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Search results 1 to 100 out of 100 for Emsy

0.086s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
56946 | EMSY
Type: gene
Organism: human
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Gene
361607 | Emsy
Type: gene
Organism: rat
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Gene
466716 | EMSY
Type: gene
Organism: chimpanzee
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Gene
476800 | EMSY
Type: gene
Organism: dog, domestic
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Gene
540919 | EMSY
Type: gene
Organism: cattle
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Gene
335889 | emsy
Type: gene
Organism: zebrafish
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Gene
697319 | EMSY
Type: gene
Organism: macaque, rhesus
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Gene
100136947 | emsy
Type: gene
Organism: frog, western clawed
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Protein Domain
IPR033482 | EMSY
Type: Family
Description: EMSY was originally reported as a transcriptional repressor and breast cancer-associated protein that interacts with the BRCA2 protein []. It contains an N-terminal ENT domain which can bind BRCA2. It is involved in DNA damage repair, genomic instability, and chromatin remodeling []. EMSY can function as an integral component of an NIF-1 complex and play an important role in the regulation of nuclear receptor-mediated transcription []. It is also part of the EMSY/KDM5A/SIN3B complex that may function as a transcriptional repressor [].
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Gene
419090 | EMSY
Type: gene
Organism: chicken
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Protein Coding Gene
MGI:1924203 | Emsy
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
26841866 | J:232727
First Author: Varier RA
Year: 2016
Journal: J Biol Chem
Title: Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131.
Volume: 291
Issue: 14
Pages: 7313-24
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Protein
A0A0U1RNQ4
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: true
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Protein
A0A0U1RQ63
Organism: Mus musculus/domesticus
Length: 246  
Fragment?: true
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Protein
A0A0U1RPN4
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: true
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Publication
14651845 | -
First Author: Hughes-Davies L
Year: 2003
Journal: Cell
Title: EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer.
Volume: 115
Issue: 5
Pages: 523-35
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Protein
Q8BMB0
Organism: Mus musculus/domesticus
Length: 1264  
Fragment?: false
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Protein
A0A0U1RNN7
Organism: Mus musculus/domesticus
Length: 316  
Fragment?: true
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Protein
A0A0U1RPW3
Organism: Mus musculus/domesticus
Length: 735  
Fragment?: true
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Protein
A0A0U1RPK1
Organism: Mus musculus/domesticus
Length: 1070  
Fragment?: false
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Gene
124902718 | EMSY-DT
Type: gene
Organism: human
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Protein
Q3USB6
Organism: Mus musculus/domesticus
Length: 123  
Fragment?: false
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Publication
19131338 | -
First Author: Garapaty S
Year: 2009
Journal: J Biol Chem
Title: Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation.
Volume: 284
Issue: 12
Pages: 7542-52
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Publication
15947784 | J:99579
First Author: Ekblad CM
Year: 2005
Journal: EMBO Rep
Title: Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69.
Volume: 6
Issue: 7
Pages: 675-80
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Publication
34963055 | J:319532
First Author: Marzio A
Year: 2022
Journal: Cell
Title: EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion.
Volume: 185
Issue: 1
Pages: 169-183.e19
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Publication
15978617 | -
First Author: Chavali GB
Year: 2005
Journal: J Mol Biol
Title: Crystal structure of the ENT domain of human EMSY.
Volume: 350
Issue: 5
Pages: 964-73
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Publication
22315412 | J:182010
First Author: Ezell SA
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: The protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY.
Volume: 109
Issue: 10
Pages: E613-21
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Protein Coding Gene
MGP_CAROLIEiJ_G0030019 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032541 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032515 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032451 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032526 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0032241 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1924203 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0033024 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031568 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0032208 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032360 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032317 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032449 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032349 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0033046 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031286 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0031685 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0013240 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0031129 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:94077
     
First Author: Mutant Mouse Regional Resource Centers
Year: 2004
Journal: Unpublished
Title: Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC)
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 1
Description: BRCA2-interacting transcriptional repressor EMSY
Type: chain
End: 1264
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Protein
Q8BMB0-2
Organism: Mus musculus/domesticus
Length: 1118  
Fragment?: false
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Protein
Q8BMB0-3
Organism: Mus musculus/domesticus
Length: 1250  
Fragment?: false
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Publication
21830950 | -
First Author: Tsuchiya T
Year: 2011
Journal: Mol Plant Microbe Interact
Title: EMSY-like genes are required for full RPP7-mediated race-specific immunity and basal defense in Arabidopsis.
