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Search results 1 to 100 out of 1229 for Fadd

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Type Details Score
Protein Domain
IPR016729 | FADD
Type: Family
Description: This entry represents the Fas-associated death domain protein FADD. This is an apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate, called the death-inducing signalling complex (DISC), performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. For further information see [, , , , ].
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Gene
8772 | FADD
Type: gene
Organism: human
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Gene
100379789 | fadd
Type: gene
Organism: frog, western clawed
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Gene
266610 | Fadd
Type: gene
Organism: rat
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Gene
451389 | FADD
Type: gene
Organism: chimpanzee
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Gene
611694 | FADD
Type: gene
Organism: dog, domestic
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Gene
493720 | FADD
Type: gene
Organism: cattle
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Gene
423146 | FADD
Type: gene
Organism: chicken
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Gene
562317 | fadd
Type: gene
Organism: zebrafish
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Gene
708606 | FADD
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:109324 | Fadd
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
11034606 | J:65176
First Author: Rochat-Steiner V
Year: 2000
Journal: J Exp Med
Title: FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation.
Volume: 192
Issue: 8
Pages: 1165-74
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Publication
9582077 | -
First Author: Eberstadt M
Year: 1998
Journal: Nature
Title: NMR structure and mutagenesis of the FADD (Mort1) death-effector domain.
Volume: 392
Issue: 6679
Pages: 941-5
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Publication
7538907 | -
First Author: Chinnaiyan AM
Year: 1995
Journal: Cell
Title: FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis.
Volume: 81
Issue: 4
Pages: 505-12
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Publication
12702765 | -
First Author: Screaton RA
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis.
Volume: 100
Issue: 9
Pages: 5211-6
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Publication
16127453 | -
First Author: Kawai T
Year: 2005
Journal: Nat Immunol
Title: IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction.
Volume: 6
Issue: 10
Pages: 981-8
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Protein
Q61160
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: false
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Protein
Q8CD57
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: false
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Publication
25641109 | J:310725
First Author: Yao C
Year: 2015
Journal: J Cell Physiol
Title: FADD phosphorylation impaired islet morphology and function.
Volume: 230
Issue: 7
Pages: 1448-56
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Publication
21115735 | J:168722
First Author: Rosenberg S
Year: 2011
Journal: J Immunol
Title: FADD deficiency impairs early hematopoiesis in the bone marrow.
Volume: 186
Issue: 1
Pages: 203-13
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Publication
25078620 | J:220125
First Author: Zhang XY
Year: 2014
Journal: Biochem Biophys Res Commun
Title: FADD is essential for glucose uptake and survival of thymocytes.
Volume: 451
Issue: 2
Pages: 202-7
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Publication
19301394 | J:147039
First Author: Shackleton M
Year: 2009
Journal: Dev Dyn
Title: Impaired lactation in mice expressing dominant-negative FADD in mammary epithelium.
Volume: 238
Issue: 4
Pages: 1010-6
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Publication
21068410 | J:167475
First Author: Mc Guire C
Year: 2010
Journal: J Immunol
Title: Oligodendrocyte-specific FADD deletion protects mice from autoimmune-mediated demyelination.
Volume: 185
Issue: 12
Pages: 7646-53
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Publication
27357657 | J:273986
First Author: Zhuang H
Year: 2016
Journal: EMBO Mol Med
Title: FADD is a key regulator of lipid metabolism.
Volume: 8
Issue: 8
Pages: 895-918
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Publication
16009710 | J:101165
First Author: Imtiyaz HZ
Year: 2005
Journal: J Biol Chem
Title: Structural requirements for signal-induced target binding of FADD determined by functional reconstitution of FADD deficiency.
Volume: 280
Issue: 36
Pages: 31360-7
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Publication
25628462 | J:260326
First Author: Bowman BM
Year: 2015
Journal: Sci Signal
Title: Phosphorylation of FADD by the kinase CK1α promotes KRASG12D-induced lung cancer.
Volume: 8
Issue: 361
Pages: ra9
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Publication
21368761 | J:170816
First Author: Zhang H
Year: 2011
Journal: Nature
Title: Functional complementation between FADD and RIP1 in embryos and lymphocytes.
Volume: 471
Issue: 7338
Pages: 373-6
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Publication
25874713 | J:233505
First Author: Schock SN
Year: 2015
Journal: PLoS One
Title: Deletion of FADD in macrophages and granulocytes results in RIP3- and MyD88-dependent systemic inflammation.
Volume: 10
Issue: 4
Pages: e0124391
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Publication
21804564 | J:175865
First Author: Welz PS
Year: 2011
Journal: Nature
Title: FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation.
Volume: 477
Issue: 7364
Pages: 330-4
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Publication
36191211 | J:353327
First Author: Rodriguez DA
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Caspase-8 and FADD prevent spontaneous ZBP1 expression and necroptosis.
Volume: 119
Issue: 41
Pages: e2207240119
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Gene
8837 | CFLAR
Type: gene
Organism: human
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Publication
16688118 | J:136499
First Author: Justo P
Year: 2006
Journal: Kidney Int
Title: Lethal activity of FADD death domain in renal tubular epithelial cells.
Volume: 69
Issue: 12
Pages: 2205-11
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Publication
10026132 | J:53251
First Author: Wiegmann K
Year: 1999
Journal: J Biol Chem
Title: Requirement of FADD for tumor necrosis factor-induced activation of acid sphingomyelinase.
Volume: 274
Issue: 9
Pages: 5267-70
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Publication
27584790 | J:284571
First Author: Fan C
Year: 2016
Journal: Cell Death Dis
Title: Lack of FADD in Tie-2 expressing cells causes RIPK3-mediated embryonic lethality.
Volume: 7
Issue: 9
Pages: e2351
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Publication
11353862 | J:69617
First Author: Kabra NH
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: T cell-specific FADD-deficient mice: FADD is required for early T cell development.
Volume: 98
Issue: 11
Pages: 6307-12
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Publication
38850531 | J:360956
First Author: Rodriguez DA
Year: 2024
Journal: Cell Rep
Title: The interaction between RIPK1 and FADD controls perinatal lethality and inflammation.
Volume: 43
Issue: 6
Pages: 114335
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Publication
23935974 | J:204945
First Author: Sung TC
Year: 2013
Journal: PLoS One
Title: P45 forms a complex with FADD and promotes neuronal cell survival following spinal cord injury.
Volume: 8
Issue: 7
Pages: e69286
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Publication
10964568 | J:64514
First Author: Berglund H
Year: 2000
Journal: J Mol Biol
Title: The three-dimensional solution structure and dynamic properties of the human FADD death domain.
Volume: 302
Issue: 1
Pages: 171-88
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Publication
10347191 | J:55358
First Author: Jeong EJ
Year: 1999
Journal: J Biol Chem
Title: The solution structure of FADD death domain. Structural basis of death domain interactions of Fas and FADD.
Volume: 274
Issue: 23
Pages: 16337-42
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Publication
27498868 | J:238962
First Author: Zhang X
Year: 2016
Journal: Cell Rep
Title: MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome.
Volume: 16
Issue: 12
Pages: 3247-3259
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Publication
19203997 | J:149068
First Author: Imtiyaz HZ
Year: 2009
Journal: J Biol Chem
Title: The death domain of FADD is essential for embryogenesis, lymphocyte development, and proliferation.
Volume: 284
Issue: 15
Pages: 9917-26
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Publication
27799292 | J:245005
 
First Author: Choi SG
Year: 2017
Journal: Mol Cell Biol
Title: SUMO-Modified FADD Recruits Cytosolic Drp1 and Caspase-10 to Mitochondria for Regulated Necrosis.
Volume: 37
Issue: 2
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Publication
22000287 | J:177639
First Author: Bonnet MC
Year: 2011
Journal: Immunity
Title: The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation.
