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Search results 1 to 100 out of 389 for Fancd2

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: The Fanconi Anemia (FA) pathway is responsible for interstrand crosslink DNA repair []. The name originates the recessive syndrome known as Fanconi anemia, which causes developmental problems and cancer predisposition []. In this pathway, the FANCI-FANCD2 (ID) complex is ubiquitinated by the FA core complex and then travels to sites of damage to coordinate repair [, ]. FA pathway activation seems to trigger dissociation of FANCD2 from FANCI, coinciding with FANCD2 monoubiquitination which precedes monoubiquitination of FANCI []. This suggests a functional separation for FANCD2 from FANCI [].Monoubiquitinated FANCD2 functions to recruit DNA repair factors FAN1 (Fanconi-associated nuclease 1) []and SLX4 [], suggesting that chromatin-bound FANCD2Ub is a docking platform for certain DNA repair nucleases. FANCD2 has also a role in replication fork recovery [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Sareen A
Year: 2012
Journal: Nucleic Acids Res
Title: Fanconi anemia proteins FANCD2 and FANCI exhibit different DNA damage responses during S-phase.
Volume: 40
Issue: 17
Pages: 8425-39
Publication
First Author: Chaudhury I
Year: 2013
Journal: Nucleic Acids Res
Title: FANCD2 regulates BLM complex functions independently of FANCI to promote replication fork recovery.
Volume: 41
Issue: 13
Pages: 6444-59
Protein
Organism: Mus musculus/domesticus
Length: 1450  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1450  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1429  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1437  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1450  
Fragment?: false
Publication
First Author: Yamashita T
Year: 2001
Journal: Int J Hematol
Title: Current knowledge on the pathophysiology of Fanconi anemia: from genes to phenotypes.
Volume: 74
Issue: 1
Pages: 33-41
Publication
First Author: Smogorzewska A
Year: 2010
Journal: Mol Cell
Title: A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.
Volume: 39
Issue: 1
Pages: 36-47
Publication
First Author: MacKay C
Year: 2010
Journal: Cell
Title: Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2.
Volume: 142
Issue: 1
Pages: 65-76
Publication
First Author: Yamamoto KN
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway.
Volume: 108
Issue: 16
Pages: 6492-6
Publication
First Author: Yeo JE
Year: 2014
Journal: Hum Mol Genet
Title: CtIP mediates replication fork recovery in a FANCD2-regulated manner.
Volume: 23
Issue: 14
Pages: 3695-705
Protein
Organism: Mus musculus/domesticus
Length: 1144  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 84  
Fragment?: true
Publication
First Author: Yao CJ
Year: 2013
Journal: Pharmazie
Title: Fanconi anemia pathway--the way of DNA interstrand cross-link repair.
Volume: 68
Issue: 1
Pages: 5-11
Publication
First Author: Kratz K
Year: 2010
Journal: Cell
Title: Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents.
Volume: 142
Issue: 1
Pages: 77-88
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Protein
Organism: Mus musculus/domesticus
Length: 246  
Fragment?: true
Publication
First Author: Park E
Year: 2013
Journal: Mol Cell
Title: FANCD2 activates transcription of TAp63 and suppresses tumorigenesis.
Volume: 50
Issue: 6
Pages: 908-18
Publication
First Author: Du W
Year: 2014
Journal: Blood
Title: Deletion of Fanca or Fancd2 dysregulates Treg in mice.
Volume: 123
Issue: 12
Pages: 1938-47
Publication
First Author: Yang Q
Year: 2019
Journal: Biochem Biophys Res Commun
Title: Severe Fanconi Anemia phenotypes in Fancd2 depletion mice.
Volume: 514
Issue: 3
Pages: 713-719
Publication
First Author: Song X
Year: 2016
Journal: Biochem Biophys Res Commun
Title: FANCD2 protects against bone marrow injury from ferroptosis.
Volume: 480
Issue: 3
Pages: 443-449
Publication
First Author: Nie Y
Year: 2020
Journal: Reproduction
Title: FANCD2 is required for the repression of germline transposable elements.
Volume: 159
Issue: 6
Pages: 659-668
Publication
First Author: Lachaud C
Year: 2016
Journal: Science
Title: Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability.
Volume: 351
Issue: 6275
Pages: 846-9
Publication
First Author: Parmar K
Year: 2010
Journal: Stem Cells
Title: Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1.
Volume: 28
Issue: 7
Pages: 1186-95
Publication
First Author: Bogliolo M
Year: 2007
Journal: EMBO J
Title: Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability.
