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Search results 1 to 100 out of 329 for Fbxw7

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
55294 | FBXW7
Type: gene
Organism: human
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Gene
100145670 | fbxw7
Type: gene
Organism: frog, western clawed
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Gene
461542 | FBXW7
Type: gene
Organism: chimpanzee
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Gene
475465 | FBXW7
Type: gene
Organism: dog, domestic
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Gene
540932 | FBXW7
Type: gene
Organism: cattle
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Gene
100360914 | Fbxw7
Type: gene
Organism: rat
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Gene
422481 | FBXW7
Type: gene
Organism: chicken
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Gene
564991 | fbxw7
Type: gene
Organism: zebrafish
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Gene
695101 | FBXW7
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1354695 | Fbxw7
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
102191832 | FBXW7-AS1
Type: gene
Organism: human
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GXD Expression
GXD Expression
   
Probe: MGI:7427604
Assay Type: RT-PCR
Annotation Date: 2023-01-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685326
Stage: TS26
Assay Id: MGI:7427621
Age: embryonic day 18.5
Image: 1
Specimen Label: Fbxw7 mutant
Detected: true
Specimen Num: 2
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Publication
22848434 | J:189707
First Author: Izumi N
Year: 2012
Journal: PLoS One
Title: Fbxw7 controls angiogenesis by regulating endothelial Notch activity.
Volume: 7
Issue: 7
Pages: e41116
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Publication
27764699 | J:320224
First Author: Zhang Q
Year: 2016
Journal: Neoplasia
Title: Fbxw7 Deletion Accelerates KrasG12D-Driven Pancreatic Tumorigenesis via Yap Accumulation.
Volume: 18
Issue: 11
Pages: 666-673
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Publication
23518349 | J:197046
First Author: Takeishi S
Year: 2013
Journal: Cancer Cell
Title: Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence.
Volume: 23
Issue: 3
Pages: 347-61
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Publication
26774286 | J:232858
First Author: Zhang Q
Year: 2016
Journal: Mol Cell
Title: FBXW7 Facilitates Nonhomologous End-Joining via K63-Linked Polyubiquitylation of XRCC4.
Volume: 61
Issue: 3
Pages: 419-433
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Publication
34998785 | J:320419
 
First Author: Li R
Year: 2022
Journal: Dev Biol
Title: E3 ubiquitin ligase FBXW7 balances airway cell fates.
Volume: 483
Pages: 89-97
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Publication
25555218 | J:220397
First Author: Yumimoto K
Year: 2015
Journal: J Clin Invest
Title: F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner.
Volume: 125
Issue: 2
Pages: 621-35
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Publication
36104351 | J:330850
First Author: Gong L
Year: 2022
Journal: Cell Death Dis
Title: FBXW7 inactivation induces cellular senescence via accumulation of p53.
Volume: 13
Issue: 9
Pages: 788
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Publication
35069531 | J:318845
 
First Author: He J
Year: 2021
Journal: Front Immunol
Title: Myeloid Fbxw7 Prevents Pulmonary Fibrosis by Suppressing TGF-β Production.
Volume: 12
Pages: 760138
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Publication
31246581 | J:325935
First Author: He J
Year: 2019
Journal: J Clin Invest
Title: Fbxw7 increases CCL2/7 in CX3CR1hi macrophages to promote intestinal inflammation.
Volume: 129
Issue: 9
Pages: 3877-3893
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Publication
21503901 | J:172214
First Author: Davis H
Year: 2011
Journal: J Pathol
Title: FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development.
Volume: 224
Issue: 2
Pages: 180-9
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Publication
33260160 | J:305978
First Author: Zhong L
Year: 2020
Journal: Aging (Albany NY)
Title: E3 ligase FBXW7 restricts M2-like tumor-associated macrophage polarization by targeting c-Myc.
Volume: 12
Issue: 23
Pages: 24394-24423
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Publication
29475832 | J:261135
First Author: Zhao J
Year: 2018
Journal: Diabetes
Title: Hepatic F-Box Protein FBXW7 Maintains Glucose Homeostasis Through Degradation of Fetuin-A.
Volume: 67
Issue: 5
Pages: 818-830
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Publication
28422719 | J:256304
First Author: Jiang Y
Year: 2017
Journal: Oncotarget
Title: Fbxw7 haploinsufficiency loses its protection against DNA damage and accelerates MNU-induced gastric carcinogenesis.
Volume: 8
Issue: 20
Pages: 33444-33456
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Publication
18787170 | J:138766
First Author: Mao JH
Year: 2008
Journal: Science
Title: FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression.
Volume: 321
Issue: 5895
Pages: 1499-502
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Publication
23791182 | J:200006
First Author: King B
Year: 2013
Journal: Cell
Title: The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability.
Volume: 153
Issue: 7
Pages: 1552-66
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Publication
28287082 | J:244688
 
First Author: Song Y
Year: 2017
Journal: Nat Commun
Title: E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responses.
Volume: 8
Pages: 14654
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Publication
33070870 | J:312820
First Author: Meyer AE
Year: 2020
Journal: Neoplasia
Title: Loss of Fbxw7 triggers mammary tumorigenesis associated with E2F/c-Myc activation and Trp53 mutation.
Volume: 22
Issue: 11
Pages: 644-658
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Publication
37843504 | J:343877
First Author: Song Y
Year: 2023
Journal: J Immunol
Title: Epigenetic Regulation of IL-23 by E3 Ligase FBXW7 in Dendritic Cells Is Critical for Psoriasis-like Inflammation.
Volume: 211
Issue: 11
Pages: 1701-1713
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Publication
30275535 | J:295584
First Author: Chong Z
Year: 2018
Journal: Cell Mol Immunol
Title: E3 ligase FBXW7 aggravates TMPD-induced systemic lupus erythematosus by promoting cell apoptosis.
Volume: 15
Issue: 12
Pages: 1057-1070
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Publication
29633504 | J:325934
First Author: Xiao Y
Year: 2018
Journal: Mol Oncol
Title: FBXW7 deletion contributes to lung tumor development and confers resistance to gefitinib therapy.
Volume: 12
Issue: 6
Pages: 883-895
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Publication
31883011 | J:289161
First Author: Zhang H
Year: 2020
Journal: Biol Reprod
Title: Loss of Fbxw7 in Sertoli cells impairs testis development and causes infertility in mice†.
Volume: 102
Issue: 4
Pages: 963-974
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Publication
39031722 | J:352093
First Author: Zhao H
Year: 2024
Journal: J Cell Mol Med
Title: Deletion of Fbxw7 in oocytes causes follicle loss and premature ovarian insufficiency in mice.
Volume: 28
Issue: 12
Pages: e18487
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Publication
22897623 | J:213966
First Author: Okita Y
Year: 2012
Journal: Genes Cells
Title: Increased efficiency in the generation of induced pluripotent stem cells by Fbxw7 ablation.
Volume: 17
Issue: 9
Pages: 768-77
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Publication
18367647 | J:133773
First Author: Matsuoka S
Year: 2008
Journal: Genes Dev
Title: Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.
Volume: 22
Issue: 8
Pages: 986-91
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Publication
20534483 | J:161392
First Author: Bengoechea-Alonso MT
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradation.
Volume: 107
Issue: 26
Pages: 11817-22
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Publication
28581198 | J:320946
First Author: Aydin IT
Year: 2017
Journal: Pigment Cell Melanoma Res
Title: FBXW7 inactivation in a BrafV600E -driven mouse model leads to melanoma development.
Volume: 30
Issue: 6
Pages: 571-574
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Publication
33234509 | J:300141
First Author: Onoyama I
Year: 2020
Journal: Cancer Res
Title: Loss of Fbxw7 Impairs Development of and Induces Heterogeneous Tumor Formation in the Mouse Mammary Gland.
Volume: 80
Issue: 24
Pages: 5515-5530
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Publication
22513362 | J:205391
First Author: Kwon YW
Year: 2012
Journal: Mol Cancer Res
Title: Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development.
Volume: 10
Issue: 6
Pages: 834-44
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Publication
21282377 | J:176848
First Author: Babaei-Jadidi R
Year: 2011
Journal: J Exp Med
Title: FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation.
Volume: 208
Issue: 2
Pages: 295-312
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Publication
31772025 | J:282812
First Author: Cuevas IC
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Fbxw7 is a driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition.
Volume: 116
Issue: 51
Pages: 25880-25890
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Publication
24879440 | J:211643
First Author: Kanatsu-Shinohara M
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Skp1-Cullin-F-box (SCF)-type ubiquitin ligase FBXW7 negatively regulates spermatogonial stem cell self-renewal.
Volume: 111
Issue: 24
Pages: 8826-31
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Publication
21123947 | J:171853
First Author: Onoyama I
Year: 2011
Journal: J Clin Invest
Title: Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver.
Volume: 121
Issue: 1
Pages: 342-54
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Publication
22348067 | J:285311
First Author: Perez-Losada J
Year: 2012
Journal: PLoS One
Title: Allele-specific deletions in mouse tumors identify Fbxw7 as germline modifier of tumor susceptibility.
Volume: 7
Issue: 2
Pages: e31301
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Publication
17984302 | J:128523
First Author: Onoyama I
Year: 2007
Journal: J Exp Med
Title: Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis.
Volume: 204
Issue: 12
Pages: 2875-88
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Publication
21076392 | J:167167
First Author: Balamurugan K
Year: 2010
Journal: EMBO J
Title: The tumour suppressor C/EBPδ inhibits FBXW7 expression and promotes mammary tumour metastasis.
Volume: 29
Issue: 24
Pages: 4106-17
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Publication
23676439 | J:197128
First Author: Davis H
Year: 2014
Journal: Gut
Title: Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines.
Volume: 63
Issue: 5
Pages: 792-9
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Publication
29386660 | J:258194
First Author: Ikenoue T
Year: 2018
Journal: Sci Rep
Title: Establishment and analysis of a novel mouse line carrying a conditional knockin allele of a cancer-specific FBXW7 mutation.
Volume: 8
Issue: 1
Pages: 2021
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Publication
22665065 | J:197229
First Author: Ishikawa Y
Year: 2013
Journal: Oncogene
Title: Opposing functions of Fbxw7 in keratinocyte growth, differentiation and skin tumorigenesis mediated through negative regulation of c-Myc and Notch.
Volume: 32
Issue: 15
Pages: 1921-32
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GXD Expression
GXD Expression
   