Volume: 35
Issue: 4
Pages: 572-82
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Publication
24453255 | J:209447
First Author: Gurung P
Year: 2014
Journal: J Immunol
Title: FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes.
Volume: 192
Issue: 4
Pages: 1835-46
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Publication
23898178 | J:200693
First Author: Thapa RJ
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases.
Volume: 110
Issue: 33
Pages: E3109-18
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Publication
17785432 | J:129077
First Author: Zhande R
Year: 2007
Journal: Mol Cell Biol
Title: FADD negatively regulates lipopolysaccharide signaling by impairing interleukin-1 receptor-associated kinase 1-MyD88 interaction.
Volume: 27
Issue: 21
Pages: 7394-404
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Publication
16116191 | J:113207
First Author: Zhang Y
Year: 2005
Journal: J Immunol
Title: Conditional Fas-associated death domain protein (FADD): GFP knockout mice reveal FADD is dispensable in thymic development but essential in peripheral T cell homeostasis.
Volume: 175
Issue: 5
Pages: 3033-44
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Publication
18946037 | J:248272
First Author: Bell BD
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells.
Volume: 105
Issue: 43
Pages: 16677-82
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Publication
10862756 | J:63946
First Author: Kuang AA
Year: 2000
Journal: J Biol Chem
Title: FADD is required for DR4- and DR5-mediated apoptosis: lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts.
Volume: 275
Issue: 33
Pages: 25065-8
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Publication
12743602 | J:83474
First Author: Tourneur L
Year: 2003
Journal: Oncogene
Title: Loss of FADD protein expression results in a biased Fas-signaling pathway and correlates with the development of tumoral status in thyroid follicular cells.
Volume: 22
Issue: 18
Pages: 2795-804
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Publication
20889682 | J:166543
First Author: Villa-Morales M
Year: 2010
Journal: Carcinogenesis
Title: Modulation of the Fas-apoptosis-signalling pathway by functional polymorphisms at Fas, FasL and Fadd and their implication in T-cell lymphoblastic lymphoma susceptibility.
Volume: 31
Issue: 12
Pages: 2165-71
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Publication
24971483 | J:230157
First Author: Ehlken H
Year: 2014
Journal: Cell Death Differ
Title: Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout.
Volume: 21
Issue: 11
Pages: 1721-32
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Publication
21876153 | J:176448
First Author: Lu JV
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity.
Volume: 108
Issue: 37
Pages: 15312-7
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Publication
16709845 | J:131791
First Author: Imtiyaz HZ
Year: 2006
Journal: J Immunol
Title: The Fas-associated death domain protein is required in apoptosis and TLR-induced proliferative responses in B cells.
Volume: 176
Issue: 11
Pages: 6852-61
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Publication
20615958 | J:162312
First Author: Osborn SL
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis.
Volume: 107
Issue: 29
Pages: 13034-9
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Publication
24058479 | J:206043
First Author: Fan Q
Year: 2013
Journal: PLoS One
Title: Inhibition of Fas-associated death domain-containing protein (FADD) protects against myocardial ischemia/reperfusion injury in a heart failure mouse model.
Volume: 8
Issue: 9
Pages: e73537
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Publication
12887920 | J:341414
First Author: Micheau O
Year: 2003
Journal: Cell
Title: Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes.
Volume: 114
Issue: 2
Pages: 181-90
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Publication
12817005 | J:132831
First Author: Beisner DR
Year: 2003
Journal: J Immunol
Title: The requirements for Fas-associated death domain signaling in mature T cell activation and survival.
Volume: 171
Issue: 1
Pages: 247-56
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Strain
MGI:4834638 | B6.Cg-Tg(Lck-FADD)1Hed/Ieg
Attribute String: transgenic, mutant strain, congenic
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Publication
16177127 | J:118958
First Author: Sun J
Year: 2005
Journal: J Immunol
Title: Essential roles of the Fas-associated death domain in autoimmune encephalomyelitis.
