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Search results 1 to 100 out of 608 for Ext1

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Hits by Strain

Type Details Score
Gene
2131 | EXT1
Type: gene
Organism: human
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Gene
448393 | ext1
Type: gene
Organism: frog, western clawed
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Gene
107976420 | EXT1
Type: gene
Organism: chimpanzee
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Gene
299907 | Ext1
Type: gene
Organism: rat
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Gene
482024 | EXT1
Type: gene
Organism: dog, domestic
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Gene
538602 | EXT1
Type: gene
Organism: cattle
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Gene
100858205 | EXT1
Type: gene
Organism: chicken
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Gene
701488 | EXT1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:894663 | Ext1
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
108491824 | LOC108491824
Type: gene
Organism: human
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Publication
15161920 | J:91757
First Author: Yamada S
Year: 2004
Journal: J Biol Chem
Title: Embryonic fibroblasts with a gene trap mutation in Ext1 produce short heparan sulfate chains.
Volume: 279
Issue: 31
Pages: 32134-41
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Publication
15777636 | J:104933
First Author: Hilton MJ
Year: 2005
Journal: Bone
Title: EXT1 regulates chondrocyte proliferation and differentiation during endochondral bone development.
Volume: 36
Issue: 3
Pages: 379-86
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Publication
19850926 | J:286758
First Author: Osterholm C
Year: 2009
Journal: J Biol Chem
Title: Mutation in the heparan sulfate biosynthesis enzyme EXT1 influences growth factor signaling and fibroblast interactions with the extracellular matrix.
Volume: 284
Issue: 50
Pages: 34935-43
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Publication
10864928 | J:64512
First Author: Wei G
Year: 2000
Journal: J Biol Chem
Title: Location of the glucuronosyltransferase domain in the heparan sulfate copolymerase EXT1 by analysis of Chinese hamster ovary cell mutants.
Volume: 275
Issue: 36
Pages: 27733-40
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Publication
12644256 | J:82657
First Author: Inatani M
Year: 2003
Journal: Brain Res Dev Brain Res
Title: Gene expression of EXT1 and EXT2 during mouse brain development.
Volume: 141
Issue: 1-2
Pages: 129-36
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Publication
9620772 | J:113833
First Author: McCormick C
Year: 1998
Journal: Nat Genet
Title: The putative tumour suppressor EXT1 alters the expression of cell-surface heparan sulfate.
Volume: 19
Issue: 2
Pages: 158-61
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Publication
20080592 | J:157599
First Author: Jones KB
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes.
Volume: 107
Issue: 5
Pages: 2054-9
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Publication
9254013 | J:42532
First Author: Lin X
Year: 1997
Journal: DNA Seq
Title: Isolation of the mouse cDNA homologous to the human EXT1 gene responsible for Hereditary Multiple Exostoses.
Volume: 7
Issue: 3-4
Pages: 199-202
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Publication
25741008 | J:297355
First Author: O'Hearn A
Year: 2015
Journal: J Virol
Title: Role of EXT1 and Glycosaminoglycans in the Early Stage of Filovirus Entry.
Volume: 89
Issue: 10
Pages: 5441-9
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Publication
33028660 | J:303971
First Author: Ohkawa Y
Year: 2021
Journal: Mol Cancer Res
Title: Heparan Sulfate Synthesized by Ext1 Regulates Receptor Tyrosine Kinase Signaling and Promotes Resistance to EGFR Inhibitors in GBM.
Volume: 19
Issue: 1
Pages: 150-161
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Publication
- | J:145524
     
First Author: Sheffield VC
Year: 2009
Journal: MGI Direct Data Submission
Title: Generation of a floxed allele of Ext1
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Publication
8981950 | J:48119
First Author: Hecht JT
Year: 1997
Journal: Am J Hum Genet
Title: Hereditary multiple exostoses (EXT): mutational studies of familial EXT1 cases and EXT-associated malignancies.
Volume: 60
Issue: 1
Pages: 80-6
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Publication
25568062 | J:220029
First Author: Mooij HL
Year: 2015
Journal: J Lipid Res
Title: Ext1 heterozygosity causes a modest effect on postprandial lipid clearance in humans.
Volume: 56
Issue: 3
Pages: 665-673
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Publication
39675407 | J:361651
 
First Author: Zhang H
Year: 2025
Journal: Bone
Title: Deficiency of EXT1 and FGFR3 genes promotes chondrocyte differentiation, leading to the induction of osteochondroma formation.
Volume: 192
Pages: 117370
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Publication
18337501 | J:133353
First Author: Presto J
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation.
Volume: 105
Issue: 12
Pages: 4751-6
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Publication
25644707 | J:221064
First Author: de Andrea CE
Year: 2015
Journal: J Pathol
Title: Cell cycle deregulation and mosaic loss of Ext1 drive peripheral chondrosarcomagenesis in the mouse and reveal an intrinsic cilia deficiency.
Volume: 236
Issue: 2
Pages: 210-8
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Publication
21310272 | J:286741
First Author: Zak BM
Year: 2011
Journal: Bone
Title: Compound heterozygous loss of Ext1 and Ext2 is sufficient for formation of multiple exostoses in mouse ribs and long bones.
Volume: 48
Issue: 5
Pages: 979-87
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Publication
9186511 | J:41009
First Author: Lohmann DR
Year: 1997
Journal: Cytogenet Cell Genet
Title: The murine Ext1 gene shows a high level of sequence similarity with its human homologue and is part of a conserved linkage group on chromosome 15.
Volume: 76
Issue: 3-4
Pages: 164-6
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Publication
21185280 | J:170582
First Author: Mundy C
Year: 2011
Journal: Dev Biol
Title: Synovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryo limbs and spine.
Volume: 351
Issue: 1
Pages: 70-81
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Publication
20534475 | J:161395
First Author: Matsumoto K
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: A mouse model of chondrocyte-specific somatic mutation reveals a role for Ext1 loss of heterozygosity in multiple hereditary exostoses.
Volume: 107
Issue: 24
Pages: 10932-7
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Publication
20404326 | J:164551
First Author: Matsumoto Y
Year: 2010
Journal: J Biol Chem
Title: Conditional ablation of the heparan sulfate-synthesizing enzyme Ext1 leads to dysregulation of bone morphogenic protein signaling and severe skeletal defects.
Volume: 285
Issue: 25
Pages: 19227-34
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Publication
25468659 | J:293600
First Author: Mooij HL
Year: 2014
Journal: J Am Heart Assoc
Title: Loss of function in heparan sulfate elongation genes EXT1 and EXT 2 results in improved nitric oxide bioavailability and endothelial function.
Volume: 3
Issue: 6
Pages: e001274
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Publication
10639137 | J:113870
First Author: McCormick C
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate.
Volume: 97
Issue: 2
Pages: 668-73
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Publication
23458899 | J:196289
First Author: Huegel J
Year: 2013
Journal: Dev Biol
Title: Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: a mechanism likely deranged in Hereditary Multiple Exostoses.
Volume: 377
Issue: 1
Pages: 100-12
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Publication
23192691 | J:237157
First Author: Jones KB
Year: 2013
Journal: J Orthop Res
Title: Toward an understanding of the short bone phenotype associated with multiple osteochondromas.
Volume: 31
Issue: 4
Pages: 651-7
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Publication
15177029 | J:92212
First Author: Koziel L
Year: 2004
Journal: Dev Cell
Title: Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification.
Volume: 6
Issue: 6
Pages: 801-13
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Publication
27030596 | J:269142
First Author: Liu CC
Year: 2016
Journal: Sci Transl Med
Title: Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-? clearance and aggregation in Alzheimer's disease.
Volume: 8
Issue: 332
Pages: 332ra44
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Publication
33278339 | J:306988
First Author: Brestoff JR
Year: 2021
Journal: Cell Metab
Title: Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity.
Volume: 33
Issue: 2
Pages: 270-282.e8
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Publication
28445472 | J:242977
First Author: Sinha S
Year: 2017
Journal: PLoS Genet
Title: Unsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice.
Volume: 13
Issue: 4
Pages: e1006742
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Publication
42070715 | J:385368
 
