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Search results 1 to 100 out of 126 for Elp3

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Hits by Strain

Hits by Category

Type Details Score
Gene
55140 | ELP3
Type: gene
Organism: human
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Gene
784720 | ELP3
Type: gene
Organism: cattle
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Gene
100362548 | Elp3
Type: gene
Organism: rat
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Gene
422021 | ELP3
Type: gene
Organism: chicken
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Gene
541509 | elp3
Type: gene
Organism: zebrafish
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Gene
713512 | ELP3
Type: gene
Organism: macaque, rhesus
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Gene
407885 | elp3
Type: gene
Organism: frog, western clawed
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Gene
477370 | ELP3
Type: gene
Organism: dog, domestic
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Gene
464081 | ELP3
Type: gene
Organism: chimpanzee
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Protein
P97782
Organism: Mus musculus/domesticus
Length: 463  
Fragment?: false
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Protein Coding Gene
MGI:1921445 | Elp3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR039661 | ELP3
Type: Family
Description: This entry includes proteins with a radical SAM domain and a radical SAM C-terminal extension domain. One such protein is elongator complex protein 3 (ELP3): the catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is itself part of the RNA polymerase II (RNAPII) holoenzyme responsible for transcriptional elongation []. A bacterial ELP3 homologue known as tRNA uridine(34) acetyltransferase, reflecting its role in mediating the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs is also included in this family []. This entry also includes protein YhcC from Escherichia coli , which binds an [4Fe-4S]cluster, coordinated with three cysteines and an exchangeable S-adenosyl-L-methionine. YhcC cleaves S-adenosyl-L-methionine into methionine and 5'-deoxyadenosine []. This entry also includes archaeosine synthase subunit beta (RaSEA) from archaea, it is a SAM enzyme which plays a role in the synthesis of archaeosine []. Uncharacterised homologues are known from bacteria, archaea and eukaryotes.ELP3 is required for the complex integrity and for the association of the complex with nascent RNA transcript []. ELP3 is thought to act as a highly conserved histone acetyltransferase (HAT) capable of acetylating core histones in vitro, however, it is clearly a multi-domain protein. The HAT activity is thought to be present only in the C-terminal GNAT domain (histone acyltransferase domain) []. Studies suggest that both the histone acetyltransferase and radical S-adenosylmethionine domains are essential for function, although the exact role of the Radical SAM domain is still unclear []. The radical SAM domain is important for the structural integrity of the protein complex, as in yeast (previously demonstrated) []. However, an alternative may be that ELP3 binds ands cleave SAM, as seen in the archaea M. jannaschii. It has also been shown in previous studies that the mouse ELP3 does not require the histone acyltransferase domain for zygotic paternal genome demethylation [].
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Publication
27455459 | -
First Author: Glatt S
Year: 2016
Journal: Nat Struct Mol Biol
Title: Structural basis for tRNA modification by Elp3 from Dehalococcoides mccartyi.
Volume: 23
Issue: 9
Pages: 794-802
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Publication
26527802 | J:227334
First Author: Ladang A
Year: 2015
Journal: J Exp Med
Title: Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine.
Volume: 212
Issue: 12
Pages: 2057-75
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Publication
16420352 | -
First Author: Paraskevopoulou C
Year: 2006
Journal: Mol Microbiol
Title: The Elongator subunit Elp3 contains a Fe4S4 cluster and binds S-adenosylmethionine.
Volume: 59
Issue: 3
Pages: 795-806
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Publication
18986986 | -
First Author: Greenwood C
Year: 2009
Journal: J Biol Chem
Title: An iron-sulfur cluster domain in Elp3 important for the structural integrity of elongator.
Volume: 284
Issue: 1
Pages: 141-9
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Publication
11893502 | J:75354
First Author: Chinenov Y
Year: 2002
Journal: Trends Biochem Sci
Title: A second catalytic domain in the Elp3 histone acetyltransferases: a candidate for histone demethylase activity?
Volume: 27
Issue: 3
Pages: 115-7
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Publication
37640114 | J:340593
First Author: Pereira M
Year: 2023
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Amyloid pathology reduces ELP3 expression and tRNA modifications leading to impaired proteostasis.
Volume: 1870
Issue: 1
Pages: 166857
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Publication
27476491 | J:238986
First Author: Yoo H
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Indispensable role for mouse ELP3 in embryonic stem cell maintenance and early development.
Volume: 478
Issue: 2
Pages: 631-6
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Publication
33507234 | J:304421
 
First Author: Rosu A
Year: 2021
Journal: J Exp Med
Title: Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis.
Volume: 218
Issue: 3
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Publication
8543574 | J:28634
First Author: Ninomiya Y
Year: 1995
Journal: J Biochem
Title: Genomic organization and isoforms of the mouse ELP gene.
Volume: 118
Issue: 2
Pages: 380-9
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Publication
28507509 | J:273516
 
First Author: Laguesse S
Year: 2017
Journal: Front Cell Neurosci
Title: Loss of Elp3 Impairs the Acetylation and Distribution of Connexin-43 in the Developing Cerebral Cortex.
Volume: 11
Pages: 122
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Publication
33483347 | J:303888
First Author: Lemaitre P
Year: 2021
Journal: J Immunol
Title: Loss of the Transfer RNA Wobble Uridine-Modifying Enzyme Elp3 Delays T Cell Cycle Entry and Impairs T Follicular Helper Cell Responses through Deregulation of Atf4.
Volume: 206
Issue: 5
Pages: 1077-1087
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Publication
20054296 | J:156756
First Author: Okada Y
Year: 2010
Journal: Nature
Title: A role for the elongator complex in zygotic paternal genome demethylation.
Volume: 463
Issue: 7280
Pages: 554-8
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GXD Expression
GXD Expression
   
Probe: MGI:6401514
Assay Type: Western blot
Annotation Date: 2020-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754422
Stage: TS22
Assay Id: MGI:6401848
Age: embryonic day 14.5
Image: 1
Specimen Label: Elp3
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:5634911
Assay Type: Western blot
Annotation Date: 2020-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754422
Stage: TS22
Assay Id: MGI:6401849
Age: embryonic day 14.5
Image: 1
Specimen Label: Elp3
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:5634911
Assay Type: Western blot
Annotation Date: 2020-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754422
Stage: TS22
Assay Id: MGI:6401852
Age: embryonic day 14.5
Image: 1
Specimen Label: Elp3
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6401514
Assay Type: Western blot
Annotation Date: 2020-03-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754422
Stage: TS22
Assay Id: MGI:6401854
Age: embryonic day 14.5
Image: 1
Specimen Label: Elp3
Detected: true
Specimen Num: 3
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Publication
10445034 | -
First Author: Wittschieben BO
Year: 1999
Journal: Mol Cell
Title: A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme.
Volume: 4
Issue: 1
Pages: 123-8
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Publication
23856002 | -
 
