 2
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6509660
Assay Type: RT-PCR
Annotation Date: 2021-03-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6510256
Age: postnatal month 2
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6509660
Assay Type: RT-PCR
Annotation Date: 2021-03-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6510256
Age: postnatal month 7
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6509660
Assay Type: RT-PCR
Annotation Date: 2021-03-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6510256
Age: postnatal month 7
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6505999
Assay Type: RT-PCR
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3674122
Stage: TS22
Assay Id: MGI:6506020
Age: embryonic day 14.5
Image: 1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6505999
Assay Type: RT-PCR
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3674224
Stage: TS24
Assay Id: MGI:6506020
Age: embryonic day 16.5
Image: 1
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:5300967
Assay Type: Immunohistochemistry
Annotation Date: 2012-01-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716320
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:5301165
Age: embryonic day 12.5
Image: 8A E12.5
Note: Expression is at the apical tips of lens fiber cells.
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5300967
Assay Type: Immunohistochemistry
Annotation Date: 2012-01-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716319
Stage: TS19
Assay Id: MGI:5301165
Age: embryonic day 11.5
Image: 8A E11.5
Detected: false
Specimen Num: 1
GXD Expression
Probe: MGI:6506007
Assay Type: RNA in situ
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3288027
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:6506026
Age: postnatal day 0
Image: 4a
Note: Expression along in or near ameloblasts and odontoblasts.
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:6506007
Assay Type: RNA in situ
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3288227
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:6506026
Age: postnatal day 0
Image: 4a
Note: Expression along in or near ameloblasts and odontoblasts.
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:6506007
Assay Type: RNA in situ
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3289224
Pattern: Ubiquitous
Stage: TS24
Assay Id: MGI:6506026
Age: embryonic day 16.5
Image: 3a
Note: Ubiquitous expression in inner enamel epithelium and dental papilla.
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:5300967
Assay Type: Immunohistochemistry
Annotation Date: 2012-01-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1784124
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:5301165
Age: embryonic day 16.5
Image: 8B E16.5
Note: Expression is at the apical tips of lens fiber cells, specifically at the apical tips of newly forming lens fiber cells.
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:5300967
Assay Type: Immunohistochemistry
Annotation Date: 2012-01-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1784126
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:5301165
Age: embryonic day 18.5
Image: 8C E18.5
Note: Expression is in the peripheral fiber cells.
Detected: true
Specimen Num: 5
GXD Expression
Probe: MGI:5300967
Assay Type: Immunohistochemistry
Annotation Date: 2012-01-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1784128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5301165
Age: postnatal month 3
Image: 8D 3 mo
Note: Expression is in lens fiber cells that are degrading their nuclei.
Detected: true
Specimen Num: 6
GXD Expression
Probe: MGI:5300967
Assay Type: Immunohistochemistry
Annotation Date: 2012-01-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1784122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5301165
Age: embryonic day 14.5
Image: 8B E14.5
Note: Expression is at the apical tips of lens fiber cells, specifically at the apical tips of newly forming lens fiber cells.
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:6506007
Assay Type: RNA in situ
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3527522
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:6506026
Age: embryonic day 14.5
Image: 2a
Note: Similar expression in enamel knot, cervical loop region and along dental follicle.
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:6506007
Assay Type: RNA in situ
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3674122
Pattern: Uniform
Stage: TS22
Assay Id: MGI:6506026
Age: embryonic day 14.5
Image: 2a
Note: Authors report uniform (ubiquitous) expression along epithelium and mesenchyme.
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:6506007
Assay Type: RNA in situ
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3674224
Pattern: Uniform
Stage: TS24
Assay Id: MGI:6506026
Age: embryonic day 16.5
Image: 3a
Note: Uniform expression along epithelium and mesenchyme.
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:6506007
Assay Type: RNA in situ
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3808524
Pattern: Ubiquitous
Stage: TS24
Assay Id: MGI:6506026
Age: embryonic day 16.5
Image: 3a
Note: Ubiquitous expression in inner enamel epithelium and dental papilla.
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:6506007
Assay Type: RNA in situ
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3808022
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:6506026
Age: embryonic day 14.5
Image: 2a
Note: Similar expression in enamel knot, cervical loop region and along dental follicle.
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:6506007
Assay Type: RNA in situ
Annotation Date: 2021-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3809222
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:6506026
Age: embryonic day 14.5
Image: 2a
Note: Similar expression in enamel knot, cervical loop region and along dental follicle.
Detected: true
Specimen Num: 1
Publication
First Author: Avivar-Valderas A
Year: 2011
Journal: Mol Cell Biol
Title: PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment.
Volume: 31
Issue: 17
Pages: 3616-29
Publication
First Author: Gao Y
Year: 2012
Journal: Mol Cell Biol
Title: PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis.
Volume: 32
Issue: 24
Pages: 5129-39
Publication
First Author: Lépine S
Year: 2011
Journal: Cell Death Differ
Title: Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy.
Volume: 18
Issue: 2
Pages: 350-61
Publication
First Author: Guo C
Year: 2013
Journal: EMBO J
Title: SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia.
Volume: 32
Issue: 11
Pages: 1514-28
Publication
First Author: Muñoz JP
Year: 2013
Journal: EMBO J
Title: Mfn2 modulates the UPR and mitochondrial function via repression of PERK.
Volume: 32
Issue: 17
Pages: 2348-61
Publication
First Author: Cardoso AC
Year: 2020
Journal: Nat Metab
Title: Mitochondrial Substrate Utilization Regulates Cardiomyocyte Cell Cycle Progression.
Volume: 2
Issue: 2
Pages: 167-178
Publication
First Author: Bobrovnikova-Marjon E
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation.
Volume: 105
Issue: 42
Pages: 16314-9
Publication
First Author: Blais JD
Year: 2004
Journal: Mol Cell Biol
Title: Activating transcription factor 4 is translationally regulated by hypoxic stress.
Volume: 24
Issue: 17
Pages: 7469-82
Publication
First Author: Zhang M
Year: 2017
Journal: FEBS Lett
Title: NDRG2 acts as a PERK co-factor to facilitate PERK branch and ERS-induced cell death.
Volume: 591
Issue: 21
Pages: 3670-3681
Publication
First Author: Bunpo P
Year: 2009
Journal: J Biol Chem
Title: GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase.
Volume: 284
Issue: 47
Pages: 32742-9