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Search results 1 to 100 out of 385 for Eif4ebp1

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: This entry represents eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1). EIF4EBP1 is a repressor of translation that binds to EIF4E and prevents its assembly into the eIF4F complex. EIF4EBP1 has to be hypophosphorylated to bind to EIF4E; the hyperphosphorylated form dissociates from EIF4E []. The phosphorylation state of EIF4EBP1 is affected by hormones such as insulin []and is regulated by mTORC1 []. When eIF4E levels are low, hypophosphorylated EIF4EBP1 is ubiquitinated by the BCR(KLHL25) complex, leading to its degradation, and translation is maintained [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
GXD Expression  
Probe: MGI:1407123
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3564922
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3826144
Age: embryonic day 14.5
Image: Additional file 4 Eif4ebp1
Specimen Label: Additional file 4 Eif4ebp1
Detected: true
Specimen Num: 1
Publication
First Author: Pause A
Year: 1994
Journal: Nature
Title: Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function.
Volume: 371
Issue: 6500
Pages: 762-7
Publication
First Author: Burnett PE
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1.
Volume: 95
Issue: 4
Pages: 1432-7
Protein
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: false
Publication
First Author: Yanagiya A
Year: 2012
Journal: Mol Cell
Title: Translational homeostasis via the mRNA cap-binding protein, eIF4E.
Volume: 46
Issue: 6
Pages: 847-58
Publication
First Author: Romasko EJ
Year: 2013
Journal: Genetics
Title: Association of maternal mRNA and phosphorylated EIF4EBP1 variants with the spindle in mouse oocytes: localized translational control supporting female meiosis in mammals.
Volume: 195
Issue: 2
Pages: 349-58
Publication
First Author: Tsai SY
Year: 2016
Journal: Cell Rep
Title: Increased 4E-BP1 Expression Protects against Diet-Induced Obesity and Insulin Resistance in Male Mice.
Volume: 16
Issue: 7
Pages: 1903-14
Publication
First Author: Cao R
Year: 2013
Journal: Neuron
Title: Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling.
Volume: 79
Issue: 4
Pages: 712-24
Publication
First Author: Tsai S
Year: 2015
Journal: J Clin Invest
Title: Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity.
Volume: 125
Issue: 8
Pages: 2952-64
Publication
First Author: Colina R
Year: 2008
Journal: Nature
Title: Translational control of the innate immune response through IRF-7.
Volume: 452
Issue: 7185
Pages: 323-8
Publication
First Author: Yamaguchi S
Year: 2008
Journal: Cell Metab
Title: ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress.
Volume: 7
Issue: 3
Pages: 269-76
Publication
First Author: Ang SJ
Year: 2022
Journal: Nat Commun
Title: Muscle 4EBP1 activation modifies the structure and function of the neuromuscular junction in mice.
Volume: 13
Issue: 1
Pages: 7792
Publication
First Author: Sayano T
Year: 2013
Journal: FEBS J
Title: L-serine deficiency caused by genetic Phgdh deletion leads to robust induction of 4E-BP1 and subsequent repression of translation initiation in the developing central nervous system.
Volume: 280
Issue: 6
Pages: 1502-17
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Lin TA
Year: 1995
Journal: J Biol Chem
Title: Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway.
Volume: 270
Issue: 31
Pages: 18531-8
Publication
First Author: Cao S
Year: 2023
Journal: PLoS One
Title: Mitotic CDK1 and 4E-BP1 II: A single phosphomimetic mutation in 4E-BP1 induces glucose intolerance in mice.
Volume: 18
Issue: 3
Pages: e0282914
Publication
First Author: Blackshear PJ
Year: 1997
Journal: J Biol Chem
Title: Disruption of the gene encoding the mitogen-regulated translational modulator PHAS-I in mice.
Volume: 272
Issue: 50
Pages: 31510-4
Publication
First Author: Tsukiyama-Kohara K
Year: 2001
Journal: Nat Med
Title: Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1.
Volume: 7
Issue: 10
Pages: 1128-32
Publication
First Author: Tsukiyama-Kohara K
Year: 2013
Journal: Genes Cells
Title: 4E-BP1 regulates the differentiation of white adipose tissue.
Volume: 18
Issue: 7
Pages: 602-7
Publication
First Author: Lawrence JC Jr
Year: 1997
Journal: Trends Biochem Sci
Title: PHAS/4E-BPs as regulators of mRNA translation and cell proliferation.
Volume: 22
Issue: 9
Pages: 345-9
Publication  
First Author: Sun X
Year: 2019
Journal: Cell Signal
Title: Inhibition of 4E-BP1 phosphorylation promotes tubular cell escaping from G2/M arrest and ameliorates kidney fibrosis.
