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Search results 1 to 100 out of 927 for Fabp4

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Type Details Score
Gene
key_979915 | Fabp4
Type: gene
Organism: Not Specified
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Gene
2167 | FABP4
Type: gene
Organism: human
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Gene
608476 | FABP4
Type: gene
Organism: dog, domestic
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Gene
281759 | FABP4
Type: gene
Organism: cattle
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Gene
374165 | FABP4
Type: gene
Organism: chicken
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Gene
701365 | FABP4
Type: gene
Organism: macaque, rhesus
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Gene
100124818 | fabp4
Type: gene
Organism: frog, western clawed
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Gene
79451 | Fabp4
Type: gene
Organism: rat
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Gene
464255 | FABP4
Type: gene
Organism: chimpanzee
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Protein Domain
IPR033073 | FABP4
Type: Family
Description: Fatty acid-binding proteins (FABPs) have been designated according to the first tissue they were isolated from: intestinal (I-FABP), liver (L-FABP), adipocyte(A-FABP), heart (H-FABP), ileal, myelin, brain, epidermal, and sperm. However, each of these FABPs may be expressed in more than one tissue.This entry includes Fatty acid-binding protein (FABP4) also known as Fatty acid-binding protein, adipocyte, and related fatty acid binding proteins. FABP4 is an adipose tissue-secreted adipokine implicated in the regulation of energetic metabolism and inflammation []. It is mainly expressed in adipocytes and macrophages and plays an important role in the development of insulin resistance and atherosclerosis in relation to metaflammation []. FABP4 can reversibly bind to fatty acids and other lipids with high affinities [].
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Protein Coding Gene
MGI:88038 | Fabp4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q99M00
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: false
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Publication
25037742 | -
First Author: Saavedra P
Year: 2015
Journal: Clin Investig Arterioscler
Title: [Interaction of FABP4 with plasma membrane proteins of endothelial cells].
Volume: 27
Issue: 1
Pages: 26-33
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Publication
19303874 | J:147986
First Author: Tsuda M
Year: 2009
Journal: FEBS Lett
Title: Induction of gene encoding FABP4 in Pten-null keratinocytes.
Volume: 583
Issue: 8
Pages: 1319-22
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Publication
29212659 | J:258243
First Author: Villeneuve J
Year: 2018
Journal: J Cell Biol
Title: Unconventional secretion of FABP4 by endosomes and secretory lysosomes.
Volume: 217
Issue: 2
Pages: 649-665
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Publication
25674026 | -
First Author: Furuhashi M
Year: 2014
Journal: Clin Med Insights Cardiol
Title: Fatty Acid-Binding Protein 4 (FABP4): Pathophysiological Insights and Potent Clinical Biomarker of Metabolic and Cardiovascular Diseases.
Volume: 8
Issue: Suppl 3
Pages: 23-33
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Publication
26580122 | -
First Author: Li Y
Year: 2015
Journal: Phys Chem Chem Phys
Title: Exploration of gated ligand binding recognizes an allosteric site for blocking FABP4-protein interaction.
Volume: 17
Issue: 48
Pages: 32257-67
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Publication
27294862 | J:253441
First Author: Zhang J
Year: 2016
Journal: PLoS One
Title: Cardiomyocyte Overexpression of FABP4 Aggravates Pressure Overload-Induced Heart Hypertrophy.
Volume: 11
Issue: 6
Pages: e0157372
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Publication
29696987 | J:267284
First Author: Ge XN
Year: 2018
Journal: Am J Physiol Lung Cell Mol Physiol
Title: FABP4 regulates eosinophil recruitment and activation in allergic airway inflammation.
Volume: 315
Issue: 2
Pages: L227-L240
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Protein
P04117
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: false
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Protein
Q542H7
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: false
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Publication
37279064 | J:339978
 
