|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 120 for Eif6

<< First    < Previous  |  Next >    Last >>
0.044s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: This family includes eukaryotic translation initiation factor 6 (eIF6) as well as presumed archaeal homologues.The assembly of 80S ribosomes requires joining of the 40S and 60S subunits, which is triggered by the formation of an initiation complex on the 40S subunit. This event is rate-limiting for translation, and depends on external stimuli and the status of the cell. Eukaryotic translation initiation factor 6 (eIF6) binds specifically to the free 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit ribosomes []. Furthermore, eIF6 interacts in the cytoplasm with RACK1, a receptor for activated protein kinase C (PKC). RACK1 is a major component of translating ribosomes, which harbour significant amounts of PKC. Loading 60S subunits with eIF6 caused a dose-dependent translational block and impairment of 80S formation, which are reversed by expression of RACK1 and stimulation of PKC in vivo and in vitro. PKC stimulation leads to eIF6 phosphorylation and its release, promoting 80S subunit formation. RACK1 provides a physical and functional link between PKC signalling and ribosome activation [, , ].All members of this family have a conserved pentameric fold referred to as a beta/alpha propeller. The eukaryotic IF6 members have a moderately conserved C-terminal extension which is not required for ribosomal binding, and may have an alternative function [].
Publication
First Author: Wood LC
Year: 1999
Journal: J Biol Chem
Title: Cloning of murine translation initiation factor 6 and functional analysis of the homologous sequence YPR016c in Saccharomyces cerevisiae.
Volume: 274
Issue: 17
Pages: 11653-9
Protein
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
Publication  
First Author: Brina D
Year: 2015
Journal: Nat Commun
Title: eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription.
Volume: 6
Pages: 8261
Publication  
First Author: Scagliola A
Year: 2022
Journal: Int J Mol Sci
Title: Inhibition of eIF6 Activity Reduces Hepatocellular Carcinoma Growth: An In Vivo and In Vitro Study.
Volume: 23
Issue: 14
Publication
First Author: Miluzio A
Year: 2011
Journal: Cancer Cell
Title: Impairment of cytoplasmic eIF6 activity restricts lymphomagenesis and tumor progression without affecting normal growth.
Volume: 19
Issue: 6
Pages: 765-75
Publication
First Author: Finch AJ
Year: 2011
Journal: Genes Dev
Title: Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome.
Volume: 25
Issue: 9
Pages: 917-29
Publication
First Author: Clarke K
Year: 2017
Journal: Cell Rep
Title: The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks.
Volume: 21
Issue: 6
Pages: 1507-1520
Publication  
First Author: Manfrini N
Year: 2017
Journal: Data Brief
Title: Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation.
Volume: 14
Pages: 653-658
Protein
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 58  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 81  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 71  
Fragment?: false
Publication
First Author: Si K
Year: 1999
Journal: Mol Cell Biol
Title: The Saccharomyces cerevisiae homologue of mammalian translation initiation factor 6 does not function as a translation initiation factor.
Volume: 19
Issue: 2
Pages: 1416-26
Publication
First Author: Basu U
Year: 2001
Journal: Mol Cell Biol
Title: The Saccharomyces cerevisiae TIF6 gene encoding translation initiation factor 6 is required for 60S ribosomal subunit biogenesis.
Volume: 21
Issue: 5
Pages: 1453-62
Publication
First Author: Si K
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Molecular cloning and functional expression of a human cDNA encoding translation initiation factor 6.
Volume: 94
Issue: 26
Pages: 14285-90
Publication
First Author: Paoli M
Year: 2001
Journal: Nat Struct Biol
Title: An elusive propeller-like fold.
Volume: 8
Issue: 9
Pages: 744-5
Publication  
First Author: Manfrini N
Year: 2017
Journal: Dev Comp Immunol
Title: High levels of eukaryotic Initiation Factor 6 (eIF6) are required for immune system homeostasis and for steering the glycolytic flux of TCR-stimulated CD4+ T cells in both mice and humans.
