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Search results 1 to 100 out of 338 for Enpp1

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0.067s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1) possesses alkaline phosphodiesterase I and nucleotide pyrophosphatase activities []. ENPP1 hydrolyses extracellular nucleotide triphosphates to produce pyrophosphate and regulates bone mineralization, soft tissue calcification, and insulin signalling [, , ].Mutations in the ENPP1 gene cause several pathological calcification syndromes, such as idiopathic infantile arterial calcification (IIAC) []and ossification of the posterior longitudinal ligament of the spine (OPLL) [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Kato K
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling.
Volume: 109
Issue: 42
Pages: 16876-81
Publication
First Author: Hessle L
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization.
Volume: 99
Issue: 14
Pages: 9445-9
Publication
First Author: Rutsch F
Year: 2003
Journal: Nat Genet
Title: Mutations in ENPP1 are associated with 'idiopathic' infantile arterial calcification.
Volume: 34
Issue: 4
Pages: 379-81
Publication
First Author: Liang J
Year: 2007
Journal: PLoS One
Title: Role of ENPP1 on adipocyte maturation.
Volume: 2
Issue: 9
Pages: e882
Publication
First Author: Palazzo L
Year: 2016
Journal: FEBS J
Title: ENPP1 processes protein ADP-ribosylation in vitro.
Volume: 283
Issue: 18
Pages: 3371-88
Publication
First Author: Li L
Year: 2014
Journal: Nat Chem Biol
Title: Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs.
Volume: 10
Issue: 12
Pages: 1043-8
Publication
First Author: Takabayashi S
Year: 2014
Journal: Exp Anim
Title: A new Enpp1 allele, Enpp1(ttw-Ham), identified in an ICR closed colony.
Volume: 63
Issue: 2
Pages: 193-204
Publication
First Author: Watanabe R
Year: 2017
Journal: Sci Rep
Title: Enpp1 is an anti-aging factor that regulates Klotho under phosphate overload conditions.
Volume: 7
Issue: 1
Pages: 7786
Publication
First Author: Belli SI
Year: 1994
Journal: Eur J Biochem
Title: Biochemical characterization of human PC-1, an enzyme possessing alkaline phosphodiesterase I and nucleotide pyrophosphatase activities.
Volume: 226
Issue: 2
Pages: 433-43
Publication
First Author: Abate N
Year: 2006
Journal: Nat Clin Pract Endocrinol Metab
Title: Mechanisms of disease: Ectonucleotide pyrophosphatase phosphodiesterase 1 as a 'gatekeeper' of insulin receptors.
Volume: 2
Issue: 12
Pages: 694-701
Publication
First Author: Nakamura I
Year: 1999
Journal: Hum Genet
Title: Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL).
Volume: 104
Issue: 6
Pages: 492-7
Publication
First Author: Babij P
Year: 2009
Journal: J Bone Miner Res
Title: New variants in the Enpp1 and Ptpn6 genes cause low BMD, crystal-related arthropathy, and vascular calcification.
Volume: 24
Issue: 9
Pages: 1552-64
Publication
First Author: Serrano RL
Year: 2014
Journal: Atherosclerosis
Title: Mono-allelic and bi-allelic ENPP1 deficiency promote post-injury neointimal hyperplasia associated with increased C/EBP homologous protein expression.
Volume: 233
Issue: 2
Pages: 493-502
Protein
Organism: Mus musculus
Length: 64  
Fragment?: true
Protein
Organism: Mus musculus
Length: 695  
Fragment?: true
Publication
First Author: Li Q
Year: 2014
Journal: PLoS One
Title: Spontaneous asj-2J mutant mouse as a model for generalized arterial calcification of infancy: a large deletion/insertion mutation in the Enpp1 gene.
Volume: 9
Issue: 12
Pages: e113542
Protein
Organism: Mus musculus
Length: 906  
Fragment?: false
Protein
Organism: Mus musculus
Length: 905  
Fragment?: false
Protein
Organism: Mus musculus
Length: 906  
Fragment?: false
Protein
Organism: Mus musculus
Length: 369  
Fragment?: false
Publication      
First Author: Harris BS
Year: 2011
Journal: MGI Direct Data Submission
Title: Ages with stiffened joints, A new mutation in Enpp1
Publication  
First Author: Jin Y
Year: 2018
Journal: Development
Title: Enpp1 inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling.
