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Search results 1 to 100 out of 231 for Fanci

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
55215 | FANCI
Type: gene
Organism: human
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Gene
522442 | FANCI
Type: gene
Organism: cattle
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Gene
100360594 | Fanci
Type: gene
Organism: rat
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Gene
100856370 | FANCI
Type: gene
Organism: dog, domestic
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Gene
415491 | FANCI
Type: gene
Organism: chicken
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Gene
324185 | fanci
Type: gene
Organism: zebrafish
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Gene
699878 | FANCI
Type: gene
Organism: macaque, rhesus
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Gene
100038061 | fanci
Type: gene
Organism: frog, western clawed
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Gene
453636 | FANCI
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:2384790 | Fanci
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR026171 | FANCI
Type: Family
Description: Fanconi anemia complementation group I (FANCI) protein is a component of the Fanconi anemia DNA damage-response pathway []. The protein directly binds to a variety of DNA substrates []and plays an essential role in the repair of DNA double-strand breaks by homologous recombination. It is also involved in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL [].Defects in the FANCI gene are a cause of Fanconi anemia complementation group I []- a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
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Publication
31219578 | J:285384
First Author: Dubois EL
Year: 2019
Journal: Nucleic Acids Res
Title: A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2.
Volume: 47
Issue: 14
Pages: 7532-7547
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Protein
A0A0U1RQ41
Organism: Mus musculus/domesticus
Length: 111  
Fragment?: true
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Protein
A0A0U1RQ89
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: true
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Publication
34373449 | J:312543
First Author: Xu L
Year: 2021
Journal: Cell Death Dis
Title: FANCI plays an essential role in spermatogenesis and regulates meiotic histone methylation.
Volume: 12
Issue: 8
Pages: 780
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Publication
18931676 | J:155922
First Author: Ishiai M
Year: 2008
Journal: Nat Struct Mol Biol
Title: FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway.
Volume: 15
Issue: 11
Pages: 1138-46
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Protein
F2Z414
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: false
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Publication
19561358 | -
First Author: Yuan F
Year: 2009
Journal: J Biol Chem
Title: FANCI protein binds to DNA and interacts with FANCD2 to recognize branched structures.
Volume: 284
Issue: 36
Pages: 24443-52
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Publication
17460694 | -
First Author: Sims AE
Year: 2007
Journal: Nat Struct Mol Biol
Title: FANCI is a second monoubiquitinated member of the Fanconi anemia pathway.
Volume: 14
Issue: 6
Pages: 564-7
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Protein
Q8K368
Organism: Mus musculus/domesticus
Length: 1330  
Fragment?: false
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Protein
F7ALG5
Organism: Mus musculus/domesticus
Length: 850  
Fragment?: true
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Gene
22909 | FAN1
Type: gene
Organism: human
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Publication
17452773 | -
First Author: Dorsman JC
Year: 2007
Journal: Cell Oncol
Title: Identification of the Fanconi anemia complementation group I gene, FANCI.
Volume: 29
Issue: 3
Pages: 211-8
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DO Term
DOID:0111091 | Fanconi anemia complementation group I
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Publication
26658019 | J:242195
First Author: Juan HC
Year: 2016
Journal: Cell Death Differ
Title: Cdk12 is essential for embryonic development and the maintenance of genomic stability.
Volume: 23
Issue: 6
Pages: 1038-48
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Protein Coding Gene
MGP_CAROLIEiJ_G0029879 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032388 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032367 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032303 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032379 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0032092 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2384790 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0032871 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031420 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0032058 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032213 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032168 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032294 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032205 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0032889 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031140 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0031538 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0013101 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0030981 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:6287135
Assay Type: RT-PCR
Annotation Date: 2019-04-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160404
Stage: TS04
Assay Id: MGI:6287213
Age: embryonic day 3.0
Image: 4
Specimen Label: fx/fx
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6287135
Assay Type: RT-PCR
Annotation Date: 2019-04-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160404
Stage: TS04
Assay Id: MGI:6287213
Age: embryonic day 3.0
Image: 4
Specimen Label: fx/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6287135
Assay Type: RT-PCR
Annotation Date: 2019-04-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160404
Stage: TS04
Assay Id: MGI:6287213
Age: embryonic day 3.0
Image: 4
Specimen Label: -/-
Detected: true
Specimen Num: 3
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Publication
31472450 | J:290355
 
First Author: Chatla S
Year: 2019
Journal: Stem Cell Res
Title: Fancd2-deficient hematopoietic stem and progenitor cells depend on augmented mitochondrial translation for survival and proliferation.
Volume: 40
Pages: 101550
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Publication
35969748 | J:327430
First Author: Yang Y
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Transcription-replication conflicts in primordial germ cells necessitate the Fanconi anemia pathway to safeguard genome stability.
Volume: 119
Issue: 34
Pages: e2203208119
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Publication
27073218 | J:241332
First Author: Chen HR
Year: 2017
Journal: Cereb Cortex
Title: Cdk12 Regulates Neurogenesis and Late-Arising Neuronal Migration in the Developing Cerebral Cortex.
Volume: 27
Issue: 3
Pages: 2289-2302
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Publication
- | J:175295
     
