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Search results 1 to 100 out of 193 for F7

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0.036s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: rabbit, European
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: Factor VII (F7) initiates the extrinsic pathway of blood coagulation. It contains an N-terminal Gla domain followed by two epidermal growth factor-like domains (EGF1 and EGF2) and a C-terminal trypsin-like serine protease domain. It can be transformed into active forms (FVIIa) by proteolytic cleavage of the activation peptide located in the connecting region between the EGF2 and the protease domain; this results in the formation of a two-chain FVIIa molecule and a heavy chain held together by a single disulfide bond []. Its first EGF domain (EGF1) binds a calcium ion at its N terminus [].At an injury site, initiation of coagulation begins by exposure of blood to tissue factor (TF) in the extravascular space and formation of the Ca2+-dependent complex between TF and plasma FVIIa. The Ca2+/FVIIa/TF complex formed on the cell surfaces then activates both FX and FIX leading to thrombin generation and fibrin formation []. Mutations in the F7 gene cause Factor VII deficiency (FA7D), the most frequent among rare congenital bleeding disorders [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Cell Line
Name: F7
Derivation . Parent Cell Line . Name: D3H
Cell Line Type: ES Cell
GXD Expression      
Probe: MGI:2681703
Assay Type: RT-PCR
Annotation Date: 2003-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:2681778
Age: postnatal day 21
Specimen Label: F7
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:2681702
Assay Type: RT-PCR
Annotation Date: 2003-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:2681779
Age: postnatal day 21
Specimen Label: F7
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:2681701
Assay Type: RT-PCR
Annotation Date: 2003-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:2681780
Age: postnatal day 21
Specimen Label: F7
Detected: true
Specimen Num: 5
Publication
First Author: Norledge BV
Year: 2003
Journal: Proteins
Title: The tissue factor/factor VIIa/factor Xa complex: a model built by docking and site-directed mutagenesis.
Volume: 53
Issue: 3
Pages: 640-8
Publication
First Author: Lapecorella M
Year: 2008
Journal: Haemophilia
Title: Factor VII deficiency: defining the clinical picture and optimizing therapeutic options.
Volume: 14
Issue: 6
Pages: 1170-5
Publication  
First Author: Vadivel K
Year: 2012
Journal: Front Biosci (Landmark Ed)
Title: Structural biology of factor VIIa/tissue factor initiated coagulation.
Volume: 17
Pages: 2476-94
Protein
Organism: Mus musculus/domesticus
Length: 446  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 234  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 446  
Fragment?: false
Publication
First Author: Xu H
Year: 2009
Journal: J Pathol
Title: Severe deficiency of coagulation Factor VII results in spontaneous cardiac fibrosis in mice.
Volume: 217
Issue: 3
Pages: 362-71
Publication
First Author: Shinagawa K
Year: 2009
Journal: Am J Physiol Lung Cell Mol Physiol
Title: A severe deficiency of coagulation factor VIIa results in attenuation of the asthmatic response in mice.
Volume: 296
Issue: 5
Pages: L763-70
Publication
First Author: Rosen ED
Year: 2006
Journal: Blood Cells Mol Dis
Title: Searching for hemostatic modifier genes affecting the phenotype of mice with very low levels of FVII.
Volume: 36
Issue: 2
Pages: 131-4
Publication
First Author: Rosen ED
Year: 2005
Journal: Thromb Haemost
Title: Generation of genetically-altered mice producing very low levels of coagulation factorVII.
Volume: 94
Issue: 3
Pages: 493-7
Protein Domain
Type: Family
Description: The function of the orthopoxvirus F7L proteins are unknown.
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Idusogie E
Year: 1996
Journal: Thromb Haemost
Title: Characterization of a cDNA encoding murine coagulation factor VII.
Volume: 75
Issue: 3
Pages: 481-7
Publication
First Author: Idusogie E
Year: 1996
Journal: Thromb Haemost
Title: Nucleotide structure and characterization of the murine blood coagulation factor VII gene.
Volume: 76
Issue: 6
Pages: 957-64
Publication      
First Author: Pendurthi U
Year: 2012
Journal: MGI Direct Data Submission
Title: Direct Data Submission 2012/01/11
Publication  
First Author: Chan JC
Year: 2001
Journal: Front Biosci
Title: Gene targeting in hemostasis. Factor VII.
Volume: 6
Pages: D98-D104
Publication
First Author: Binny C
Year: 2012
Journal: Blood
Title: AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage.
Volume: 119
Issue: 4
Pages: 957-66
Publication
First Author: Xu H
Year: 2006
Journal: J Pathol
Title: A coagulation factor VII deficiency protects against acute inflammatory responses in mice.
Volume: 210
Issue: 4
Pages: 488-96
Publication
First Author: Stauffer DR
Year: 1998
Journal: J Biol Chem
Title: Characterization of transcriptional regulatory elements in the promoter region of the murine blood coagulation factor VII gene.
Volume: 273
Issue: 4
Pages: 2277-87
Publication
First Author: Aljamali MN
Year: 2008
Journal: J Clin Invest
Title: Long-term expression of murine activated factor VII is safe, but elevated levels cause premature mortality.
Volume: 118
Issue: 5
Pages: 1825-34
Publication
First Author: Margaritis P
Year: 2011
Journal: Blood
Title: Catalytic domain modification and viral gene delivery of activated factor VII confers hemostasis at reduced expression levels and vector doses in vivo.
Volume: 117
Issue: 15
Pages: 3974-82
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:3284528
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1697428
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1754928
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: false
Specimen Num: 5
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:3280928
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: false
Specimen Num: 6
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: false
Specimen Num: 8
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3599828
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 12
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 14
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 15
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1720228
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 16
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1750328
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: false
Specimen Num: 17
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: false
Specimen Num: 18
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1832128
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 19
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 20
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 21
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3511228
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 22
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1914328
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 23
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1742828
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 24
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3288928
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 25
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1718528
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: false
Specimen Num: 26
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1775128
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 27
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1683328
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 28
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1788628
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: false
Specimen Num: 29
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1789128
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 30
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1885228
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 31
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1866628
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: false
Specimen Num: 32
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3276428
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 33
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3519728
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 34
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3515128
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 35
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3528528
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 36
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3514028
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 37
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 38
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Female
Emaps: EMAPS:1775928
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 39
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Female
Emaps: EMAPS:1775928
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 40
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 41
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Male
Emaps: EMAPS:1929028
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 42
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 43
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Female
Emaps: EMAPS:2992728
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 44
GXD Expression    
Probe: MGI:1205208
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Female
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:1205210
Age: postnatal week 6-8
Image: st96_427
Specimen Label: None
Detected: true
Specimen Num: 45