|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 92 out of 92 for Fcho2

0.037s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: F-BAR domain only protein 2 (FCHo2) belongs to the F-BAR family, whose members have been implicated in cell membrane processes such as membrane invagination, tubulation and endocytosis []. FCHo2 organises clathrin-coated structures and interacts with adaptor Disabled-2 for low-density lipoprotein receptor endocytosis [, ]. The structure of the FCHo2 F-BAR domain has been solved [].
Publication
First Author: Henne WM
Year: 2007
Journal: Structure
Title: Structure and analysis of FCHo2 F-BAR domain: a dimerizing and membrane recruitment module that effects membrane curvature.
Volume: 15
Issue: 7
Pages: 839-52
Protein
Organism: Mus musculus
Length: 288  
Fragment?: true
Publication
First Author: Katoh M
Year: 2004
Journal: Int J Mol Med
Title: Identification and characterization of human FCHO2 and mouse Fcho2 genes in silico.
Volume: 14
Issue: 2
Pages: 327-31
Publication
First Author: Mulkearns EE
Year: 2012
Journal: Mol Biol Cell
Title: FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis.
Volume: 23
Issue: 7
Pages: 1330-42
Publication
First Author: Teckchandani A
Year: 2012
Journal: Mol Biol Cell
Title: The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin β1 endocytosis.
Volume: 23
Issue: 15
Pages: 2905-16
Protein
Organism: Mus musculus
Length: 538  
Fragment?: false
Protein
Organism: Mus musculus
Length: 181  
Fragment?: false
Publication
First Author: Chen Y
Year: 2013
Journal: Semin Cell Dev Biol
Title: Biochemical and functional significance of F-BAR domain proteins interaction with WASP/N-WASP.
Volume: 24
Issue: 4
Pages: 280-6
Protein
Organism: Mus musculus
Length: 809  
Fragment?: false
Protein
Organism: Mus musculus
Length: 395  
Fragment?: false
Protein
Organism: Mus musculus
Length: 281  
Fragment?: true
Protein
Organism: Mus musculus
Length: 356  
Fragment?: false
Protein
Organism: Mus musculus
Length: 414  
Fragment?: false
Publication
First Author: Henne WM
Year: 2010
Journal: Science
Title: FCHo proteins are nucleators of clathrin-mediated endocytosis.
Volume: 328
Issue: 5983
Pages: 1281-4
Publication
First Author: Umasankar PK
Year: 2012
Journal: Nat Cell Biol
Title: Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning.
Volume: 14
Issue: 5
Pages: 488-501
Publication
First Author: Uezu A
Year: 2011
Journal: Genes Cells
Title: Characterization of the EFC/F-BAR domain protein, FCHO2.
Volume: 16
Issue: 8
Pages: 868-78
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression  
Probe: MGI:3510033
Assay Type: RNA in situ
Annotation Date: 2004-12-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1699417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3510366
Age: embryonic day 10.5
Note: Endolymphatic duct.
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3510033
Assay Type: RNA in situ
Annotation Date: 2004-12-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3510366
Age: embryonic day 10.5
Note: General or ubiquitous expression throughout cranial region.
Detected: true
Specimen Num: 1
Publication
First Author: Powles N
Year: 2004
Journal: Dev Biol
Title: Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization.
Volume: 268
Issue: 1
Pages: 24-38
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication      
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics, the Protein Information Resource and the Protein Ontology Consortium
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Protein Domain
Type: Domain
Description: F-BAR domain only protein 1 (FCHo1) belongs to the F-BAR family, whose members have been implicated in cell membrane processes such as membrane invagination, tubulation and endocytosis []. FCHo1 functions in an early step of clathrin-mediated endocytosis. It has a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits []. It contains an N-terminal F-BAR domain and a C-terminal domain of unknown function named SAFF which is also present in FCHo2 and endophilin interacting protein 1. This entry represents the F-BAR domain, which forms banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. It can induce membrane deformation in the form of long tubules [, ].
Publication
First Author: Lippincott J
Year: 2000
Journal: Microsc Res Tech
Title: Involvement of PCH family proteins in cytokinesis and actin distribution.
Volume: 49
Issue: 2
Pages: 168-72
Publication
First Author: Chitu V
Year: 2007
Journal: Trends Cell Biol
Title: Pombe Cdc15 homology (PCH) proteins: coordinators of membrane-cytoskeletal interactions.
Volume: 17
Issue: 3
Pages: 145-56
Publication
First Author: Cooper KM
Year: 2008
Journal: Mol Biol Cell
Title: The PCH family member proline-serine-threonine phosphatase-interacting protein 1 targets to the leukocyte uropod and regulates directed cell migration.