Volume: 24
Issue: 12
Pages: 1573-81
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Protein Domain
IPR033485 | EMSY-LIKE_plant
Type: Family
Description: This entry represents the EMSY-like proteins from plants. They contain an EMSY N-terminal (ENT) domain, a central Agenet domain, and a putative C-terminal coiled-coil structure. Arabidopsis EMSY-like proteins contribute to RPP7-mediated and basal immunity, especially against Hyaloperonospora arabidopsidis isolate Hiks1 [].
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Publication
25183522 | -
First Author: Xu Y
Year: 2014
Journal: Nucleic Acids Res
Title: Arabidopsis MRG domain proteins bridge two histone modifications to elevate expression of flowering genes.
Volume: 42
Issue: 17
Pages: 10960-74
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Protein Domain
IPR014002 | Agenet_dom_plant
Type: Domain
Description: This entry represents an agenet domain found in EMSY-like (AtEML) proteins, which have possible roles in chromatin regulation and are related to the BRCA2-interacting human oncoprotein EMSY []. Proteins containing this domain also include MRG2 (AT1G02740) from Arabidopsis and PHD finger protein 20-like protein 1 (PHF20L1) from animals. MRG2 binds to the FLOWERING LOCUS T locus and elevates the expression in an H3K36me3-dependent manner []. The function of PHF20L1 is not clear.
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Protein Domain
IPR036142 | ENT_dom-like_sf
Type: Homologous_superfamily
Description: The EMSY N-terminal (ENT) domain is a ~90-residue module, which is unique in the human proteome, although multiple copies are found in Arabidopsis proteins. In the plant proteins, the ENT domains are accompanied by Agenet domains, plant specific homologues of Tudor domains [, ].The ENT domain consists of a unique arrangement of five α-helices that fold into a helical bundle arrangement. Overall, the three-dimensional structure adopts a club-like shape that consists of an extended N-terminal α-helix that connects to a helical bundle substructure. The ENT domain forms a homodimer via the anti-parallel packing of the long N-terminal α-helix from each subunit [, ].
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Protein Domain
IPR005491 | ENT_dom
Type: Domain
Description: The EMSY N-terminal (ENT) domain is a ~90-residue module, which is unique in the human proteome, although multiple copies are found in Arabidopsis proteins. In the plant proteins, the ENT domains are accompanied by Agenet domains, plant specific homologues of Tudor domains [, ].The ENT domain consists of a unique arrangement of five α-helices that fold into a helical bundle arrangement. Overall, the three-dimensional structure adopts a club-like shape that consists of an extended N-terminal α-helix that connects to a helical bundle substructure. The ENT domain forms a homodimer via the anti-parallel packing of the long N-terminal α-helix from each subunit [, ].
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Publication
16452088 | -
First Author: Vosseller K
Year: 2006
Journal: Mol Cell Proteomics
Title: O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry.
Volume: 5
Issue: 5
Pages: 923-34
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Publication
12575993 | -
First Author: Maurer-Stroh S
Year: 2003
Journal: Trends Biochem Sci
Title: The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains.
Volume: 28
Issue: 2
Pages: 69-74
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Protein
Q63ZX6
Organism: Mus musculus/domesticus
Length: 578  
Fragment?: true
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Protein
A0A2R8VKH6
Organism: Mus musculus/domesticus
Length: 567  
Fragment?: false
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Protein
Q6P7V2
Organism: Mus musculus/domesticus
Length: 532  
Fragment?: true
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Protein
Q8CCJ9
Organism: Mus musculus/domesticus
Length: 1013  
Fragment?: false
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Protein
A0A2R8VHV1
Organism: Mus musculus/domesticus
Length: 987  
Fragment?: false
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Protein
A0A5S8DHC4
Organism: Mus musculus/domesticus
Length: 1014  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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