Volume: 26
Issue: 5
Pages: 1340-51
Publication
First Author: Li X
Year: 2015
Journal: J Biol Chem
Title: Fancd2 is required for nuclear retention of Foxo3a in hematopoietic stem cell maintenance.
Volume: 290
Issue: 5
Pages: 2715-27
Publication
First Author: Hays LE
Year: 2008
Journal: Br J Cancer
Title: Cigarette smoke induces genetic instability in airway epithelial cells by suppressing FANCD2 expression.
Volume: 98
Issue: 10
Pages: 1653-61
Publication
First Author: Houghtaling S
Year: 2005
Journal: Hum Mol Genet
Title: Fancd2 functions in a double strand break repair pathway that is distinct from non-homologous end joining.
Volume: 14
Issue: 20
Pages: 3027-33
Publication
First Author: Ho GP
Year: 2006
Journal: Mol Cell Biol
Title: Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance.
Volume: 26
Issue: 18
Pages: 7005-15
Publication
First Author: Reliene R
Year: 2010
Journal: Cancer Res
Title: Genomic instability in mice is greater in Fanconi anemia caused by deficiency of Fancd2 than Fancg.
Volume: 70
Issue: 23
Pages: 9703-10
Publication
First Author: van de Vrugt HJ
Year: 2009
Journal: Cancer Res
Title: Embryonic lethality after combined inactivation of Fancd2 and Mlh1 in mice.
Volume: 69
Issue: 24
Pages: 9431-8
Publication
First Author: Wu L
Year: 2021
Journal: Br J Haematol
Title: FANCD2 and HES1 suppress inflammation-induced PPARÉ£ to prevent haematopoietic stem cell exhaustion.
Volume: 192
Issue: 3
Pages: 652-663
Publication
First Author: Langevin F
Year: 2011
Journal: Nature
Title: Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice.
Volume: 475
Issue: 7354
Pages: 53-8
Publication
First Author: Zhao S
Year: 2023
Journal: J Biol Chem
Title: DNA repair protein FANCD2 has both ubiquitination-dependent and ubiquitination-independent functions during germ cell development.
Volume: 299
Issue: 3
Pages: 102905
Publication
First Author: Li X
Year: 2014
Journal: Antioxid Redox Signal
Title: Concomitant inactivation of foxo3a and fancc or fancd2 reveals a two-tier protection from oxidative stress-induced hydrocephalus.
Volume: 21
Issue: 12
Pages: 1675-92
Publication
First Author: Balcerek J
Year: 2018
Journal: Nat Commun
Title: Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia.
Volume: 9
Issue: 1
Pages: 3915
Publication
First Author: Wang J
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage.
Volume: 107
Issue: 37
Pages: 16131-6
Gene
Type: gene
Organism: human
Protein
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: false
GXD Expression  
Probe: MGI:7544970
Assay Type: Immunohistochemistry
Annotation Date: 2023-11-01
Strength: Present
Sex: Female
Emaps: EMAPS:1657819
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:7545022
Age: embryonic day 11.5
Note: The proportion of Fancd2 positive cells was significantly decreased compared with the wild-type (quantified in Fig 7B).
Specimen Label: 7A E11.5 -/-
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:7544970
Assay Type: Immunohistochemistry
Annotation Date: 2023-11-01
Strength: Present
Sex: Female
Emaps: EMAPS:1657820
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:7545022
Age: embryonic day 12.5
Note: The proportion of Fancd2 positive cells was significantly decreased compared with the wild-type (quantified in Fig 7B).
Specimen Label: 7A E12.5 -/-
Detected: true
Specimen Num: 4
Gene
Type: gene
Organism: human
Publication
First Author: García-Rubio ML
Year: 2015
Journal: PLoS Genet
Title: The Fanconi Anemia Pathway Protects Genome Integrity from R-loops.
Volume: 11
Issue: 11
Pages: e1005674
Publication
First Author: Kim JM
Year: 2009
Journal: Dev Cell
Title: Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype.
Volume: 16
Issue: 2
Pages: 314-20
Publication
First Author: Park JW
Year: 2010
Journal: Cancer Res
Title: Deficiencies in the Fanconi anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer.
Volume: 70
Issue: 23
Pages: 9959-68
Publication
First Author: Moore ES
Year: 2019
Journal: J Biol Chem
Title: Sex-specific hepatic lipid and bile acid metabolism alterations in Fancd2-deficient mice following dietary challenge.
Volume: 294
Issue: 43
Pages: 15623-15637
Publication  
First Author: Sabol M
Year: 2020
Journal: DNA Repair (Amst)
Title: Novel TALEN-generated mCitrine-FANCD2 fusion reporter mouse model for in vivo research of DNA damage response.
