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Search results 1 to 100 out of 499 for Eps8

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
2059 | EPS8
Type: gene
Organism: human
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Gene
779963 | eps8
Type: gene
Organism: frog, western clawed
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Gene
312812 | Eps8
Type: gene
Organism: rat
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Gene
477686 | EPS8
Type: gene
Organism: dog, domestic
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Gene
473379 | EPS8
Type: gene
Organism: chimpanzee
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Gene
538419 | EPS8
Type: gene
Organism: cattle
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Gene
418174 | EPS8
Type: gene
Organism: chicken
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Gene
702777 | EPS8
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR030222 | EPS8
Type: Family
Description: Epidermal growth factor receptor kinase substrate 8 (EPS8) is a signalling adapter that possesses actin binding, bundling, and barbed-end capping activities []. It forms a complex with Sos-1, Abi1 and the lipid kinase phosphoinositide 3-kinase (PI3-K) to regulate Rac activation that leads to actin cytoskeletal remodeling []. It is critical for dendritic cell migration []. It is involved in the initial growth of stereocilia in both inner hair cells and outer hair cells []. It also regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF) []. It has been linked to proliferation, metastasis and prognosis of many malignant tumours [].
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Protein Coding Gene
MGI:104684 | Eps8
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
21835647 | J:176428
First Author: Frittoli E
Year: 2011
Journal: Immunity
Title: The signaling adaptor Eps8 is an essential actin capping protein for dendritic cell migration.
Volume: 35
Issue: 3
Pages: 388-99
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Publication
19564905 | J:150646
First Author: Menna E
Year: 2009
Journal: PLoS Biol
Title: Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF).
Volume: 7
Issue: 6
Pages: e1000138
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Publication
14565974 | J:90061
First Author: Offenhäuser N
Year: 2004
Journal: Mol Biol Cell
Title: The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway.
Volume: 15
Issue: 1
Pages: 91-8
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Publication
24475274 | J:212708
First Author: Olt J
Year: 2014
Journal: PLoS One
Title: The actin-binding proteins eps8 and gelsolin have complementary roles in regulating the growth and stability of mechanosensory hair bundles of mammalian cochlear outer hair cells.
Volume: 9
Issue: 1
Pages: e87331
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GXD Expression
GXD Expression
Probe: MGI:6723839
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1906128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6723931
Age: postnatal day 12
Image: S6b Eps8 tm1a/tm1a
Note: Expression localized at stereocilia tips.
Specimen Label: S6b Eps8 tm1a/tm1a
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6723839
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1906128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6723931
Age: postnatal day 12
Image: S6b Eps8 tm1a/+
Note: Expression localized at stereocilia tips.
Specimen Label: S6b Eps8 tm1a/+
Detected: true
Specimen Num: 1
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Gene
79574 | EPS8L3
Type: gene
Organism: human
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Gene
64787 | EPS8L2
Type: gene
Organism: human
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Gene
54869 | EPS8L1
Type: gene
Organism: human
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Publication
23628062 | -
First Author: Sun J
Year: 2013
Journal: Zhongguo Shi Yan Xue Ye Xue Za Zhi
Title: [Correlation of Eps8 with proliferation, metastasis and prognosis of malignant tumors].
Volume: 21
Issue: 2
Pages: 493-7
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Publication
10499589 | J:116237
First Author: Scita G
Year: 1999
Journal: Nature
Title: EPS8 and E3B1 transduce signals from Ras to Rac.
Volume: 401
Issue: 6750
Pages: 290-3
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Publication
24533597 | J:321656
 
First Author: Huang CC
Year: 2014
Journal: BMC Neurosci
Title: Cell type-specific expression of Eps8 in the mouse hippocampus.
Volume: 15
Pages: 26
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Publication
23685357 | J:198999
First Author: Menna E
Year: 2013
Journal: EMBO J
Title: Eps8 controls dendritic spine density and synaptic plasticity through its actin-capping activity.
Volume: 32
Issue: 12
Pages: 1730-44
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Publication
27450093 | J:237769
First Author: Wang YT
Year: 2017
Journal: Neuropharmacology
Title: Conditional deletion of Eps8 reduces hippocampal synaptic plasticity and impairs cognitive function.
Volume: 112
Issue: Pt A
Pages: 113-123
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Publication
8084614 | J:20918
First Author: Wong WT
Year: 1994
Journal: Oncogene
Title: Evolutionary conservation of the EPS8 gene and its mapping to human chromosome 12q23-q24.
Volume: 9
Issue: 10
Pages: 3057-61
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Publication
19528316 | J:155180
First Author: Zhang W
Year: 2009
Journal: Genes Dev
Title: Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione.
Volume: 23
Issue: 12
Pages: 1387-92
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Publication
27132230 | J:235973
 
