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Search results 1 to 100 out of 113 for Eif4g1

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: This entry represents eukaryotic translation initiation factor 4 gamma 1 (EIF4G1), which is a component of the eIF4F complex. The eIF4F complex is required for recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Mitogen-activated protein kinases control translation by post-translational modification of translation initiation factors, and eIF4G1 is a substrate for protein kinase C [[cite:PUB00087286]]. Mutations in the EIF4G1 gene cause Parkinson disease 18, which is a neurodegenerative disorder with the following symptoms: bradykinesia, resting tremor, muscular rigidity and postural instability, and loss of dopaminergic neurons from the substantia nigra [[cite:PUB00087287]]. Viral infection can lead to the shutdown of translation by cleavage of EIF4G1, for example, by HIV-1 retropepsin [[cite:PUB00087288]], rhinovirus picornain 2A [[cite:PUB00087289]]and foot-and-mouth disease virus L-peptidase [[cite:PUB00087289]].
Protein
Organism: Mus musculus
Length: 823  
Fragment?: true
Protein
Organism: Mus musculus
Length: 642  
Fragment?: false
Protein
Organism: Mus musculus
Length: 842  
Fragment?: true
Protein
Organism: Mus musculus
Length: 479  
Fragment?: true
Publication
First Author: Dhungel N
Year: 2015
Journal: Neuron
Title: Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein.
Volume: 85
Issue: 1
Pages: 76-87
Publication
First Author: Chartier-Harlin MC
Year: 2011
Journal: Am J Hum Genet
Title: Translation initiator EIF4G1 mutations in familial Parkinson disease.
Volume: 89
Issue: 3
Pages: 398-406
Publication
First Author: Liew CW
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells.
Volume: 111
Issue: 22
Pages: E2319-28
Publication
First Author: Dobrikov M
Year: 2011
Journal: Mol Cell Biol
Title: Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1.
Volume: 31
Issue: 14
Pages: 2947-59
Protein
Organism: Mus musculus
Length: 137  
Fragment?: true
Protein
Organism: Mus musculus
Length: 79  
Fragment?: false
Protein
Organism: Mus musculus
Length: 129  
Fragment?: true
Protein
Organism: Mus musculus
Length: 471  
Fragment?: true
Protein
Organism: Mus musculus
Length: 202  
Fragment?: true
Protein
Organism: Mus musculus
Length: 119  
Fragment?: true
Protein
Organism: Mus musculus
Length: 209  
Fragment?: true
Protein
Organism: Mus musculus
Length: 170  
Fragment?: true
Protein
Organism: Mus musculus
Length: 186  
Fragment?: true
Publication
First Author: Ventoso I
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: HIV-1 protease cleaves eukaryotic initiation factor 4G and inhibits cap-dependent translation.
Volume: 98
Issue: 23
Pages: 12966-71
Publication
First Author: Foeger N
Year: 2003
Journal: J Biol Chem
Title: Human rhinovirus 2 2Apro recognition of eukaryotic initiation factor 4GI. Involvement of an exosite.
Volume: 278
Issue: 35
Pages: 33200-7
Protein
Organism: Mus musculus
Length: 175  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1600  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1553  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1593  
Fragment?: false
Protein
Organism: Mus musculus
Length: 900  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1594  
Fragment?: false
Protein
Organism: Mus musculus
Length: 958  
Fragment?: true
Protein
Organism: Mus musculus
Length: 795  
Fragment?: true
Protein
Organism: Mus musculus
Length: 831  
Fragment?: true
Protein
Organism: Mus musculus
Length: 866  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1303  
Fragment?: false
Protein
Organism: Mus musculus
Length: 826  
Fragment?: true
Protein
Organism: Mus musculus
Length: 958  
Fragment?: true
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:5708394
Assay Type: Western blot
Annotation Date: 2016-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:5708495
Age: postnatal adult
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5708394
Assay Type: Western blot
Annotation Date: 2016-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:5708495
Age: postnatal adult
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5708394
Assay Type: Western blot
Annotation Date: 2016-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5708495
Age: postnatal adult
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5708394
Assay Type: Western blot
Annotation Date: 2016-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5708495
Age: postnatal adult
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:5708394
Assay Type: Western blot
Annotation Date: 2016-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:5708495
Age: postnatal adult
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5708394
Assay Type: Western blot
Annotation Date: 2016-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:5708495
Age: postnatal adult
Detected: true
Specimen Num: 3
Publication
First Author: Orton KC
Year: 2004
Journal: J Biol Chem
Title: Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk.
Volume: 279
Issue: 37
Pages: 38649-57
Publication
First Author: Loh PG
Year: 2009
Journal: EMBO J
Title: Structural basis for translational inhibition by the tumour suppressor Pdcd4.
Volume: 28
Issue: 3
Pages: 274-85
Publication
First Author: Joshi B
Year: 2004
Journal: Eur J Biochem
Title: Characterization of mammalian eIF4E-family members.
Volume: 271
Issue: 11
Pages: 2189-203
Publication
First Author: Huynh TN
Year: 2014
Journal: J Neurosci
Title: Requirement of Mammalian target of rapamycin complex 1 downstream effectors in cued fear memory reconsolidation and its persistence.
Volume: 34
Issue: 27
Pages: 9034-9
Publication
First Author: Hu SI
Year: 2012
Journal: Sci Signal
Title: MNK2 inhibits eIF4G activation through a pathway involving serine-arginine-rich protein kinase in skeletal muscle.
Volume: 5
Issue: 211
Pages: ra14
Publication
First Author: Santini E
Year: 2013
Journal: Nature
Title: Exaggerated translation causes synaptic and behavioural aberrations associated with autism.
Volume: 493
Issue: 7432
Pages: 411-5
Publication
First Author: Harris TE
Year: 2006
Journal: EMBO J
Title: mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin.
Volume: 25
Issue: 8
Pages: 1659-68
Publication
First Author: Truitt ML
Year: 2015
Journal: Cell
Title: Differential Requirements for eIF4E Dose in Normal Development and Cancer.
Volume: 162
Issue: 1
Pages: 59-71
Publication
First Author: Otulakowski G
Year: 2007
Journal: Am J Respir Cell Mol Biol
Title: Steroid and oxygen effects on eIF4F complex, mTOR, and ENaC translation in fetal lung epithelia.
Volume: 37
Issue: 4
Pages: 457-66
Publication
First Author: Kimball SR
Year: 2003
Journal: Am J Physiol Cell Physiol
Title: Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes.
Volume: 284
Issue: 2
Pages: C273-84
Publication
First Author: Yang G
Year: 2014
Journal: Neuron
Title: An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program.
Volume: 84
Issue: 4
Pages: 723-39
Publication
First Author: Kraushar ML
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Temporally defined neocortical translation and polysome assembly are determined by the RNA-binding protein Hu antigen R.
Volume: 111
Issue: 36
Pages: E3815-24
Publication
First Author: Cobellis G
Year: 2005
Journal: Nucleic Acids Res
Title: Tagging genes with cassette-exchange sites.
Volume: 33
Issue: 4
Pages: e44
Publication      
First Author: The Jackson Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from The Jackson Laboratory, Bar Harbor, ME
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
Publication
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics, the Protein Information Resource and the Protein Ontology Consortium
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations