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Search results 1 to 100 out of 288 for Etv2

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Type Details Score
Gene
Type: gene
Organism: Not Specified
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Rasmussen TL
Year: 2013
Journal: Genesis
Title: Etv2 rescues Flk1 mutant embryoid bodies.
Volume: 51
Issue: 7
Pages: 471-80
Publication
First Author: Rasmussen TL
Year: 2012
Journal: PLoS One
Title: VEGF/Flk1 signaling cascade transactivates Etv2 gene expression.
Volume: 7
Issue: 11
Pages: e50103
Publication
First Author: Sinha T
Year: 2022
Journal: Cell Rep
Title: Differential Etv2 threshold requirement for endothelial and erythropoietic development.
Volume: 39
Issue: 9
Pages: 110881
Publication
First Author: Singh BN
Year: 2019
Journal: Sci Rep
Title: Etv2 transcriptionally regulates Yes1 and promotes cell proliferation during embryogenesis.
Volume: 9
Issue: 1
Pages: 9736
Publication
First Author: Singh BN
Year: 2020
Journal: Arterioscler Thromb Vasc Biol
Title: ETV2 (Ets Variant Transcription Factor 2)-Rhoj Cascade Regulates Endothelial Progenitor Cell Migration During Embryogenesis.
Volume: 40
Issue: 12
Pages: 2875-2890
Publication
First Author: Hayashi M
Year: 2012
Journal: Exp Hematol
Title: Endothelialization and altered hematopoiesis by persistent Etv2 expression in mice.
Volume: 40
Issue: 9
Pages: 738-750.e11
Publication
First Author: Koyano-Nakagawa N
Year: 2022
Journal: Nat Commun
Title: Etv2 regulates enhancer chromatin status to initiate Shh expression in the limb bud.
Volume: 13
Issue: 1
Pages: 4221
Publication
First Author: Koyano-Nakagawa N
Year: 2012
Journal: Stem Cells
Title: Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression.
Volume: 30
Issue: 8
Pages: 1611-23
Publication
First Author: Shi X
Year: 2014
Journal: Dev Biol
Title: Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages.
Volume: 389
Issue: 2
Pages: 208-18
Publication
First Author: Wareing S
Year: 2012
Journal: Dev Dyn
Title: ETV2 expression marks blood and endothelium precursors, including hemogenic endothelium, at the onset of blood development.
Volume: 241
Issue: 9
Pages: 1454-64
Publication
First Author: Wareing S
Year: 2012
Journal: Stem Cells
Title: The Flk1-Cre-mediated deletion of ETV2 defines its narrow temporal requirement during embryonic hematopoietic development.
Volume: 30
Issue: 7
Pages: 1521-31
Publication
First Author: Yamamizu K
Year: 2012
Journal: Stem Cells
Title: PKA/CREB signaling triggers initiation of endothelial and hematopoietic cell differentiation via Etv2 induction.
Volume: 30
Issue: 4
Pages: 687-96
Publication
First Author: Kataoka H
Year: 2013
Journal: Exp Hematol
Title: Region-specific Etv2 ablation revealed the critical origin of hemogenic capacity from Hox6-positive caudal-lateral primitive mesoderm.
Volume: 41
Issue: 6
Pages: 567-581.e9
Publication
First Author: Abedin MJ
Year: 2014
Journal: Circ Res
Title: Fli1 acts downstream of Etv2 to govern cell survival and vascular homeostasis via positive autoregulation.
Volume: 114
Issue: 11
Pages: 1690-9
GXD Expression      
Probe: MGI:6172197
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6190237
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Etv2
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:6172197
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6190237
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Etv2
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:6172197
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:6190237
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Etv2
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:6172197
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6190237
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Etv2
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:6172197
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190237
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Etv2
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:6172197
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190237
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Etv2
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:6172197
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6190237
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Etv2
Detected: false
Specimen Num: 7
Allele
Name: ets variant 2; endonuclease-mediated mutation 1, Daniel J Garry
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Publication
First Author: Singh BN
Year: 2017
Journal: PLoS One
Title: Etv2-miR-130a-Jarid2 cascade regulates vascular patterning during embryogenesis.
Volume: 12
Issue: 12
Pages: e0189010
Publication
First Author: Singh BN
Year: 2015
Journal: Cell Rep
Title: The Etv2-miR-130a Network Regulates Mesodermal Specification.