First Author: Mundy C
Year: 2026
Journal: Bone
Title: Progenitors from distinct perichondrium layers initiate tumor formation in hereditary multiple osteochondromas as revealed in a mouse model.
Volume: 209
Pages: 117913
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Publication
41056386 | J:377611
First Author: Catheline SE
Year: 2025
Journal: Sci Signal
Title: An ectopic Hedgehog signaling axis drives directional tumor outgrowth in a mouse model of hereditary multiple osteochondromas.
Volume: 18
Issue: 907
Pages: eadu6357
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Publication
25202142 | J:297354
First Author: Saez B
Year: 2014
Journal: Blood
Title: Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning.
Volume: 124
Issue: 19
Pages: 2937-47
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Publication
9703997 | J:49122
First Author: Lin X
Year: 1998
Journal: Biochem Biophys Res Commun
Title: Expression and functional analysis of mouse EXT1, a homolog of the human multiple exostoses type 1 gene.
Volume: 248
Issue: 3
Pages: 738-43
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Publication
17130131 | J:120294
First Author: Mahalingam Y
Year: 2007
Journal: J Biol Chem
Title: Cellular adhesion responses to the heparin-binding (HepII) domain of fibronectin require heparan sulfate with specific properties.
Volume: 282
Issue: 5
Pages: 3221-30
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Publication
29545125 | J:267570
 
First Author: Piombo V
Year: 2018
Journal: Bone
Title: Signaling systems affecting the severity of multiple osteochondromas.
Volume: 111
Pages: 71-81
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Publication
28768899 | J:286959
 
First Author: Inubushi T
Year: 2017
Journal: JCI Insight
Title: Aberrant perichondrial BMP signaling mediates multiple osteochondromagenesis in mice.
Volume: 2
Issue: 15
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Publication
34790962 | J:369350
First Author: Kinoshita T
Year: 2021
Journal: Discov Oncol
Title: Endothelial cell-specific reduction of heparan sulfate suppresses glioma growth in mice.
Volume: 12
Issue: 1
Pages: 50
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Publication
29605295 | J:270542
First Author: Matsuzawa T
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Heparan sulfate in pancreatic ?-cells contributes to normal glucose homeostasis by regulating insulin secretion.
Volume: 499
Issue: 3
Pages: 688-695
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Publication
33600795 | J:304812
 
First Author: Hsu HP
Year: 2021
Journal: J Biol Chem
Title: Heparan sulfate is essential for thymus growth.
Volume: 296
Pages: 100419
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Publication
29120519 | J:377415
First Author: Inubushi T
Year: 2018
Journal: J Bone Miner Res
Title: Palovarotene Inhibits Osteochondroma Formation in a Mouse Model of Multiple Hereditary Exostoses.
Volume: 33
Issue: 4
Pages: 658-666
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Publication
18480751 | J:152871
First Author: Chen S
Year: 2008
Journal: Kidney Int
Title: Loss of heparan sulfate glycosaminoglycan assembly in podocytes does not lead to proteinuria.
Volume: 74
Issue: 3
Pages: 289-99
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Publication
33962942 | J:373550
 