First Author: Tavazzani E
Year: 2016
Journal: Neuroscience
Title: Distinct roles of Eps8 in the maturation of cochlear and vestibular hair cells.
Volume: 328
Pages: 80-91
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Publication
9010225 | J:114805
First Author: Biesova Z
Year: 1997
Journal: Oncogene
Title: Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth.
Volume: 14
Issue: 2
Pages: 233-41
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Publication
20209148 | J:158694
First Author: Tocchetti A
Year: 2010
Journal: PLoS One
Title: Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice.
Volume: 5
Issue: 3
Pages: e9468
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Publication
20532239 | J:161597
First Author: Hertzog M
Year: 2010
Journal: PLoS Biol
Title: Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping.
Volume: 8
Issue: 6
Pages: e1000387
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Publication
21526224 | J:173926
First Author: Zampini V
Year: 2011
Journal: PLoS Biol
Title: Eps8 regulates hair bundle length and functional maturation of mammalian auditory hair cells.
Volume: 9
Issue: 4
Pages: e1001048
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Publication
23314863 | J:195223
First Author: Werner A
Year: 2013
Journal: Nat Cell Biol
Title: SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression.
Volume: 15
Issue: 2
Pages: 179-88
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Publication
26668327 | J:230723
First Author: Giampietro C
Year: 2015
Journal: J Cell Biol
Title: The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling.
Volume: 211
Issue: 6
Pages: 1177-92
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Publication
12620401 | J:82467
First Author: Tocchetti A
Year: 2003
Journal: Genomics
Title: In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure.
Volume: 81
Issue: 2
Pages: 234-44
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Publication
7566980 | J:29079
First Author: Avantaggiato V
Year: 1995
Journal: Oncogene
Title: Expression of the receptor tyrosine kinase substrate genes eps8 and eps15 during mouse development.
Volume: 11
Issue: 6
Pages: 1191-8
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Publication
17018287 | J:116055
First Author: Offenhäuser N
Year: 2006
Journal: Cell
Title: Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics.
Volume: 127
Issue: 1
Pages: 213-26
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Publication
15558031 | J:196111
First Author: Disanza A
Year: 2004
Journal: Nat Cell Biol
Title: Eps8 controls actin-based motility by capping the barbed ends of actin filaments.
Volume: 6
Issue: 12
Pages: 1180-8
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Protein
Q3TMV3
Organism: Mus musculus/domesticus
Length: 561  
Fragment?: false
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Protein
Q08509
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
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Protein
Q3UGL1
Organism: Mus musculus/domesticus
Length: 587  
Fragment?: true
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Protein
Q3U2Z5
Organism: Mus musculus/domesticus
Length: 847  
Fragment?: false
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Protein
D3Z5I5
Organism: Mus musculus/domesticus
Length: 329  
Fragment?: true
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Protein
A0A0A0MQF0
Organism: Mus musculus/domesticus
Length: 77  
Fragment?: true
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Protein
D3Z7F4
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: true
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Protein
Q3UFL4
Organism: Mus musculus/domesticus
Length: 463  
Fragment?: true
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Publication
11524436 | J:196125
First Author: Scita G
Year: 2001
Journal: J Cell Biol
Title: An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine.
Volume: 154
Issue: 5
Pages: 1031-44
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Publication
23918390 | J:200669
First Author: Furness DN
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2.
Volume: 110
Issue: 34
Pages: 13898-903
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Publication
23392693 | J:194269
First Author: Stamatakou E
Year: 2013
Journal: J Neurosci
Title: Activity-dependent spine morphogenesis: a role for the actin-capping protein Eps8.
Volume: 33
Issue: 6
Pages: 2661-70
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Publication
8404850 | J:34029
First Author: Fazioli F
Year: 1993
Journal: EMBO J
Title: Eps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signals.
Volume: 12
Issue: 10
Pages: 3799-808
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Publication
24741995 | J:215946
 
