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Search results 1 to 88 out of 88 for Fbxo3

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Categories

Hits by Category

Hits by Strain

Type Details Score
Gene
26273 | FBXO3
Type: gene
Organism: human
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Gene
100158620 | fbxo3
Type: gene
Organism: frog, western clawed
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Gene
690634 | Fbxo3
Type: gene
Organism: rat
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Gene
475944 | FBXO3
Type: gene
Organism: dog, domestic
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Gene
451112 | FBXO3
Type: gene
Organism: chimpanzee
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Gene
534287 | FBXO3
Type: gene
Organism: cattle
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Gene
429495 | FBXO3
Type: gene
Organism: chicken
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Gene
553731 | fbxo3
Type: gene
Organism: zebrafish
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Gene
693281 | FBXO3
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR028388 | FBXO3
Type: Family
Description: F-box only protein 3 (FBXO3) is a substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination of transcription factor coactivators such as HIPK2 and EP300, leading to their rapid degradation by the proteasome []. FBX03 interacts with a nuclear protein PML, which stabilises the transcription factor complex by protecting HIPK2 and p300 from SCFFbx3-induced degradation until transcription is completed []. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation [].
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Protein Coding Gene
MGI:1929084 | Fbxo3
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
101928440 | FBXO3-DT
Type: gene
Organism: human
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Publication
18809579 | -
First Author: Shima Y
Year: 2008
Journal: Mol Cell Biol
Title: PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation.
Volume: 28
Issue: 23
Pages: 7126-38
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Protein
Q9CVV6
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: true
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Protein
Q8CDU1
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: true
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Protein
Q9DC63
Organism: Mus musculus/domesticus
Length: 480  
Fragment?: false
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Protein
A2BHN6
Organism: Mus musculus/domesticus
Length: 361  
Fragment?: false
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Publication
23542741 | J:196439
First Author: Chen BB
Year: 2013
Journal: Nat Immunol
Title: A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation.
Volume: 14
Issue: 5
Pages: 470-9
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Protein Coding Gene
MGP_CAROLIEiJ_G0024022 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0026210 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0026171 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026152 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0026180 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0025931 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1929084 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0026631 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0025396 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0025909 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026046 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026008 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0026149 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026034 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0026685 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0025131 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0025463 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0025458 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0024932 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
10945468 | J:66302
First Author: Ilyin GP
Year: 2000
Journal: Genomics
Title: cDNA cloning and expression analysis of new members of the mammalian F-box protein family.
Volume: 67
Issue: 1
Pages: 40-7
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Publication
15520277 | J:93441
First Author: Jin J
Year: 2004
Journal: Genes Dev
Title: Systematic analysis and nomenclature of mammalian F-box proteins.
Volume: 18
Issue: 21
Pages: 2573-80
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Publication
26745185 | J:229930
 
First Author: Nechiporuk T
Year: 2016
Journal: Elife
Title: The REST remodeling complex protects genomic integrity during embryonic neurogenesis.
Volume: 5
Pages: e09584
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Publication
16919269 | J:112701
First Author: Bailey PJ
Year: 2006
Journal: Exp Cell Res
Title: A global genomic transcriptional code associated with CNS-expressed genes.
Volume: 312
Issue: 16
Pages: 3108-19
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Publication
- | J:342601
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniPathway vocabulary mapping
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
36362432 | -
 
First Author: Gao Y
Year: 2022
Journal: Int J Mol Sci
Title: E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to Aggravate Cerebral Ischemia/Reperfusion Injury.
Volume: 23
Issue: 21
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Interaction Experiment
Gao Y (2022)
Description: E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to Aggravate Cerebral Ischemia/Reperfusion Injury.
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Protein
Q66JT5
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: false
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Protein
E9QLP0
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: false
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Protein
E9PUD7
Organism: Mus musculus/domesticus
Length: 241  
Fragment?: false
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Publication
10206705 | -
 
