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Search results 1 to 100 out of 136 for Eif4g1

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
1981 | EIF4G1
Type: gene
Organism: human
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Gene
100380114 | eif4g1
Type: gene
Organism: frog, western clawed
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Gene
287986 | Eif4g1
Type: gene
Organism: rat
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Gene
460888 | EIF4G1
Type: gene
Organism: chimpanzee
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Gene
444858 | EIF4G1
Type: gene
Organism: cattle
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Gene
100688785 | EIF4G1
Type: gene
Organism: dog, domestic
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Gene
424953 | EIF4G1
Type: gene
Organism: chicken
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Gene
704923 | EIF4G1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:2384784 | Eif4g1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR037584 | EIF4G1
Type: Family
Description: This entry represents eukaryotic translation initiation factor 4 gamma 1 (EIF4G1), which is a component of the eIF4F complex. The eIF4F complex is required for recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Mitogen-activated protein kinases control translation by post-translational modification of translation initiation factors, and eIF4G1 is a substrate for protein kinase C []. As part of the eIF4F complex, EIF4G1 mediates endoplasmic reticulum stress-induced ATF4 (a master stress-induced transcription factor) mRNA translation []. Mutations in the EIF4G1 gene cause Parkinson disease 18, which is a neurodegenerative disorder with the following symptoms: bradykinesia, resting tremor, muscular rigidity and postural instability, and loss of dopaminergic neurons from the substantia nigra []. Viral infection can lead to the shutdown of translation by cleavage of EIF4G1, for example, by HIV-1 retropepsin [], rhinovirus picornain 2A []and foot-and-mouth disease virus L-peptidase [].
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Protein
A0PJB5
Organism: Mus musculus/domesticus
Length: 842  
Fragment?: true
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Protein
Q8R2V4
Organism: Mus musculus/domesticus
Length: 479  
Fragment?: true
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Protein
Q8K0J8
Organism: Mus musculus/domesticus
Length: 642  
Fragment?: false
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Protein
Q6PD42
Organism: Mus musculus/domesticus
Length: 823  
Fragment?: true
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Publication
25533483 | J:219342
First Author: Dhungel N
Year: 2015
Journal: Neuron
Title: Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein.
Volume: 85
Issue: 1
Pages: 76-87
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Publication
37307456 | J:343470
First Author: Kim SH
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: The mRNA translation initiation factor eIF4G1 controls mitochondrial oxidative phosphorylation, axonal morphogenesis, and memory.
Volume: 120
Issue: 25
Pages: e2300008120
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Publication
31300553 | J:281152
First Author: Jo S
Year: 2019
Journal: J Biol Chem
Title: eIF4G1 and carboxypeptidase E axis dysregulation in O-GlcNAc transferase-deficient pancreatic β-cells contributes to hyperproinsulinemia in mice.
Volume: 294
Issue: 35
Pages: 13040-13050
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Publication
21907011 | -
First Author: Chartier-Harlin MC
Year: 2011
Journal: Am J Hum Genet
Title: Translation initiator EIF4G1 mutations in familial Parkinson disease.
Volume: 89
Issue: 3
Pages: 398-406
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Publication
24843127 | J:211360
First Author: Liew CW
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells.
Volume: 111
Issue: 22
Pages: E2319-28
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Publication
21576361 | -
First Author: Dobrikov M
Year: 2011
Journal: Mol Cell Biol
Title: Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1.
Volume: 31
Issue: 14
Pages: 2947-59
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Publication
11606767 | -
First Author: Ventoso I
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: HIV-1 protease cleaves eukaryotic initiation factor 4G and inhibits cap-dependent translation.
Volume: 98
Issue: 23
Pages: 12966-71
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Publication
12791690 | -
First Author: Foeger N
Year: 2003
Journal: J Biol Chem
Title: Human rhinovirus 2 2Apro recognition of eukaryotic initiation factor 4GI. Involvement of an exosite.
Volume: 278
Issue: 35
Pages: 33200-7
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Publication
29062139 | -
First Author: Adjibade P
Year: 2017
Journal: Sci Rep
Title: DDX3 regulates endoplasmic reticulum stress-induced ATF4 expression.
