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Search results 1 to 100 out of 315 for Fancc

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
2176 | FANCC
Type: gene
Organism: human
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Gene
465257 | FANCC
Type: gene
Organism: chimpanzee
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Gene
281762 | FANCC
Type: gene
Organism: cattle
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Gene
427468 | FANCC
Type: gene
Organism: chicken
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Gene
692127 | fancc
Type: gene
Organism: zebrafish
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Gene
709398 | FANCC
Type: gene
Organism: macaque, rhesus
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Gene
100493280 | fancc
Type: gene
Organism: frog, western clawed
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Gene
24361 | Fancc
Type: gene
Organism: rat
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Gene
607277 | FANCC
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:95480 | Fancc
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR000686 | FANCC
Type: Family
Description: Fanconi anemia (FA) is a human disorder characterized by cancer susceptibility and cellular sensitivity to DNA crosslinks and other damages. The FA complex repairs the interstrand cross-linking (ICL) lesions and coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination. It is required for the monoubiquitylation of FANCD2 and FANCI heterodimer. The FA core complex consists of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FANCT (UBET2), FAAP100 and FAAP24 [, ].This entry represents FANCC [].
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Publication
20554974 | J:164505
First Author: Hays LE
Year: 2010
Journal: Blood
Title: Human FANCC is hypomorphic in murine Fancc-deficient cells.
Volume: 116
Issue: 12
Pages: 2057-60
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Publication
30213274 | J:265352
First Author: Huang F
Year: 2018
Journal: BMC Res Notes
Title: FANCC localizes with UNC5A at neurite outgrowth and promotes neuritogenesis.
Volume: 11
Issue: 1
Pages: 662
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Publication
20022886 | J:157096
First Author: Rhee DB
Year: 2010
Journal: Hum Mol Genet
Title: FANCC suppresses short telomere-initiated telomere sister chromatid exchange.
Volume: 19
Issue: 5
Pages: 879-87
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Publication
26895835 | J:330996
First Author: Sertorio M
Year: 2016
Journal: J Immunol
Title: Loss of Fancc Impairs Antibody-Secreting Cell Differentiation in Mice through Deregulating the Wnt Signaling Pathway.
Volume: 196
Issue: 7
Pages: 2986-94
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Publication
24005041 | J:211173
First Author: Luebben SW
Year: 2013
Journal: Nucleic Acids Res
Title: Helq acts in parallel to Fancc to suppress replication-associated genome instability.
Volume: 41
Issue: 22
Pages: 10283-97
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Publication
24483844 | J:226736
First Author: Li X
Year: 2014
Journal: Antioxid Redox Signal
Title: Concomitant inactivation of foxo3a and fancc or fancd2 reveals a two-tier protection from oxidative stress-induced hydrocephalus.
Volume: 21
Issue: 12
Pages: 1675-92
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Publication
24046015 | J:204066
First Author: Garbati MR
Year: 2013
Journal: Blood
Title: FANCA and FANCC modulate TLR and p38 MAPK-dependent expression of IL-1β in macrophages.
Volume: 122
Issue: 18
Pages: 3197-205
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Publication
10848598 | J:124518
First Author: Pang Q
Year: 2000
Journal: Mol Cell Biol
Title: The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors.
Volume: 20
Issue: 13
Pages: 4724-35
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Publication
20606166 | J:165874
First Author: Pulliam-Leath AC
Year: 2010
Journal: Blood
Title: Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia.
Volume: 116
Issue: 16
Pages: 2915-20
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Publication
11493445 | J:71134
First Author: Hadjur S
Year: 2001
Journal: Blood
Title: Defective hematopoiesis and hepatic steatosis in mice with combined deficiencies of the genes encoding Fancc and Cu/Zn superoxide dismutase.
Volume: 98
Issue: 4
Pages: 1003-11
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Protein
P50652
Organism: Mus musculus/domesticus
Length: 591  
Fragment?: false
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Protein
Q3UI88
Organism: Mus musculus/domesticus
Length: 660  
Fragment?: true
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Protein
E0CYQ7
Organism: Mus musculus/domesticus
Length: 229  
Fragment?: true
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Protein
A0A1Y7VKS5
Organism: Mus musculus/domesticus
Length: 412  
Fragment?: false
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Protein
E0CXC4
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: true
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Protein
E0CYI2
Organism: Mus musculus/domesticus
Length: 43  
Fragment?: true
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Protein
E9QAE8
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: false
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Protein
F7DEE2
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: true
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Protein
E0CYC3
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: true
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Protein
Q3V2X6
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: false
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Protein
Q8CBR3
Organism: Mus musculus/domesticus
Length: 558  
Fragment?: false
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Publication
20347428 | -
First Author: Yan Z
Year: 2010
Journal: Mol Cell
Title: A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability.