Probe: MGI:6172787
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190253
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Fbxw7
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6172787
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190253
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Fbxw7
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6172787
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190253
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Fbxw7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6172787
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190253
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Fbxw7
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6172787
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190253
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Fbxw7
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6172787
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190253
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Fbxw7
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6172787
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190253
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Fbxw7
Detected: true
Specimen Num: 7
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Publication
37589076 | J:341493
First Author: Brown M
Year: 2023
Journal: EMBO Mol Med
Title: Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis.
Volume: 15
Issue: 10
Pages: e17094
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Publication
16061623 | J:100782
First Author: Perez-Losada J
Year: 2005
Journal: Cancer Res
Title: Control of genomic instability and epithelial tumor development by the p53-Fbxw7/Cdc4 pathway.
Volume: 65
Issue: 15
Pages: 6488-92
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Protein
Q0VGT7
Organism: Mus musculus/domesticus
Length: 347  
Fragment?: false
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Publication
34518642 | J:325936
First Author: Petsouki E
Year: 2021
Journal: Commun Biol
Title: FBW7 couples structural integrity with functional output of primary cilia.
Volume: 4
Issue: 1
Pages: 1066
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Publication
31150734 | J:348707
 
First Author: Chen Z
Year: 2019
Journal: J Mol Cell Cardiol
Title: MiR322 mediates cardioprotection against ischemia/reperfusion injury via FBXW7/notch pathway.
Volume: 133
Pages: 67-74
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Publication
35225231 | J:327547
   