Volume: 62
Pages: 109331
Publication
First Author: Dastidar SG
Year: 2020
Journal: J Neurosci
Title: 4E-BP1 Protects Neurons from Misfolded Protein Stress and Parkinson's Disease Toxicity by Inducing the Mitochondrial Unfolded Protein Response.
Volume: 40
Issue: 45
Pages: 8734-8745
GXD Expression      
Probe: MGI:5708516
Assay Type: Western blot
Annotation Date: 2016-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:5708504
Age: postnatal adult
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5708516
Assay Type: Western blot
Annotation Date: 2016-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:5708504
Age: postnatal adult
Specimen Label: Eif4e+/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5708516
Assay Type: Western blot
Annotation Date: 2016-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:5708504
Age: postnatal adult
Specimen Label: WT
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5708516
Assay Type: Western blot
Annotation Date: 2016-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:5708504
Age: postnatal adult
Specimen Label: Eif4e+/-
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5708516
Assay Type: Western blot
Annotation Date: 2016-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5708504
Age: postnatal adult
Specimen Label: WT
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5708516
Assay Type: Western blot
Annotation Date: 2016-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5708504
Age: postnatal adult
Specimen Label: Eif4e+/-
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5708398
Assay Type: Western blot
Annotation Date: 2016-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:5708526
Age: postnatal adult
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5708398
Assay Type: Western blot
Annotation Date: 2016-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:5708526
Age: postnatal adult
Specimen Label: Eif4e+/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5708398
Assay Type: Western blot
Annotation Date: 2016-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:5708526
Age: postnatal adult
Specimen Label: WT
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5708398
Assay Type: Western blot
Annotation Date: 2016-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:5708526
Age: postnatal adult
Specimen Label: Eif4e+/-
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5708398
Assay Type: Western blot
Annotation Date: 2016-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5708526
Age: postnatal adult
Specimen Label: WT
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5708398
Assay Type: Western blot
Annotation Date: 2016-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5708526
Age: postnatal adult
Specimen Label: Eif4e+/-
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6754109
Assay Type: Western blot
Annotation Date: 2021-08-30
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:6754111
Age: postnatal adult
Specimen Label: O
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6754109
Assay Type: Western blot
Annotation Date: 2021-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360411
Stage: TS01
Assay Id: MGI:6754111
Age: embryonic day 0.5
Specimen Label: 1C
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6754109
Assay Type: Western blot
Annotation Date: 2021-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:6754111
Age: embryonic day 1.0
Specimen Label: 2C
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6754109
Assay Type: Western blot
Annotation Date: 2021-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360433
Stage: TS03
Assay Id: MGI:6754111
Age: embryonic day 2.0
Specimen Label: 4C
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6754109
Assay Type: Western blot
Annotation Date: 2021-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360443
Stage: TS03
Assay Id: MGI:6754111
Age: embryonic day 2.5
Specimen Label: 8C
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6754109
Assay Type: Western blot
Annotation Date: 2021-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:6754111
Age: embryonic day 3.0
Specimen Label: MO
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6754109
Assay Type: Western blot
Annotation Date: 2021-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:6754111
Age: embryonic day 3.5
Specimen Label: BL
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:7331391
Assay Type: Western blot
Annotation Date: 2022-08-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914628
Stage: TS28
Assay Id: MGI:7331418
Age: postnatal day 17
Image: S8
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7331391
Assay Type: Western blot
Annotation Date: 2022-08-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914628
Stage: TS28
Assay Id: MGI:7331418
Age: postnatal day 17
Image: S8
Specimen Label: WT
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7331391
Assay Type: Western blot
Annotation Date: 2022-08-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914628
Stage: TS28
Assay Id: MGI:7331418
Age: postnatal day 17
Image: S8
Specimen Label: KO
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:7331391
Assay Type: Western blot
Annotation Date: 2022-08-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914628
Stage: TS28
Assay Id: MGI:7331418
Age: postnatal day 17
Image: S8
Specimen Label: KO
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:7331392
Assay Type: Western blot
Annotation Date: 2022-08-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914628
Stage: TS28
Assay Id: MGI:7331419
Age: postnatal day 17
Image: S8
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7331392
Assay Type: Western blot
Annotation Date: 2022-08-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914628
Stage: TS28
Assay Id: MGI:7331419
Age: postnatal day 17
Image: S8
Specimen Label: WT
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7331392