Volume: 13
Issue: 5
Pages: 915-23
Publication
First Author: Koyano-Nakagawa N
Year: 2015
Journal: J Biol Chem
Title: Feedback Mechanisms Regulate Ets Variant 2 (Etv2) Gene Expression and Hematoendothelial Lineages.
Volume: 290
Issue: 47
Pages: 28107-19
Publication
First Author: Xu CX
Year: 2017
Journal: J Exp Med
Title: ETV2/ER71 regulates hematopoietic regeneration by promoting hematopoietic stem cell proliferation.
Volume: 214
Issue: 6
Pages: 1643-1653
Publication
First Author: Shi X
Year: 2015
Journal: J Biol Chem
Title: The transcription factor Mesp1 interacts with cAMP-responsive element binding protein 1 (Creb1) and coactivates Ets variant 2 (Etv2) gene expression.
Volume: 290
Issue: 15
Pages: 9614-25
Publication
First Author: Rasmussen TL
Year: 2011
Journal: Development
Title: ER71 directs mesodermal fate decisions during embryogenesis.
Volume: 138
Issue: 21
Pages: 4801-12
Publication
First Author: Park C
Year: 2016
Journal: Arterioscler Thromb Vasc Biol
Title: Injury-Mediated Vascular Regeneration Requires Endothelial ER71/ETV2.
Volume: 36
Issue: 1
Pages: 86-96
Publication
First Author: Kobayashi K
Year: 2013
Journal: Genes Cells
Title: Role of Etv2-positive cells in the remodeling morphogenesis during vascular development.
Volume: 18
Issue: 8
Pages: 704-21
Publication
First Author: Ding G
Year: 2013
Journal: Dev Dyn
Title: PDGF receptor alpha+ mesoderm contributes to endothelial and hematopoietic cells in mice.
Volume: 242
Issue: 3
Pages: 254-68
Publication
First Author: Kataoka H
Year: 2011
Journal: Blood
Title: Etv2/ER71 induces vascular mesoderm from Flk1+PDGFRα+ primitive mesoderm.
Volume: 118
Issue: 26
Pages: 6975-86
Publication
First Author: Liu F
Year: 2015
Journal: EMBO Rep
Title: Induction of hematopoietic and endothelial cell program orchestrated by ETS transcription factor ER71/ETV2.
Volume: 16
Issue: 5
Pages: 654-69
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: De Haro L
Year: 2005
Journal: Genomics
Title: Cloning of the murine ER71 gene (Etsrp71) and initial characterization of its promoter.
Volume: 85
Issue: 4
Pages: 493-502
Publication
First Author: Lee D
Year: 2011
Journal: Stem Cells
Title: The Er71 is an important regulator of hematopoietic stem cells in adult mice.
Volume: 29
Issue: 3
Pages: 539-48
Publication
First Author: De Haro L
Year: 2002
Journal: Nucleic Acids Res
Title: Functional analysis of the transcription factor ER71 and its activation of the matrix metalloproteinase-1 promoter.
Volume: 30
Issue: 13
Pages: 2972-9
GXD Expression    
Probe: MGI:2673657
Assay Type: Northern blot
Annotation Date: 2003-09-16
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2673664
Age: postnatal month 18
Image: 3
Specimen Label: heart
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:2673657
Assay Type: Northern blot
Annotation Date: 2003-09-16
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2673664
Age: postnatal month 18
Image: 3
Specimen Label: liver
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:2673657
Assay Type: Northern blot
Annotation Date: 2003-09-16
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2673664
Age: postnatal month 18
Image: 3
Specimen Label: spleen
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:2673657
Assay Type: Northern blot
Annotation Date: 2003-09-16
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3287428
Stage: TS28
Assay Id: MGI:2673664
Age: postnatal month 18
Image: 3
Specimen Label: intestine
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:2673657
Assay Type: Northern blot
Annotation Date: 2003-09-16
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2673664
Age: postnatal month 18
Image: 3
Specimen Label: brain
Detected: false
Specimen Num: 5
GXD Expression    
Probe: MGI:2673657
Assay Type: Northern blot
Annotation Date: 2003-09-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:2673664
Age: postnatal month 18
Image: 3
Specimen Label: testis
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:2673657
Assay Type: Northern blot
Annotation Date: 2003-09-16
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2673664
Age: postnatal month 18
Image: 3
Specimen Label: lung
Detected: false
Specimen Num: 7
GXD Expression    
Probe: MGI:2673657
Assay Type: Northern blot
Annotation Date: 2003-09-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:2673664
Age: embryonic day 10.5
Image: 3
Specimen Label: embryo 10.5 d
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:2673657
Assay Type: Northern blot
Annotation Date: 2003-09-16
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2673664
Age: postnatal month 18
Image: 3
Specimen Label: kidney
Detected: false
Specimen Num: 9
GXD Expression    
Probe: MGI:2673657
Assay Type: Northern blot
Annotation Date: 2003-09-16
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:2673664
Age: postnatal month 18
Image: 3
Specimen Label: thymus
Detected: false
Specimen Num: 10
GXD Expression    
Probe: MGI:6390915
Assay Type: RT-PCR
Annotation Date: 2020-02-18
Strength: Present
Sex: Male
Emaps: EMAPS:1797221
Stage: TS21
Assay Id: MGI:6390922