Volume: 175
Issue: 7
Pages: 4783-8
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Publication
12705854 | J:83011
First Author: Hua ZC
Year: 2003
Journal: Immunity
Title: A function of Fas-associated death domain protein in cell cycle progression localized to a single amino acid at its C-terminal region.
Volume: 18
Issue: 4
Pages: 513-21
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Publication
9506948 | J:46527
First Author: Yeh WC
Year: 1998
Journal: Science
Title: FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis.
Volume: 279
Issue: 5358
Pages: 1954-8
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Publication
17553783 | J:124580
First Author: Osborn SL
Year: 2007
Journal: J Biol Chem
Title: Constitutive phosphorylation mutation in Fas-associated death domain (FADD) results in early cell cycle defects.
Volume: 282
Issue: 31
Pages: 22786-92
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Publication
23828893 | J:317057
First Author: Yao C
Year: 2013
Journal: Mol Cell Proteomics
Title: Role of Fas-associated death domain-containing protein (FADD) phosphorylation in regulating glucose homeostasis: from proteomic discovery to physiological validation.
Volume: 12
Issue: 10
Pages: 2689-700
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Publication
24375410 | J:213026
First Author: Cheng W
Year: 2014
Journal: J Biol Chem
Title: Self-renewal and differentiation of muscle satellite cells are regulated by the Fas-associated death domain.
Volume: 289
Issue: 8
Pages: 5040-50
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Publication
8565075 | J:38183
First Author: Hsu H
Year: 1996
Journal: Cell
Title: TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways.
Volume: 84
Issue: 2
Pages: 299-308
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Publication
9521326 | J:46526
First Author: Zhang J
Year: 1998
Journal: Nature
Title: Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1.
Volume: 392
Issue: 6673
Pages: 296-300
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Publication
22582393 | J:188376
First Author: Cheng W
Year: 2012
Journal: J Biol Chem
Title: Regulation of protein kinase C inactivation by Fas-associated protein with death domain.
Volume: 287
Issue: 31
Pages: 26126-35
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Publication
15635090 | J:98624
First Author: Thorburn J
Year: 2005
Journal: Mol Biol Cell
Title: Selective inactivation of a Fas-associated death domain protein (FADD)-dependent apoptosis and autophagy pathway in immortal epithelial cells.
Volume: 16
Issue: 3
Pages: 1189-99
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Publication
17277150 | J:143977
First Author: Balachandran S
Year: 2007
Journal: J Immunol
Title: Fas-associated death domain-containing protein-mediated antiviral innate immune signaling involves the regulation of Irf7.
Volume: 178
Issue: 4
Pages: 2429-39
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Publication
30250469 | J:295700
 
First Author: Zhang X
Year: 2018
Journal: Front Immunol
Title: Dominant Negative FADD/MORT1 Inhibits the Development of Intestinal Intraepithelial Lymphocytes With a Marked Defect on CD8αα+TCRγδ+ T Cells.
Volume: 9
Pages: 2038
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Publication
27523270 | J:254600
First Author: Alvarez-Diaz S
Year: 2016
Journal: Immunity
Title: The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis.
Volume: 45
Issue: 3
Pages: 513-526
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Publication
28445730 | J:254599
First Author: Zhao Q
Year: 2017
Journal: Cell Rep
Title: RIPK3 Mediates Necroptosis during Embryonic Development and Postnatal Inflammation in Fadd-Deficient Mice.
Volume: 19
Issue: 4
Pages: 798-808
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Publication
10072523 | J:53223
First Author: Kabra NH
Year: 1999
Journal: J Immunol
Title: A tailless fas-FADD death-effector domain chimera is sufficient to execute Fas function in T cells but not B cells of MRL-lpr/lpr mice.
Volume: 162
Issue: 5
Pages: 2766-74
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Publication
19176810 | J:144828
First Author: Ho CC
Year: 2009
Journal: J Neurosci
Title: The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration.
Volume: 29
Issue: 4
Pages: 1011-6
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Publication
22406316 | J:183243
First Author: Schattenberg JM
Year: 2012
Journal: Free Radic Biol Med
Title: The role of death effector domain-containing proteins in acute oxidative cell injury in hepatocytes.
Volume: 52
Issue: 9
Pages: 1911-7
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Publication
19342627 | J:147749
First Author: Lohmann C
Year: 2009
Journal: J Immunol
Title: Induction of tumor cell apoptosis or necrosis by conditional expression of cell death proteins: analysis of cell death pathways and in vitro immune stimulatory potential.
Volume: 182
Issue: 8
Pages: 4538-46
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Publication
25443631 | J:269068
   
First Author: Kumari S
Year: 2014
Journal: Elife
Title: Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.
Volume: 3
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Publication
17292824 | J:118336
First Author: Luedde T
Year: 2007
Journal: Cancer Cell
Title: Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma.
Volume: 11
Issue: 2
Pages: 119-32
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Publication
30741936 | J:275412
First Author: Dowling JP
Year: 2019
Journal: Nat Commun
Title: TRADD regulates perinatal development and adulthood survival in mice lacking RIPK1 and RIPK3.
Volume: 10
Issue: 1
Pages: 705
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Publication
24813850 | J:214393
First Author: Dillon CP
Year: 2014
Journal: Cell
Title: RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3.
Volume: 157
Issue: 5
Pages: 1189-202
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Publication
23727238 | J:199316
First Author: Young JA
Year: 2013
Journal: Cell Rep
Title: Commensal microbiota are required for systemic inflammation triggered by necrotic dendritic cells.
Volume: 3
Issue: 6
Pages: 1932-44
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Publication
18445587 | J:138177
First Author: Tourneur L
Year: 2008
Journal: J Biol Chem
Title: Adenosine receptors control a new pathway of Fas-associated death domain protein expression regulation by secretion.
Volume: 283
Issue: 26
Pages: 17929-38
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Publication
28919893 | J:280177
 
First Author: Fa Z
Year: 2017
Journal: Front Immunol
Title: RIPK3/Fas-Associated Death Domain Axis Regulates Pulmonary Immunopathology to Cryptococcal Infection Independent of Necroptosis.
Volume: 8
Pages: 1055
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Publication
12884866 | J:203409
First Author: Shikama Y
Year: 2003
Journal: Eur J Immunol
Title: Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases.
Volume: 33
Issue: 7
Pages: 1998-2006
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Publication
15549108 | J:94554
First Author: Balachandran S
Year: 2004
Journal: Nature
Title: A FADD-dependent innate immune mechanism in mammalian cells.
Volume: 432
Issue: 7015
Pages: 401-5
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Publication
32428502 | J:296046
First Author: Tummers B
Year: 2020
Journal: Immunity
Title: Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis.
Volume: 52
Issue: 6
Pages: 994-1006.e8
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Publication
29167229 | J:255496
First Author: Xu C
Year: 2018
Journal: J Immunol
Title: Embryonic Lethality and Host Immunity of RelA-Deficient Mice Are Mediated by Both Apoptosis and Necroptosis.
Volume: 200
Issue: 1
Pages: 271-285
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Publication
34625557 | J:312467
First Author: Schünke H
Year: 2021
Journal: Nat Commun
Title: OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice.
Volume: 12
Issue: 1
Pages: 5912
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Publication
21746883 | J:175071
First Author: Irrinki KM
Year: 2011
Journal: Mol Cell Biol
Title: Requirement of FADD, NEMO, and BAX/BAK for aberrant mitochondrial function in tumor necrosis factor alpha-induced necrosis.
Volume: 31
Issue: 18
Pages: 3745-58
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Publication
30692261 | J:271660
First Author: Fang X
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Ferroptosis as a target for protection against cardiomyopathy.
Volume: 116
Issue: 7
Pages: 2672-2680
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Publication
25767797 | J:291252
 
First Author: Dowling JP
Year: 2015
Journal: Front Cell Dev Biol
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