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Search results 1 to 100 out of 320 for Fbxw7

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
55294 | FBXW7
Type: gene
Organism: human
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Gene
461542 | FBXW7
Type: gene
Organism: chimpanzee
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Gene
475465 | FBXW7
Type: gene
Organism: dog, domestic
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Gene
540932 | FBXW7
Type: gene
Organism: cattle
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Gene
100360914 | Fbxw7
Type: gene
Organism: rat
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Gene
422481 | FBXW7
Type: gene
Organism: chicken
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Gene
564991 | fbxw7
Type: gene
Organism: zebrafish
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Gene
695101 | FBXW7
Type: gene
Organism: macaque, rhesus
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Gene
100145670 | fbxw7
Type: gene
Organism: frog, western clawed
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Protein Coding Gene
MGI:1354695 | Fbxw7
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
102191832 | FBXW7-AS1
Type: gene
Organism: human
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GXD Expression
GXD Expression
   
Probe: MGI:7427604
Assay Type: RT-PCR
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685326
Stage: TS26
Assay Id: MGI:7427621
Age: embryonic day 18.5
Image: 1
Specimen Label: Fbxw7 mutant
Detected: true
Specimen Num: 2
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Publication
22848434 | J:189707
First Author: Izumi N
Year: 2012
Journal: PLoS One
Title: Fbxw7 controls angiogenesis by regulating endothelial Notch activity.
Volume: 7
Issue: 7
Pages: e41116
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Publication
27764699 | J:320224
First Author: Zhang Q
Year: 2016
Journal: Neoplasia
Title: Fbxw7 Deletion Accelerates KrasG12D-Driven Pancreatic Tumorigenesis via Yap Accumulation.
Volume: 18
Issue: 11
Pages: 666-673
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Publication
23518349 | J:197046
First Author: Takeishi S
Year: 2013
Journal: Cancer Cell
Title: Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence.
Volume: 23
Issue: 3
Pages: 347-61
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Publication
26774286 | J:232858
First Author: Zhang Q
Year: 2016
Journal: Mol Cell
Title: FBXW7 Facilitates Nonhomologous End-Joining via K63-Linked Polyubiquitylation of XRCC4.
Volume: 61
Issue: 3
Pages: 419-433
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Publication
34998785 | J:320419
 
First Author: Li R
Year: 2022
Journal: Dev Biol
Title: E3 ubiquitin ligase FBXW7 balances airway cell fates.
Volume: 483
Pages: 89-97
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Publication
25555218 | J:220397
First Author: Yumimoto K
Year: 2015
Journal: J Clin Invest
Title: F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner.
Volume: 125
Issue: 2
Pages: 621-35
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Publication
35069531 | J:318845
 
First Author: He J
Year: 2021
Journal: Front Immunol
Title: Myeloid Fbxw7 Prevents Pulmonary Fibrosis by Suppressing TGF-β Production.
Volume: 12
Pages: 760138
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Publication
36104351 | J:330850
First Author: Gong L
Year: 2022
Journal: Cell Death Dis
Title: FBXW7 inactivation induces cellular senescence via accumulation of p53.
Volume: 13
Issue: 9
Pages: 788
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Publication
31246581 | J:325935
First Author: He J
Year: 2019
Journal: J Clin Invest
Title: Fbxw7 increases CCL2/7 in CX3CR1hi macrophages to promote intestinal inflammation.
Volume: 129
Issue: 9
Pages: 3877-3893
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Publication
21503901 | J:172214
First Author: Davis H
Year: 2011
Journal: J Pathol
Title: FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development.
Volume: 224
Issue: 2
Pages: 180-9
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Publication
33260160 | J:305978
First Author: Zhong L
Year: 2020
Journal: Aging (Albany NY)
Title: E3 ligase FBXW7 restricts M2-like tumor-associated macrophage polarization by targeting c-Myc.
Volume: 12
Issue: 23
Pages: 24394-24423
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Publication
29475832 | J:261135
First Author: Zhao J
Year: 2018
Journal: Diabetes
Title: Hepatic F-Box Protein FBXW7 Maintains Glucose Homeostasis Through Degradation of Fetuin-A.
Volume: 67
Issue: 5
Pages: 818-830
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Publication
28422719 | J:256304
First Author: Jiang Y
Year: 2017
Journal: Oncotarget
Title: Fbxw7 haploinsufficiency loses its protection against DNA damage and accelerates MNU-induced gastric carcinogenesis.
Volume: 8
Issue: 20
Pages: 33444-33456
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Publication
18787170 | J:138766
First Author: Mao JH
Year: 2008
Journal: Science
Title: FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression.
Volume: 321
Issue: 5895
Pages: 1499-502
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Publication
23791182 | J:200006
First Author: King B
Year: 2013
Journal: Cell
Title: The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability.
Volume: 153
Issue: 7
Pages: 1552-66
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Publication
28287082 | J:244688
 