Volume: 77
Pages: 69-76
Publication
First Author: Scagliola A
Year: 2021
Journal: Nat Commun
Title: Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma.
Volume: 12
Issue: 1
Pages: 4878
Publication
First Author: Ricciardi S
Year: 2015
Journal: J Thromb Haemost
Title: Eukaryotic translation initiation factor 6 is a novel regulator of reactive oxygen species-dependent megakaryocyte maturation.
Volume: 13
Issue: 11
Pages: 2108-18
Publication
First Author: Yang SS
Year: 2015
Journal: J Cell Sci
Title: Eukaryotic initiation factor 6 modulates myofibroblast differentiation at transforming growth factor-β1 transcription level via H2A.Z occupancy and Sp1 recruitment.
Volume: 128
Issue: 21
Pages: 3977-89
Publication
First Author: Gandin V
Year: 2008
Journal: Nature
Title: Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation.
Volume: 455
Issue: 7213
Pages: 684-8
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Biffo S
Year: 1997
Journal: J Biol Chem
Title: Isolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cells.
Volume: 272
Issue: 48
Pages: 30314-21
Publication
First Author: Cho SH
Year: 1998
Journal: Biochem Biophys Res Commun
Title: Identification and characterization of the inducible murine mast cell gene, imc-415.
Volume: 252
Issue: 1
Pages: 123-7
Publication
First Author: Ceci M
Year: 2002
Journal: Biochem Biophys Res Commun
Title: Formation of nuclear matrix filaments by p27(BBP)/eIF6.
Volume: 295
Issue: 2
Pages: 295-9
GXD Expression      
Probe: MGI:6871058
Assay Type: Western blot
Annotation Date: 2022-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:6871060
Age: embryonic day 17.5
Specimen Label: Wild type Efl1+/-
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6871058
Assay Type: Western blot
Annotation Date: 2022-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:6871060
Age: embryonic day 17.5
Specimen Label: Wild type Efl1+/+
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6871058
Assay Type: Western blot
Annotation Date: 2022-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:6871060
Age: embryonic day 17.5
Specimen Label: Comp. het. Efl1m/-
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6871058
Assay Type: Western blot
Annotation Date: 2022-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:6871060
Age: embryonic day 17.5
Specimen Label: Comp. het. Efl1m/-
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6871058
Assay Type: Western blot
Annotation Date: 2022-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:6871060
Age: embryonic day 17.5
Specimen Label: Comp. het. Efl1m/-
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6871058
Assay Type: Western blot
Annotation Date: 2022-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:6871060
Age: embryonic day 17.5
Specimen Label: Comp. het. Efl1m/-
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6871058
Assay Type: Western blot
Annotation Date: 2022-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:6871060
Age: embryonic day 17.5
Specimen Label: Comp. het. Efl1m/-
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:938929
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3271122
Stage: TS22
Assay Id: MGI:4354880
Age: embryonic day 14.5
Note: There is no expression in either the upper or lower cortical plate.
Specimen Label: Table S5 - Itgb4bp
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:938929
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4354880
Age: embryonic day 14.5
Specimen Label: Table S5 - Itgb4bp
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:938929
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3270422
Stage: TS22
Assay Id: MGI:4354880
Age: embryonic day 14.5
Specimen Label: Table S5 - Itgb4bp
Detected: false
Specimen Num: 1
Publication    
First Author: Ha SH
Year: 1999
Journal: GenBank Submission
Title: Mus musculus b4 integrin interactor homolog mRNA, complete cds
Pages: AF108462
Publication
First Author: Lee S
Year: 2021
Journal: Blood
Title: Somatic uniparental disomy mitigates the most damaging EFL1 allele combination in Shwachman-Diamond syndrome.
Volume: 138
Issue: 21
Pages: 2117-2128
Publication
First Author: Distler U
Year: 2014
Journal: Proteomics
Title: In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics.
Volume: 14
Issue: 21-22
Pages: 2607-13
Publication
First Author: Sansom SN
Year: 2009
Journal: PLoS Genet
Title: The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.
Volume: 5
Issue: 6
Pages: e1000511
Publication      
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference