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Search results 1 to 100 out of 977 for Fabp4

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Categories

Hits by Pathway

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Hits by Strain

Type Details Score
Gene
key_979915 | Fabp4
Type: gene
Organism: Not Specified
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Gene
2167 | FABP4
Type: gene
Organism: human
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Gene
100124818 | fabp4
Type: gene
Organism: frog, western clawed
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Gene
79451 | Fabp4
Type: gene
Organism: rat
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Gene
464255 | FABP4
Type: gene
Organism: chimpanzee
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Gene
608476 | FABP4
Type: gene
Organism: dog, domestic
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Gene
281759 | FABP4
Type: gene
Organism: cattle
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Gene
374165 | FABP4
Type: gene
Organism: chicken
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Gene
701365 | FABP4
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR033073 | FABP4
Type: Family
Description: Fatty acid-binding proteins (FABPs) have been designated according to the first tissue they were isolated from: intestinal (I-FABP), liver (L-FABP), adipocyte(A-FABP), heart (H-FABP), ileal, myelin, brain, epidermal, and sperm. However, each of these FABPs may be expressed in more than one tissue.This entry includes Fatty acid-binding protein (FABP4) also known as Fatty acid-binding protein, adipocyte, and related fatty acid binding proteins. FABP4 is an adipose tissue-secreted adipokine implicated in the regulation of energetic metabolism and inflammation []. It is mainly expressed in adipocytes and macrophages and plays an important role in the development of insulin resistance and atherosclerosis in relation to metaflammation []. FABP4 can reversibly bind to fatty acids and other lipids with high affinities [].
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Protein Coding Gene
MGI:88038 | Fabp4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q99M00
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: false
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Publication
25037742 | -
First Author: Saavedra P
Year: 2015
Journal: Clin Investig Arterioscler
Title: [Interaction of FABP4 with plasma membrane proteins of endothelial cells].
Volume: 27
Issue: 1
Pages: 26-33
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Publication
19303874 | J:147986
First Author: Tsuda M
Year: 2009
Journal: FEBS Lett
Title: Induction of gene encoding FABP4 in Pten-null keratinocytes.
Volume: 583
Issue: 8
Pages: 1319-22
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Publication
25674026 | -
First Author: Furuhashi M
Year: 2014
Journal: Clin Med Insights Cardiol
Title: Fatty Acid-Binding Protein 4 (FABP4): Pathophysiological Insights and Potent Clinical Biomarker of Metabolic and Cardiovascular Diseases.
Volume: 8
Issue: Suppl 3
Pages: 23-33
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Publication
26580122 | -
First Author: Li Y
Year: 2015
Journal: Phys Chem Chem Phys
Title: Exploration of gated ligand binding recognizes an allosteric site for blocking FABP4-protein interaction.
Volume: 17
Issue: 48
Pages: 32257-67
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Publication
29212659 | J:258243
First Author: Villeneuve J
Year: 2018
Journal: J Cell Biol
Title: Unconventional secretion of FABP4 by endosomes and secretory lysosomes.
Volume: 217
Issue: 2
Pages: 649-665
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Publication
27294862 | J:253441
First Author: Zhang J
Year: 2016
Journal: PLoS One
Title: Cardiomyocyte Overexpression of FABP4 Aggravates Pressure Overload-Induced Heart Hypertrophy.
Volume: 11
Issue: 6
Pages: e0157372
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Publication
37172691 | J:353890
First Author: Prentice KJ
Year: 2023
Journal: J Lipid Res
Title: Sympathetic tone dictates the impact of lipolysis on FABP4 secretion.
Volume: 64
Issue: 6
Pages: 100386
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Publication
29696987 | J:267284
First Author: Ge XN
Year: 2018
Journal: Am J Physiol Lung Cell Mol Physiol
Title: FABP4 regulates eosinophil recruitment and activation in allergic airway inflammation.
Volume: 315
Issue: 2
Pages: L227-L240
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Protein
P04117
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: false
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Protein
Q542H7
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: false
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Publication
38216738 | J:357400
First Author: Yu HC
Year: 2024
Journal: Nat Metab
Title: p21-activated kinase 4 counteracts PKA-dependent lipolysis by phosphorylating FABP4 and HSL.
Volume: 6
Issue: 1
Pages: 94-112
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Publication
37279064 | J:339978
 
