| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
ER membrane protein complex subunit 7 (EMC7) is a component of the endoplasmic reticulum membrane protein complex (EMC). This complex was first found to interact with the degradation of misfolded proteins by the ubiquitin- and proteasome-dependent process known as ER-associated degradation (ERAD) [], thus suggesting a role in the biosynthesis of transmembrane proteins. More recently, it was shown that EMC acts as a conserved co- and post-translational insertase at the endoplasmic reticulum in an energy-independent manner [, ]. EMC7 has been misnamed C11orf3, but is more correctly named C15orf24 because the gene is actually on human chromosome 15. |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xiong L |
| Year: |
2019 |
| Journal: |
Cell Death Differ |
| Title: |
ER complex proteins are required for rhodopsin biosynthesis and photoreceptor survival in Drosophila and mice. |
|
|
|
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
241
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
241
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Christianson JC |
| Year: |
2011 |
| Journal: |
Nat Cell Biol |
| Title: |
Defining human ERAD networks through an integrative mapping strategy. |
| Volume: |
14 |
| Issue: |
1 |
| Pages: |
93-105 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pleiner T |
| Year: |
2020 |
| Journal: |
Science |
| Title: |
Structural basis for membrane insertion by the human ER membrane protein complex. |
| Volume: |
369 |
| Issue: |
6502 |
| Pages: |
433-436 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6456899 |
| Assay Type: |
Western blot |
| Annotation Date: |
2020-09-24 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672826 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:6456979 |
| Age: |
embryonic day 18.5 |
| Image: |
1 |
|
| Specimen Label: |
+/+ |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6456899 |
| Assay Type: |
Western blot |
| Annotation Date: |
2020-09-24 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672826 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:6456979 |
| Age: |
embryonic day 18.5 |
| Image: |
1 |
|
| Specimen Label: |
+/+ |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6456899 |
| Assay Type: |
Western blot |
| Annotation Date: |
2020-09-24 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672826 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:6456979 |
| Age: |
embryonic day 18.5 |
| Image: |
1 |
|
| Specimen Label: |
+/+ |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6456899 |
| Assay Type: |
Western blot |
| Annotation Date: |
2020-09-24 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672826 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:6456979 |
| Age: |
embryonic day 18.5 |
| Image: |
1 |
|
| Specimen Label: |
+/- |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6456899 |
| Assay Type: |
Western blot |
| Annotation Date: |
2020-09-24 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672826 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:6456979 |
| Age: |
embryonic day 18.5 |
| Image: |
1 |
|
| Specimen Label: |
+/- |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6456899 |
| Assay Type: |
Western blot |
| Annotation Date: |
2020-09-24 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672826 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:6456979 |
| Age: |
embryonic day 18.5 |
| Image: |
1 |
|
| Specimen Label: |
+/- |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6456899 |
| Assay Type: |
Western blot |
| Annotation Date: |
2020-09-24 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672826 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:6456979 |
| Age: |
embryonic day 18.5 |
| Image: |
1 |
|
| Specimen Label: |
-/- |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6456899 |
| Assay Type: |
Western blot |
| Annotation Date: |
2020-09-24 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672826 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:6456979 |
| Age: |
embryonic day 18.5 |
| Image: |
1 |
|
| Specimen Label: |
-/- |
| Detected: |
true |
| Specimen Num: |
8 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6456899 |
| Assay Type: |
Western blot |
| Annotation Date: |
2020-09-24 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672826 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:6456979 |
| Age: |
embryonic day 18.5 |
| Image: |
1 |
|
| Specimen Label: |
-/- |
| Detected: |
true |
| Specimen Num: |
9 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3584584 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1915528 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:3585809 |
| Age: |
postnatal day 6-7 |
| Image: |
P6/7 |
|
| Specimen Label: |
P6/7 |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3584584 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-08-30 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1915528 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:3585809 |
| Age: |
postnatal day 8-10 |
| Image: |
P8/10 |
|
| Specimen Label: |
P8/10 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3584584 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3598824 |
| Pattern: |
Not Specified |
| Stage: |
TS24 |
