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Search results 1 to 100 out of 2601 for Esr1

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Type Details Score
Gene
2099 | ESR1
Type: gene
Organism: human
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Gene
463079 | ESR1
Type: gene
Organism: chimpanzee
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Gene
407238 | ESR1
Type: gene
Organism: cattle
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Gene
396099 | ESR1
Type: gene
Organism: chicken
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Gene
259252 | esr1
Type: gene
Organism: zebrafish
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Gene
613025 | ESR1
Type: gene
Organism: macaque, rhesus
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Gene
394461 | esr1
Type: gene
Organism: frog, western clawed
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Gene
key_81019 | ESR1
Type: gene
Organism: pig, domestic
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Gene
key_32730 | ESR1
Type: gene
Organism: sheep
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Gene
key_81014 | ESR1
Type: gene
Organism: horse
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Gene
24890 | Esr1
Type: gene
Organism: rat
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Gene
403640 | ESR1
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:1352467 | Esr1
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
101928745 | BNAT1
Type: gene
Organism: human
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Protein
A0A1W7GYX1
Organism: Mus musculus/domesticus
Length: 135  
Fragment?: true
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Publication
32242619 | J:295332
 
First Author: Li Y
Year: 2020
Journal: Endocrinology
Title: ESR1 Mutations Associated With Estrogen Insensitivity Syndrome Change Conformation of Ligand-Receptor Complex and Altered Transcriptome Profile.
Volume: 161
Issue: 6
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Publication
22367588 | J:185308
First Author: Sánchez-Criado JE
Year: 2012
Journal: Reproduction
Title: Estrogen receptor (ESR) 2 partially offsets the absence of ESR1 in gonadotropes of pituitary-specific Esr1 knockout female mice.
Volume: 143
Issue: 4
Pages: 549-58
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Publication
28266530 | J:276113
 
First Author: Oh YS
Year: 2017
Journal: Sci Rep
Title: ESR1 inhibits hCG-induced steroidogenesis and proliferation of progenitor Leydig cells in mice.
Volume: 7
Pages: 43459
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Publication
24735329 | J:214259
First Author: Royston SE
Year: 2014
Journal: Endocrinology
Title: ESR1 and ESR2 differentially regulate daily and circadian activity rhythms in female mice.
Volume: 155
Issue: 7
Pages: 2613-23
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Publication
31145462 | J:277745
First Author: Porteous R
Year: 2019
Journal: Endocrinology
Title: Genetic Deletion of Esr1 in the Mouse Preoptic Area Disrupts the LH Surge and Estrous Cyclicity.
Volume: 160
Issue: 8
Pages: 1821-1829
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Publication
36279950 | J:344480
 
First Author: Zhang Y
Year: 2023
Journal: Gene
Title: Low expression of ESR1 correlates with ascending aortic dilation and acute type A aortic dissection.
Volume: 851
Pages: 147001
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Publication
17310981 | J:120985
First Author: Manuylov NL
Year: 2007
Journal: Oncogene
Title: Fog2 excision in mice leads to premature mammary gland involution and reduced Esr1 gene expression.
Volume: 26
Issue: 36
Pages: 5204-13
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Publication
19864317 | J:159557
First Author: Miyagawa S
Year: 2010
Journal: Biol Reprod
Title: Estrogen receptor ESR1 is indispensable for the induction of persistent vaginal change by neonatal 5alpha-dihydrotestosterone exposure in mice.
Volume: 82
Issue: 3
Pages: 497-503
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Publication
36464512 | J:332269
First Author: Furth PA
Year: 2023
Journal: Am J Pathol
Title: Esr1 but Not CYP19A1 Overexpression in Mammary Epithelial Cells during Reproductive Senescence Induces Pregnancy-Like Proliferative Mammary Disease Responsive to Anti-Hormonals.
Volume: 193
Issue: 1
Pages: 84-102
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GXD Expression
GXD Expression
   