First Author: Behlouli A
Year: 2014
Journal: Orphanet J Rare Dis
Title: EPS8, encoding an actin-binding protein of cochlear hair cell stereocilia, is a new causal gene for autosomal recessive profound deafness.
Volume: 9
Pages: 55
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Publication
15289329 | J:137488
First Author: Funato Y
Year: 2004
Journal: Cancer Res
Title: IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness.
Volume: 64
Issue: 15
Pages: 5237-44
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Publication
26252776 | J:242788
First Author: Stamatakou E
Year: 2015
Journal: PLoS One
Title: Wnt Signalling Promotes Actin Dynamics during Axon Remodelling through the Actin-Binding Protein Eps8.
Volume: 10
Issue: 8
Pages: e0134976
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Publication
30233314 | J:311999
 
First Author: Morini R
Year: 2018
Journal: Front Mol Neurosci
Title: Lack of the Actin Capping Protein, Eps8, Affects NMDA-Type Glutamate Receptor Function and Composition.
Volume: 11
Pages: 313
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Publication
17115031 | J:196106
First Author: Disanza A
Year: 2006
Journal: Nat Cell Biol
Title: Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex.
Volume: 8
Issue: 12
Pages: 1337-47
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Publication
19933840 | J:156390
First Author: Robens JM
Year: 2010
Journal: Mol Cell Biol
Title: Regulation of IRSp53-dependent filopodial dynamics by antagonism between 14-3-3 binding and SH3-mediated localization.
Volume: 30
Issue: 3
Pages: 829-44
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Gene
295361 | Eps8l3
Type: gene
Organism: rat
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Gene
361674 | Eps8l2
Type: gene
Organism: rat
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Gene
361503 | Eps8l1
Type: gene
Organism: rat
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Gene
484302 | EPS8L1
Type: gene
Organism: dog, domestic
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Gene
490118 | EPS8L3
Type: gene
Organism: dog, domestic
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Gene
450932 | EPS8L2
Type: gene
Organism: chimpanzee
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Gene
456294 | EPS8L1
Type: gene
Organism: chimpanzee
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Gene
504611 | EPS8L3
Type: gene
Organism: cattle
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Gene
514504 | EPS8L1
Type: gene
Organism: cattle
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Gene
614857 | EPS8L2
Type: gene
Organism: cattle
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Gene
100856027 | EPS8L2
Type: gene
Organism: dog, domestic
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Gene
770081 | EPS8L2
Type: gene
Organism: chicken
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Gene
100334248 | eps8l3a
Type: gene
Organism: zebrafish
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Gene
393332 | eps8l3b
Type: gene
Organism: zebrafish
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Gene
503735 | eps8l1a
Type: gene
Organism: zebrafish
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Gene
553062 | eps8l1b
Type: gene
Organism: zebrafish
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Gene
798252 | eps8l2
Type: gene
Organism: zebrafish
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Gene
700441 | EPS8L3
Type: gene
Organism: macaque, rhesus
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Gene
720824 | EPS8L2
Type: gene
Organism: macaque, rhesus
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Gene
100494819 | eps8l1
Type: gene
Organism: frog, western clawed
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Gene
107973660 | EPS8L3
Type: gene
Organism: chimpanzee
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Gene
114673994 | EPS8L1
Type: gene
Organism: macaque, rhesus
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Publication
30314980 | J:319925
First Author: Lampasona AA
Year: 2019
Journal: RNA
Title: Hnrnpab regulates neural cell motility through transcription of Eps8.
Volume: 25
Issue: 1
Pages: 45-59
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Publication
21236676 | J:171832
First Author: Manor U
Year: 2011
Journal: Curr Biol
Title: Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8.
Volume: 21
Issue: 2
Pages: 167-72
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Publication
35044843 | J:334959
First Author: Halford J
Year: 2022
Journal: Mol Biol Cell
Title: Ca2+ entry through mechanotransduction channels localizes BAIAP2L2 to stereocilia tips.
Volume: 33
Issue: 4
Pages: br6
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Publication
30827920 | J:271898
First Author: Tadenev ALD
Year: 2019
Journal: Curr Biol
Title: GPSM2-GNAI Specifies the Tallest Stereocilia and Defines Hair Bundle Row Identity.
Volume: 29
Issue: 6
Pages: 921-934.e4
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Publication
19208628 | J:148808
First Author: Sawallisch C
Year: 2009
Journal: J Biol Chem
Title: The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity.
Volume: 284
Issue: 14
Pages: 9225-36
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Protein Coding Gene
MGP_CAROLIEiJ_G0029009 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0031436 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0031411 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0031339 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0031418 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0031140 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_104684 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0031880 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0030508 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0031100 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0031257 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0031208 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0031341 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0031248 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0031912 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0030235 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0030601 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0022772 | -
Type: protein_coding_gene
Organism: Mus pahari
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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