Volume: 145
Issue: 18
Publication
First Author: Kato K
Year: 2018
Journal: Nat Commun
Title: Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1.
Volume: 9
Issue: 1
Pages: 4424
Publication
First Author: Pan W
Year: 2011
Journal: Am J Physiol Endocrinol Metab
Title: Metabolic consequences of ENPP1 overexpression in adipose tissue.
Volume: 301
Issue: 5
Pages: E901-11
Publication
First Author: Nam HK
Year: 2011
Journal: J Biol Chem
Title: Ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) protein regulates osteoblast differentiation.
Volume: 286
Issue: 45
Pages: 39059-71
Publication
First Author: Li Q
Year: 2013
Journal: Dis Model Mech
Title: Mutant Enpp1asj mice as a model for generalized arterial calcification of infancy.
Volume: 6
Issue: 5
Pages: 1227-35
Publication
First Author: Kingman J
Year: 2017
Journal: Oncotarget
Title: Elevated dietary magnesium during pregnancy and postnatal life prevents ectopic mineralization in Enpp1asj mice, a model for generalized arterial calcification of infancy.
Volume: 8
Issue: 24
Pages: 38152-38160
Publication
First Author: Li Q
Year: 2016
Journal: J Invest Dermatol
Title: Dual Effects of Bisphosphonates on Ectopic Skin and Vascular Soft Tissue Mineralization versus Bone Microarchitecture in a Mouse Model of Generalized Arterial Calcification of Infancy.
Volume: 136
Issue: 1
Pages: 275-83
Publication
First Author: Tian C
Year: 2016
Journal: PLoS One
Title: Ectopic Mineralization and Conductive Hearing Loss in Enpp1asj Mutant Mice, a New Model for Otitis Media and Tympanosclerosis.
Volume: 11
Issue: 12
Pages: e0168159
Publication
First Author: Anderson HC
Year: 2005
Journal: Am J Pathol
Title: Sustained osteomalacia of long bones despite major improvement in other hypophosphatasia-related mineral deficits in tissue nonspecific alkaline phosphatase/nucleotide pyrophosphatase phosphodiesterase 1 double-deficient mice.
Volume: 166
Issue: 6
Pages: 1711-20
Publication
First Author: Zhao J
Year: 2017
Journal: J Invest Dermatol
Title: Plasma PPi Deficiency Is the Major, but Not the Exclusive, Cause of Ectopic Mineralization in an Abcc6-/- Mouse Model of PXE.
Volume: 137
Issue: 11
Pages: 2336-2343
Publication
First Author: Li Q
Year: 2014
Journal: Lab Invest
Title: Genetic modulation of nephrocalcinosis in mouse models of ectopic mineralization: the Abcc6(tm1Jfk) and Enpp1(asj) mutant mice.
Volume: 94
Issue: 6
Pages: 623-32
Publication
First Author: Dedinszki D
Year: 2017
Journal: EMBO Mol Med
Title: Oral administration of pyrophosphate inhibits connective tissue calcification.
Volume: 9
Issue: 11
Pages: 1463-1470
Publication
First Author: Harmey D
Year: 2004
Journal: Am J Pathol
Title: Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders.
Volume: 164
Issue: 4
Pages: 1199-209
Publication
First Author: Neunaber C
Year: 2010
Journal: J Bone Miner Res
Title: Increased trabecular bone formation in mice lacking the growth factor midkine.
Volume: 25
Issue: 8
Pages: 1724-35
Publication
First Author: Koshizuka Y
Year: 2001
Journal: Cytogenet Cell Genet
Title: Isolation of novel mouse genes associated with ectopic ossification by differential display method using ttw, a mouse model for ectopic ossification.
Volume: 94
Issue: 3-4
Pages: 163-8
Publication  
First Author: Motch Perrine SM
Year: 2019
Journal: Dis Model Mech
Title: Mandibular dysmorphology due to abnormal embryonic osteogenesis in FGFR2-related craniosynostosis mice.
Volume: 12
Issue: 5
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: van Driel IR
Year: 1987
Journal: J Biol Chem
Title: Plasma cell membrane glycoprotein PC-1. Primary structure deduced from cDNA clones.
