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Search results 1 to 100 out of 326 for Fancd2

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Type Details Score
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: The Fanconi Anemia (FA) pathway is responsible for interstrand crosslink DNA repair []. The name originates the recessive syndrome known as Fanconi anemia, which causes developmental problems and cancer predisposition []. In this pathway, the FANCI-FANCD2 (ID) complex is ubiquitinated by the FA core complex and then travels to sites of damage to coordinate repair [, ]. FA pathway activation seems to trigger dissociation of FANCD2 from FANCI, coinciding with FANCD2 monoubiquitination which precedes monoubiquitination of FANCI []. This suggests a functional separation for FANCD2 from FANCI [].Monoubiquitinated FANCD2 functions to recruit DNA repair factors FAN1 (Fanconi-associated nuclease 1) []and SLX4 [], suggesting that chromatin-bound FANCD2Ub is a docking platform for certain DNA repair nucleases. FANCD2 has also a role in replication fork recovery [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Chaudhury I
Year: 2013
Journal: Nucleic Acids Res
Title: FANCD2 regulates BLM complex functions independently of FANCI to promote replication fork recovery.
Volume: 41
Issue: 13
Pages: 6444-59
Publication
First Author: Sareen A
Year: 2012
Journal: Nucleic Acids Res
Title: Fanconi anemia proteins FANCD2 and FANCI exhibit different DNA damage responses during S-phase.
Volume: 40
Issue: 17
Pages: 8425-39
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Protein
Organism: Mus musculus
Length: 1450  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1450  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1429  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1450  
Fragment?: false
Protein
Organism: Mus musculus
Length: 84  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1437  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1144  
Fragment?: true
Publication
First Author: Yao CJ
Year: 2013
Journal: Pharmazie
Title: Fanconi anemia pathway--the way of DNA interstrand cross-link repair.
Volume: 68
Issue: 1
Pages: 5-11
Publication
First Author: Yamashita T
Year: 2001
Journal: Int J Hematol
Title: Current knowledge on the pathophysiology of Fanconi anemia: from genes to phenotypes.
Volume: 74
Issue: 1
Pages: 33-41
Publication
First Author: Smogorzewska A
Year: 2010
Journal: Mol Cell
Title: A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.
Volume: 39
Issue: 1
Pages: 36-47
Publication
First Author: Kratz K
Year: 2010
Journal: Cell
Title: Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents.
Volume: 142
Issue: 1
Pages: 77-88
Publication
First Author: MacKay C
Year: 2010
Journal: Cell
Title: Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2.
Volume: 142
Issue: 1
Pages: 65-76
Publication
First Author: Yamamoto KN
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway.
Volume: 108
Issue: 16
Pages: 6492-6
Publication
First Author: Yeo JE
Year: 2014
Journal: Hum Mol Genet
Title: CtIP mediates replication fork recovery in a FANCD2-regulated manner.
Volume: 23
Issue: 14
Pages: 3695-705
Protein
Organism: Mus musculus
Length: 246  
Fragment?: true
Publication
First Author: Park E
Year: 2013
Journal: Mol Cell
Title: FANCD2 activates transcription of TAp63 and suppresses tumorigenesis.
Volume: 50
Issue: 6
Pages: 908-18
Publication
First Author: Song X
Year: 2016
Journal: Biochem Biophys Res Commun
Title: FANCD2 protects against bone marrow injury from ferroptosis.
Volume: 480
Issue: 3
Pages: 443-449
Publication
First Author: Du W
Year: 2014
Journal: Blood
Title: Deletion of Fanca or Fancd2 dysregulates Treg in mice.
Volume: 123
Issue: 12
Pages: 1938-47
Publication
First Author: Lachaud C
Year: 2016
Journal: Science
Title: Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability.
Volume: 351
Issue: 6275
Pages: 846-9
Publication
First Author: Parmar K
Year: 2010
Journal: Stem Cells
Title: Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1.
Volume: 28
Issue: 7
Pages: 1186-95
Publication
First Author: Houghtaling S
Year: 2005
Journal: Hum Mol Genet
Title: Fancd2 functions in a double strand break repair pathway that is distinct from non-homologous end joining.
Volume: 14
Issue: 20
Pages: 3027-33
Publication
First Author: Bogliolo M
Year: 2007
Journal: EMBO J
Title: Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability.
Volume: 26
Issue: 5
Pages: 1340-51
Publication
First Author: Ho GP
Year: 2006
Journal: Mol Cell Biol
Title: Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance.
Volume: 26
Issue: 18
Pages: 7005-15
Publication
First Author: Hays LE
Year: 2008
Journal: Br J Cancer
Title: Cigarette smoke induces genetic instability in airway epithelial cells by suppressing FANCD2 expression.
Volume: 98
Issue: 10
Pages: 1653-61
Publication
First Author: Li X
Year: 2015
Journal: J Biol Chem
Title: Fancd2 is required for nuclear retention of Foxo3a in hematopoietic stem cell maintenance.
Volume: 290
Issue: 5
Pages: 2715-27
Publication
First Author: van de Vrugt HJ
Year: 2009
Journal: Cancer Res
Title: Embryonic lethality after combined inactivation of Fancd2 and Mlh1 in mice.
Volume: 69
Issue: 24
Pages: 9431-8
Publication
First Author: Reliene R
Year: 2010
Journal: Cancer Res
Title: Genomic instability in mice is greater in Fanconi anemia caused by deficiency of Fancd2 than Fancg.
Volume: 70
Issue: 23
Pages: 9703-10
Publication
First Author: Langevin F
Year: 2011
Journal: Nature
Title: Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice.
Volume: 475
Issue: 7354
Pages: 53-8
Publication
First Author: Li X
Year: 2014
Journal: Antioxid Redox Signal
Title: Concomitant inactivation of foxo3a and fancc or fancd2 reveals a two-tier protection from oxidative stress-induced hydrocephalus.
Volume: 21
Issue: 12
Pages: 1675-92
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Balcerek J
Year: 2018
Journal: Nat Commun
Title: Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia.
Volume: 9
Issue: 1
Pages: 3915
Publication
First Author: Wang J
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage.
Volume: 107
Issue: 37
Pages: 16131-6
Protein
Organism: Mus musculus
Length: 178  
Fragment?: false
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: García-Rubio ML
Year: 2015
Journal: PLoS Genet
Title: The Fanconi Anemia Pathway Protects Genome Integrity from R-loops.
Volume: 11
Issue: 11
Pages: e1005674
Publication
First Author: Park JW
Year: 2010
Journal: Cancer Res
Title: Deficiencies in the Fanconi anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer.
Volume: 70
Issue: 23
Pages: 9959-68
Publication
First Author: Zhang QS
Year: 2010
Journal: Blood
Title: Fancd2-/- mice have hematopoietic defects that can be partially corrected by resveratrol.
Volume: 116
Issue: 24
Pages: 5140-8
Publication
First Author: Kim JM
Year: 2009
Journal: Dev Cell
Title: Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype.
Volume: 16
Issue: 2
Pages: 314-20
Publication
First Author: Kim M
Year: 2016
Journal: FEBS Lett
Title: The role of USP1 autocleavage in DNA interstrand crosslink repair.
Volume: 590
Issue: 3
Pages: 340-8
Publication
First Author: Houghtaling S
Year: 2003
Journal: Genes Dev
Title: Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice.
Volume: 17
Issue: 16
Pages: 2021-35
Publication
First Author: Jiang Q
Year: 2015
Journal: Genes Dev
Title: MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links.
Volume: 29
Issue: 18
Pages: 1955-68
Publication
First Author: Vinciguerra P
Year: 2010
Journal: J Clin Invest
Title: Cytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cells.
Volume: 120
Issue: 11
Pages: 3834-42
Publication
First Author: Hemphill AW
Year: 2008
Journal: Mol Genet Metab
Title: Mammalian SNM1 is required for genome stability.
Volume: 94
Issue: 1
Pages: 38-45
Publication
First Author: Bunting SF
Year: 2012
Journal: Mol Cell
Title: BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair.
Volume: 46
Issue: 2
Pages: 125-35
Publication
First Author: Houghtaling S
Year: 2005
Journal: Cancer Res
Title: Heterozygosity for p53 (Trp53+/-) accelerates epithelial tumor formation in fanconi anemia complementation group D2 (Fancd2) knockout mice.
Volume: 65
Issue: 1
Pages: 85-91
Publication
First Author: Alavattam KG
Year: 2016
Journal: Cell Rep
Title: Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.
Volume: 17
Issue: 4
Pages: 1141-1157
Publication
First Author: Park JW
Year: 2013
Journal: PLoS One
Title: High incidence of HPV-associated head and neck cancers in FA deficient mice is associated with E7's induction of DNA damage through its inactivation of pocket proteins.
Volume: 8
Issue: 9
Pages: e75056
Publication
First Author: Jamsai D
Year: 2013
Journal: PLoS One
Title: Loss of GGN leads to pre-implantation embryonic lethality and compromised male meiotic DNA double strand break repair in the mouse.
Volume: 8
Issue: 2
Pages: e56955
Publication
First Author: Park E
Year: 2013
Journal: Mol Cell Biol
Title: Inactivation of Uaf1 causes defective homologous recombination and early embryonic lethality in mice.