Volume: 37
Issue: 6
Pages: 865-78
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Publication
29017571 | -
First Author: Bhattacharjee S
Year: 2017
Journal: Cell Commun Signal
Title: DNA damage response and cancer therapeutics through the lens of the Fanconi Anemia DNA repair pathway.
Volume: 15
Issue: 1
Pages: 41
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Publication
27133164 | J:234489
First Author: Sumpter R Jr
Year: 2016
Journal: Cell
Title: Fanconi Anemia Proteins Function in Mitophagy and Immunity.
Volume: 165
Issue: 4
Pages: 867-81
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Publication
14764578 | J:89528
First Author: Saadatzadeh MR
Year: 2004
Journal: J Biol Chem
Title: Oxidant hypersensitivity of Fanconi anemia type C-deficient cells is dependent on a redox-regulated apoptotic pathway.
Volume: 279
Issue: 16
Pages: 16805-12
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Publication
15356134 | J:92746
First Author: Fagerlie SR
Year: 2004
Journal: J Immunol
Title: Impaired type I IFN-induced Jak/STAT signaling in FA-C cells and abnormal CD4+ Th cell subsets in Fancc-/- mice.
Volume: 173
Issue: 6
Pages: 3863-70
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Publication
27507053 | J:313242
First Author: Du W
Year: 2016
Journal: Oncotarget
Title: The Fanconi anemia pathway controls oncogenic response in hematopoietic stem and progenitor cells by regulating PRMT5-mediated p53 arginine methylation.
Volume: 7
Issue: 37
Pages: 60005-60020
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Publication
10951504 | J:64334
First Author: Nadler JJ
Year: 2000
Journal: Genesis
Title: Fanconi anemia complementation group C is required for proliferation of murine primordial germ cells.
Volume: 27
Issue: 3
Pages: 117-23
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Publication
23925293 | J:201618
First Author: Hu L
Year: 2013
Journal: J Clin Invest
Title: Increased Fanconi C expression contributes to the emergency granulopoiesis response.
Volume: 123
Issue: 9
Pages: 3952-66
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Publication
25056314 | J:218118
First Author: Larin M
Year: 2014
Journal: Nucleic Acids Res
Title: Fanconi anemia signaling and Mus81 cooperate to safeguard development and crosslink repair.
Volume: 42
Issue: 15
Pages: 9807-20
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Publication
28341737 | J:285820
First Author: Zhou Y
Year: 2017
Journal: Haematologica
Title: An abnormal bone marrow microenvironment contributes to hematopoietic dysfunction in Fanconi anemia.
Volume: 102
Issue: 6
Pages: 1017-1027
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Publication
18475298 | J:137293
First Author: Hays LE
Year: 2008
Journal: Br J Cancer
Title: Cigarette smoke induces genetic instability in airway epithelial cells by suppressing FANCD2 expression.
Volume: 98
Issue: 10
Pages: 1653-61
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Publication
12135664 | J:77903
First Author: Noll M
Year: 2002
Journal: Exp Hematol
Title: Fanconi anemia group A and C double-mutant mice: functional evidence for a multi-protein Fanconi anemia complex.
Volume: 30
Issue: 7
Pages: 679-88
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Publication
17960249 | J:127384
First Author: Li J
Year: 2007
Journal: J Clin Invest
Title: TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells.
Volume: 117
Issue: 11
Pages: 3283-95
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Publication
17404312 | J:145270
First Author: Sejas DP
Year: 2007
Journal: J Immunol
Title: Inflammatory reactive oxygen species-mediated hemopoietic suppression in Fancc-deficient mice.
Volume: 178
Issue: 8
Pages: 5277-87
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Publication
12855557 | J:84980
First Author: Freie B
Year: 2003
Journal: Blood
Title: Fanconi anemia type C and p53 cooperate in apoptosis and tumorigenesis.
Volume: 102
Issue: 12
Pages: 4146-52
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Publication
27760317 | J:240753
First Author: Alavattam KG
Year: 2016
Journal: Cell Rep
Title: Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.
Volume: 17
Issue: 4
Pages: 1141-1157
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Publication
19850743 | J:155700
First Author: Vanderwerf SM
Year: 2009
Journal: Blood
Title: TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells.
Volume: 114
Issue: 26
Pages: 5290-8
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Publication
23303816 | J:194756
First Author: Huard CC
Year: 2013
Journal: Blood
Title: Fanconi anemia proteins interact with CtBP1 and modulate the expression of the Wnt antagonist Dickkopf-1.
Volume: 121
Issue: 10
Pages: 1729-39
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Publication
7690622 | J:13598
First Author: Wevrick R
Year: 1993
Journal: Mamm Genome
Title: Mapping of the murine and rat Facc genes and assessment of flexed-tail as a candidate mouse homolog of Fanconi anemia group C.
Volume: 4
Issue: 8
Pages: 440-4
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Publication
29377497 | J:268797
First Author: Xu J
Year: 2018
Journal: Stem Cells
Title: Reduced Cell Division Control Protein 42 Activity Compromises Hematopoiesis-Supportive Function of Fanconi Anemia Mesenchymal Stromal Cells.
Volume: 36
Issue: 5
Pages: 785-795
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Publication
15377654 | J:95193
First Author: Freie BW
Year: 2004
Journal: J Biol Chem
Title: A role for the Fanconi anemia C protein in maintaining the DNA damage-induced G2 checkpoint.
Volume: 279
Issue: 49
Pages: 50986-93
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Publication
35703178 | J:326162
 
First Author: Lin Q
Year: 2022
Journal: J Clin Invest
Title: Hematopoietic stem cell regeneration through paracrine regulation of the Wnt5a/Prox1 signaling axis.
Volume: 132
Issue: 12
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Protein Coding Gene
MGP_CAROLIEiJ_G0018633 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0020669 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0020623 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0020600 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0020621 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0020416 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_95480 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0021057 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0019933 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0020376 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0020501 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0020480 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0020575 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0020509 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0021099 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0019687 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0019993 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0019697 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0019513 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
7689006 | J:12592
First Author: Wevrick R
Year: 1993
Journal: Hum Mol Genet
Title: Cloning and analysis of the murine Fanconi anemia group C cDNA.
Volume: 2
Issue: 6
Pages: 655-62
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Publication
8630504 | J:32080
First Author: Chen M
Year: 1996
Journal: Nat Genet
Title: Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia.
Volume: 12
Issue: 4
Pages: 448-51
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Publication
23315168 | J:195426
First Author: Kamimae-Lanning AN
Year: 2013
Journal: Blood
Title: Fetal origins of hematopoietic failure in a murine model of Fanconi anemia.
Volume: 121
Issue: 11
Pages: 2008-12
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Publication
15113761 | J:92640
First Author: Li X
Year: 2004
Journal: Blood
Title: Continuous in vivo infusion of interferon-gamma (IFN-gamma) preferentially reduces myeloid progenitor numbers and enhances engraftment of syngeneic wild-type cells in Fancc-/- mice.
Volume: 104
Issue: 4
Pages: 1204-9
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Publication
15644418 | J:98974
First Author: Li X
Year: 2005
Journal: Blood
Title: Ex vivo culture of Fancc-/- stem/progenitor cells predisposes cells to undergo apoptosis, and surviving stem/progenitor cells display cytogenetic abnormalities and an increased risk of malignancy.
Volume: 105
Issue: 9
Pages: 3465-71
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Publication
22234699 | J:182556
First Author: Anur P
Year: 2012
Journal: Blood
Title: p38 MAPK inhibition suppresses the TLR-hypersensitive phenotype in FANCC- and FANCA-deficient mononuclear phagocytes.
Volume: 119
Issue: 9
Pages: 1992-2002
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Publication
15769896 | J:107448
First Author: Zhang X
Year: 2005
Journal: Blood
Title: Hypoxia-reoxygenation induces premature senescence in FA bone marrow hematopoietic cells.
Volume: 106
Issue: 1
Pages: 75-85
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Publication
26860989 | J:317004
First Author: Cerabona D
Year: 2016
Journal: Exp Hematol
Title: Leukemia and chromosomal instability in aged Fancc-/- mice.
Volume: 44
Issue: 5
Pages: 352-7
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Publication
9596654 | J:47897
First Author: Haneline LS
Year: 1998
Journal: Blood
Title: Multiple inhibitory cytokines induce deregulated progenitor growth and apoptosis in hematopoietic cells from Fac-/- mice.
Volume: 91
Issue: 11
Pages: 4092-8
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Publication
22106009 | J:181159
First Author: Liu Y
Year: 2012
Journal: J Leukoc Biol
Title: Impaired function of Fanconi anemia type C-deficient macrophages.
Volume: 91
Issue: 2
Pages: 333-40
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Publication
8704201 | J:61512
First Author: Whitney MA
Year: 1996
Journal: Blood
Title: Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene.