Volume: 7
Issue: 1
Pages: 13832
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Protein
A0A0J9YTV0
Organism: Mus musculus/domesticus
Length: 137  
Fragment?: true
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Protein
A0A338P758
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: true
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Protein
Q8BUW8
Organism: Mus musculus/domesticus
Length: 471  
Fragment?: true
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Protein
D3YWC6
Organism: Mus musculus/domesticus
Length: 186  
Fragment?: true
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Protein
D3Z439
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: true
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Protein
A0A0J9YUL1
Organism: Mus musculus/domesticus
Length: 129  
Fragment?: true
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Protein
A0A0J9YU44
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: true
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Protein
D3YWY7
Organism: Mus musculus/domesticus
Length: 170  
Fragment?: true
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Protein
D6RCH1
Organism: Mus musculus/domesticus
Length: 79  
Fragment?: false
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Protein
A0A338P7C5
Organism: Mus musculus/domesticus
Length: 61  
Fragment?: true
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Protein
D3YWM1
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: true
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Protein
Q6EVH9
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: true
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Protein
A0A0J9YVC1
Organism: Mus musculus/domesticus
Length: 795  
Fragment?: true
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Protein
Q3UQI5
Organism: Mus musculus/domesticus
Length: 831  
Fragment?: true
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Protein
Q3UYM6
Organism: Mus musculus/domesticus
Length: 866  
Fragment?: true
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Protein
Q3UZD9
Organism: Mus musculus/domesticus
Length: 958  
Fragment?: true
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Protein
E9Q770
Organism: Mus musculus/domesticus
Length: 958  
Fragment?: true
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Protein
A0A0J9YUC1
Organism: Mus musculus/domesticus
Length: 900  
Fragment?: true
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Protein
Q3UTK0
Organism: Mus musculus/domesticus
Length: 826  
Fragment?: true
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Protein
Q6NZJ6
Organism: Mus musculus/domesticus
Length: 1600  
Fragment?: false
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Protein
E9PVC5
Organism: Mus musculus/domesticus
Length: 1594  
Fragment?: false
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Protein
E9Q9E1
Organism: Mus musculus/domesticus
Length: 1593  
Fragment?: false
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Protein
E9PVC6
Organism: Mus musculus/domesticus
Length: 1553  
Fragment?: false
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Protein
A0A0J9YUS5
Organism: Mus musculus/domesticus
Length: 1303  
Fragment?: false
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Publication
31999954 | J:287743
First Author: Gonatopoulos-Pournatzis T
Year: 2020
Journal: Mol Cell
Title: Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions.
Volume: 77
Issue: 6
Pages: 1176-1192.e16
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Protein Coding Gene
MGP_CAROLIEiJ_G0020586 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0022651 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0022613 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0022588 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0022617 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0022382 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2384784 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0023068 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0021912 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0022354 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0022486 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0022461 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0022553 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0022481 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0023079 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0021653 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0021956 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0016290 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0021483 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:5708394
Assay Type: Western blot
Annotation Date: 2016-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:5708495
Age: postnatal adult
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5708394
Assay Type: Western blot
Annotation Date: 2016-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:5708495
Age: postnatal adult
Specimen Label: Eif4e+/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:5708394
Assay Type: Western blot
Annotation Date: 2016-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:5708495
Age: postnatal adult
Specimen Label: WT
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:5708394
Assay Type: Western blot
Annotation Date: 2016-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:5708495
Age: postnatal adult
Specimen Label: Eif4e+/-
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:5708394
Assay Type: Western blot
Annotation Date: 2016-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5708495
Age: postnatal adult
Specimen Label: WT
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:5708394
Assay Type: Western blot
Annotation Date: 2016-02-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5708495
Age: postnatal adult
Specimen Label: Eif4e+/-
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:7564038
Assay Type: Immunohistochemistry
Annotation Date: 2023-12-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7564069
Age: embryonic day 14.5
Specimen Label: 3A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7564038
Assay Type: Immunohistochemistry
Annotation Date: 2023-12-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7564069
Age: embryonic day 14.5
Specimen Label: 3A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7564038
Assay Type: Immunohistochemistry
Annotation Date: 2023-12-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7564069
Age: embryonic day 14.5
Note: Expression localized to punctate radial precursors
Specimen Label: 3B
Detected: true
Specimen Num: 2
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Publication
15153109 | J:91394
First Author: Joshi B
Year: 2004
Journal: Eur J Biochem
Title: Characterization of mammalian eIF4E-family members.