First Author: Inouye KE
Year: 2023
Journal: JCI Insight
Title: Endothelial-derived FABP4 constitutes the majority of basal circulating hormone and regulates lipolysis-driven insulin secretion.
Volume: 8
Issue: 14
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Publication
30462529 | J:287993
First Author: Liang X
Year: 2019
Journal: FASEB J
Title: Macrophage FABP4 is required for neutrophil recruitment and bacterial clearance in Pseudomonas aeruginosa pneumonia.
Volume: 33
Issue: 3
Pages: 3562-3574
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Publication
26606905 | J:228208
First Author: Yang AN
Year: 2015
Journal: FEBS Lett
Title: High-methionine diets accelerate atherosclerosis by HHcy-mediated FABP4 gene demethylation pathway via DNMT1 in ApoE(-/-) mice.
Volume: 589
Issue: 24 Pt B
Pages: 3998-4009
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Publication
27297106 | J:238296
First Author: Chen RA
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Hyperglycemia-induced PATZ1 negatively modulates endothelial vasculogenesis via repression of FABP4 signaling.
Volume: 477
Issue: 4
Pages: 548-555
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Publication
30401801 | J:268388
First Author: Shrestha S
Year: 2018
Journal: Sci Rep
Title: Circulating FABP4 is eliminated by the kidney via glomerular filtration followed by megalin-mediated reabsorption.
Volume: 8
Issue: 1
Pages: 16451
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Publication
29401617 | J:274296
First Author: Song C
Year: 2018
Journal: FASEB J
Title: REV-ERB agonism suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss partially via FABP4 upregulation.
Volume: 32
Issue: 6
Pages: 3215-3228
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Publication
27885273 | J:241800
First Author: Yan F
Year: 2017
Journal: Leukemia
Title: Fatty acid-binding protein FABP4 mechanistically links obesity with aggressive AML by enhancing aberrant DNA methylation in AML cells.
Volume: 31
Issue: 6
Pages: 1434-1442
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Publication
28385723 | J:271854
First Author: Xiong X
Year: 2017
Journal: J Endocrinol
Title: Fabp4-Cre-mediated Sirt6 deletion impairs adipose tissue function and metabolic homeostasis in mice.
Volume: 233
Issue: 3
Pages: 307-314
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Publication
17516629 | J:261845
First Author: Ayers SD
Year: 2007
Journal: Biochemistry
Title: Continuous nucleocytoplasmic shuttling underlies transcriptional activation of PPARgamma by FABP4.
Volume: 46
Issue: 23
Pages: 6744-52
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Publication
17761196 | J:261830
First Author: Gillilan RE
Year: 2007
Journal: J Mol Biol
Title: Structural basis for activation of fatty acid-binding protein 4.
Volume: 372
Issue: 5
Pages: 1246-60
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Publication
19625659 | J:154489
First Author: Elmasri H
Year: 2009
Journal: FASEB J
Title: Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells.
Volume: 23
Issue: 11
Pages: 3865-73
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Publication
28903937 | J:317707
 
First Author: Fuseya T
Year: 2017
Journal: J Am Heart Assoc
Title: Ectopic Fatty Acid-Binding Protein 4 Expression in the Vascular Endothelium is Involved in Neointima Formation After Vascular Injury.
Volume: 6
Issue: 9
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Publication
27013610 | J:246226
First Author: Furuhashi M
Year: 2016
Journal: Arterioscler Thromb Vasc Biol
Title: Local Production of Fatty Acid-Binding Protein 4 in Epicardial/Perivascular Fat and Macrophages Is Linked to Coronary Atherosclerosis.
Volume: 36
Issue: 5
Pages: 825-34
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Publication
31286669 | J:294569
First Author: Tan Z
Year: 2019
Journal: J Cell Mol Med
Title: Pharmacological and genetic inhibition of fatty acid-binding protein 4 alleviated cisplatin-induced acute kidney injury.
Volume: 23
Issue: 9
Pages: 6260-6270
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Publication
33101287 | J:337300
 
First Author: Feng Y
Year: 2020
Journal: Front Immunol
Title: Inhibition of Fatty Acid-Binding Protein 4 Attenuated Kidney Fibrosis by Mediating Macrophage-to-Myofibroblast Transition.
Volume: 11
Pages: 566535
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Publication
33690220 | J:332690
 