First Author: Inouye KE
Year: 2023
Journal: JCI Insight
Title: Endothelial-derived FABP4 constitutes the majority of basal circulating hormone and regulates lipolysis-driven insulin secretion.
Volume: 8
Issue: 14
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Publication
30462529 | J:287993
First Author: Liang X
Year: 2019
Journal: FASEB J
Title: Macrophage FABP4 is required for neutrophil recruitment and bacterial clearance in Pseudomonas aeruginosa pneumonia.
Volume: 33
Issue: 3
Pages: 3562-3574
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Publication
27297106 | J:238296
First Author: Chen RA
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Hyperglycemia-induced PATZ1 negatively modulates endothelial vasculogenesis via repression of FABP4 signaling.
Volume: 477
Issue: 4
Pages: 548-555
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Publication
26606905 | J:228208
First Author: Yang AN
Year: 2015
Journal: FEBS Lett
Title: High-methionine diets accelerate atherosclerosis by HHcy-mediated FABP4 gene demethylation pathway via DNMT1 in ApoE(-/-) mice.
Volume: 589
Issue: 24 Pt B
Pages: 3998-4009
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Publication
30401801 | J:268388
First Author: Shrestha S
Year: 2018
Journal: Sci Rep
Title: Circulating FABP4 is eliminated by the kidney via glomerular filtration followed by megalin-mediated reabsorption.
Volume: 8
Issue: 1
Pages: 16451
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Publication
29401617 | J:274296
First Author: Song C
Year: 2018
Journal: FASEB J
Title: REV-ERB agonism suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss partially via FABP4 upregulation.
Volume: 32
Issue: 6
Pages: 3215-3228
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Publication
27885273 | J:241800
First Author: Yan F
Year: 2017
Journal: Leukemia
Title: Fatty acid-binding protein FABP4 mechanistically links obesity with aggressive AML by enhancing aberrant DNA methylation in AML cells.
Volume: 31
Issue: 6
Pages: 1434-1442
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Publication
28385723 | J:271854
First Author: Xiong X
Year: 2017
Journal: J Endocrinol
Title: Fabp4-Cre-mediated Sirt6 deletion impairs adipose tissue function and metabolic homeostasis in mice.
Volume: 233
Issue: 3
Pages: 307-314
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Publication
17516629 | J:261845
First Author: Ayers SD
Year: 2007
Journal: Biochemistry
Title: Continuous nucleocytoplasmic shuttling underlies transcriptional activation of PPARgamma by FABP4.
Volume: 46
Issue: 23
Pages: 6744-52
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Publication
17761196 | J:261830
First Author: Gillilan RE
Year: 2007
Journal: J Mol Biol
Title: Structural basis for activation of fatty acid-binding protein 4.
Volume: 372
Issue: 5
Pages: 1246-60
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Publication
19625659 | J:154489
First Author: Elmasri H
Year: 2009
Journal: FASEB J
Title: Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells.
Volume: 23
Issue: 11
Pages: 3865-73
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Publication
28903937 | J:317707
 
First Author: Fuseya T
Year: 2017
Journal: J Am Heart Assoc
Title: Ectopic Fatty Acid-Binding Protein 4 Expression in the Vascular Endothelium is Involved in Neointima Formation After Vascular Injury.
Volume: 6
Issue: 9
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Publication
27013610 | J:246226
First Author: Furuhashi M
Year: 2016
Journal: Arterioscler Thromb Vasc Biol
Title: Local Production of Fatty Acid-Binding Protein 4 in Epicardial/Perivascular Fat and Macrophages Is Linked to Coronary Atherosclerosis.
Volume: 36
Issue: 5
Pages: 825-34
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Publication
31286669 | J:294569
First Author: Tan Z
Year: 2019
Journal: J Cell Mol Med
Title: Pharmacological and genetic inhibition of fatty acid-binding protein 4 alleviated cisplatin-induced acute kidney injury.
Volume: 23
Issue: 9
Pages: 6260-6270
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Publication
33101287 | J:337300
 