Probe: MGI:6172162
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190228
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Esr1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6172162
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190228
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Esr1
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6172162
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190228
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Esr1
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6172162
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190228
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Esr1
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:6172162
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6190228
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Esr1
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6172162
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190228
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Esr1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6172162
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190228
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Esr1
Detected: true
Specimen Num: 7
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Publication
26511244 | J:226680
First Author: Cheong RY
Year: 2015
Journal: J Neurosci
Title: Expression of ESR1 in Glutamatergic and GABAergic Neurons Is Essential for Normal Puberty Onset, Estrogen Feedback, and Fertility in Female Mice.
Volume: 35
Issue: 43
Pages: 14533-43
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GXD Expression
GXD Expression
Probe: MGI:5501247
Assay Type: In situ reporter (knock in)
Annotation Date: 2015-03-23
Strength: Present
Sex: Female
Emaps: EMAPS:3591628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5619783
Age: postnatal adult
Image: 1e/h
Note: Similar to the endogenous Esr1 expression, staining in the ventrolateral subdivision of the ventromedial hypothalamus is higher in females than in males.
Specimen Label: 1e/h
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:5501247
Assay Type: In situ reporter (knock in)
Annotation Date: 2015-03-23
Strength: Present
Sex: Male
Emaps: EMAPS:3591628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5619783
Age: postnatal adult
Image: 1d/g
Note: Similar to the endogenous Esr1 expression, staining in the ventrolateral subdivision of the ventromedial hypothalamus is higher in females than in males.
Specimen Label: 1d/g
Detected: true
Specimen Num: 1
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Publication
29973689 | J:267409
First Author: Hodgkinson K
Year: 2018
Journal: Oncogene
Title: GREB1 is an estrogen receptor-regulated tumour promoter that is frequently expressed in ovarian cancer.
Volume: 37
Issue: 44
Pages: 5873-5886
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Publication
29115049 | J:250442
 
First Author: Park CJ
Year: 2017
Journal: Genesis
Title: Generation and characterization of an estrogen receptor alpha-iCre knock-in mouse.
Volume: 55
Issue: 12
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Publication
36130016 | J:335552
First Author: Liang J
Year: 2022
Journal: Sci Transl Med
Title: Giredestrant reverses progesterone hypersensitivity driven by estrogen receptor mutations in breast cancer.
Volume: 14
Issue: 663
Pages: eabo5959
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Publication
8013372 | J:19507
First Author: Davis VL
Year: 1994
Journal: Endocrinology
Title: Aberrant reproductive phenotypes evident in transgenic mice expressing the wild-type mouse estrogen receptor.
Volume: 135
Issue: 1
Pages: 379-86
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UniProt Feature
UniProt Feature
Begin: 604
Description: Interaction with SRC and ESR1
Type: short sequence motif
End: 607
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Publication
28827707 | J:255751
First Author: Winuthayanon W
Year: 2017
Journal: Sci Rep
Title: Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation.
Volume: 7
Issue: 1
Pages: 8377
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Publication
31100494 | J:282923
 
First Author: Fatima LA
Year: 2019
Journal: Mol Cell Endocrinol
Title: Estradiol stimulates adipogenesis and Slc2a4/GLUT4 expression via ESR1-mediated activation of CEBPA.
Volume: 498
Pages: 110447
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Publication
30413705 | J:268522
First Author: Cagnet S
Year: 2018
Journal: Nat Commun
Title: Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium.
Volume: 9
Issue: 1
Pages: 4723
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Publication
26430118 | J:243466
First Author: Cho J
Year: 2015
Journal: Science
Title: Multiple repressive mechanisms in the hippocampus during memory formation.
Volume: 350
Issue: 6256
Pages: 82-7
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Publication
36460649 | J:336063
First Author: McQuillan HJ
Year: 2022
Journal: Nat Commun
Title: Definition of the estrogen negative feedback pathway controlling the GnRH pulse generator in female mice.
Volume: 13
Issue: 1
Pages: 7433
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Publication
12082175 | J:77730
First Author: Davis VL
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: An estrogen receptor repressor induces cataract formation in transgenic mice.
Volume: 99
Issue: 14
Pages: 9427-32
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Publication
32749219 | J:302396
   