Volume: 19
Issue: 8
Pages: 3180-91
Publication
First Author: Starnes TW
Year: 2014
Journal: Blood
Title: The F-BAR protein PSTPIP1 controls extracellular matrix degradation and filopodia formation in macrophages.
Volume: 123
Issue: 17
Pages: 2703-14
Publication
First Author: Demidowich AP
Year: 2012
Journal: Arthritis Rheum
Title: Brief report: genotype, phenotype, and clinical course in five patients with PAPA syndrome (pyogenic sterile arthritis, pyoderma gangrenosum, and acne).
Volume: 64
Issue: 6
Pages: 2022-7
Publication
First Author: Shoham NG
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway.
Volume: 100
Issue: 23
Pages: 13501-6
Protein Domain
Type: Family
Description: Proline-serine-threonine phosphatase-interacting protein 2 (PSTPIP2), also known as MAYP, belongs to the PCH (Pombe Cdc15 homology) family of proteins involved in the regulation of actin-related functions, including cell adhesion and motility []. In mice, it regulates F-actin bundling and enhances filopodia formation and motility in macrophages []. It may play an anti-inflammatory role in macrophages [].Pombe Cdc15 homology (PCH) family proteins were initially identified as adaptor proteins involved in the regulation of cytokinesis and actin dynamics []. They share a similar domain architecture, consisting of an N-terminal FCH domain followed by a coiled coil (CC) region and by one or two C-terminal SH3 domains. However, in some family members the SH3 domain is absent (FCHO1, FCHO2 and PSTPIP2) or there are tissue-specific alternatively spliced isoforms with and without an SH3 domain (CIP4b, CIP4c, CIP4V, Fbp17b). PCH family proteins interact with receptors, adaptors, enzymes and structural proteins to regulate their localisation and activity. Through these interactions, PCH proteins regulate cell morphology and motility, organelle integrity, protein trafficking and the organisation of the actin cytoskeleton [].
Protein Domain
Type: Domain
Description: This entry represents the SH3 domain of proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1).Proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1) belongs to the PCH family. It interacts with Wiskott-Aldrich syndrome protein (WASP) and PTPN12, which are important regulators of the cytoskeleton and cell migration, suggesting that PSTPIP1 functions in these pathways []. PSTPIP1 has been identified as a component of the leukocyte uropod that regulates endocytosis and cell migration []. It also controls extracellular matrix degradation and filopodia formation in macrophages []. It interacts with pyrin, a protein that associates with the cytoskeleton in myeloid/monocytic cells and modulates IL-1beta processing, NF-kappaB activation, and apoptosis []. Mutations in the PSTPIP1 gene have been linked to PAPA syndrome, an inflammatory disease [].Pombe Cdc15 homology (PCH) family proteins were initially identified as adaptor proteins involved in the regulation of cytokinesis and actin dynamics []. They share a similar domain architecture, consisting of an N-terminal FCH domain followed by a coiled coil (CC) region and by one or two C-terminal SH3 domains. However, in some family members the SH3 domain is absent (FCHO1, FCHO2 and PSTPIP2) or there are tissue-specific alternatively spliced isoforms with and without an SH3 domain (CIP4b, CIP4c, CIP4V, Fbp17b). PCH family proteins interact with receptors, adaptors, enzymes and structural proteins to regulate their localisation and activity. Through these interactions, PCH proteins regulate cell morphology and motility, organelle integrity, protein trafficking and the organisation of the actin cytoskeleton [].
Publication
First Author: Chitu V
Year: 2005
Journal: Mol Biol Cell
Title: The PCH family member MAYP/PSTPIP2 directly regulates F-actin bundling and enhances filopodia formation and motility in macrophages.
Volume: 16
Issue: 6
Pages: 2947-59
Publication
First Author: Grosse J
Year: 2006
Journal: Blood
Title: Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory disease.
Volume: 107
Issue: 8
Pages: 3350-8
Publication
First Author: Heath RJ
Year: 2008
Journal: J Cell Sci
Title: F-BAR domains: multifunctional regulators of membrane curvature.
Volume: 121
Issue: Pt 12
Pages: 1951-4
Protein
Organism: Mus musculus
Length: 334  
Fragment?: false
Protein
Organism: Mus musculus
Length: 873  
Fragment?: false
Protein
Organism: Mus musculus
Length: 334  
Fragment?: false
Protein
Organism: Mus musculus
Length: 334  
Fragment?: false
Protein
Organism: Mus musculus
Length: 415  
Fragment?: false
Protein
Organism: Mus musculus
Length: 415  
Fragment?: false
Publication
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7