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Search results 1 to 100 out of 394 for Fancd2

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
2177 | FANCD2
Type: gene
Organism: human
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Gene
100487938 | fancd2
Type: gene
Organism: frog, western clawed
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Gene
312641 | Fancd2
Type: gene
Organism: rat
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Gene
484659 | FANCD2
Type: gene
Organism: dog, domestic
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Gene
460163 | FANCD2
Type: gene
Organism: chimpanzee
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Gene
515845 | FANCD2
Type: gene
Organism: cattle
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Gene
415935 | FANCD2
Type: gene
Organism: chicken
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Gene
394241 | fancd2
Type: gene
Organism: zebrafish
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Protein Domain
IPR029448 | FANCD2
Type: Family
Description: The Fanconi Anemia (FA) pathway is responsible for interstrand crosslink DNA repair []. The name originates the recessive syndrome known as Fanconi anemia, which causes developmental problems and cancer predisposition []. In this pathway, the FANCI-FANCD2 (ID) complex is ubiquitinated by the FA core complex and then travels to sites of damage to coordinate repair [, ]. FA pathway activation seems to trigger dissociation of FANCD2 from FANCI, coinciding with FANCD2 monoubiquitination which precedes monoubiquitination of FANCI []. This suggests a functional separation for FANCD2 from FANCI [].Monoubiquitinated FANCD2 functions to recruit DNA repair factors FAN1 (Fanconi-associated nuclease 1) []and SLX4 [], suggesting that chromatin-bound FANCD2Ub is a docking platform for certain DNA repair nucleases. FANCD2 has also a role in replication fork recovery [].
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Protein Coding Gene
MGI:2448480 | Fancd2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
22753026 | -
First Author: Sareen A
Year: 2012
Journal: Nucleic Acids Res
Title: Fanconi anemia proteins FANCD2 and FANCI exhibit different DNA damage responses during S-phase.
Volume: 40
Issue: 17
Pages: 8425-39
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Publication
23658231 | -
First Author: Chaudhury I
Year: 2013
Journal: Nucleic Acids Res
Title: FANCD2 regulates BLM complex functions independently of FANCI to promote replication fork recovery.
Volume: 41
Issue: 13
Pages: 6444-59
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Protein
Q80V62
Organism: Mus musculus/domesticus
Length: 1450  
Fragment?: false
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Protein
B2RSU4
Organism: Mus musculus/domesticus
Length: 1450  
Fragment?: false
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Protein
Q3U202
Organism: Mus musculus/domesticus
Length: 1429  
Fragment?: true
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Protein
Q3TLN3
Organism: Mus musculus/domesticus
Length: 1144  
Fragment?: true
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Protein
A0A0N4SV29
Organism: Mus musculus/domesticus
Length: 1437  
Fragment?: false
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Protein
A0A0N4SVS0
Organism: Mus musculus/domesticus
Length: 84  
Fragment?: true
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Protein
Q3UQJ0
Organism: Mus musculus/domesticus
Length: 1450  
Fragment?: false
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Publication
23444773 | -
First Author: Yao CJ
Year: 2013
Journal: Pharmazie
Title: Fanconi anemia pathway--the way of DNA interstrand cross-link repair.
Volume: 68
Issue: 1
Pages: 5-11
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Publication
11530803 | -
First Author: Yamashita T
Year: 2001
Journal: Int J Hematol
Title: Current knowledge on the pathophysiology of Fanconi anemia: from genes to phenotypes.
Volume: 74
Issue: 1
Pages: 33-41
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Publication
20603073 | -
First Author: Smogorzewska A
Year: 2010
Journal: Mol Cell
Title: A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.
Volume: 39
Issue: 1
Pages: 36-47
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Publication
20603016 | -
First Author: Kratz K
Year: 2010
Journal: Cell
Title: Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents.
Volume: 142
Issue: 1
Pages: 77-88
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Publication
20603015 | -
First Author: MacKay C
Year: 2010
Journal: Cell
Title: Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2.
Volume: 142
Issue: 1
Pages: 65-76
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Publication
21464321 | -
First Author: Yamamoto KN
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway.
Volume: 108
Issue: 16
Pages: 6492-6
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Publication
24556218 | -
First Author: Yeo JE
Year: 2014
Journal: Hum Mol Genet
Title: CtIP mediates replication fork recovery in a FANCD2-regulated manner.