Volume: 94
Pages: 102936
Publication
First Author: Zhang QS
Year: 2010
Journal: Blood
Title: Fancd2-/- mice have hematopoietic defects that can be partially corrected by resveratrol.
Volume: 116
Issue: 24
Pages: 5140-8
Publication
First Author: Houghtaling S
Year: 2003
Journal: Genes Dev
Title: Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice.
Volume: 17
Issue: 16
Pages: 2021-35
Publication
First Author: Kim M
Year: 2016
Journal: FEBS Lett
Title: The role of USP1 autocleavage in DNA interstrand crosslink repair.
Volume: 590
Issue: 3
Pages: 340-8
Publication
First Author: Hemphill AW
Year: 2008
Journal: Mol Genet Metab
Title: Mammalian SNM1 is required for genome stability.
Volume: 94
Issue: 1
Pages: 38-45
Publication
First Author: Jiang Q
Year: 2015
Journal: Genes Dev
Title: MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links.
Volume: 29
Issue: 18
Pages: 1955-68
Publication
First Author: Vinciguerra P
Year: 2010
Journal: J Clin Invest
Title: Cytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cells.
Volume: 120
Issue: 11
Pages: 3834-42
Publication
First Author: Houghtaling S
Year: 2005
Journal: Cancer Res
Title: Heterozygosity for p53 (Trp53+/-) accelerates epithelial tumor formation in fanconi anemia complementation group D2 (Fancd2) knockout mice.
Volume: 65
Issue: 1
Pages: 85-91
Publication
First Author: Bunting SF
Year: 2012
Journal: Mol Cell
Title: BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair.
Volume: 46
Issue: 2
Pages: 125-35
Publication
First Author: Dubois EL
Year: 2019
Journal: Nucleic Acids Res
Title: A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2.
Volume: 47
Issue: 14
Pages: 7532-7547
Publication
First Author: Park JW
Year: 2013
Journal: PLoS One
Title: High incidence of HPV-associated head and neck cancers in FA deficient mice is associated with E7's induction of DNA damage through its inactivation of pocket proteins.
Volume: 8
Issue: 9
Pages: e75056
Publication
First Author: Park E
Year: 2013
Journal: Mol Cell Biol
Title: Inactivation of Uaf1 causes defective homologous recombination and early embryonic lethality in mice.
Volume: 33
Issue: 22
Pages: 4360-70
Publication  
First Author: Chatla S
Year: 2019
Journal: Stem Cell Res
Title: Fancd2-deficient hematopoietic stem and progenitor cells depend on augmented mitochondrial translation for survival and proliferation.
Volume: 40
Pages: 101550
Publication
First Author: Alavattam KG
Year: 2016
Journal: Cell Rep
Title: Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.
Volume: 17
Issue: 4
Pages: 1141-1157
Publication
First Author: Jamsai D
Year: 2013
Journal: PLoS One
Title: Loss of GGN leads to pre-implantation embryonic lethality and compromised male meiotic DNA double strand break repair in the mouse.
Volume: 8
Issue: 2
Pages: e56955
Publication
First Author: Freie BW
Year: 2004
Journal: J Biol Chem
Title: A role for the Fanconi anemia C protein in maintaining the DNA damage-induced G2 checkpoint.
Volume: 279
Issue: 49
Pages: 50986-93
Publication
First Author: Wong JC
Year: 2003
Journal: Hum Mol Genet
Title: Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia.
Volume: 12
Issue: 16
Pages: 2063-76
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication  
First Author: Sczelecki S
Year: 2023
Journal: Cancers (Basel)
Title: The Validation of a Precursor Lesion of Epithelial Ovarian Cancer in Fancd2-KO Mice.
Volume: 15
Issue: 9
Publication
First Author: Ruiz-Torres S
Year: 2021
Journal: Cell Stem Cell
Title: Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin.
Volume: 28
Issue: 3
Pages: 424-435.e6
Publication
First Author: Zhang X
Year: 2016
Journal: Oncotarget
Title: Evolution of malignant plasmacytoma cell lines from K14E7 Fancd2-/- mouse long-term bone marrow cultures.
Volume: 7
Issue: 42
Pages: 68449-68472
GXD Expression    
Probe: MGI:6287134
Assay Type: RT-PCR
Annotation Date: 2019-04-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160404
Stage: TS04
Assay Id: MGI:6287212
Age: embryonic day 3.0
Image: 4
Specimen Label: fx/fx
Detected: true
Specimen Num: 1