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Search results 1 to 100 out of 124 for Eif6

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Hits by Category

Hits by Strain

Type Details Score
Gene
3692 | EIF6
Type: gene
Organism: human
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Gene
448711 | eif6
Type: gene
Organism: frog, western clawed
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Gene
305506 | Eif6
Type: gene
Organism: rat
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Gene
477210 | EIF6
Type: gene
Organism: dog, domestic
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Gene
458200 | EIF6
Type: gene
Organism: chimpanzee
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Gene
286811 | EIF6
Type: gene
Organism: cattle
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Gene
419140 | EIF6
Type: gene
Organism: chicken
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Gene
386850 | eif6
Type: gene
Organism: zebrafish
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Gene
709602 | EIF6
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR002769 | eIF6
Type: Family
Description: This family includes eukaryotic translation initiation factor 6 (eIF6) as well as presumed archaeal homologues.The assembly of 80S ribosomes requires joining of the 40S and 60S subunits, which is triggered by the formation of an initiation complex on the 40S subunit. This event is rate-limiting for translation, and depends on external stimuli and the status of the cell. Eukaryotic translation initiation factor 6 (eIF6) binds specifically to the free 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit ribosomes []. Furthermore, eIF6 interacts in the cytoplasm with RACK1, a receptor for activated protein kinase C (PKC). RACK1 is a major component of translating ribosomes, which harbour significant amounts of PKC. Loading 60S subunits with eIF6 caused a dose-dependent translational block and impairment of 80S formation, which are reversed by expression of RACK1 and stimulation of PKC in vivo and in vitro. PKC stimulation leads to eIF6 phosphorylation and its release, promoting 80S subunit formation. RACK1 provides a physical and functional link between PKC signalling and ribosome activation [, , ].All members of this family have a conserved pentameric fold referred to as a beta/alpha propeller. The eukaryotic IF6 members have a moderately conserved C-terminal extension which is not required for ribosomal binding, and may have an alternative function [].
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Protein Coding Gene
MGI:1196288 | Eif6
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
10206977 | J:54867
First Author: Wood LC
Year: 1999
Journal: J Biol Chem
Title: Cloning of murine translation initiation factor 6 and functional analysis of the homologous sequence YPR016c in Saccharomyces cerevisiae.
Volume: 274
Issue: 17
Pages: 11653-9
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Protein
Q3U818
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
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Protein
Q3UA13
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
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Protein
Q9R071
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
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Protein
Q545K4
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
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Protein
Q3U740
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
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Protein
Q3UBJ6
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
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Publication
35322020 | J:337804
First Author: Jaako P
Year: 2022
Journal: Nat Commun
Title: eIF6 rebinding dynamically couples ribosome maturation and translation.
Volume: 13
Issue: 1
Pages: 1562
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Publication
26383020 | J:226984
 
First Author: Brina D
Year: 2015
Journal: Nat Commun
Title: eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription.
Volume: 6
Pages: 8261
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Publication
35887068 | J:326841
 
First Author: Scagliola A
Year: 2022
Journal: Int J Mol Sci
Title: Inhibition of eIF6 Activity Reduces Hepatocellular Carcinoma Growth: An In Vivo and In Vitro Study.
Volume: 23
Issue: 14
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Publication
21665150 | J:173559
First Author: Miluzio A
Year: 2011
Journal: Cancer Cell
Title: Impairment of cytoplasmic eIF6 activity restricts lymphomagenesis and tumor progression without affecting normal growth.
Volume: 19
Issue: 6
Pages: 765-75
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Publication
21536732 | J:171416
First Author: Finch AJ
Year: 2011
Journal: Genes Dev
Title: Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome.
Volume: 25
Issue: 9
Pages: 917-29
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Publication
29117557 | J:250090
First Author: Clarke K
Year: 2017
Journal: Cell Rep
Title: The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks.
Volume: 21
Issue: 6
Pages: 1507-1520
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Publication
28924581 | J:332751
 
First Author: Manfrini N
Year: 2017
Journal: Data Brief
Title: Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation.
Volume: 14
Pages: 653-658
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Protein
O55135
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
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Protein
A6PWZ2
Organism: Mus musculus/domesticus
Length: 58  
Fragment?: true
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Protein
B1AZQ4
Organism: Mus musculus/domesticus
Length: 81  
Fragment?: false
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Protein
D6RJJ3
Organism: Mus musculus/domesticus
Length: 71  
Fragment?: false
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Publication
9891075 | -
First Author: Si K
Year: 1999
Journal: Mol Cell Biol
Title: The Saccharomyces cerevisiae homologue of mammalian translation initiation factor 6 does not function as a translation initiation factor.
Volume: 19
Issue: 2
Pages: 1416-26
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Publication
11238882 | -
First Author: Basu U
Year: 2001
Journal: Mol Cell Biol
Title: The Saccharomyces cerevisiae TIF6 gene encoding translation initiation factor 6 is required for 60S ribosomal subunit biogenesis.
Volume: 21
Issue: 5
Pages: 1453-62
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Publication
9405604 | -
First Author: Si K
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Molecular cloning and functional expression of a human cDNA encoding translation initiation factor 6.
Volume: 94
Issue: 26
Pages: 14285-90
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Publication
11524672 | -
First Author: Paoli M
Year: 2001
Journal: Nat Struct Biol
Title: An elusive propeller-like fold.
Volume: 8
Issue: 9
Pages: 744-5
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Publication
28743432 | J:250096
 