Volume: 23
Issue: 14
Pages: 3695-705
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Gene
115795 | FANCD2OS
Type: gene
Organism: human
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Gene
100421239 | FANCD2P1
Type: gene
Organism: human
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Gene
101929530 | FANCD2P2
Type: gene
Organism: human
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Protein
F7CAP1
Organism: Mus musculus/domesticus
Length: 246  
Fragment?: true
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Publication
23806336 | J:199241
First Author: Park E
Year: 2013
Journal: Mol Cell
Title: FANCD2 activates transcription of TAp63 and suppresses tumorigenesis.
Volume: 50
Issue: 6
Pages: 908-18
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Publication
24501220 | J:210175
First Author: Du W
Year: 2014
Journal: Blood
Title: Deletion of Fanca or Fancd2 dysregulates Treg in mice.
Volume: 123
Issue: 12
Pages: 1938-47
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Publication
27773819 | J:240814
First Author: Song X
Year: 2016
Journal: Biochem Biophys Res Commun
Title: FANCD2 protects against bone marrow injury from ferroptosis.
Volume: 480
Issue: 3
Pages: 443-449
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Publication
31078270 | J:284566
First Author: Yang Q
Year: 2019
Journal: Biochem Biophys Res Commun
Title: Severe Fanconi Anemia phenotypes in Fancd2 depletion mice.
Volume: 514
Issue: 3
Pages: 713-719
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Publication
32163912 | J:303275
First Author: Nie Y
Year: 2020
Journal: Reproduction
Title: FANCD2 is required for the repression of germline transposable elements.
Volume: 159
Issue: 6
Pages: 659-668
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Publication
26797144 | J:229449
First Author: Lachaud C
Year: 2016
Journal: Science
Title: Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability.
Volume: 351
Issue: 6275
Pages: 846-9
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Publication
20506303 | J:168056
First Author: Parmar K
Year: 2010
Journal: Stem Cells
Title: Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1.
Volume: 28
Issue: 7
Pages: 1186-95
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Publication
17304220 | J:200413
First Author: Bogliolo M
Year: 2007
Journal: EMBO J
Title: Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability.
Volume: 26
Issue: 5
Pages: 1340-51
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Publication
18475298 | J:137293
First Author: Hays LE
Year: 2008
Journal: Br J Cancer
Title: Cigarette smoke induces genetic instability in airway epithelial cells by suppressing FANCD2 expression.
Volume: 98
Issue: 10
Pages: 1653-61
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Publication
16135554 | J:102754
First Author: Houghtaling S
Year: 2005
Journal: Hum Mol Genet
Title: Fancd2 functions in a double strand break repair pathway that is distinct from non-homologous end joining.
Volume: 14
Issue: 20
Pages: 3027-33
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Publication
25505262 | J:217876
First Author: Li X
Year: 2015
Journal: J Biol Chem
Title: Fancd2 is required for nuclear retention of Foxo3a in hematopoietic stem cell maintenance.
Volume: 290
Issue: 5
Pages: 2715-27
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Publication
16943440 | J:152661
First Author: Ho GP
Year: 2006
Journal: Mol Cell Biol
Title: Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance.
Volume: 26
Issue: 18
Pages: 7005-15
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Publication
21118969 | J:167132
First Author: Reliene R
Year: 2010
Journal: Cancer Res
Title: Genomic instability in mice is greater in Fanconi anemia caused by deficiency of Fancd2 than Fancg.
Volume: 70
Issue: 23
Pages: 9703-10
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Publication
19934329 | J:155534
First Author: van de Vrugt HJ
Year: 2009
Journal: Cancer Res
Title: Embryonic lethality after combined inactivation of Fancd2 and Mlh1 in mice.
Volume: 69
Issue: 24
Pages: 9431-8
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Publication
33222180 | J:303436
First Author: Wu L
Year: 2021
Journal: Br J Haematol
Title: FANCD2 and HES1 suppress inflammation-induced PPARÉ£ to prevent haematopoietic stem cell exhaustion.
Volume: 192
Issue: 3
Pages: 652-663
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Publication
21734703 | J:193232
First Author: Langevin F
Year: 2011
Journal: Nature
Title: Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice.