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein
D3YVC7
Organism: Mus musculus/domesticus
Length: 73  
Fragment?: true
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Protein Domain
IPR029305 | FANCI_S1-cap
Type: Domain
Description: FANCI and FANCD2 form a complex central to the Fanconi anemia (FA) pathway, which is essential for the repair of DNA interstrand cross-links. FANCI has four distinct alpha solenoid (α-α superhelical) segments (S1-S4). Two mostly helical segments intervene between solenoids 1 and 2 (HD1), and between solenoids 2 and 3 (HD2) [].This entry represents the solenoid 1 cap (S1-cap) domain of the Fanconi anemia complementation group I protein (FANCI).
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Protein Domain
IPR029308 | FANCI_S1
Type: Domain
Description: FANCI and FANCD2 form a complex central to the Fanconi anemia (FA) pathway, which is essential for the repair of DNA interstrand cross-links. FANCI has four distinct alpha solenoid (α-α superhelical) segments (S1-S4). Two mostly helical segments intervene between solenoids 1 and 2 (HD1), and between solenoids 2 and 3 (HD2) [].This is the solenoid 1 (S1) domain of the Fanconi anemia group I protein (FANCI).
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Protein Domain
IPR029310 | FANCI_HD1
Type: Domain
Description: FANCI and FANCD2 form a complex central to the Fanconi anemia (FA) pathway, which is essential for the repair of DNA interstrand cross-links. FANCI has four distinct alpha solenoid (α-α superhelical) segments (S1-S4). Two mostly helical segments intervene between solenoids 1 and 2 (HD1), and between solenoids 2 and 3 (HD2) [].This is the helical domain 1 (HD1) of the Fanconi anemia complementation group I protein (FANCI).
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Protein Domain
IPR029312 | FANCI_HD2
Type: Domain
Description: FANCI and FANCD2 form a complex central to the Fanconi anemia (FA) pathway, which is essential for the repair of DNA interstrand cross-links. FANCI has four distinct alpha solenoid (α-α superhelical) segments (S1-S4). Two mostly helical segments intervene between solenoids 1 and 2 (HD1), and between solenoids 2 and 3 (HD2) [].This is the helical domain 2 (HD2) of the Fanconi anemia complementation group I protein (FANCI).
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Protein Domain
IPR029313 | FANCI_S3
Type: Domain
Description: FANCI and FANCD2 form a complex central to the Fanconi anemia (FA) pathway, which is essential for the repair of DNA interstrand cross-links. FANCI has four distinct alpha solenoid (α-α superhelical) segments (S1-S4). Two mostly helical segments intervene between solenoids 1 and 2 (HD1), and between solenoids 2 and 3 (HD2) [].This is the solenoid 3 (S3) domain of the Fanconi anemia group I protein (FANCI).
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Protein Domain
IPR029314 | FANCI_S4
Type: Domain
Description: FANCI and FANCD2 form a complex central to the Fanconi anemia (FA) pathway, which is essential for the repair of DNA interstrand cross-links. FANCI has four distinct alpha solenoid (α-α superhelical) segments (S1-S4). Two mostly helical segments intervene between solenoids 1 and 2 (HD1), and between solenoids 2 and 3 (HD2) [].This is the solenoid 4 (S4) domain of the Fanconi anemia group I protein (FANCI).
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Protein Domain
IPR029315 | FANCI_S2
Type: Domain
Description: FANCI and FANCD2 form a complex central to the Fanconi anemia (FA) pathway, which is essential for the repair of DNA interstrand cross-links. FANCI has four distinct alpha solenoid (α-α superhelical) segments (S1-S4). Two mostly helical segments intervene between solenoids 1 and 2 (HD1), and between solenoids 2 and 3 (HD2) [].This is the solenoid 2 (S2) domain of the Fanconi anemia group I protein (FANCI).
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Gene
309256 | Fan1
Type: gene
Organism: rat
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Gene
453282 | FAN1
Type: gene
Organism: chimpanzee
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Gene
479017 | FAN1
Type: gene
Organism: dog, domestic
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Gene
508171 | FAN1
Type: gene
Organism: cattle
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Gene
565458 | fan1
Type: gene
Organism: zebrafish
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Gene
713125 | FAN1
Type: gene
Organism: macaque, rhesus
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Publication
22753026 | -
First Author: Sareen A
Year: 2012
Journal: Nucleic Acids Res
Title: Fanconi anemia proteins FANCD2 and FANCI exhibit different DNA damage responses during S-phase.
Volume: 40
Issue: 17
Pages: 8425-39
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Publication
23658231 | -
First Author: Chaudhury I
Year: 2013
Journal: Nucleic Acids Res
Title: FANCD2 regulates BLM complex functions independently of FANCI to promote replication fork recovery.
Volume: 41
Issue: 13
Pages: 6444-59
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Publication
21764741 | -
First Author: Joo W
Year: 2011
Journal: Science
Title: Structure of the FANCI-FANCD2 complex: insights into the Fanconi anemia DNA repair pathway.
Volume: 333
Issue: 6040
Pages: 312-6
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Publication
17412408 | -
First Author: Smogorzewska A
Year: 2007
Journal: Cell
Title: Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.
Volume: 129
Issue: 2
Pages: 289-301
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Protein
Q80V62
Organism: Mus musculus/domesticus
Length: 1450  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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Cambridge CB2 3EH, United Kingdom