Assay Type: Western blot
Annotation Date: 2022-08-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914628
Stage: TS28
Assay Id: MGI:7331419
Age: postnatal day 17
Image: S8
Specimen Label: KO
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:7331392
Assay Type: Western blot
Annotation Date: 2022-08-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914628
Stage: TS28
Assay Id: MGI:7331419
Age: postnatal day 17
Image: S8
Specimen Label: KO
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:7331392
Assay Type: Western blot
Annotation Date: 2022-11-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:7378531
Age: postnatal adult
Image: 4
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7378525
Assay Type: Western blot
Annotation Date: 2022-11-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:7378532
Age: postnatal adult
Image: 4
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7579013
Assay Type: Western blot
Annotation Date: 2024-01-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284220
Stage: TS20
Assay Id: MGI:7579046
Age: embryonic day 12.5
Specimen Label: E12.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7579013
Assay Type: Western blot
Annotation Date: 2024-01-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284220
Stage: TS20
Assay Id: MGI:7579046
Age: embryonic day 12.5
Specimen Label: E12.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7579013
Assay Type: Western blot
Annotation Date: 2024-01-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284222
Stage: TS22
Assay Id: MGI:7579046
Age: embryonic day 14.5
Specimen Label: E14.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:7579013
Assay Type: Western blot
Annotation Date: 2024-01-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284222
Stage: TS22
Assay Id: MGI:7579046
Age: embryonic day 14.5
Specimen Label: E14.5
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:7579013
Assay Type: Western blot
Annotation Date: 2024-01-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284223
Stage: TS23
Assay Id: MGI:7579046
Age: embryonic day 15.5
Specimen Label: E15.5
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:7579013
Assay Type: Western blot
Annotation Date: 2024-01-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284223
Stage: TS23
Assay Id: MGI:7579046
Age: embryonic day 15.5
Specimen Label: E15.5
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:7579013
Assay Type: Western blot
Annotation Date: 2024-01-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284225
Stage: TS25
Assay Id: MGI:7579046
Age: embryonic day 17.0
Specimen Label: E17
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:7579013
Assay Type: Western blot
Annotation Date: 2024-01-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284225
Stage: TS25
Assay Id: MGI:7579046
Age: embryonic day 17.0
Specimen Label: E17
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:7579013
Assay Type: Western blot
Annotation Date: 2024-01-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284227
Stage: TS27
Assay Id: MGI:7579046
Age: postnatal day 0
Specimen Label: P0
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:7579013
Assay Type: Western blot
Annotation Date: 2024-01-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284227
Stage: TS27
Assay Id: MGI:7579046
Age: postnatal day 0
Specimen Label: P0
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:6754109
Assay Type: Western blot
Annotation Date: 2024-01-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284220
Stage: TS20
Assay Id: MGI:7579048
Age: embryonic day 12.5
Specimen Label: E12.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6754109
Assay Type: Western blot
Annotation Date: 2024-01-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284220
Stage: TS20
Assay Id: MGI:7579048
Age: embryonic day 12.5
Specimen Label: E12.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6754109
Assay Type: Western blot
Annotation Date: 2024-01-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284222
Stage: TS22
Assay Id: MGI:7579048
Age: embryonic day 14.5
Specimen Label: E14.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6754109
Assay Type: Western blot
Annotation Date: 2024-01-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284222
Stage: TS22
Assay Id: MGI:7579048
Age: embryonic day 14.5
Specimen Label: E14.5
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6754109
Assay Type: Western blot
Annotation Date: 2024-01-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284223
Stage: TS23
Assay Id: MGI:7579048
Age: embryonic day 15.5
Specimen Label: E15.5
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6754109
Assay Type: Western blot
Annotation Date: 2024-01-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284223
Stage: TS23
Assay Id: MGI:7579048
Age: embryonic day 15.5
Specimen Label: E15.5
Detected: true
Specimen Num: 6
GXD Expression        
Probe: MGI:6754109
Assay Type: Western blot
Annotation Date: 2024-01-31
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3284225
Stage: TS25
Assay Id: MGI:7579048
Age: embryonic day 17.0
Specimen Label: E17
Specimen Num: 7
GXD Expression        
Probe: MGI:6754109
Assay Type: Western blot
Annotation Date: 2024-01-31
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3284225
Stage: TS25
Assay Id: MGI:7579048
Age: embryonic day 17.0
Specimen Label: E17
Specimen Num: 8
GXD Expression        
Probe: MGI:6754109
Assay Type: Western blot
Annotation Date: 2024-01-31
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3284227
Stage: TS27
Assay Id: MGI:7579048
Age: postnatal day 0
Specimen Label: P0
Specimen Num: 9
GXD Expression        
Probe: MGI:6754109
Assay Type: Western blot
Annotation Date: 2024-01-31
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3284227
Stage: TS27
Assay Id: MGI:7579048
Age: postnatal day 0
Specimen Label: P0
Specimen Num: 10