First Author: Kerselidou D
Year: 2021
Journal: Sci Adv
Title: Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells.
Volume: 7
Issue: 19
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Publication
14605369 | J:86465
First Author: Inatani M
Year: 2003
Journal: Science
Title: Mammalian brain morphogenesis and midline axon guidance require heparan sulfate.
Volume: 302
Issue: 5647
Pages: 1044-6
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Publication
23958822 | J:203836
First Author: Sgariglia F
Year: 2013
Journal: Bone
Title: Epiphyseal abnormalities, trabecular bone loss and articular chondrocyte hypertrophy develop in the long bones of postnatal Ext1-deficient mice.
Volume: 57
Issue: 1
Pages: 220-31
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Publication
20377530 | J:163045
First Author: Okada M
Year: 2010
Journal: Biochem J
Title: Biosynthesis of heparan sulfate in EXT1-deficient cells.
Volume: 428
Issue: 3
Pages: 463-71
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Publication
39062860 | J:352526
 
First Author: Garcia SA
Year: 2024
Journal: Int J Mol Sci
Title: Analysis of the Actions of RAR? Agonists on Growing Osteochondromas in a Mouse Model.
Volume: 25
Issue: 14
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Publication
26491162 | J:227920
First Author: Zaiss AK
Year: 2016
Journal: J Virol
Title: Hepatocyte Heparan Sulfate Is Required for Adeno-Associated Virus 2 but Dispensable for Adenovirus 5 Liver Transduction In Vivo.
Volume: 90
Issue: 1
Pages: 412-20
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Publication
10878610 | J:63309
First Author: Stickens D
Year: 2000
Journal: Dev Dyn
Title: EXT genes are differentially expressed in bone and cartilage during mouse embryogenesis.
Volume: 218
Issue: 3
Pages: 452-64
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Publication
10926768 | J:64021
First Author: Lin X
Year: 2000
Journal: Dev Biol
Title: Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient mice.
Volume: 224
Issue: 2
Pages: 299-311
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Publication
34310946 | J:338711
First Author: Matsuzawa T
Year: 2021
Journal: J Biol Chem
Title: Heparan sulfate promotes differentiation of white adipocytes to maintain insulin sensitivity and glucose homeostasis.
Volume: 297
Issue: 3
Pages: 101006
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Publication
26024086 | J:230966
First Author: Coulson-Thomas VJ
Year: 2015
Journal: Invest Ophthalmol Vis Sci
Title: Loss of corneal epithelial heparan sulfate leads to corneal degeneration and impaired wound healing.
Volume: 56
Issue: 5
Pages: 3004-14
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Publication
18667431 | J:142318
First Author: Nadanaka S
Year: 2008
Journal: J Biol Chem
Title: Chondroitin 4-O-sulfotransferase-1 modulates Wnt-3a signaling through control of E disaccharide expression of chondroitin sulfate.
Volume: 283
Issue: 40
Pages: 27333-43
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Publication
17761672 | J:126958
First Author: Busse M
Year: 2007
Journal: J Biol Chem
Title: Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation.
Volume: 282
Issue: 45
Pages: 32802-10
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Publication
39979343 | J:369455
First Author: He H
Year: 2025
Journal: Nat Commun
Title: Heparan sulfate regulates myofibroblast heterogeneity and function to mediate niche homeostasis during alveolar morphogenesis.
Volume: 16
Issue: 1
Pages: 1834
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Publication
22556407 | J:286754
First Author: Kraushaar DC
Year: 2012
Journal: J Biol Chem
Title: Heparan sulfate facilitates FGF and BMP signaling to drive mesoderm differentiation of mouse embryonic stem cells.
Volume: 287
Issue: 27
Pages: 22691-700
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Publication
21586278 | J:173613
First Author: Garner OB
Year: 2011
Journal: Dev Biol
Title: Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling.
Volume: 355
Issue: 2
Pages: 394-403
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Publication
32201365 | J:297362
 