Volume: 33
Issue: 22
Pages: 4360-70
Publication
First Author: Wong JC
Year: 2003
Journal: Hum Mol Genet
Title: Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia.
Volume: 12
Issue: 16
Pages: 2063-76
Publication
First Author: Freie BW
Year: 2004
Journal: J Biol Chem
Title: A role for the Fanconi anemia C protein in maintaining the DNA damage-induced G2 checkpoint.
Volume: 279
Issue: 49
Pages: 50986-93
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression    
Probe: MGI:6287134
Assay Type: RT-PCR
Annotation Date: 2019-04-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160404
Stage: TS04
Assay Id: MGI:6287212
Age: embryonic day 3.0
Image: 4
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6287134
Assay Type: RT-PCR
Annotation Date: 2019-04-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160404
Stage: TS04
Assay Id: MGI:6287212
Age: embryonic day 3.0
Image: 4
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6287134
Assay Type: RT-PCR
Annotation Date: 2019-04-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160404
Stage: TS04
Assay Id: MGI:6287212
Age: embryonic day 3.0
Image: 4
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5804802
Assay Type: Immunohistochemistry
Annotation Date: 2016-10-26
Strength: Present
Sex: Male
Emaps: EMAPS:3148428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5805292
Age: postnatal week 3
Note: Expressed in discrete foci along the synapsed axes in pachynema, specifically stained the unpaired sex chromosomes in late pachynema.
Detected: true
Specimen Num: 1
Gene
Type: gene
Organism: Rattus norvegicus
Publication
First Author: Ceccaldi R
Year: 2015
Journal: Nature
Title: Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair.
Volume: 518
Issue: 7538
Pages: 258-62
Publication
First Author: Matsuzaki K
Year: 2015
Journal: Genes Dev
Title: FANCJ suppresses microsatellite instability and lymphomagenesis independent of the Fanconi anemia pathway.
Volume: 29
Issue: 24
Pages: 2532-46
Publication
First Author: Zhang QS
Year: 2008
Journal: Cancer Res
Title: Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia mice.
Volume: 68
Issue: 5
Pages: 1601-8
Publication
First Author: Zhang QS
Year: 2016
Journal: Blood
Title: Metformin improves defective hematopoiesis and delays tumor formation in Fanconi anemia mice.
Volume: 128
Issue: 24
Pages: 2774-2784
Publication
First Author: Zhang H
Year: 2016
Journal: Cell Stem Cell
Title: TGF-β Inhibition Rescues Hematopoietic Stem Cell Defects and Bone Marrow Failure in Fanconi Anemia.
Volume: 18
Issue: 5
Pages: 668-81
Publication
First Author: Lachaud C
Year: 2016
Journal: Genes Dev
Title: Karyomegalic interstitial nephritis and DNA damage-induced polyploidy in Fan1 nuclease-defective knock-in mice.
Volume: 30
Issue: 6
Pages: 639-44
Publication
First Author: Adelman CA
Year: 2013
Journal: Nature
Title: HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis.
Volume: 502
Issue: 7471
Pages: 381-4
Publication
First Author: Thongthip S
Year: 2016
Journal: Genes Dev
Title: Fan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction.
Volume: 30
Issue: 6
Pages: 645-59
Publication
First Author: Amarachintha S
Year: 2015
Journal: Stem Cells
Title: Fanconi Anemia Mesenchymal Stromal Cells-Derived Glycerophospholipids Skew Hematopoietic Stem Cell Differentiation Through Toll-Like Receptor Signaling.
Volume: 33
Issue: 11
Pages: 3382-96
Publication
First Author: Park JW
Year: 2014
Journal: Oncogene
Title: High incidence of female reproductive tract cancers in FA-deficient HPV16-transgenic mice correlates with E7's induction of DNA damage response, an activity mediated by E7's inactivation of pocket proteins.
Volume: 33
Issue: 26
Pages: 3383-91
Publication
First Author: Skinner AM
Year: 2008
Journal: Exp Hematol
Title: CXCR4 induction in hematopoietic progenitor cells from Fanca(-/-), -c(-/-), and -d2(-/-) mice.
Volume: 36
Issue: 3
Pages: 273-82
Publication
First Author: Garaycoechea JI
Year: 2012
Journal: Nature
Title: Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function.
Volume: 489
Issue: 7417
Pages: 571-5
Publication
First Author: Garaycoechea JI
Year: 2018
Journal: Nature
Title: Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells.
Volume: 553
Issue: 7687
Pages: 171-177
Publication
First Author: Juan HC
Year: 2016
Journal: Cell Death Differ
Title: Cdk12 is essential for embryonic development and the maintenance of genomic stability.
Volume: 23
Issue: 6
Pages: 1038-48