First Author: Geng A
Year: 2020
Journal: Elife
Title: A novel function of R-spondin1 in regulating estrogen receptor expression independent of Wnt/β-catenin signaling.
Volume: 9
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Allele
Esr1<tm1Neg> | MGI:6383863
 
Name: estrogen receptor 1 (alpha); targeted mutation 1, Masahiko Negishi
Allele Type: Targeted
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Publication
28743985 | J:250194
First Author: Roepke TA
Year: 2017
Journal: Sci Rep
Title: Loss of ERα partially reverses the effects of maternal high-fat diet on energy homeostasis in female mice.
Volume: 7
Issue: 1
Pages: 6381
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Publication
38464972 | J:346193
 
First Author: Schröder SK
Year: 2024
Journal: Front Endocrinol (Lausanne)
Title: Ovaries of estrogen receptor 1-deficient mice show iron overload and signs of aging.
Volume: 15
Pages: 1325386
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Publication
26971397 | J:269182
 
First Author: Javurek AB
Year: 2016
Journal: Sci Rep
Title: Discovery of a Novel Seminal Fluid Microbiome and Influence of Estrogen Receptor Alpha Genetic Status.
Volume: 6
Pages: 23027
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Publication
19920214 | J:170064
First Author: Ribas V
Year: 2010
Journal: Am J Physiol Endocrinol Metab
Title: Impaired oxidative metabolism and inflammation are associated with insulin resistance in ERalpha-deficient mice.
Volume: 298
Issue: 2
Pages: E304-19
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Publication
27145009 | J:239467
First Author: Nanjappa MK
Year: 2016
Journal: Endocrinology
Title: Membrane-Localized Estrogen Receptor 1 Is Required for Normal Male Reproductive Development and Function in Mice.
Volume: 157
Issue: 7
Pages: 2909-19
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Publication
26438838 | J:225944
First Author: Miyagawa S
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Epithelial estrogen receptor 1 intrinsically mediates squamous differentiation in the mouse vagina.
Volume: 112
Issue: 42
Pages: 12986-91
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Publication
26241171 | J:227283
 
First Author: Blattner MS
Year: 2015
Journal: Behav Brain Res
Title: Changes in estrogen receptor signaling alters the timekeeping system in male mice.
Volume: 294
Pages: 43-9
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Publication
23345419 | J:193820
First Author: Windahl SH
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Estrogen receptor-α in osteocytes is important for trabecular bone formation in male mice.
Volume: 110
Issue: 6
Pages: 2294-9
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Publication
29378845 | J:262855
First Author: Zhou Z
Year: 2018
Journal: J Biol Chem
Title: Estrogen receptor α protects pancreatic β-cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress.
Volume: 293
Issue: 13
Pages: 4735-4751
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Publication
37942801 | J:343568
 
First Author: McGlade EA
Year: 2023
Journal: Endocrinology
Title: Classical Estrogen Signaling in Ciliated Epithelial Cells of the Oviduct Is Nonessential for Fertility in Female Mice.
Volume: 165
Issue: 1
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Publication
30050124 | J:268387
First Author: Li S
Year: 2018
Journal: Sci Rep
Title: Estrogen Action in the Epithelial Cells of the Mouse Vagina Regulates Neutrophil Infiltration and Vaginal Tissue Integrity.
Volume: 8
Issue: 1
Pages: 11247
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Publication
28490809 | J:271766
First Author: Qiu S
Year: 2017
Journal: Sci Rep
Title: Hepatic estrogen receptor α is critical for regulation of gluconeogenesis and lipid metabolism in males.
Volume: 7
Issue: 1
Pages: 1661
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Publication
15579449 | J:94954
First Author: Polanczyk MJ
Year: 2004
Journal: Am J Pathol
Title: T lymphocytes do not directly mediate the protective effect of estrogen on experimental autoimmune encephalomyelitis.
Volume: 165
Issue: 6
Pages: 2069-77
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Publication
25653281 | J:221801
First Author: Nanjappa MK
Year: 2015
Journal: Biol Reprod
Title: Neonatal uterine and vaginal cell proliferation and adenogenesis are independent of estrogen receptor 1 (ESR1) in the mouse.
Volume: 92
Issue: 3
Pages: 78
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Publication
19423761 | J:151908
First Author: Lee S
Year: 2009
Journal: Endocrinology
Title: Theca-specific estrogen receptor-alpha knockout mice lose fertility prematurely.
Volume: 150
Issue: 8
Pages: 3855-62
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Publication
22883149 | J:203253
First Author: Blattner MS
Year: 2012
Journal: Genes Brain Behav
Title: Circadian parameters are altered in two strains of mice with transgenic modifications of estrogen receptor subtype 1.
Volume: 11
Issue: 7
Pages: 828-36
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Publication
26098212 | J:224544
First Author: Xu P
Year: 2015
Journal: J Clin Invest
Title: Estrogen receptor-α in medial amygdala neurons regulates body weight.
Volume: 125
Issue: 7
Pages: 2861-76
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Publication
21211522 | J:175590
First Author: de Souza FS
Year: 2011
Journal: Eur J Pharmacol
Title: The estrogen receptor α colocalizes with proopiomelanocortin in hypothalamic neurons and binds to a conserved motif present in the neuron-specific enhancer nPE2.
Volume: 660
Issue: 1
Pages: 181-7
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Publication
32759275 | J:310476
 