Volume: 262
Issue: 10
Pages: 4882-7
Publication
First Author: Belli SI
Year: 1993
Journal: Eur J Biochem
Title: Identification and characterization of a soluble form of the plasma cell membrane glycoprotein PC-1 (5'-nucleotide phosphodiesterase).
Volume: 217
Issue: 1
Pages: 421-8
Publication
First Author: van Driel IR
Year: 1985
Journal: Proc Natl Acad Sci U S A
Title: Murine plasma cell membrane antigen PC-1: molecular cloning of cDNA and analysis of expression.
Volume: 82
Issue: 24
Pages: 8619-23
Publication
First Author: Buckley MF
Year: 1990
Journal: J Biol Chem
Title: Plasma cell membrane glycoprotein PC-1. cDNA cloning of the human molecule, amino acid sequence, and chromosomal location.
Volume: 265
Issue: 29
Pages: 17506-11
Publication
First Author: Okawa A
Year: 1998
Journal: Nat Genet
Title: Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine.
Volume: 19
Issue: 3
Pages: 271-3
Publication
First Author: Jansen S
Year: 2012
Journal: Structure
Title: Structure of NPP1, an ectonucleotide pyrophosphatase/phosphodiesterase involved in tissue calcification.
Volume: 20
Issue: 11
Pages: 1948-59
Publication
First Author: Gijsbers R
Year: 2003
Journal: Biochem J
Title: Functional characterization of the non-catalytic ectodomains of the nucleotide pyrophosphatase/phosphodiesterase NPP1.
Volume: 371
Issue: Pt 2
Pages: 321-30
Publication
First Author: Zhu D
Year: 2011
Journal: PLoS One
Title: The appearance and modulation of osteocyte marker expression during calcification of vascular smooth muscle cells.
Volume: 6
Issue: 5
Pages: e19595
Publication  
First Author: Hajjawi MO
Year: 2014
Journal: Bone
Title: Mineralisation of collagen rich soft tissues and osteocyte lacunae in Enpp1(-/-) mice.
Volume: 69
Pages: 139-47
Publication      
First Author: Sali A
Year: 1999
Title: Germline deletion of the nucleoside triphosphate pyrophosphohydrolase (NTPPPH) plasma cell membrane glycoprotein (PC-1) produces abnormal calcification of periarticular tissues
Pages: 267-282
Publication
First Author: Huesa C
Year: 2014
Journal: Dis Model Mech
Title: Deficiency of the bone mineralization inhibitor NPP1 protects mice against obesity and diabetes.
Volume: 7
Issue: 12
Pages: 1341-50
Publication  
First Author: Albright RA
Year: 2015
Journal: Nat Commun
Title: ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy.
Volume: 6
Pages: 10006
Publication  
First Author: Hosoda Y
Year: 1981
Journal: Ryumachi
Title: A new breed of mouse showing multiple osteochondral lesions--twy mouse.
Volume: 21 Suppl
Pages: 157-64
Publication
First Author: Uchida K
Year: 1998
Journal: J Neurol
Title: Histological investigation of spinal cord lesions in the spinal hyperostotic mouse (twy/twy): morphological changes in anterior horn cells and immunoreactivity to neurotropic factors.
Volume: 245
Issue: 12
Pages: 781-93
Publication
First Author: Ohtsuki T
Year: 1998
Journal: Calcif Tissue Int
Title: Gene expression of noncollagenous bone matrix proteins in the limb joints and intervertebral disks of the twy mouse.
Volume: 63
Issue: 2
Pages: 167-72
Publication  
First Author: Esaki K
Year: 1990
Journal: Mouse Genome
Title: Tip-toe walking (ttw).
Volume: 86
Pages: 242
Publication
First Author: Bertrand J
Year: 2012
Journal: Ann Rheum Dis
Title: Decreased levels of nucleotide pyrophosphatase phosphodiesterase 1 are associated with cartilage calcification in osteoarthritis and trigger osteoarthritic changes in mice.
Volume: 71
Issue: 7
Pages: 1249-53
Publication
First Author: Baba H
Year: 1996
Journal: J Neurol
Title: Quantitative analysis of the spinal cord motoneuron under chronic compression: an experimental observation in the mouse.
Volume: 243
Issue: 2
Pages: 109-16
Publication
First Author: Kobayashi Y
Year: 1998
Journal: Calcif Tissue Int
Title: Regional variations in the progression of bone loss in two different mouse osteopenia models.