Volume: 271
Issue: 11
Pages: 2189-203
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Publication
19153607 | J:145850
First Author: Loh PG
Year: 2009
Journal: EMBO J
Title: Structural basis for translational inhibition by the tumour suppressor Pdcd4.
Volume: 28
Issue: 3
Pages: 274-85
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Publication
15234964 | J:92819
First Author: Orton KC
Year: 2004
Journal: J Biol Chem
Title: Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk.
Volume: 279
Issue: 37
Pages: 38649-57
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Publication
24990923 | J:212538
First Author: Huynh TN
Year: 2014
Journal: J Neurosci
Title: Requirement of Mammalian target of rapamycin complex 1 downstream effectors in cued fear memory reconsolidation and its persistence.
Volume: 34
Issue: 27
Pages: 9034-9
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Publication
22337810 | J:260391
First Author: Hu SI
Year: 2012
Journal: Sci Signal
Title: MNK2 inhibits eIF4G activation through a pathway involving serine-arginine-rich protein kinase in skeletal muscle.
Volume: 5
Issue: 211
Pages: ra14
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Publication
23263185 | J:194400
First Author: Santini E
Year: 2013
Journal: Nature
Title: Exaggerated translation causes synaptic and behavioural aberrations associated with autism.
Volume: 493
Issue: 7432
Pages: 411-5
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Publication
19239892 | J:320123
First Author: Sonenberg N
Year: 2009
Journal: Cell
Title: Regulation of translation initiation in eukaryotes: mechanisms and biological targets.
Volume: 136
Issue: 4
Pages: 731-45
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Publication
16541103 | J:109360
First Author: Harris TE
Year: 2006
Journal: EMBO J
Title: mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin.
Volume: 25
Issue: 8
Pages: 1659-68
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Publication
26095252 | J:224214
First Author: Truitt ML
Year: 2015
Journal: Cell
Title: Differential Requirements for eIF4E Dose in Normal Development and Cancer.
Volume: 162
Issue: 1
Pages: 59-71
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Publication
17556672 | J:141655
First Author: Otulakowski G
Year: 2007
Journal: Am J Respir Cell Mol Biol
Title: Steroid and oxygen effects on eIF4F complex, mTOR, and ENaC translation in fetal lung epithelia.
Volume: 37
Issue: 4
Pages: 457-66
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Publication
34704401 | J:350800
First Author: Liang R
Year: 2021
Journal: J Cachexia Sarcopenia Muscle
Title: H19X-encoded miR-322(424)/miR-503 regulates muscle mass by targeting translation initiation factors.
Volume: 12
Issue: 6
Pages: 2174-2186
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Publication
12388085 | J:82058
First Author: Kimball SR
Year: 2003
Journal: Am J Physiol Cell Physiol
Title: Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes.
Volume: 284
Issue: 2
Pages: C273-84
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Publication
25456498 | J:217461
First Author: Yang G
Year: 2014
Journal: Neuron
Title: An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program.
Volume: 84
Issue: 4
Pages: 723-39
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Publication
34031387 | J:306063
First Author: Morandell J
Year: 2021
Journal: Nat Commun
Title: Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development.
Volume: 12
Issue: 1
Pages: 3058
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Publication
25157170 | J:216392
First Author: Kraushar ML
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Temporally defined neocortical translation and polysome assembly are determined by the RNA-binding protein Hu antigen R.
Volume: 111
Issue: 36
Pages: E3815-24
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Publication
38849354 | J:349721
First Author: Borisova E
Year: 2024
Journal: Nat Commun
Title: Protein translation rate determines neocortical neuron fate.
Volume: 15
Issue: 1
Pages: 4879
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Publication
15741177 | J:126097
First Author: Cobellis G
Year: 2005
Journal: Nucleic Acids Res
Title: Tagging genes with cassette-exchange sites.
Volume: 33
Issue: 4
Pages: e44
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Publication
- | J:101977
     
First Author: The Jackson Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from The Jackson Laboratory, Bar Harbor, ME
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom