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Search results 1 to 64 out of 64 for Enpp7

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
339221 | ENPP7
Type: gene
Organism: human
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Gene
100422804 | enpp7
Type: gene
Organism: frog, western clawed
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Gene
303729 | Enpp7
Type: gene
Organism: rat
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Gene
608627 | ENPP7
Type: gene
Organism: dog, domestic
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Gene
742055 | ENPP7
Type: gene
Organism: chimpanzee
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Gene
505388 | ENPP7
Type: gene
Organism: cattle
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Gene
426249 | ENPP7
Type: gene
Organism: chicken
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Gene
717416 | ENPP7
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:3027917 | Enpp7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR029895 | ENPP7
Type: Family
Description: Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (ENPP7), also known as alkaline sphingomyelin phosphodiesterase or intestinal alkaline sphingomyelinase, converts sphingomyelin to ceramide in the intestinal tract [, ]. Crystal structure reveals a specific aromatic box composed of tyrosine residues which recognises the choline moiety in its substrates, a hydrophobic loop, and positively charged surfaces for contacting bile salt micelles []. It is also able to inactivate the pro-inflammatory phospholipid PAF (platelet-activating factor) by a phospholipase C activity, and may counteract the development of intestinal inflammation and cancer [, ]. It does not appear to have nucleotide pyrophosphatase activity [].
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Publication
12885774 | J:85836
First Author: Duan RD
Year: 2003
Journal: J Biol Chem
Title: Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family.
Volume: 278
Issue: 40
Pages: 38528-36
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Protein
B7ZWB9
Organism: Mus musculus/domesticus
Length: 439  
Fragment?: false
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Protein
Q3TIW9
Organism: Mus musculus/domesticus
Length: 439  
Fragment?: false
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Protein
A0A6I8MWV7
Organism: Mus musculus/domesticus
Length: 446  
Fragment?: false
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Publication
12671034 | -
First Author: Duan RD
Year: 2003
Journal: J Lipid Res
Title: Purification, localization, and expression of human intestinal alkaline sphingomyelinase.
Volume: 44
Issue: 6
Pages: 1241-50
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Publication
16255717 | -
First Author: Wu J
Year: 2006
Journal: Biochem J
Title: Intestinal alkaline sphingomyelinase hydrolyses and inactivates platelet-activating factor by a phospholipase C activity.
Volume: 394
Issue: Pt 1
Pages: 299-308
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Publication
18989780 | -
First Author: Andersson D
Year: 2009
Journal: Dig Dis Sci
Title: Expression of alkaline sphingomyelinase in yeast cells and anti-inflammatory effects of the expressed enzyme in a rat colitis model.
Volume: 54
Issue: 7
Pages: 1440-8
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Publication
19598106 | -
First Author: Massé K
Year: 2010
Journal: Int J Dev Biol
Title: Ectophosphodiesterase/nucleotide phosphohydrolase (Enpp) nucleotidases: cloning, conservation and developmental restriction.
Volume: 54
Issue: 1
Pages: 181-93
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Publication
28292932 | -
First Author: Gorelik A
Year: 2017
Journal: J Biol Chem
Title: Crystal structure of the human alkaline sphingomyelinase provides insights into substrate recognition.
Volume: 292
Issue: 17
Pages: 7087-7094
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Protein Coding Gene
MGP_CAROLIEiJ_G0017488 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0019471 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0019439 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0019409 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0019414 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0019220 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_3027917 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0019863 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0018774 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0019191 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0019303 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0019295 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0019373 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0019328 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0019902 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0018540 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0018826 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0018615 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0018332 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
21177474 | J:170667
First Author: Zhang Y
Year: 2011
Journal: J Lipid Res
Title: Crucial role of alkaline sphingomyelinase in sphingomyelin digestion: a study on enzyme knockout mice.
Volume: 52
Issue: 4
Pages: 771-81
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Publication
24650549 | J:211198
First Author: Zhang P
Year: 2014
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Alkaline sphingomyelinase (NPP7) promotes cholesterol absorption by affecting sphingomyelin levels in the gut: A study with NPP7 knockout mice.
Volume: 306
Issue: 10
Pages: G903-8
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Publication
16631405 | J:112853
First Author: Duan RD
Year: 2006
Journal: Biochim Biophys Acta
Title: Alkaline sphingomyelinase: an old enzyme with novel implications.
Volume: 1761
Issue: 3
Pages: 281-91
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Publication
25381265 | J:317260
First Author: Chen Y
Year: 2015
Journal: Mol Cancer Ther
Title: Enhanced colonic tumorigenesis in alkaline sphingomyelinase (NPP7) knockout mice.
Volume: 14
Issue: 1
Pages: 259-67
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Publication
30087205 | J:266041
First Author: Zhang P
Year: 2018
Journal: J Lipid Res
Title: Deficiency of alkaline SMase enhances dextran sulfate sodium-induced colitis in mice with upregulation of autotaxin.
Volume: 59
Issue: 10
Pages: 1841-1850
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Publication
20562862 | J:161922
First Author: Tang T
Year: 2010
Journal: Nat Biotechnol
Title: A mouse knockout library for secreted and transmembrane proteins.
Volume: 28
Issue: 7
Pages: 749-55
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Publication
- | J:171883
     
First Author: Lexicon Genetics, Inc
Year: 2011
Journal: Database Download
Title: MGI download of Lexicon knockout data
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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