Volume: 475
Issue: 7354
Pages: 53-8
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Publication
36642183 | J:333722
First Author: Zhao S
Year: 2023
Journal: J Biol Chem
Title: DNA repair protein FANCD2 has both ubiquitination-dependent and ubiquitination-independent functions during germ cell development.
Volume: 299
Issue: 3
Pages: 102905
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Publication
24483844 | J:226736
First Author: Li X
Year: 2014
Journal: Antioxid Redox Signal
Title: Concomitant inactivation of foxo3a and fancc or fancd2 reveals a two-tier protection from oxidative stress-induced hydrocephalus.
Volume: 21
Issue: 12
Pages: 1675-92
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Publication
30254368 | J:268393
First Author: Balcerek J
Year: 2018
Journal: Nat Commun
Title: Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia.
Volume: 9
Issue: 1
Pages: 3915
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Publication
20805509 | J:164358
First Author: Wang J
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage.
Volume: 107
Issue: 37
Pages: 16131-6
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Gene
107303338 | LOC107303338
Type: gene
Organism: human
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Protein
Q9D4K4
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: false
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Protein
A0A0R4J1W5
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: false
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GXD Expression
GXD Expression
 
Probe: MGI:7544970
Assay Type: Immunohistochemistry
Annotation Date: 2023-11-01
Strength: Present
Sex: Female
Emaps: EMAPS:1657819
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:7545022
Age: embryonic day 11.5
Note: The proportion of Fancd2 positive cells was significantly decreased compared with the wild-type (quantified in Fig 7B).
Specimen Label: 7A E11.5 -/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:7544970
Assay Type: Immunohistochemistry
Annotation Date: 2023-11-01
Strength: Present
Sex: Female
Emaps: EMAPS:1657820
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:7545022
Age: embryonic day 12.5
Note: The proportion of Fancd2 positive cells was significantly decreased compared with the wild-type (quantified in Fig 7B).
Specimen Label: 7A E12.5 -/-
Detected: true
Specimen Num: 4
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Gene
22909 | FAN1
Type: gene
Organism: human
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Publication
26584049 | J:231698
First Author: García-Rubio ML
Year: 2015
Journal: PLoS Genet
Title: The Fanconi Anemia Pathway Protects Genome Integrity from R-loops.
Volume: 11
Issue: 11
Pages: e1005674
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Publication
19217432 | J:146616
First Author: Kim JM
Year: 2009
Journal: Dev Cell
Title: Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype.
Volume: 16
Issue: 2
Pages: 314-20
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Publication
31434739 | J:283056
First Author: Moore ES
Year: 2019
Journal: J Biol Chem
Title: Sex-specific hepatic lipid and bile acid metabolism alterations in Fancd2-deficient mice following dietary challenge.
Volume: 294
Issue: 43
Pages: 15623-15637
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Publication
20935219 | J:166730
First Author: Park JW
Year: 2010
Journal: Cancer Res
Title: Deficiencies in the Fanconi anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer.
Volume: 70
Issue: 23
Pages: 9959-68
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Publication
32717583 | J:329506
 
First Author: Sabol M
Year: 2020
Journal: DNA Repair (Amst)
Title: Novel TALEN-generated mCitrine-FANCD2 fusion reporter mouse model for in vivo research of DNA damage response.
Volume: 94
Pages: 102936
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Publication
20826722 | J:167414
First Author: Zhang QS
Year: 2010
Journal: Blood
Title: Fancd2-/- mice have hematopoietic defects that can be partially corrected by resveratrol.
Volume: 116
Issue: 24
Pages: 5140-8
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Publication
12893777 | J:84892
First Author: Houghtaling S
Year: 2003
Journal: Genes Dev
Title: Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice.
Volume: 17
Issue: 16
Pages: 2021-35
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Publication
26783108 | J:229978
First Author: Kim M
Year: 2016
Journal: FEBS Lett
Title: The role of USP1 autocleavage in DNA interstrand crosslink repair.
Volume: 590
Issue: 3
Pages: 340-8
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Publication
18180189 | J:134461
First Author: Hemphill AW
Year: 2008
Journal: Mol Genet Metab
Title: Mammalian SNM1 is required for genome stability.
Volume: 94
Issue: 1
Pages: 38-45
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Publication
26338419 | J:238472
First Author: Jiang Q
Year: 2015
Journal: Genes Dev
Title: MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links.