First Author: Defraia CT
Year: 2013
Journal: BMC Plant Biol
Title: Elongator subunit 3 positively regulates plant immunity through its histone acetyltransferase and radical S-adenosylmethionine domains.
Volume: 13
Pages: 102
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Publication
25117543 | -
First Author: Estellon J
Year: 2014
Journal: Metallomics
Title: An integrative computational model for large-scale identification of metalloproteins in microbial genomes: a focus on iron-sulfur cluster proteins.
Volume: 6
Issue: 10
Pages: 1913-30
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Publication
31740832 | -
First Author: Yokogawa T
Year: 2019
Journal: Nat Chem Biol
Title: Identification of a radical SAM enzyme involved in the synthesis of archaeosine.
Volume: 15
Issue: 12
Pages: 1148-1155
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Protein
Q9CZX0
Organism: Mus musculus/domesticus
Length: 547  
Fragment?: false
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Protein
A0A286YDB8
Organism: Mus musculus/domesticus
Length: 553  
Fragment?: false
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Publication
29415125 | J:258732
First Author: Bento-Abreu A
Year: 2018
Journal: Hum Mol Genet
Title: Elongator subunit 3 (ELP3) modifies ALS through tRNA modification.
Volume: 27
Issue: 7
Pages: 1276-1289
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Publication
23878194 | J:203548
First Author: Stilger KL
Year: 2013
Journal: J Biol Chem
Title: Elongator protein 3 (Elp3) lysine acetyltransferase is a tail-anchored mitochondrial protein in Toxoplasma gondii.
Volume: 288
Issue: 35
Pages: 25318-29
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Publication
35920020 | J:328901
First Author: Chen D
Year: 2022
Journal: EMBO J
Title: Elp3-mediated codon-dependent translation promotes mTORC2 activation and regulates macrophage polarization.
Volume: 41
Issue: 18
Pages: e109353
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Publication
22854966 | J:187591
First Author: Close P
Year: 2012
Journal: J Biol Chem
Title: DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator.
Volume: 287
Issue: 39
Pages: 32535-45
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Publication
19185337 | J:150477
First Author: Creppe C
Year: 2009
Journal: Cell
Title: Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin.
Volume: 136
Issue: 3
Pages: 551-64
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Protein Coding Gene
MGP_CAROLIEiJ_G0019425 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0021481 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0021440 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0021416 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0021446 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0021223 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1921445 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0021885 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0020740 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0021190 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0021313 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0021292 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0021388 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0021321 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0021908 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0020484 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0020793 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0030443 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0020317 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:5634913
Assay Type: Western blot
Annotation Date: 2015-05-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754424
Stage: TS24
Assay Id: MGI:5635061
Age: embryonic day 16.0
Specimen Label: Cortex
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5634913
Assay Type: Western blot
Annotation Date: 2015-05-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266524
Stage: TS24
Assay Id: MGI:5635061
Age: embryonic day 16.0
Specimen Label: GE
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7493960
Assay Type: RT-PCR
Annotation Date: 2023-06-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7494020
Age: postnatal day 56
Image: S6
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7493960
Assay Type: RT-PCR
Annotation Date: 2023-06-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7494020
Age: postnatal day 56
Image: S6
Specimen Label: KO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6401513
Assay Type: Immunohistochemistry
Annotation Date: 2020-03-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:6401523
Age: embryonic day 14.5
Image: 1B
Note: Co-expressed with Gja1 in cortical neurons.
Specimen Label: 1B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5634913
Assay Type: Immunohistochemistry
Annotation Date: 2015-05-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Widespread
Stage: TS22
Assay Id: MGI:5635080
Age: embryonic day 14.5
Note: Expressed in all cells.
Specimen Label: 1P
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5634913
Assay Type: Immunohistochemistry
Annotation Date: 2015-05-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Widespread
Stage: TS22
Assay Id: MGI:5635080
Age: embryonic day 14.5
Specimen Label: 1Q
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6401513
Assay Type: Immunohistochemistry
Annotation Date: 2020-03-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:6401523
Age: embryonic day 14.5
Image: 1B
Note: Co-expressed with Gja1 in cortical neurons.
Specimen Label: 1B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5634913
Assay Type: Immunohistochemistry
Annotation Date: 2015-05-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271222
Pattern: Widespread
Stage: TS22
Assay Id: MGI:5635080
Age: embryonic day 14.5
Note: Expressed in all cells.
Specimen Label: 1P
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5634913
Assay Type: Immunohistochemistry
Annotation Date: 2015-05-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271222
Pattern: Widespread
Stage: TS22
Assay Id: MGI:5635080
Age: embryonic day 14.5
Specimen Label: 1Q
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5634913
Assay Type: Immunohistochemistry
Annotation Date: 2015-05-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:5635080
Age: embryonic day 14.5
Note: Expressed in the cytoplasm.
Specimen Label: 1R/R'
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:6401513
Assay Type: Immunohistochemistry
Annotation Date: 2020-03-26
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:6401523
Age: embryonic day 14.5
Image: 1B
Note: Co-expressed with Gja1 in cortical progenitor cells lining the ventricle.
Specimen Label: 1B
Detected: true
Specimen Num: 1
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Publication
24769394 | J:211669
First Author: Wang YP
Year: 2014
Journal: EMBO J
Title: Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress.
Volume: 33
Issue: 12
Pages: 1304-20
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Publication
21540835 | J:173167
First Author: Ura H
Year: 2011
Journal: EMBO J
Title: Eed/Sox2 regulatory loop controls ES cell self-renewal through histone methylation and acetylation.
Volume: 30
Issue: 11
Pages: 2190-204
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Publication
26356530 | J:226406
First Author: Wang S
Year: 2015
Journal: PLoS Biol
Title: Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1.
Volume: 13
Issue: 9
Pages: e1002243
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Publication
34620845 | J:312377
First Author: Even A
Year: 2021
Journal: Nat Commun
Title: ATP-citrate lyase promotes axonal transport across species.
Volume: 12
Issue: 1
Pages: 5878
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Publication
31321879 | J:280869
First Author: Freeman S
Year: 2019
Journal: EMBO Rep
Title: Proteostasis is essential during cochlear development for neuron survival and hair cell polarity.
Volume: 20
Issue: 9
Pages: e47097
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Publication
27997532 | J:237480
First Author: Naftelberg S
Year: 2016
Journal: PLoS Genet
Title: Phosphatidylserine Ameliorates Neurodegenerative Symptoms and Enhances Axonal Transport in a Mouse Model of Familial Dysautonomia.
Volume: 12
Issue: 12
Pages: e1006486
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Publication
31600191 | J:280803
First Author: Ma J
Year: 2019
Journal: PLoS Biol
Title: Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin.
Volume: 17
Issue: 10
Pages: e3000461
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Publication
26651292 | J:240003
First Author: Laguesse S
Year: 2015
Journal: Dev Cell
Title: A Dynamic Unfolded Protein Response Contributes to the Control of Cortical Neurogenesis.
Volume: 35
Issue: 5
Pages: 553-67
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Publication
19015235 | J:145561
First Author: Chen YT
Year: 2009
Journal: Mol Cell Biol
Title: Loss of mouse Ikbkap, a subunit of elongator, leads to transcriptional deficits and embryonic lethality that can be rescued by human IKBKAP.
Volume: 29
Issue: 3
Pages: 736-44
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Publication
18022353 | J:126799
First Author: Allis CD
Year: 2007
Journal: Cell
Title: New nomenclature for chromatin-modifying enzymes.
Volume: 131
Issue: 4
Pages: 633-6
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Publication
15741177 | J:126097
First Author: Cobellis G
Year: 2005
Journal: Nucleic Acids Res
Title: Tagging genes with cassette-exchange sites.
Volume: 33
Issue: 4
Pages: e44
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Publication
- | J:165964
     
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
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Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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