Volume: 88
Issue: 1
Pages: 49-58
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Publication
10477746 | J:57637
First Author: Battaile KP
Year: 1999
Journal: Blood
Title: In vivo selection of wild-type hematopoietic stem cells in a murine model of Fanconi anemia.
Volume: 94
Issue: 6
Pages: 2151-8
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Publication
1303234 | J:1087
First Author: Strathdee CA
Year: 1992
Journal: Nat Genet
Title: Evidence for at least four Fanconi anaemia genes including FACC on chromosome 9.
Volume: 1
Issue: 3
Pages: 196-8
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Publication
8789444 | J:30903
First Author: Krasnoshtein F
Year: 1996
Journal: Hum Mol Genet
Title: Developmental expression of the Fac gene correlates with congenital defects in Fanconi anemia patients.
Volume: 5
Issue: 1
Pages: 85-93
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GXD Expression
GXD Expression
   
Probe: MGI:5475278
Assay Type: RT-PCR
Annotation Date: 2013-04-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3291019
Stage: TS19
Assay Id: MGI:5475292
Age: embryonic day 11.5
Image: 1
Specimen Label: E11.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5475278
Assay Type: RT-PCR
Annotation Date: 2013-04-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1674419
Stage: TS19
Assay Id: MGI:5475292
Age: embryonic day 11.5
Image: 1
Specimen Label: E11.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5475278
Assay Type: RT-PCR
Annotation Date: 2013-04-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1738319
Stage: TS19
Assay Id: MGI:5475292
Age: embryonic day 11.5
Image: 1
Specimen Label: E11.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5475278
Assay Type: RT-PCR
Annotation Date: 2013-04-25
Strength: Present
Sex: Male
Emaps: EMAPS:2913822
Stage: TS22
Assay Id: MGI:5475292
Age: embryonic day 14.5
Image: 1
Specimen Label: E14.5 Male
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5475278
Assay Type: RT-PCR
Annotation Date: 2013-04-25
Strength: Present
Sex: Male
Emaps: EMAPS:1797222
Stage: TS22
Assay Id: MGI:5475292
Age: embryonic day 14.5
Image: 1
Specimen Label: E14.5 Male
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5475278
Assay Type: RT-PCR
Annotation Date: 2013-04-25
Strength: Present
Sex: Male
Emaps: EMAPS:1674424
Stage: TS24
Assay Id: MGI:5475292
Age: embryonic day 16.5
Image: 1
Specimen Label: E16.5 Male
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:5475278
Assay Type: RT-PCR
Annotation Date: 2013-04-25
Strength: Present
Sex: Male
Emaps: EMAPS:1797224
Stage: TS24
Assay Id: MGI:5475292
Age: embryonic day 16.5
Image: 1
Specimen Label: E16.5 Male
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:5475278
Assay Type: RT-PCR
Annotation Date: 2013-04-25
Strength: Present
Sex: Female
Emaps: EMAPS:2890922
Stage: TS22
Assay Id: MGI:5475292
Age: embryonic day 14.5
Image: 1
Specimen Label: E14.5 Female
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:5475278
Assay Type: RT-PCR
Annotation Date: 2013-04-25
Strength: Present
Sex: Female
Emaps: EMAPS:1796222
Stage: TS22
Assay Id: MGI:5475292
Age: embryonic day 14.5
Image: 1
Specimen Label: E14.5 Female
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:5475278
Assay Type: RT-PCR
Annotation Date: 2013-04-25
Strength: Present
Sex: Female
Emaps: EMAPS:1674424
Stage: TS24
Assay Id: MGI:5475292
Age: embryonic day 16.5
Image: 1
Specimen Label: E16.5 Female
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:5475278
Assay Type: RT-PCR
Annotation Date: 2013-04-25
Strength: Present
Sex: Female
Emaps: EMAPS:1796224
Stage: TS24
Assay Id: MGI:5475292
Age: embryonic day 16.5
Image: 1
Specimen Label: E16.5 Female
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:5766537
Assay Type: RNA in situ
Annotation Date: 2016-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1870524
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:5766629
Age: embryonic day 16.0
Note: Expressed in the occipital bone, in the periosteum and at the site of osteogenesis in the zone of endochondral ossification.
Specimen Label: 2D/E
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:5766537
Assay Type: RNA in situ
Annotation Date: 2016-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737327
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:5766629
Age: postnatal newborn
Note: Expressed in the mesenchyme. Expression becomes less abundant as embryogenesis progresses.
Specimen Label: not shown
Detected: true
Specimen Num: 28
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