First Author: Zhou Z
Year: 2020
Journal: Sci Transl Med
Title: Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling.
Volume: 12
Issue: 555
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Publication
20130267 | J:159712
First Author: Joseph A
Year: 2010
Journal: Biol Reprod
Title: Absence of estrogen receptor alpha leads to physiological alterations in the mouse epididymis and consequent defects in sperm function.
Volume: 82
Issue: 5
Pages: 948-57
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Publication
20130266 | J:159713
First Author: Joseph A
Year: 2010
Journal: Biol Reprod
Title: Epididymal hypo-osmolality induces abnormal sperm morphology and function in the estrogen receptor alpha knockout mouse.
Volume: 82
Issue: 5
Pages: 958-67
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Publication
22306083 | J:186221
First Author: Chimento A
Year: 2012
Journal: Mol Cell Endocrinol
Title: 17β-Estradiol activates GPER- and ESR1-dependent pathways inducing apoptosis in GC-2 cells, a mouse spermatocyte-derived cell line.
Volume: 355
Issue: 1
Pages: 49-59
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Publication
31883000 | J:287967
 
First Author: Herrera GGB
Year: 2020
Journal: Endocrinology
Title: Oviductal Retention of Embryos in Female Mice Lacking Estrogen Receptor α in the Isthmus and the Uterus.
Volume: 161
Issue: 2
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Publication
29196616 | J:323716
First Author: Vuong NH
Year: 2017
Journal: Sci Rep
Title: 17β-Estradiol sensitizes ovarian surface epithelium to transformation by suppressing Disabled-2 expression.
Volume: 7
Issue: 1
Pages: 16702
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Publication
28373182 | J:242302
First Author: Rossi EL
Year: 2017
Journal: Cancer Res
Title: Energy Balance Modulation Impacts Epigenetic Reprogramming, ERα and ERβ Expression, and Mammary Tumor Development in MMTV-neu Transgenic Mice.
Volume: 77
Issue: 9
Pages: 2500-2511
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Publication
36464513 | J:332257
First Author: Furth PA
Year: 2023
Journal: Am J Pathol
Title: Overexpression of Estrogen Receptor α in Mammary Glands of Aging Mice Is Associated with a Proliferative Risk Signature and Generation of Estrogen Receptor α-Positive Mammary Adenocarcinomas.
Volume: 193
Issue: 1
Pages: 103-120
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Publication
18653624 | J:139965
First Author: Toda K
Year: 2008
Journal: J Endocrinol
Title: Preserved tissue structure of efferent ductules in aromatase-deficient mice.
Volume: 199
Issue: 1
Pages: 137-46
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Publication
20018910 | J:159742
First Author: Kim TH
Year: 2010
Journal: Biol Reprod
Title: ERBB receptor feedback inhibitor 1 regulation of estrogen receptor activity is critical for uterine implantation in mice.
Volume: 82
Issue: 4
Pages: 706-13
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Publication
29532467 | J:265845
First Author: Son J
Year: 2018
Journal: J Pathol
Title: Epithelial oestrogen receptor α is dispensable for the development of oestrogen-induced cervical neoplastic diseases.
Volume: 245
Issue: 2
Pages: 147-152
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Publication
26356837 | J:243105
First Author: Kabir ME
Year: 2015
Journal: PLoS One
Title: G Protein-Coupled Estrogen Receptor 1 Mediates Acute Estrogen-Induced Cardioprotection via MEK/ERK/GSK-3β Pathway after Ischemia/Reperfusion.
Volume: 10
Issue: 9
Pages: e0135988
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Publication
37335379 | J:339770
First Author: Omotehara T
Year: 2023
Journal: Cell Tissue Res
Title: Expression patterns of sex steroid receptors in developing mesonephros of the male mouse: three-dimensional analysis.
Volume: 393