| Assay Id: |
MGI:3585809 |
| Age: |
embryonic day 16.0 |
|
|
| Specimen Label: |
Embryo |
| Detected: |
true |
| Specimen Num: |
8 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3584584 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1647028 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:3585809 |
| Age: |
postnatal day 6 |
|
| Note: |
Expression was widespread. |
| Specimen Label: |
CNS |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3584584 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1915727 |
| Pattern: |
Not Specified |
| Stage: |
TS27 |
| Assay Id: |
MGI:3585809 |
| Age: |
postnatal day 2-3 |
|
| Note: |
Expression was detected in the outer neuroblastic layer. |
| Specimen Label: |
P2/3 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3584584 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1915728 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:3585809 |
| Age: |
postnatal day 4-5 |
| Image: |
P4/5 |
| Note: |
Expression was detected in the outer neuroblastic layer. |
| Specimen Label: |
P4/5 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3584584 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1915728 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:3585809 |
| Age: |
postnatal day 6-7 |
| Image: |
P6/7 |
| Note: |
Expression was detected in the inner segment. |
| Specimen Label: |
P6/7 |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3584584 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1915728 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:3585809 |
| Age: |
postnatal day 8-10 |
| Image: |
P8/10 |
| Note: |
Expression was detected in the inner segment. |
| Specimen Label: |
P8/10 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3584584 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1915728 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:3585809 |
| Age: |
postnatal adult |
|
| Note: |
Expression was detected in the inner segment. |
| Specimen Label: |
Adult |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3584584 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684624 |
| Pattern: |
Not Specified |
| Stage: |
TS24 |
| Assay Id: |
MGI:3585809 |
| Age: |
embryonic day 16.0 |
|
|
| Specimen Label: |
Embryo |
| Detected: |
true |
| Specimen Num: |
8 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3584584 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1859224 |
| Pattern: |
Regionally restricted |
| Stage: |
TS24 |
| Assay Id: |
MGI:3585809 |
| Age: |
embryonic day 16.0 |
| Image: |
E16 |
| Note: |
Expression was detected in the outer neuroblastic layer and the scleral inner neuroblastic layer. The expression level was higher in the scleral inner neuroblastic layer. |
| Specimen Label: |
E16 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
O'Brien KP |
| Year: |
2000 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Characterization of five novel human genes in the 11q13-q22 region. |
| Volume: |
273 |
| Issue: |
1 |
| Pages: |
90-4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guna A |
| Year: |
2018 |
| Journal: |
Science |
| Title: |
The ER membrane protein complex is a transmembrane domain insertase. |
| Volume: |
359 |
| Issue: |
6374 |
| Pages: |
470-473 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tang X |
| Year: |
2017 |
| Journal: |
J Clin Invest |
| Title: |
EMC3 coordinates surfactant protein and lipid homeostasis required for respiration. |
| Volume: |
127 |
| Issue: |
12 |
| Pages: |
4314-4325 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tang T |
| Year: |
2010 |
| Journal: |
Nat Biotechnol |
| Title: |
A mouse knockout library for secreted and transmembrane proteins. |
| Volume: |
28 |
| Issue: |
7 |
| Pages: |
749-55 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lexicon Genetics, Inc |
| Year: |
2011 |
| Journal: |
Database Download |
| Title: |
MGI download of Lexicon knockout data |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom |
| Year: |
2023 |
|
| Title: |
Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Blackshaw S |
| Year: |
2004 |
| Journal: |
PLoS Biol |
| Title: |
Genomic analysis of mouse retinal development. |
| Volume: |
2 |
| Issue: |
9 |
| Pages: |
E247 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
University of California, Davis |
| Year: |
2010 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by the University of California, Davis |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stryke D |
| Year: |
2003 |
| Journal: |
Nucleic Acids Res |
| Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
| Volume: |
31 |
| Issue: |
1 |
| Pages: |
278-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
International Knockout Mouse Consortium |
| Year: |
2014 |
| Journal: |
Database Download |
| Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
| Year: |
2014 |
| Journal: |
Database Release |
| Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
| Year: |
2001 |
|
| Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2003 |
|
| Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kawai J |
| Year: |
2001 |
| Journal: |
Nature |
| Title: |
Functional annotation of a full-length mouse cDNA collection. |
| Volume: |
409 |
| Issue: |
6821 |
| Pages: |
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