First Author: Martin H
Year: 1999
Journal: Microbiology
Title: KNR4, a suppressor of Saccharomyces cerevisiae cwh mutants, is involved in the transcriptional control of chitin synthase genes.
Volume: 145 ( Pt 1)
Pages: 249-58
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Publication
8289782 | -
First Author: Hong Z
Year: 1994
Journal: Mol Cell Biol
Title: Cloning and characterization of KNR4, a yeast gene involved in (1,3)-beta-glucan synthesis.
Volume: 14
Issue: 2
Pages: 1017-25
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Publication
7937796 | -
First Author: Enderlin CS
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: Cloning and characterization of a Neurospora crassa gene required for (1,3) beta-glucan synthase activity and cell wall formation.
Volume: 91
Issue: 20
Pages: 9500-4
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Publication
12185498 | -
First Author: Martin-Yken H
Year: 2002
Journal: Curr Genet
Title: KNR4 is a member of the PKC1 signalling pathway and genetically interacts with BCK2, a gene involved in cell cycle progression in Saccharomyces cerevisiae.
Volume: 41
Issue: 5
Pages: 323-32
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Publication
12823808 | -
First Author: Martin-Yken H
Year: 2003
Journal: Mol Microbiol
Title: The interaction of Slt2 MAP kinase with Knr4 is necessary for signalling through the cell wall integrity pathway in Saccharomyces cerevisiae.
Volume: 49
Issue: 1
Pages: 23-35
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Publication
11410349 | -
First Author: Dagkessamanskaia A
Year: 2001
Journal: FEMS Microbiol Lett
Title: Interaction of Knr4 protein, a protein involved in cell wall synthesis, with tyrosine tRNA synthetase encoded by TYS1 in Saccharomyces cerevisiae.
Volume: 200
Issue: 1
Pages: 53-8
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Publication
8516310 | -
First Author: Fishel BR
Year: 1993
Journal: Proc Natl Acad Sci U S A
Title: Yeast calmodulin and a conserved nuclear protein participate in the in vivo binding of a matrix association region.
Volume: 90
Issue: 12
Pages: 5623-7
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Protein Domain
IPR018958 | Knr4/Smi1-like_dom
Type: Domain
Description: This domain is found in the yeast cell wall assembly regulator Smi1 (also known as Knr4) [, ]. Saccharomyces cerevisiae Knr4 has a regulatory role in chitin deposition and in cell wall assembly []. It is believed to connect the PKC1-SLT2 MAPK pathway with cell proliferation. It has been shown to interact with Bck2, a gene involved in cell cycle progression in S. cerevisiae (forming a complex) to allow PKC1 to coordinate the cell cycle (cell proliferation) with cell wall integrity [, ]. Knr4 also interacts with the tyrosine-tRNA synthetase protein encoded by Tys1 and is involved in sporulation process []. Proteins containing this domain also include the animal F-box only protein 3 (FBXO3). In humans, FBXO3 is a substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex [].Interestingly, Smi1/Knr4 homologues from bacteria are potential immunity proteins in a subset of these contact-dependent inhibitory toxin systems [].Note: previously reported evidence that Knr4 may interact with nuclear matrix-association region []may be due to an artefact [].
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Protein Domain
IPR037883 | Knr4/Smi1-like_sf
Type: Homologous_superfamily
Description: This domain superfamily is found in the yeast cell wall assembly regulator Smi1 (also known as Knr4) [, ]. Saccharomyces cerevisiae Knr4 has a regulatory role in chitin deposition and in cell wall assembly []. It is believed to connect the PKC1-SLT2 MAPK pathway with cell proliferation. It has been shown to interact with Bck2, a gene involved in cell cycle progression in S. cerevisiae (forming a complex) to allow PKC1 to coordinate the cell cycle (cell proliferation) with cell wall integrity [, ]. Knr4 also interacts with the tyrosine-tRNA synthetase protein encoded by Tys1 and is involved in sporulation process []. Proteins containing this domain also include the animal F-box only protein 3 (FBXO3). In humans, FBXO3 is a substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex [].Interestingly, Smi1/Knr4 homologues from bacteria are potential immunity proteins in a subset of these contact-dependent inhibitory toxin systems [, ].Note: previously reported evidence that Knr4 may interact with nuclear matrix-association region []may be due to an artefact [].This domain superfamily is also found in the Syd protein which interacts with the SecY protein.
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Publication
21306995 | -
First Author: Zhang D
Year: 2011
Journal: Nucleic Acids Res
Title: A novel immunity system for bacterial nucleic acid degrading toxins and its recruitment in various eukaryotic and DNA viral systems.
Volume: 39
Issue: 11
Pages: 4532-52
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Publication
34280190 | -
First Author: Kobayashi K
Year: 2021
Journal: PLoS Genet
Title: Diverse LXG toxin and antitoxin systems specifically mediate intraspecies competition in Bacillus subtilis biofilms.
Volume: 17
Issue: 7
Pages: e1009682
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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