Age: embryonic day 13.5
Image: 3
Specimen Label: XY Wt
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6390915
Assay Type: RT-PCR
Annotation Date: 2020-02-18
Strength: Present
Sex: Male
Emaps: EMAPS:1797221
Stage: TS21
Assay Id: MGI:6390922
Age: embryonic day 13.5
Image: 3
Specimen Label: XY We
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6390915
Assay Type: RT-PCR
Annotation Date: 2020-02-18
Strength: Present
Sex: Female
Emaps: EMAPS:1796221
Stage: TS21
Assay Id: MGI:6390922
Age: embryonic day 13.5
Image: 3
Specimen Label: XX Wt
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6390915
Assay Type: RT-PCR
Annotation Date: 2020-02-18
Strength: Present
Sex: Female
Emaps: EMAPS:1796221
Stage: TS21
Assay Id: MGI:6390922
Age: embryonic day 13.5
Image: 3
Specimen Label: XX We
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6406382
Assay Type: RT-PCR
Annotation Date: 2020-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:6406439
Age: embryonic day 8.5
Specimen Label: Fli1+/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6406382
Assay Type: RT-PCR
Annotation Date: 2020-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:6406439
Age: embryonic day 8.5
Specimen Label: Fli1+/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6406382
Assay Type: RT-PCR
Annotation Date: 2020-04-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:6406439
Age: embryonic day 8.5
Specimen Label: Fli1-/-
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:7523294
Assay Type: RT-PCR
Annotation Date: 2023-06-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:7488082
Age: embryonic day 8.5
Image: 1
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7523294
Assay Type: RT-PCR
Annotation Date: 2023-06-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:7488082
Age: embryonic day 8.5
Image: 1
Specimen Label: Mut
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3506182
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3185821
Stage: TS21
Assay Id: MGI:3507699
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506182
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1647021
Stage: TS21
Assay Id: MGI:3507699
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506182
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754421
Stage: TS21
Assay Id: MGI:3507699
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506182
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754921
Stage: TS21
Assay Id: MGI:3507699
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506182
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754021
Stage: TS21
Assay Id: MGI:3507699
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506182
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1753621
Stage: TS21
Assay Id: MGI:3507699
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506182
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1697421
Stage: TS21
Assay Id: MGI:3507699
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506182
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691621
Stage: TS21
Assay Id: MGI:3507699
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506182
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757721
Stage: TS21
Assay Id: MGI:3507699
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506182
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1665921
Stage: TS21
Assay Id: MGI:3507699
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506182
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1666821
Stage: TS21
Assay Id: MGI:3507699
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506182
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3267921
Stage: TS21
Assay Id: MGI:3507699
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506182
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716821
Stage: TS21
Assay Id: MGI:3507699
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:3506182
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619321
Stage: TS21
Assay Id: MGI:3507699
Age: embryonic day 13.5
Image: 1
Note: The tissue was inner ear and ear structures.
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:3506182
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1777821
Stage: TS21
Assay Id: MGI:3507699
Age: embryonic day 13.5
Image: 1
Note: The tissue was olfactory epithelium and/or bulb.
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:3506182
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1647017
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3508889
Age: embryonic day 10.5
Image: 1 - left embryo
Note: Authors stated that in some instances they could not determine expression levels with certainty.
Specimen Label: 1 - left embryo
Specimen Num: 1
GXD Expression  
Probe: MGI:3506182
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1647018
Pattern: Not Specified
Stage: TS18
Assay Id: MGI:3508889
Age: embryonic day 10.5
Image: 2 - right embryo
Note: Authors stated that in some instances they could not determine expression levels with certainty.
Specimen Label: 2 - right embryo
Specimen Num: 2