First Author: Thirimanne HN
Year: 2022
Journal: Elife
Title: Global and context-specific transcriptional consequences of oncogenic Fbw7 mutations.
Volume: 11
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Publication
30783098 | J:298755
First Author: Li N
Year: 2019
Journal: Oncogenesis
Title: An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.
Volume: 8
Issue: 3
Pages: 13
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Publication
27238018 | J:271692
First Author: Zhao X
Year: 2016
Journal: Cell
Title: Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation.
Volume: 165
Issue: 7
Pages: 1644-1657
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Publication
37914694 | J:342224
First Author: Xia H
Year: 2023
Journal: Nat Commun
Title: Hepatocyte FBXW7-dependent activity of nutrient-sensing nuclear receptors controls systemic energy homeostasis and NASH progression in male mice.
Volume: 14
Issue: 1
Pages: 6982
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Publication
23454868 | J:267894
First Author: Liu Y
Year: 2013
Journal: Aging (Albany NY)
Title: Temporal mTOR inhibition protects Fbxw7-deficient mice from radiation-induced tumor development.
Volume: 5
Issue: 2
Pages: 111-9
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Publication
31278268 | J:294393
First Author: Harty BL
Year: 2019
Journal: Nat Commun
Title: Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7.
Volume: 10
Issue: 1
Pages: 2976
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Publication
24446488 | J:208344
First Author: Hu J
Year: 2014
Journal: J Exp Med
Title: Müller glia cells regulate Notch signaling and retinal angiogenesis via the generation of 19,20-dihydroxydocosapentaenoic acid.
Volume: 211
Issue: 2
Pages: 281-95
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Publication
21205095 | J:297018
First Author: Matsumoto A
Year: 2011
Journal: Cancer Sci
Title: Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress.
Volume: 102
Issue: 4
Pages: 749-55
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Publication
35440636 | J:342225
First Author: Xia H
Year: 2022
Journal: Nat Commun
Title: Insulin action and resistance are dependent on a GSK3β-FBXW7-ERRα transcriptional axis.
Volume: 13
Issue: 1
Pages: 2105
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Publication
15592418 | J:95108
First Author: Mao JH
Year: 2004
Journal: Nature
Title: Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene.
Volume: 432
Issue: 7018
Pages: 775-9
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Publication
25918410 | J:221663
First Author: Park JH
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Inactivation of EWS reduces PGC-1α protein stability and mitochondrial homeostasis.
Volume: 112
Issue: 19
Pages: 6074-9
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Publication
22117044 | J:181784
First Author: Jen KY
Year: 2012
Journal: Blood
Title: Sequential mutations in Notch1, Fbxw7, and Tp53 in radiation-induced mouse thymic lymphomas.
Volume: 119
Issue: 3
Pages: 805-9
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Publication
26575021 | J:253418
First Author: Snijders AM
Year: 2015
Journal: Oncotarget
Title: Expression profiling reveals transcriptional regulation by Fbxw7/mTOR pathway in radiation-induced mouse thymic lymphomas.
Volume: 6
Issue: 42
Pages: 44794-805
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Publication
23955342 | J:207218
First Author: Yumimoto K
Year: 2013
Journal: J Biol Chem
Title: F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation.
Volume: 288
Issue: 40
Pages: 28488-502
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Publication
29282223 | J:261891
First Author: Sakai E
Year: 2018
Journal: Cancer Res
Title: Combined Mutation of Apc, Kras, and Tgfbr2 Effectively Drives Metastasis of Intestinal Cancer.
Volume: 78
Issue: 5
Pages: 1334-1346
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Publication
21349854 | J:171254
First Author: Matsumoto A
Year: 2011
Journal: J Biol Chem
Title: Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells.
Volume: 286
Issue: 15
Pages: 13754-64
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Publication
29472293 | J:262785
First Author: Nakayama S
Year: 2018
Journal: J Biol Chem
Title: Degradation of the endoplasmic reticulum-anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7 in a manner dependent on the kinase GSK-3.
Volume: 293
Issue: 15
Pages: 5705-5714
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Protein Coding Gene
MGP_CAROLIEiJ_G0025119 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0027347 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0027311 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0027277 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0027320 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0027064 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1354695 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027766 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0026511 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0027039 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0027175 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0027143 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0027283 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0027162 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027824 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0026245 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0026589 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0026562 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0026061 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
11425854 | J:71503
First Author: Gupta-Rossi N
Year: 2001
Journal: J Biol Chem
Title: Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor.
Volume: 276
Issue: 37
Pages: 34371-8
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Publication
18474632 | J:137138
First Author: Thompson BJ
Year: 2008
Journal: J Exp Med
Title: Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7.
Volume: 205
Issue: 6
Pages: 1395-408
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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