Volume: 29
Issue: 18
Pages: 1955-68
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Publication
15665282 | J:95530
First Author: Houghtaling S
Year: 2005
Journal: Cancer Res
Title: Heterozygosity for p53 (Trp53+/-) accelerates epithelial tumor formation in fanconi anemia complementation group D2 (Fancd2) knockout mice.
Volume: 65
Issue: 1
Pages: 85-91
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Publication
20921626 | J:166938
First Author: Vinciguerra P
Year: 2010
Journal: J Clin Invest
Title: Cytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cells.
Volume: 120
Issue: 11
Pages: 3834-42
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Publication
22445484 | J:183455
First Author: Bunting SF
Year: 2012
Journal: Mol Cell
Title: BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair.
Volume: 46
Issue: 2
Pages: 125-35
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Publication
31219578 | J:285384
First Author: Dubois EL
Year: 2019
Journal: Nucleic Acids Res
Title: A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2.
Volume: 47
Issue: 14
Pages: 7532-7547
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Publication
24086435 | J:207746
First Author: Park JW
Year: 2013
Journal: PLoS One
Title: High incidence of HPV-associated head and neck cancers in FA deficient mice is associated with E7's induction of DNA damage through its inactivation of pocket proteins.
Volume: 8
Issue: 9
Pages: e75056
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Publication
24001775 | J:206106
First Author: Park E
Year: 2013
Journal: Mol Cell Biol
Title: Inactivation of Uaf1 causes defective homologous recombination and early embryonic lethality in mice.
Volume: 33
Issue: 22
Pages: 4360-70
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Publication
31472450 | J:290355
 
First Author: Chatla S
Year: 2019
Journal: Stem Cell Res
Title: Fancd2-deficient hematopoietic stem and progenitor cells depend on augmented mitochondrial translation for survival and proliferation.
Volume: 40
Pages: 101550
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Publication
27760317 | J:240753
First Author: Alavattam KG
Year: 2016
Journal: Cell Rep
Title: Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.
Volume: 17
Issue: 4
Pages: 1141-1157
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Publication
23451117 | J:199404
First Author: Jamsai D
Year: 2013
Journal: PLoS One
Title: Loss of GGN leads to pre-implantation embryonic lethality and compromised male meiotic DNA double strand break repair in the mouse.
Volume: 8
Issue: 2
Pages: e56955
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Publication
15377654 | J:95193
First Author: Freie BW
Year: 2004
Journal: J Biol Chem
Title: A role for the Fanconi anemia C protein in maintaining the DNA damage-induced G2 checkpoint.
Volume: 279
Issue: 49
Pages: 50986-93
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Publication
12913077 | J:85108
First Author: Wong JC
Year: 2003
Journal: Hum Mol Genet
Title: Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia.
Volume: 12
Issue: 16
Pages: 2063-76
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Protein Coding Gene
MGP_CAROLIEiJ_G0028733 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0031130 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0031099 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0031030 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0031110 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0030598 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2448480 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0031569 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0030217 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0030796 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0030949 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0030903 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0031029 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0030937 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0031596 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0029933 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0030301 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0022484 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0029761 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
37174061 | J:335629
 
First Author: Sczelecki S
Year: 2023
Journal: Cancers (Basel)
Title: The Validation of a Precursor Lesion of Epithelial Ovarian Cancer in Fancd2-KO Mice.
Volume: 15
Issue: 9
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Publication
33232662 | J:316860
First Author: Ruiz-Torres S
Year: 2021
Journal: Cell Stem Cell
Title: Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin.
Volume: 28
Issue: 3
Pages: 424-435.e6
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Publication
27637088 | J:314297
First Author: Zhang X
Year: 2016
Journal: Oncotarget
Title: Evolution of malignant plasmacytoma cell lines from K14E7 Fancd2-/- mouse long-term bone marrow cultures.
Volume: 7
Issue: 42
Pages: 68449-68472
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GXD Expression
GXD Expression
   
Probe: MGI:6287134
Assay Type: RT-PCR
Annotation Date: 2019-04-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160404
Stage: TS04
Assay Id: MGI:6287212
Age: embryonic day 3.0
Image: 4
Specimen Label: fx/fx
Detected: true
Specimen Num: 1
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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