First Author: Song Y
Year: 2017
Journal: Nat Commun
Title: E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responses.
Volume: 8
Pages: 14654
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Publication
33070870 | J:312820
First Author: Meyer AE
Year: 2020
Journal: Neoplasia
Title: Loss of Fbxw7 triggers mammary tumorigenesis associated with E2F/c-Myc activation and Trp53 mutation.
Volume: 22
Issue: 11
Pages: 644-658
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Publication
37843504 | J:343877
First Author: Song Y
Year: 2023
Journal: J Immunol
Title: Epigenetic Regulation of IL-23 by E3 Ligase FBXW7 in Dendritic Cells Is Critical for Psoriasis-like Inflammation.
Volume: 211
Issue: 11
Pages: 1701-1713
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Publication
31883011 | J:289161
First Author: Zhang H
Year: 2020
Journal: Biol Reprod
Title: Loss of Fbxw7 in Sertoli cells impairs testis development and causes infertility in mice†.
Volume: 102
Issue: 4
Pages: 963-974
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Publication
22897623 | J:213966
First Author: Okita Y
Year: 2012
Journal: Genes Cells
Title: Increased efficiency in the generation of induced pluripotent stem cells by Fbxw7 ablation.
Volume: 17
Issue: 9
Pages: 768-77
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Publication
30275535 | J:295584
First Author: Chong Z
Year: 2018
Journal: Cell Mol Immunol
Title: E3 ligase FBXW7 aggravates TMPD-induced systemic lupus erythematosus by promoting cell apoptosis.
Volume: 15
Issue: 12
Pages: 1057-1070
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Publication
29633504 | J:325934
First Author: Xiao Y
Year: 2018
Journal: Mol Oncol
Title: FBXW7 deletion contributes to lung tumor development and confers resistance to gefitinib therapy.
Volume: 12
Issue: 6
Pages: 883-895
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Publication
18367647 | J:133773
First Author: Matsuoka S
Year: 2008
Journal: Genes Dev
Title: Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.
Volume: 22
Issue: 8
Pages: 986-91
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Publication
20534483 | J:161392
First Author: Bengoechea-Alonso MT
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradation.
Volume: 107
Issue: 26
Pages: 11817-22
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Publication
28581198 | J:320946
First Author: Aydin IT
Year: 2017
Journal: Pigment Cell Melanoma Res
Title: FBXW7 inactivation in a BrafV600E -driven mouse model leads to melanoma development.
Volume: 30
Issue: 6
Pages: 571-574
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Publication
33234509 | J:300141
First Author: Onoyama I
Year: 2020
Journal: Cancer Res
Title: Loss of Fbxw7 Impairs Development of and Induces Heterogeneous Tumor Formation in the Mouse Mammary Gland.
Volume: 80
Issue: 24
Pages: 5515-5530
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Publication
22513362 | J:205391
First Author: Kwon YW
Year: 2012
Journal: Mol Cancer Res
Title: Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development.
Volume: 10
Issue: 6
Pages: 834-44
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Publication
31772025 | J:282812
First Author: Cuevas IC
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Fbxw7 is a driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition.
Volume: 116
Issue: 51
Pages: 25880-25890
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Publication
21282377 | J:176848
First Author: Babaei-Jadidi R
Year: 2011
Journal: J Exp Med
Title: FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation.
Volume: 208
Issue: 2
Pages: 295-312
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Publication
21123947 | J:171853
First Author: Onoyama I
Year: 2011
Journal: J Clin Invest
Title: Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver.
Volume: 121
Issue: 1
Pages: 342-54
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Publication
24879440 | J:211643
First Author: Kanatsu-Shinohara M
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Skp1-Cullin-F-box (SCF)-type ubiquitin ligase FBXW7 negatively regulates spermatogonial stem cell self-renewal.
Volume: 111
Issue: 24
Pages: 8826-31
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Publication
22348067 | J:285311
First Author: Perez-Losada J
Year: 2012
Journal: PLoS One
Title: Allele-specific deletions in mouse tumors identify Fbxw7 as germline modifier of tumor susceptibility.
Volume: 7
Issue: 2
Pages: e31301
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Publication
17984302 | J:128523
First Author: Onoyama I
Year: 2007
Journal: J Exp Med
Title: Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis.
Volume: 204
Issue: 12
Pages: 2875-88
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Publication
21076392 | J:167167
First Author: Balamurugan K
Year: 2010
Journal: EMBO J
Title: The tumour suppressor C/EBPδ inhibits FBXW7 expression and promotes mammary tumour metastasis.
Volume: 29
Issue: 24
Pages: 4106-17
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Publication
23676439 | J:197128
First Author: Davis H
Year: 2014
Journal: Gut
Title: Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines.
Volume: 63
Issue: 5
Pages: 792-9
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Publication
29386660 | J:258194
First Author: Ikenoue T
Year: 2018
Journal: Sci Rep
Title: Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation.
Volume: 8
Issue: 1
Pages: 2021
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Publication
22665065 | J:197229
First Author: Ishikawa Y
Year: 2013
Journal: Oncogene
Title: Opposing functions of Fbxw7 in keratinocyte growth, differentiation and skin tumorigenesis mediated through negative regulation of c-Myc and Notch.
Volume: 32
Issue: 15
Pages: 1921-32
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GXD Expression
GXD Expression
   