First Author: Xiao Y
Year: 2021
Journal: JCI Insight
Title: Fatty acid binding protein 4 promotes autoimmune diabetes by recruitment and activation of pancreatic islet macrophages.
Volume: 6
Issue: 7
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Publication
34806114 | J:322751
First Author: Gruber N
Year: 2022
Journal: Diabetologia
Title: Fatty acid-binding protein 4: a key regulator of ketoacidosis in new-onset type 1 diabetes.
Volume: 65
Issue: 2
Pages: 366-374
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Publication
29549054 | J:315909
First Author: Zhang C
Year: 2018
Journal: Osteoarthritis Cartilage
Title: Knocking out or pharmaceutical inhibition of fatty acid binding protein 4 (FABP4) alleviates osteoarthritis induced by high-fat diet in mice.
Volume: 26
Issue: 6
Pages: 824-833
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Publication
24416430 | J:211941
First Author: Antonson P
Year: 2014
Journal: PLoS One
Title: aP2-Cre-mediated inactivation of estrogen receptor alpha causes hydrometra.
Volume: 9
Issue: 1
Pages: e85581
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Publication
21044951 | J:167535
First Author: Vergnes L
Year: 2011
Journal: J Biol Chem
Title: Heart-type fatty acid-binding protein is essential for efficient brown adipose tissue fatty acid oxidation and cold tolerance.
Volume: 286
Issue: 1
Pages: 380-90
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Publication
23391391 | J:195211
First Author: Ghelfi E
Year: 2013
Journal: Am J Pathol
Title: Fatty acid binding protein 4 regulates VEGF-induced airway angiogenesis and inflammation in a transgenic mouse model: implications for asthma.
Volume: 182
Issue: 4
Pages: 1425-33
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Publication
33994513 | J:310715
First Author: Umbarawan Y
Year: 2021
Journal: Int Heart J
Title: FABP5 Is a Sensitive Marker for Lipid-Rich Macrophages in the Luminal Side of Atherosclerotic Lesions.
Volume: 62
Issue: 3
Pages: 666-676
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Publication
24603714 | J:217245
First Author: Syamsunarno MR
Year: 2014
Journal: PLoS One
Title: Fatty acid binding protein 4 and 5 play a crucial role in thermogenesis under the conditions of fasting and cold stress.
Volume: 9
Issue: 6
Pages: e90825
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Publication
25096952 | J:215751
First Author: Makkar A
Year: 2014
Journal: Placenta
Title: Fatty acid binding protein-4 is expressed in the mouse placental labyrinth, yet is dispensable for placental triglyceride accumulation and fetal growth.
Volume: 35
Issue: 10
Pages: 802-7
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Publication
35457171 | J:323879
 
First Author: So SW
Year: 2022
Journal: Int J Mol Sci
Title: Microglial FABP4-UCP2 Axis Modulates Neuroinflammation and Cognitive Decline in Obese Mice.
Volume: 23
Issue: 8
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Publication
18535105 | J:138158
First Author: Zhang W
Year: 2008
Journal: Endocrinology
Title: Effect of des-acyl ghrelin on adiposity and glucose metabolism.
Volume: 149
Issue: 9
Pages: 4710-6
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Publication
20230794 | J:159231
First Author: Hesse D
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Altered GLUT4 trafficking in adipocytes in the absence of the GTPase Arfrp1.
Volume: 394
Issue: 4
Pages: 896-903
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Publication
25265869 | J:232449
First Author: He L
Year: 2014
Journal: J Cell Mol Med
Title: Fabp4-CreER lineage tracing reveals two distinctive coronary vascular populations.
Volume: 18
Issue: 11
Pages: 2152-6
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Publication
24802082 | J:216088
First Author: Saint-Geniez M
Year: 2014
Journal: PLoS One
Title: Fatty acid binding protein 4 deficiency protects against oxygen-induced retinopathy in mice.
Volume: 9
Issue: 5
Pages: e96253
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Publication
30866899 | J:291913
First Author: Iso T
Year: 2019
Journal: BMC Physiol
Title: Exercise endurance capacity is markedly reduced due to impaired energy homeostasis during prolonged fasting in FABP4/5 deficient mice.
Volume: 19
Issue: 1
Pages: 1
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Publication
24244493 | J:209701
First Author: Syamsunarno MR
Year: 2013
Journal: PLoS One
Title: A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting.
Volume: 8
Issue: 11
Pages: e79386
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Publication
28219080 | J:244055
First Author: Pan Y
Year: 2017
Journal: Nature
Title: Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism.
Volume: 543
Issue: 7644
Pages: 252-256
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Publication
28214555 | J:260970
 