First Author: Feng Y
Year: 2020
Journal: Front Immunol
Title: Inhibition of Fatty Acid-Binding Protein 4 Attenuated Kidney Fibrosis by Mediating Macrophage-to-Myofibroblast Transition.
Volume: 11
Pages: 566535
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Publication
33690220 | J:332690
 
First Author: Xiao Y
Year: 2021
Journal: JCI Insight
Title: Fatty acid binding protein 4 promotes autoimmune diabetes by recruitment and activation of pancreatic islet macrophages.
Volume: 6
Issue: 7
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Publication
34806114 | J:322751
First Author: Gruber N
Year: 2022
Journal: Diabetologia
Title: Fatty acid-binding protein 4: a key regulator of ketoacidosis in new-onset type 1 diabetes.
Volume: 65
Issue: 2
Pages: 366-374
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Publication
29549054 | J:315909
First Author: Zhang C
Year: 2018
Journal: Osteoarthritis Cartilage
Title: Knocking out or pharmaceutical inhibition of fatty acid binding protein 4 (FABP4) alleviates osteoarthritis induced by high-fat diet in mice.
Volume: 26
Issue: 6
Pages: 824-833
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Publication
24416430 | J:211941
First Author: Antonson P
Year: 2014
Journal: PLoS One
Title: aP2-Cre-mediated inactivation of estrogen receptor alpha causes hydrometra.
Volume: 9
Issue: 1
Pages: e85581
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Publication
21044951 | J:167535
First Author: Vergnes L
Year: 2011
Journal: J Biol Chem
Title: Heart-type fatty acid-binding protein is essential for efficient brown adipose tissue fatty acid oxidation and cold tolerance.
Volume: 286
Issue: 1
Pages: 380-90
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Publication
24603714 | J:217245
First Author: Syamsunarno MR
Year: 2014
Journal: PLoS One
Title: Fatty acid binding protein 4 and 5 play a crucial role in thermogenesis under the conditions of fasting and cold stress.
Volume: 9
Issue: 6
Pages: e90825
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Publication
23391391 | J:195211
First Author: Ghelfi E
Year: 2013
Journal: Am J Pathol
Title: Fatty acid binding protein 4 regulates VEGF-induced airway angiogenesis and inflammation in a transgenic mouse model: implications for asthma.
Volume: 182
Issue: 4
Pages: 1425-33
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Publication
35457171 | J:323879
 
First Author: So SW
Year: 2022
Journal: Int J Mol Sci
Title: Microglial FABP4-UCP2 Axis Modulates Neuroinflammation and Cognitive Decline in Obese Mice.
Volume: 23
Issue: 8
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Publication
25096952 | J:215751
First Author: Makkar A
Year: 2014
Journal: Placenta
Title: Fatty acid binding protein-4 is expressed in the mouse placental labyrinth, yet is dispensable for placental triglyceride accumulation and fetal growth.
Volume: 35
Issue: 10
Pages: 802-7
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Publication
33994513 | J:310715
First Author: Umbarawan Y
Year: 2021
Journal: Int Heart J
Title: FABP5 Is a Sensitive Marker for Lipid-Rich Macrophages in the Luminal Side of Atherosclerotic Lesions.
Volume: 62
Issue: 3
Pages: 666-676
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Publication
18535105 | J:138158
First Author: Zhang W
Year: 2008
Journal: Endocrinology
Title: Effect of des-acyl ghrelin on adiposity and glucose metabolism.
Volume: 149
Issue: 9
Pages: 4710-6
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Publication
20230794 | J:159231
First Author: Hesse D
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Altered GLUT4 trafficking in adipocytes in the absence of the GTPase Arfrp1.
Volume: 394
Issue: 4
Pages: 896-903
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Publication
25265869 | J:232449
First Author: He L
Year: 2014
Journal: J Cell Mol Med
Title: Fabp4-CreER lineage tracing reveals two distinctive coronary vascular populations.
Volume: 18
Issue: 11
Pages: 2152-6
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Publication
24802082 | J:216088
First Author: Saint-Geniez M
Year: 2014
Journal: PLoS One
Title: Fatty acid binding protein 4 deficiency protects against oxygen-induced retinopathy in mice.
Volume: 9
Issue: 5
Pages: e96253
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Publication
28214555 | J:260970
 
First Author: Duffy CM
Year: 2017
Journal: Mol Cell Neurosci
Title: Identification of a fatty acid binding protein4-UCP2 axis regulating microglial mediated neuroinflammation.
Volume: 80
Pages: 52-57
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Publication
24244493 | J:209701
First Author: Syamsunarno MR
Year: 2013
Journal: PLoS One
Title: A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting.
Volume: 8
Issue: 11
Pages: e79386
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Publication
30866899 | J:291913
First Author: Iso T
Year: 2019
Journal: BMC Physiol
Title: Exercise endurance capacity is markedly reduced due to impaired energy homeostasis during prolonged fasting in FABP4/5 deficient mice.
Volume: 19
Issue: 1
Pages: 1
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Publication
28219080 | J:244055
First Author: Pan Y
Year: 2017
Journal: Nature
Title: Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism.
Volume: 543
Issue: 7644
Pages: 252-256
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Publication
26070408 | J:318353
First Author: Hu B
Year: 2015
Journal: J Hepatol
Title: Fatty acid binding protein-4 (FABP4) is a hypoxia inducible gene that sensitizes mice to liver ischemia/reperfusion injury.
Volume: 63
Issue: 4
Pages: 855-62
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Publication
33757861 | J:304470
 
First Author: Whitson RH Jr
Year: 2021
Journal: Mol Cell Endocrinol
Title: Mice with Fabp4-Cre ablation of Arid5b are resistant to diet-induced obesity and hepatic steatosis.
Volume: 528
Pages: 111246
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Publication
22150821 | J:196860
First Author: Zhang J
Year: 2012
Journal: Clin Exp Pharmacol Physiol
Title: Hypoxia-inducible factor 1 activation from adipose protein 2-cre mediated knockout of von Hippel-Lindau gene leads to embryonic lethality.
Volume: 39
Issue: 2
Pages: 145-50
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Publication
29174564 | J:255349
 