Probe: MGI:6172787
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190253
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Fbxw7
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6172787
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190253
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Fbxw7
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6172787
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190253
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Fbxw7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6172787
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190253
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Fbxw7
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6172787
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190253
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Fbxw7
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6172787
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190253
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Fbxw7
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6172787
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190253
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Fbxw7
Detected: true
Specimen Num: 7
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Publication
37589076 | J:341493
First Author: Brown M
Year: 2023
Journal: EMBO Mol Med
Title: Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis.
Volume: 15
Issue: 10
Pages: e17094
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Publication
16061623 | J:100782
First Author: Perez-Losada J
Year: 2005
Journal: Cancer Res
Title: Control of genomic instability and epithelial tumor development by the p53-Fbxw7/Cdc4 pathway.
Volume: 65
Issue: 15
Pages: 6488-92
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Protein
Q0VGT7
Organism: Mus musculus/domesticus
Length: 347  
Fragment?: false
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Publication
34518642 | J:325936
First Author: Petsouki E
Year: 2021
Journal: Commun Biol
Title: FBW7 couples structural integrity with functional output of primary cilia.
Volume: 4
Issue: 1
Pages: 1066
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Publication
30783098 | J:298755
First Author: Li N
Year: 2019
Journal: Oncogenesis
Title: An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.
Volume: 8
Issue: 3
Pages: 13
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Publication
35225231 | J:327547
   