First Author: Duffy CM
Year: 2017
Journal: Mol Cell Neurosci
Title: Identification of a fatty acid binding protein4-UCP2 axis regulating microglial mediated neuroinflammation.
Volume: 80
Pages: 52-57
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Publication
26070408 | J:318353
First Author: Hu B
Year: 2015
Journal: J Hepatol
Title: Fatty acid binding protein-4 (FABP4) is a hypoxia inducible gene that sensitizes mice to liver ischemia/reperfusion injury.
Volume: 63
Issue: 4
Pages: 855-62
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Publication
33757861 | J:304470
 
First Author: Whitson RH Jr
Year: 2021
Journal: Mol Cell Endocrinol
Title: Mice with Fabp4-Cre ablation of Arid5b are resistant to diet-induced obesity and hepatic steatosis.
Volume: 528
Pages: 111246
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Publication
22150821 | J:196860
First Author: Zhang J
Year: 2012
Journal: Clin Exp Pharmacol Physiol
Title: Hypoxia-inducible factor 1 activation from adipose protein 2-cre mediated knockout of von Hippel-Lindau gene leads to embryonic lethality.
Volume: 39
Issue: 2
Pages: 145-50
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Publication
29174564 | J:255349
 
First Author: Rauch F
Year: 2018
Journal: Bone
Title: Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice.
Volume: 107
Pages: 131-142
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Protein Coding Gene
MGP_CAROLIEiJ_G0024842 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0027063 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0027027 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026997 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0027036 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026776 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_88038 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027480 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0026234 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0026754 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026890 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026857 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0027000 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026878 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027540 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0025969 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0026305 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0026290 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025772 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
6206497 | J:7568
First Author: Bernlohr DA
Year: 1984
Journal: Proc Natl Acad Sci U S A
Title: Expression of specific mRNAs during adipose differentiation: identification of an mRNA encoding a homologue of myelin P2 protein.
Volume: 81
Issue: 17
Pages: 5468-72
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Publication
3520554 | J:8305
First Author: Hunt CR
Year: 1986
Journal: Proc Natl Acad Sci U S A
Title: Adipocyte P2 gene: developmental expression and homology of 5'-flanking sequences among fat cell-specific genes.
Volume: 83
Issue: 11
Pages: 3786-90
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Publication
3968175 | J:34535
First Author: Cook KS
Year: 1985
Journal: J Cell Biol
Title: Developmentally regulated mRNAs in 3T3-adipocytes: analysis of transcriptional control.
Volume: 100
Issue: 2
Pages: 514-20
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Publication
8447836 | J:4068
First Author: Bansal MP
Year: 1993
Journal: Biochem Biophys Res Commun
Title: Expression of fatty acid-binding proteins in the developing mouse mammary gland.
Volume: 191
Issue: 1
Pages: 61-9
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Publication
12454272 | J:132835
First Author: Hertzel AV
Year: 2002
Journal: J Lipid Res
Title: Increased lipolysis in transgenic animals overexpressing the epithelial fatty acid binding protein in adipose cells.
Volume: 43
Issue: 12
Pages: 2105-11
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Publication
8910278 | J:37027
First Author: Hotamisligil GS
Year: 1996
Journal: Science
Title: Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein.
Volume: 274
Issue: 5291
Pages: 1377-9
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Publication
10224167 | J:54587
First Author: Coe NR
Year: 1999
Journal: J Lipid Res
Title: Targeted disruption of the adipocyte lipid-binding protein (aP2 protein) gene impairs fat cell lipolysis and increases cellular fatty acid levels.
Volume: 40
Issue: 5
Pages: 967-72
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Publication
10866041 | J:62315
First Author: Shaughnessy S
Year: 2000
Journal: Diabetes
Title: Adipocyte metabolism in adipocyte fatty acid binding protein knockout mice (aP2-/-) after short-term high-fat feeding: functional compensation by the keratinocyte [correction of keritinocyte] fatty acid binding protein.
Volume: 49
Issue: 6
Pages: 904-11
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Publication
17114450 | J:140699
First Author: Rolph MS
Year: 2006
Journal: J Immunol
Title: Regulation of dendritic cell function and T cell priming by the fatty acid-binding protein AP2.
Volume: 177
Issue: 11
Pages: 7794-801
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Publication
10512363 | J:57864
First Author: Scheja L
Year: 1999
Journal: Diabetes
Title: Altered insulin secretion associated with reduced lipolytic efficiency in aP2-/- mice.
Volume: 48
Issue: 10
Pages: 1987-94
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Publication
27920274 | J:247682
First Author: Zhang Y
Year: 2017
Journal: J Immunol
Title: Adipose Fatty Acid Binding Protein Promotes Saturated Fatty Acid-Induced Macrophage Cell Death through Enhancing Ceramide Production.
Volume: 198
Issue: 2
Pages: 798-807
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Publication
32213543 | J:290322
First Author: Liu L
Year: 2020
Journal: Cancer Res
Title: Consumption of the Fish Oil High-Fat Diet Uncouples Obesity and Mammary Tumor Growth through Induction of Reactive Oxygen Species in Protumor Macrophages.
Volume: 80
Issue: 12
Pages: 2564-2574
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Publication
15367400 | J:96046
First Author: Baar RA
Year: 2005
Journal: Am J Physiol Endocrinol Metab
Title: Investigation of in vivo fatty acid metabolism in AFABP/aP2(-/-) mice.
Volume: 288
Issue: 1
Pages: E187-93
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Publication
16841093 | J:113123
First Author: Shum BO
Year: 2006
Journal: J Clin Invest
Title: The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation.
Volume: 116
Issue: 8
Pages: 2183-2192
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Publication
29437708 | J:261890
First Author: Hao J
Year: 2018
Journal: Cancer Res
Title: Expression of Adipocyte/Macrophage Fatty Acid-Binding Protein in Tumor-Associated Macrophages Promotes Breast Cancer Progression.
Volume: 78
Issue: 9
Pages: 2343-2355
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Publication
28128199 | J:244397
 