First Author: Manfrini N
Year: 2017
Journal: Dev Comp Immunol
Title: High levels of eukaryotic Initiation Factor 6 (eIF6) are required for immune system homeostasis and for steering the glycolytic flux of TCR-stimulated CD4+ T cells in both mice and humans.
Volume: 77
Pages: 69-76
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Publication
26391622 | J:232943
First Author: Ricciardi S
Year: 2015
Journal: J Thromb Haemost
Title: Eukaryotic translation initiation factor 6 is a novel regulator of reactive oxygen species-dependent megakaryocyte maturation.
Volume: 13
Issue: 11
Pages: 2108-18
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Publication
34385447 | J:308947
First Author: Scagliola A
Year: 2021
Journal: Nat Commun
Title: Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma.
Volume: 12
Issue: 1
Pages: 4878
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Publication
26395397 | J:233780
First Author: Yang SS
Year: 2015
Journal: J Cell Sci
Title: Eukaryotic initiation factor 6 modulates myofibroblast differentiation at transforming growth factor-β1 transcription level via H2A.Z occupancy and Sp1 recruitment.
Volume: 128
Issue: 21
Pages: 3977-89
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Publication
18784653 | J:141257
First Author: Gandin V
Year: 2008
Journal: Nature
Title: Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation.
Volume: 455
Issue: 7213
Pages: 684-8
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Protein Coding Gene
MGP_CAROLIEiJ_G0024539 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0026745 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0026711 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026682 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0026720 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026463 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1196288 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027169 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0025924 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0026440 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026577 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026544 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0026682 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026565 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027225 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0025658 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0025994 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0025984 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025461 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
9374518 | J:44335
First Author: Biffo S
Year: 1997
Journal: J Biol Chem
Title: Isolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cells.
Volume: 272
Issue: 48
Pages: 30314-21
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Publication
9813156 | J:50849
First Author: Cho SH
Year: 1998
Journal: Biochem Biophys Res Commun
Title: Identification and characterization of the inducible murine mast cell gene, imc-415.
Volume: 252
Issue: 1
Pages: 123-7
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Publication
12150946 | J:77914
First Author: Ceci M
Year: 2002
Journal: Biochem Biophys Res Commun
Title: Formation of nuclear matrix filaments by p27(BBP)/eIF6.
Volume: 295
Issue: 2
Pages: 295-9
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Publication
39412990 | J:358159
First Author: Sjövall D
Year: 2024
Journal: Cell Rep
Title: Defective ribosome assembly impairs leukemia progression in a murine model of acute myeloid leukemia.
Volume: 43
Issue: 11
Pages: 114864
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GXD Expression
GXD Expression
     
Probe: MGI:6871058
Assay Type: Western blot
Annotation Date: 2022-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:6871060
Age: embryonic day 17.5
Specimen Label: Wild type Efl1+/-
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6871058
Assay Type: Western blot
Annotation Date: 2022-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:6871060
Age: embryonic day 17.5
Specimen Label: Wild type Efl1+/+
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6871058
Assay Type: Western blot
Annotation Date: 2022-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:6871060
Age: embryonic day 17.5
Specimen Label: Comp. het. Efl1m/-
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:6871058
Assay Type: Western blot
Annotation Date: 2022-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:6871060
Age: embryonic day 17.5
Specimen Label: Comp. het. Efl1m/-
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:6871058
Assay Type: Western blot
Annotation Date: 2022-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:6871060
Age: embryonic day 17.5
Specimen Label: Comp. het. Efl1m/-
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:6871058
Assay Type: Western blot
Annotation Date: 2022-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:6871060
Age: embryonic day 17.5
Specimen Label: Comp. het. Efl1m/-
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:6871058
Assay Type: Western blot
Annotation Date: 2022-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:6871060
Age: embryonic day 17.5
Specimen Label: Comp. het. Efl1m/-
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:938929
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3270422
Stage: TS22
Assay Id: MGI:4354880
Age: embryonic day 14.5
Specimen Label: Table S5 - Itgb4bp
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:938929
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3271122
Stage: TS22
Assay Id: MGI:4354880
Age: embryonic day 14.5
Note: There is no expression in either the upper or lower cortical plate.
Specimen Label: Table S5 - Itgb4bp
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:938929
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4354880
Age: embryonic day 14.5
Specimen Label: Table S5 - Itgb4bp
Detected: true
Specimen Num: 1
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Publication
- | J:70104
   
First Author: Ha SH
Year: 1999
Journal: GenBank Submission
Title: Mus musculus b4 integrin interactor homolog mRNA, complete cds
Pages: AF108462
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Publication
34115847 | J:315678
First Author: Lee S
Year: 2021
Journal: Blood
Title: Somatic uniparental disomy mitigates the most damaging EFL1 allele combination in Shwachman-Diamond syndrome.
Volume: 138
Issue: 21
Pages: 2117-2128
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Publication
25211037 | J:263419
First Author: Distler U
Year: 2014
Journal: Proteomics
Title: In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics.
Volume: 14
Issue: 21-22
Pages: 2607-13
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Publication
- | J:342612
       
First Author: UniProt curators
Year: 2014
Title: Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
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Publication
19521500 | J:149737
First Author: Sansom SN
Year: 2009
Journal: PLoS Genet
Title: The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.
Volume: 5
Issue: 6
Pages: e1000511
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Publication
- | J:157064
     
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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