First Author: Thirimanne HN
Year: 2022
Journal: Elife
Title: Global and context-specific transcriptional consequences of oncogenic Fbw7 mutations.
Volume: 11
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Publication
27238018 | J:271692
First Author: Zhao X
Year: 2016
Journal: Cell
Title: Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation.
Volume: 165
Issue: 7
Pages: 1644-1657
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Publication
37914694 | J:342224
First Author: Xia H
Year: 2023
Journal: Nat Commun
Title: Hepatocyte FBXW7-dependent activity of nutrient-sensing nuclear receptors controls systemic energy homeostasis and NASH progression in male mice.
Volume: 14
Issue: 1
Pages: 6982
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Publication
31278268 | J:294393
First Author: Harty BL
Year: 2019
Journal: Nat Commun
Title: Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7.
Volume: 10
Issue: 1
Pages: 2976
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Publication
23454868 | J:267894
First Author: Liu Y
Year: 2013
Journal: Aging (Albany NY)
Title: Temporal mTOR inhibition protects Fbxw7-deficient mice from radiation-induced tumor development.
Volume: 5
Issue: 2
Pages: 111-9
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Publication
21205095 | J:297018
First Author: Matsumoto A
Year: 2011
Journal: Cancer Sci
Title: Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress.
Volume: 102
Issue: 4
Pages: 749-55
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Publication
24446488 | J:208344
First Author: Hu J
Year: 2014
Journal: J Exp Med
Title: Müller glia cells regulate Notch signaling and retinal angiogenesis via the generation of 19,20-dihydroxydocosapentaenoic acid.
Volume: 211
Issue: 2
Pages: 281-95
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Publication
35440636 | J:342225
First Author: Xia H
Year: 2022
Journal: Nat Commun
Title: Insulin action and resistance are dependent on a GSK3β-FBXW7-ERRα transcriptional axis.
Volume: 13
Issue: 1
Pages: 2105
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Publication
25918410 | J:221663
First Author: Park JH
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Inactivation of EWS reduces PGC-1α protein stability and mitochondrial homeostasis.
Volume: 112
Issue: 19
Pages: 6074-9
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Publication
15592418 | J:95108
First Author: Mao JH
Year: 2004
Journal: Nature
Title: Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene.
Volume: 432
Issue: 7018
Pages: 775-9
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Publication
23955342 | J:207218
First Author: Yumimoto K
Year: 2013
Journal: J Biol Chem
Title: F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation.
Volume: 288
Issue: 40
Pages: 28488-502
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Publication
22117044 | J:181784
First Author: Jen KY
Year: 2012
Journal: Blood
Title: Sequential mutations in Notch1, Fbxw7, and Tp53 in radiation-induced mouse thymic lymphomas.
Volume: 119
Issue: 3
Pages: 805-9
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Publication
26575021 | J:253418
First Author: Snijders AM
Year: 2015
Journal: Oncotarget
Title: Expression profiling reveals transcriptional regulation by Fbxw7/mTOR pathway in radiation-induced mouse thymic lymphomas.
Volume: 6
Issue: 42
Pages: 44794-805
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Publication
29282223 | J:261891
First Author: Sakai E
Year: 2018
Journal: Cancer Res
Title: Combined Mutation of Apc, Kras, and Tgfbr2 Effectively Drives Metastasis of Intestinal Cancer.
Volume: 78
Issue: 5
Pages: 1334-1346
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Publication
21349854 | J:171254
First Author: Matsumoto A
Year: 2011
Journal: J Biol Chem
Title: Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells.
Volume: 286
Issue: 15
Pages: 13754-64
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Publication
29472293 | J:262785
First Author: Nakayama S
Year: 2018
Journal: J Biol Chem
Title: Degradation of the endoplasmic reticulum-anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7 in a manner dependent on the kinase GSK-3.
Volume: 293
Issue: 15
Pages: 5705-5714
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Protein Coding Gene
MGP_CAROLIEiJ_G0025119 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0027347 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0027311 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0027277 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0027320 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0027064 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1354695 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027766 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0026511 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0027039 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0027175 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0027143 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0027283 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0027162 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027824 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0026245 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0026589 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0026562 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0026061 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
11425854 | J:71503
First Author: Gupta-Rossi N
Year: 2001
Journal: J Biol Chem
Title: Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor.
Volume: 276
Issue: 37
Pages: 34371-8
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Publication
18474632 | J:137138
First Author: Thompson BJ
Year: 2008
Journal: J Exp Med
Title: Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7.
Volume: 205
Issue: 6
Pages: 1395-408
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Publication
22708077 | J:196027
First Author: Fukushima H
Year: 2012
Journal: Cell Rep
Title: SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction.
Volume: 1
Issue: 5
Pages: 434-43
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Publication
38485719 | J:346081
First Author: Cai Z
Year: 2024
Journal: Cell Death Dis
Title: Selective deletion of E3 ubiquitin ligase FBW7 in VE-cadherin-positive cells instigates diffuse large B-cell lymphoma in mice in vivo.
Volume: 15
Issue: 3
Pages: 212
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