First Author: Shu L
Year: 2017
Journal: Nat Commun
Title: A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes.
Volume: 8
Pages: 14147
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Publication
26186740 | J:248979
First Author: Zhou M
Year: 2015
Journal: Clin Sci (Lond)
Title: Deficiency of adipocyte fatty-acid-binding protein alleviates myocardial ischaemia/reperfusion injury and diabetes-induced cardiac dysfunction.
Volume: 129
Issue: 7
Pages: 547-59
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GXD Expression
GXD Expression
   
Probe: MGI:2181036
Assay Type: Northern blot
Annotation Date: 2002-07-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1920925
Stage: TS25
Assay Id: MGI:2181911
Age: embryonic day 17.0
Image: 2
Specimen Label: d17 wt
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:2181036
Assay Type: Northern blot
Annotation Date: 2002-07-16
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1920925
Stage: TS25
Assay Id: MGI:2181911
Age: embryonic day 17.0
Image: 2
Specimen Label: d17 -/-
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:2181036
Assay Type: Northern blot
Annotation Date: 2002-07-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1920926
Stage: TS26
Assay Id: MGI:2181911
Age: embryonic day 18.0
Image: 2
Specimen Label: d18 wt
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:2181036
Assay Type: Northern blot
Annotation Date: 2002-07-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1920926
Stage: TS26
Assay Id: MGI:2181911
Age: embryonic day 18.0
Image: 2
Specimen Label: d18 -/-
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:2181036
Assay Type: Northern blot
Annotation Date: 2002-07-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1920927
Stage: TS27
Assay Id: MGI:2181911
Age: postnatal newborn
Image: 2
Specimen Label: NB wt
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:2181036
Assay Type: Northern blot
Annotation Date: 2002-07-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1920927
Stage: TS27
Assay Id: MGI:2181911
Age: postnatal newborn
Image: 2
Specimen Label: NB -/-
Detected: true
Specimen Num: 6
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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