Issue: 3
Pages: 577-593
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Publication
20025864 | J:156703
First Author: Zhou B
Year: 2010
Journal: Dev Biol
Title: Genetic fate mapping demonstrates contribution of epicardium-derived cells to the annulus fibrosis of the mammalian heart.
Volume: 338
Issue: 2
Pages: 251-61
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Publication
33268894 | J:303328
First Author: Karigo T
Year: 2021
Journal: Nature
Title: Distinct hypothalamic control of same- and opposite-sex mounting behaviour in mice.
Volume: 589
Issue: 7841
Pages: 258-263
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Publication
15161628 | J:91109
First Author: Polanczyk M
Year: 2004
Journal: Am J Pathol
Title: Estrogen receptor-1 (Esr1) and -2 (Esr2) regulate the severity of clinical experimental allergic encephalomyelitis in male mice.
Volume: 164
Issue: 6
Pages: 1915-24
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Publication
30863326 | J:281922
 
First Author: Georgiou P
Year: 2019
Journal: Front Psychiatry
Title: Sex-Specific Involvement of Estrogen Receptors in Behavioral Responses to Stress and Psychomotor Activation.
Volume: 10
Pages: 81
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Publication
19605792 | J:154514
First Author: Yilmaz MB
Year: 2009
Journal: Biol Reprod
Title: Aromatase promoter I.f is regulated by estrogen receptor alpha (ESR1) in mouse hypothalamic neuronal cell lines.
Volume: 81
Issue: 5
Pages: 956-65
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Publication
31849948 | J:297828
 
First Author: Fuseini H
Year: 2019
Journal: Front Immunol
Title: ERα Signaling Increased IL-17A Production in Th17 Cells by Upregulating IL-23R Expression, Mitochondrial Respiration, and Proliferation.
Volume: 10
Pages: 2740
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Publication
31201420 | J:279124
First Author: Nanjappa MK
Year: 2019
Journal: Biol Reprod
Title: The histone methyltransferase EZH2 is required for normal uterine development and function in mice†.
Volume: 101
Issue: 2
Pages: 306-317
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Publication
28414719 | J:242987
First Author: Li S
Year: 2017
Journal: PLoS Genet
Title: Crucial role of estrogen for the mammalian female in regulating semen coagulation and liquefaction in vivo.
Volume: 13
Issue: 4
Pages: e1006743
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Publication
24880616 | J:226885
First Author: Tannour-Louet M
Year: 2014
Journal: Nat Med
Title: Increased gene copy number of VAMP7 disrupts human male urogenital development through altered estrogen action.
Volume: 20
Issue: 7
Pages: 715-24
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Publication
26241389 | J:233097
First Author: Pawar S
Year: 2015
Journal: Mol Endocrinol
Title: Uterine Epithelial Estrogen Receptor-α Controls Decidualization via a Paracrine Mechanism.
Volume: 29
Issue: 9
Pages: 1362-74
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Protein Coding Gene
MGP_CAROLIEiJ_G0015086 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0016981 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0016959 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0016924 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0016917 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0016742 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1352467 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0017380 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0016324 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0016714 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0016822 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0016817 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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