First Author: Bachvarova V
Year: 2020
Journal: Matrix Biol
Title: Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate.
Volume: 93
Pages: 43-59
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Publication
17442818 | J:121105
First Author: Matsumoto Y
Year: 2007
Journal: J Neurosci
Title: Netrin-1/DCC signaling in commissural axon guidance requires cell-autonomous expression of heparan sulfate.
Volume: 27
Issue: 16
Pages: 4342-50
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Publication
32818603 | J:333143
First Author: Kawashima K
Year: 2020
Journal: Osteoarthritis Cartilage
Title: Heparan sulfate deficiency leads to hypertrophic chondrocytes by increasing bone morphogenetic protein signaling.
Volume: 28
Issue: 11
Pages: 1459-1470
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Publication
19782070 | J:158330
First Author: Iwao K
Year: 2010
Journal: Exp Eye Res
Title: Heparan sulfate deficiency in periocular mesenchyme causes microphthalmia and ciliary body dysgenesis.
Volume: 90
Issue: 1
Pages: 81-8
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Publication
26295701 | J:243036
First Author: Zhang R
Year: 2015
Journal: PLoS One
Title: Heparan Sulfate Biosynthesis Enzyme, Ext1, Contributes to Outflow Tract Development of Mouse Heart via Modulation of FGF Signaling.
Volume: 10
Issue: 8
Pages: e0136518
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Publication
28859094 | J:243870
First Author: He H
Year: 2017
Journal: PLoS Genet
Title: Epithelial heparan sulfate regulates Sonic Hedgehog signaling in lung development.
Volume: 13
Issue: 8
Pages: e1006992
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Publication
29700203 | J:263185
 
First Author: Huang M
Year: 2018
Journal: J Cell Sci
Title: Multiple roles of epithelial heparan sulfate in stomach morphogenesis.
Volume: 131
Issue: 10
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Protein Coding Gene
MGP_CAROLIEiJ_G0019786 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
ENSMUSG00200019206 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00195005403 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00220017994 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00180004572 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00175020367 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_894663 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00215003191 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSTCUG00005013861 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00210026340 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00185012949 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00205013038 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00230007302 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSUMUG00000016789 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00190008391 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00225028444 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSLUMG00010012148 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSIUOG00005021117 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0019796 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
ENSMSPG00010006770 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
32810562 | J:299689
First Author: Yokoyama M
Year: 2020
Journal: Biochim Biophys Acta Gen Subj
Title: Heparan sulfate controls skeletal muscle differentiation and motor functions.
Volume: 1864
Issue: 12
Pages: 129707
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Publication
22411800 | J:182220
First Author: Irie F
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Autism-like socio-communicative deficits and stereotypies in mice lacking heparan sulfate.
Volume: 109
Issue: 13
Pages: 5052-6
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Publication
23733868 | J:205359
First Author: Tsuboi K
Year: 2013
Journal: J Immunol
Title: Role of high endothelial venule-expressed heparan sulfate in chemokine presentation and lymphocyte homing.
Volume: 191
Issue: 1
Pages: 448-55
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Publication
36809261 | J:368962
First Author: Niwa A
Year: 2023
Journal: PLoS One
Title: Conditional ablation of heparan sulfate expression in stromal fibroblasts promotes tumor growth in vivo.
Volume: 18
Issue: 2
Pages: e0281820
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Publication
36439118 | J:331954
 
First Author: Herrera-Heredia SA
Year: 2022
Journal: Front Immunol
Title: Heparin is required for the formation of granules in connective tissue mast cells.
Volume: 13
Pages: 1000405
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Publication
23744737 | J:205081
First Author: Yamamoto S
Year: 2013
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Heparan sulfate on intestinal epithelial cells plays a critical role in intestinal crypt homeostasis via Wnt/?-catenin signaling.
Volume: 305
Issue: 3
Pages: G241-9
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Publication
21148566 | J:286759
First Author: Holley RJ
Year: 2011
Journal: J Biol Chem
Title: Influencing hematopoietic differentiation of mouse embryonic stem cells using soluble heparin and heparan sulfate saccharides.
Volume: 286
Issue: 8
Pages: 6241-52
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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