First Author: Rauch F
Year: 2018
Journal: Bone
Title: Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice.
Volume: 107
Pages: 131-142
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Protein Coding Gene
MGP_CAROLIEiJ_G0024842 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0027063 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0027027 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026997 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0027036 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026776 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_88038 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027480 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0026234 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0026754 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026890 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026857 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0027000 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026878 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027540 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0025969 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0026305 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0026290 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025772 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
6206497 | J:7568
First Author: Bernlohr DA
Year: 1984
Journal: Proc Natl Acad Sci U S A
Title: Expression of specific mRNAs during adipose differentiation: identification of an mRNA encoding a homologue of myelin P2 protein.
Volume: 81
Issue: 17
Pages: 5468-72
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Publication
3520554 | J:8305
First Author: Hunt CR
Year: 1986
Journal: Proc Natl Acad Sci U S A
Title: Adipocyte P2 gene: developmental expression and homology of 5'-flanking sequences among fat cell-specific genes.
Volume: 83
Issue: 11
Pages: 3786-90
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Publication
3968175 | J:34535
First Author: Cook KS
Year: 1985
Journal: J Cell Biol
Title: Developmentally regulated mRNAs in 3T3-adipocytes: analysis of transcriptional control.
Volume: 100
Issue: 2
Pages: 514-20
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Publication
8447836 | J:4068
First Author: Bansal MP
Year: 1993
Journal: Biochem Biophys Res Commun
Title: Expression of fatty acid-binding proteins in the developing mouse mammary gland.
Volume: 191
Issue: 1
Pages: 61-9
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Publication
10512363 | J:57864
First Author: Scheja L
Year: 1999
Journal: Diabetes
Title: Altered insulin secretion associated with reduced lipolytic efficiency in aP2-/- mice.
Volume: 48
Issue: 10
Pages: 1987-94
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Publication
15367400 | J:96046
First Author: Baar RA
Year: 2005
Journal: Am J Physiol Endocrinol Metab
Title: Investigation of in vivo fatty acid metabolism in AFABP/aP2(-/-) mice.
Volume: 288
Issue: 1
Pages: E187-93
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Publication
16841093 | J:113123
First Author: Shum BO
Year: 2006
Journal: J Clin Invest
Title: The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation.
Volume: 116
Issue: 8
Pages: 2183-2192
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Publication
12454272 | J:132835
First Author: Hertzel AV
Year: 2002
Journal: J Lipid Res
Title: Increased lipolysis in transgenic animals overexpressing the epithelial fatty acid binding protein in adipose cells.
Volume: 43
Issue: 12
Pages: 2105-11
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Publication
32213543 | J:290322
First Author: Liu L
Year: 2020
Journal: Cancer Res
Title: Consumption of the Fish Oil High-Fat Diet Uncouples Obesity and Mammary Tumor Growth through Induction of Reactive Oxygen Species in Protumor Macrophages.
Volume: 80
Issue: 12
Pages: 2564-2574
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Publication
27920274 | J:247682
First Author: Zhang Y
Year: 2017
Journal: J Immunol
Title: Adipose Fatty Acid Binding Protein Promotes Saturated Fatty Acid-Induced Macrophage Cell Death through Enhancing Ceramide Production.
Volume: 198
Issue: 2
Pages: 798-807
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Publication
10866041 | J:62315
First Author: Shaughnessy S
Year: 2000
Journal: Diabetes
Title: Adipocyte metabolism in adipocyte fatty acid binding protein knockout mice (aP2-/-) after short-term high-fat feeding: functional compensation by the keratinocyte [correction of keritinocyte] fatty acid binding protein.
Volume: 49
Issue: 6
Pages: 904-11
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Publication
8910278 | J:37027
First Author: Hotamisligil GS
Year: 1996
Journal: Science
Title: Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein.
Volume: 274
Issue: 5291
Pages: 1377-9
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Publication
29437708 | J:261890
First Author: Hao J
Year: 2018
Journal: Cancer Res
Title: Expression of Adipocyte/Macrophage Fatty Acid-Binding Protein in Tumor-Associated Macrophages Promotes Breast Cancer Progression.
Volume: 78
Issue: 9
Pages: 2343-2355
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Publication
17114450 | J:140699
First Author: Rolph MS
Year: 2006
Journal: J Immunol
Title: Regulation of dendritic cell function and T cell priming by the fatty acid-binding protein AP2.
Volume: 177
Issue: 11
Pages: 7794-801
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Publication
10224167 | J:54587
First Author: Coe NR
Year: 1999
Journal: J Lipid Res
Title: Targeted disruption of the adipocyte lipid-binding protein (aP2 protein) gene impairs fat cell lipolysis and increases cellular fatty acid levels.
Volume: 40
Issue: 5
Pages: 967-72
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Publication
28128199 | J:244397
 
First Author: Shu L
Year: 2017
Journal: Nat Commun
Title: A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes.
Volume: 8
Pages: 14147
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Publication
26186740 | J:248979
First Author: Zhou M
Year: 2015
Journal: Clin Sci (Lond)
Title: Deficiency of adipocyte fatty-acid-binding protein alleviates myocardial ischaemia/reperfusion injury and diabetes-induced cardiac dysfunction.
Volume: 129
Issue: 7
Pages: 547-59
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GXD Expression
GXD Expression
   
Probe: MGI:2181036
Assay Type: Northern blot
Annotation Date: 2002-07-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1920925
Stage: TS25
Assay Id: MGI:2181911
Age: embryonic day 17.0
Image: 2
Specimen Label: d17 wt
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:2181036
Assay Type: Northern blot
Annotation Date: 2002-07-16
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1920925
Stage: TS25
Assay Id: MGI:2181911
Age: embryonic day 17.0
Image: 2
Specimen Label: d17 -/-
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:2181036
Assay Type: Northern blot
Annotation Date: 2002-07-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1920926
Stage: TS26
Assay Id: MGI:2181911
Age: embryonic day 18.0
Image: 2
Specimen Label: d18 wt
Detected: true
Specimen Num: 3
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•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:2181036
Assay Type: Northern blot
Annotation Date: 2002-07-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1920926
Stage: TS26
Assay Id: MGI:2181911
Age: embryonic day 18.0
Image: 2
Specimen Label: d18 -/-
Detected: true
Specimen Num: 4
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•
•
•
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