Volume: 62
Issue: 5
Pages: 426-36
Publication
First Author: Hirai T
Year: 2013
Journal: PLoS One
Title: The prevalence and phenotype of activated microglia/macrophages within the spinal cord of the hyperostotic mouse (twy/twy) changes in response to chronic progressive spinal cord compression: implications for human cervical compressive myelopathy.
Volume: 8
Issue: 5
Pages: e64528
Publication
First Author: Okawa A
Year: 1998
Journal: Mamm Genome
Title: Mapping of a gene responsible for twy (tip-toe walking Yoshimura), a mouse model of ossification of the posterior longitudinal ligament of the spine (OPLL).
Volume: 9
Issue: 2
Pages: 155-6
Publication
First Author: Yato Y
Year: 1997
Journal: Spinal Cord
Title: Decreased choline acetyltransferase activity in the murine spinal cord motoneurons under chronic mechanical compression.
Volume: 35
Issue: 11
Pages: 729-34
Publication
First Author: Sakamoto M
Year: 1994
Journal: Pathol Int
Title: Arthritis and ankylosis in twy mice with hereditary multiple osteochondral lesions: with special reference to calcium deposition.
Volume: 44
Issue: 6
Pages: 420-7
Publication
First Author: Kojimahara K
Year: 1993
Journal: Keio J Med
Title: Pathophysiological and biochemical studies on the vertebral and spinal cord lesions of Twy mouse (Mouse with genetic osteochondral abnormalities).
Volume: 42
Issue: 2
Pages: 87
Publication
First Author: Baba H
Year: 1997
Journal: Eur J Histochem
Title: Potential role of streptozotocin in enhancing ossification of the posterior longitudinal ligament of the cervical spine in the hereditary spinal hyperostotic mouse (twy/twy).
Volume: 41
Issue: 3
Pages: 191-202
Publication
First Author: Takahashi T
Year: 1970
Journal: J Exp Med
Title: Surface alloantigens of plasma cells.
Volume: 131
Issue: 6
Pages: 1325-41
Publication
First Author: Herberman RB
Year: 1972
Journal: J Exp Med
Title: Immune and natural antibodies to syngeneic murine plasma cell tumors.
Volume: 136
Issue: 1
Pages: 94-111
Publication
First Author: Goding JW
Year: 1982
Journal: J Immunol
Title: Structure of the murine plasma cell alloantigen PC-1: comparison with the receptor for transferrin.
Volume: 129
Issue: 6
Pages: 2636-40
Publication
First Author: Rebbe NF
Year: 1993
Journal: Mol Immunol
Title: Expression of nucleotide pyrophosphatase and alkaline phosphodiesterase I activities of PC-1, the murine plasma cell antigen.
Volume: 30
Issue: 1
Pages: 87-93
Publication
First Author: Terakado A
Year: 1995
Journal: Calcif Tissue Int
Title: Elevation of alkaline phosphatase activity induced by parathyroid hormone in osteoblast-like cells from the spinal hyperostotic mouse TWY (twy/twy).
Volume: 56
Issue: 2
Pages: 135-9
Publication
First Author: Cimpean A
Year: 2004
Journal: Biochem J
Title: Substrate-specifying determinants of the nucleotide pyrophosphatases/phosphodiesterases NPP1 and NPP2.
Volume: 381
Issue: Pt 1
Pages: 71-7
Publication
First Author: Maddux BA
Year: 2006
Journal: Am J Physiol Endocrinol Metab
Title: Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia.
Volume: 290
Issue: 4
Pages: E746-9
GXD Expression      
Probe: MGI:5310132
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876922
Stage: TS22
Assay Id: MGI:5423456
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310132
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1753622
Stage: TS22
Assay Id: MGI:5423456
Age: embryonic day 14.5
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:4885128
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753628
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945997
Age: postnatal day 42
Image: g02545 Adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4885128
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753628
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945997
Age: postnatal day 7
Image: g02545 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4885128
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753623
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945997
Age: embryonic day 15.5
Image: g02545 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5811387
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1610517
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5823611
Age: embryonic day 10.5
Image: Enpp1_a96_E10.5d_3JUNE2013
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:5811387
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1610517
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5823611
Age: embryonic day 10.5
Image: Enpp1_a96_E10.5c_3JUNE2013
Detected: true
Specimen Num: 11